DNA with Dr. Jay
With special permission from select people, Dr. Jay has recorded several actual DNA Consults! And the A.I. summary notes are excellent!
You can listen to these and get a feel for how a real-life DNA Consult might go. Episodes are found on YouTube and are DNA consults with people from all backgrounds. Click this Playlist Link to go straight to YouTube to listen in order. Detailed A.I. overviews and notes are also included below for each episode!
You can listen to these and get a feel for how a real-life DNA Consult might go. Episodes are found on YouTube and are DNA consults with people from all backgrounds. Click this Playlist Link to go straight to YouTube to listen in order. Detailed A.I. overviews and notes are also included below for each episode!
DNA with Dr. Jay, Episode 01.
MLB Pitcher David Aardsma
MLB Pitcher David Aardsma
Detailed A.I. Summary
**click here to read
Podcast Introduction and Personal Updates
00:00:00 - 00:01:48
Dr. J introduces his podcast on DNA consulting, highlighting unique client interactions and the insights gained. He mentions a recent conversation with an anti-poaching unit member in Africa. Dr. J emphasizes the power and limitations of DNA analysis, promoting his website (AJ consulting company dot com) and Patreon page (patreon.com/anthonyg) for podcast support. He also advertises a future podcast about fish and a free video on his Patreon page showcasing his family's fishing trip. He concludes the introduction by confirming readiness to begin the main discussion.
Lockdown Experiences and Location Clarification
00:01:50 - 00:02:28
Dr. J inquires about David's lockdown experience, learning that it's relatively relaxed compared to other areas. David describes spending quality time with his family. A brief clarification ensues regarding their locations: Dr. J is in Phoenix, Arizona, while David's location is not fully specified, but he mentions a more relaxed environment compared to other areas.
Dr. J's Mississippi Trip
00:02:33 - 00:04:23
Dr. J describes a family trip to Mississippi from Minnesota due to heavy April snowfall. The 18-hour drive was broken into two days with an overnight hotel stay. Most states en route were not under lockdown. They stayed in a beachfront Airbnb owned by a friend, who also owned a boat with twin 225 engines and a jetski. They spent time spear fishing for flounder at night, a technique called "gigging," using a sharpened stick. The family enjoyed fishing and sunshine. Dr. J also visited Covington, Louisiana, to see Brent Porcel at Top Velocity.
Facility Tour and Initial Impressions
00:04:23 - 00:05:37
Dr. J describes a positive experience meeting someone at a facility, noting impressive features like a display of autographed pro baseball jerseys. David corroborates the positive impression, mentioning multiple facility iterations over time and praising the current setup and the trainer, Brent Porcel, for his work with athletes. David credits Brent and Dr. J's podcasts for deepening his understanding of his body and training. The conversation highlights the facility as a supportive environment for athletic improvement.
DNA Report Comparison and Discussion
00:05:37 - 00:06:33
Dr. J acknowledges David's background as a pro baseball pitcher and mentions having analyzed both David's and Andrea's DNA reports. Dr. J notes significant differences in their athletic gene profiles. David expresses anticipation for a firsthand explanation of his DNA report, revealing he'd already checked one specific aspect.
Athleticism and Competitive Games
00:06:34 - 00:08:39
This segment begins with David and Andrea discussing pain tolerance and athletic abilities. David comments on Andrea's pain sensitivity, leading to a discussion about their athletic competitiveness in various sports. Andrea claims to have beaten David in most games they've played, excluding David's advantage in sports requiring significant power. David concedes that Andrea is a better athlete overall if power isn't a factor, but maintains an advantage when power is involved. Their discussion includes specific examples like basketball ("pop a shot"), golf, and pickleball, with Andrea pointing out recent wins in pickleball and tennis. Dr. J joins the conversation, expressing unfamiliarity with pickleball, prompting David to describe it as a game popular in Florida and Arizona. Andrea clarifies the rules, mentioning whiffle balls and paddles. Dr. J then mentions badminton, sharing a personal anecdote about playing it regularly in a swimming pool before marriage.
Discussion of a Rare Pain Sensitivity Gene
00:08:41 - 00:10:59
Andrea mentions pickleball. Dr. J reveals that Andrea and David share a rare gene linked to extremely low pain sensitivity, explaining their high pain tolerance. David confirms this observation, noting that both he and Andrea, as well as their children, exhibit this trait, although their children express pain differently emotionally. David describes his own experience with a major hip injury, attributing the severity to his delayed response to pain, and how this led him to seek further medical attention. He also mentions previous minor injuries and how he continued playing despite significant pain, worsening the damage.
David's Baseball Career and Family Life
00:10:59 - 00:12:56
Dr. J inquires about David's extensive baseball career, noting his Wikipedia page. David recounts playing professionally for 14 or 15 years with 14 different teams, listing them: Giants, Cubs, White Sox, Red Sox, Mariners, Yankees, Marlins, Indians, Orioles, Dodgers, Braves, Blue Jays, and one year in independent ball with the Long Island Ducks. He shares that his wife, Andrew, accompanied him throughout his career, experiencing various parts of the US with him, and that they have two sons born in Seattle and Phoenix. He mentions currently working in a front office and having a successful podcast, "The Bullpen with DA," with James Kudianos.
David's Podcast and Current Role
00:12:56 - 00:13:00
Dr. J asks about the duration of David's podcast, "The Bullpen with DA," which David states he ran for approximately a (the sentence cuts off here).
Transitioning from Podcast to Professional Baseball
00:13:01 - 00:13:59
David discusses his successful podcast experience and the reasons behind his decision to stop. He explains that his new job with the Blue Jays required him to cease podcasting due to potential conflicts of interest with the information he was privy to. While he enjoyed the podcast and collaboration with James, he understood the necessity of the decision, acknowledging the time commitment involved. He credits James for his significant contributions as a producer, highlighting the substantial time investment required from both of them. David reflects that neither he nor James would likely be able to manage the podcast's demands currently.
Discussing David's Athletic Genes and Pain Tolerance
00:14:04 - 00:14:56
Dr. J proposes starting the discussion with David's gym section within the pain tolerance section of the PDF, given his background as a professional baseball player. David expresses enthusiasm and acknowledges the extensive information presented. Dr. J briefly recaps the background information, noting that David and others were present during a previous discussion with Andrea. Dr. J explains the concept of having two copies of DNA in every cell, setting the stage for a deeper dive into the genetic aspects.
Genetic Analysis of Muscle Strength and Endurance
00:14:59 - 00:16:54
Dr. J explains that egg and sperm cells have only one copy of DNA, and when they fuse, the resulting offspring receives one copy from each parent. The discussion then shifts to the concept of "plus plus" and "plus minus," indicating the presence of good or bad gene versions inherited from both parents. Dr. J clarifies that the focus is on identifying bad genes to determine root causes and potential solutions. An exception is made for the ACVR1b gene, a good gene related to muscle strength, which is present in both individuals and their children. This gene provides increased muscle strength per volume, a trait common among professional athletes. The conversation then turns to the differences in muscle fiber types between the individuals' children, with one child possessing slow-twitch fiber types and additional rare endurance genes, while the other inherits the increased strength gene from both parents.
Joint Inflammation and Diet
00:16:55 - 00:19:04
Dr. J comments on David's impressive longevity despite genetic predisposition to joint inflammation, largely linked to carbohydrate intake. David reveals that he disregarded his diet until reaching peak velocity at age 15, attributing this to a fast metabolism. Later, he focused on reducing carbs, though not completely eliminating them. Dr. J explains that high insulin, triggered by many HLA genes, is the key factor in joint pain, not necessarily high blood sugar. He emphasizes that while high blood sugar often indicates high insulin, it's not always the case, depending on factors like muscle mass and activity level. Reducing carbs, especially simple carbs which spike insulin faster than complex carbs, is crucial for managing joint pain. David acknowledges his sweet tooth but notes that good muscle mass helps mitigate pain.
David's Joint Issues and Potential Underlying Causes
00:19:05 - 00:21:12
David discusses his history of joint problems, including a major hip surgery requiring reshaping of his femur head, and other surgeries. He attributes his recovery challenges to high sugar levels leading to inflammation. Dr. J agrees and suggests potential gluten sensitivity, noting that David's intense workout routine, even now, might exacerbate these issues. Dr. J mentions a surprising discovery of certain genes in David, potentially related to his condition, and highlights the "diO2 gene" related to the thyroid as an interesting finding.
Understanding Osteoarthritis and Rheumatoid Arthritis
00:21:14 - 00:23:19
Dr. J explains that the diO2 gene increases the risk of joint injuries, specifically osteoarthritis. David expresses unfamiliarity with the difference between osteoarthritis and rheumatoid arthritis. Dr. J clarifies that she learned the distinction while working with orthopedic surgeons at the Mayo Clinic. Rheumatoid arthritis is an autoimmune disease where the immune system attacks the joints, similar to the inflammatory response seen with carbs and insulin. Osteoarthritis, conversely, involves the degradation of soft tissue over time, leading to bone-on-bone friction and pain. Dr. J notes that suboptimal thyroid hormones increase the risk of osteoarthritis, especially with age, as thyroid hormone levels naturally decline. She recommends iodine supplementation for thyroid health, confirming that Andrea, who has Hashimoto's and takes selenium with iodine, is already following this advice. Dr. J concludes by recommending iodine supplementation to David as well to maintain healthy thyroid hormone levels.
Micronutrient Discussion and Joint Health
00:23:19 - 00:25:25
Dr. J suggests providing the body with building blocks for thyroid hormones to prevent bone-on-bone issues and osteoarthritis. David mentions selenium, and Dr. J notes that selenium supplementation is a matter of personal preference. The conversation shifts to chromium, a micronutrient that Dr. J relates to a sweet tooth; a chromium deficiency may manifest as a strong sweet craving, which disappears with supplementation. Dr. J suggests chromium supplementation for David's joint issues, given his high-intensity workout routine and potential for increased carb consumption. David explains his carb intake strategy, aiming for morning consumption before workouts and limiting intake on less active days. Dr. J affirms David's exercise routine as beneficial for joint health, noting the positive impact of increased blood flow.
Low Back Issues and Weightlifting
00:25:26 - 00:27:26
This segment discusses the participants' experiences with low back issues and weightlifting. Dr. J shares his personal experience of overcoming yearly back problems through deadlifting, contrasting it with the advice he initially received against it. David mentions his strong low back and reveals he recently started learning snatches, even practicing them before the call, aiming for Olympic participation in the future. Dr. J expresses excitement about David's new endeavor. Finally, Andrea shares that she incorporates deadlifts into her routine to alleviate back pain before performing clean and jerks and snatches.
Benefits and Experiences with Core Strengthening and Deadlifting
00:27:27 - 00:29:39
Andrea notes that core flexion throughout the day has been beneficial. Dr. J agrees, mentioning the importance of core strength to avoid excessive pressure on spinal discs. Dr. J shares their experience with deadlifting, highlighting its role in strengthening low back muscles, a skill they felt they'd missed out on earlier. They discuss the stigma surrounding deadlifting for women, with Dr. J emphasizing that it's beneficial for both genders and doesn't necessarily lead to excessive muscle growth. Andrea recounts her long-term experience with weight training, initially motivated by improving her performance in sports like softball, basketball, and volleyball. She mentions working out with David, who initially disliked leg workouts, and how he eventually started training with Keith at Physio or Pro Advantage. Andrea's training began in eighth grade, aiming to enhance her ability to spike volleyballs. Dr. J connects squatting to improved vertical jump and observes children naturally squatting, highlighting the natural movement pattern.
Early Childhood Fitness and Strength Training
00:29:41 - 00:31:48
Dr. J observes the impressive squatting ability of children, noting their naturally open hips. Dr. J emphasizes the importance of teaching proper lifting techniques, such as deadlifts, from a young age to prevent back injuries from improper bending. Andrea shares that she and her husband incorporate 15 push-ups and 15 squats into their children's daily routine as a condition for iPad use, after completing schoolwork and chores. Dr. J highlights the effectiveness of this approach, relating a story about her son's participation in a tractor pull competition. This event motivated her son and other children to increase their daily squats to approximately 100, leveraging the child's enthusiasm for the competition to improve their fitness. Dr. J finds it amusing to watch the children's exertion during these activities, noting the visible strain and increased blood pressure.
Blood Pressure and Genetic Predisposition
00:31:48 - 00:33:08
Dr. J expresses doubt about David having a gene linked to high blood pressure, noting David's history of low blood pressure despite inconsistent test results in spring training. Dr. J then highlights David's genetic predisposition to strong bones, suggesting a DEXA scan would likely reveal high bone density. The discussion shifts to the weighting of good versus bad genes, with Dr. J explaining the process of assessing their offsetting effects. Finally, Dr. J mentions David's pain sensitivity (previously discussed) and concludes that David's athletic genes are exceptional.
Dietary Recommendations and Aging
00:33:08 - 00:34:03
Dr. J emphasizes the importance of carb intake as David ages, referencing David's mention of the keto diet. The conversation touches upon the potential benefits of keto for joint pain. Dr. J shares his personal experience with intermittent keto diets, explaining that while beneficial for short periods (6 weeks), prolonged use disrupts sleep cycles due to increased brain activity.
Genetic Predisposition and Exercise Recommendations
00:34:03 - 00:36:12
Dr. J discusses the patient's genetic profile, highlighting genes related to inflammation (MEGF10) and their connection to both Alzheimer's risk and muscle development. Exercise, specifically muscle growth, is emphasized as crucial for mitigating potential risks associated with these genes. Dr. J explains that while exercise benefits everyone, it's particularly important for this patient due to their genetic makeup. The conversation then shifts to the BDNF gene and its role in brain health. Dr. J clarifies that while some individuals benefit from endurance exercise to increase BDNF levels, this patient's genetic profile suggests that building muscle mass is key for optimal brain function. The patient, David, seeks clarification on the type of exercise recommended, confirming his understanding that building muscle mass ("getting yoked") is the primary goal, considering his bone density.
The Effects of Exercise on Cognitive Function and Energy Levels
00:36:13 - 00:38:27
David discusses his need for a high-protein, high-carb diet to maintain optimal brain function, noting that neglecting exercise negatively impacts his cognitive abilities. Dr. J corroborates this, referencing Joe Rogan's similar experiences and highlighting the paradoxical perception of athletes as "meatheads" despite their intelligence. David confirms that while exercise initially causes fatigue, it ultimately boosts his energy and productivity later. Andrea, conversely, reports experiencing an immediate surge in energy after exercise, to the point of being overwhelming for David. Dr. J attributes Andrea's high energy levels to her endurance genes, common among elite athletes, further explaining the scientific literature supporting this observation.
Genetic Predisposition and Developed Mental Fortitude in Athletic Performance
00:38:29 - 00:40:28
This segment discusses the interplay between genetic predisposition and developed mental fortitude in athletic performance. David explains that while he lacks the endurance genes typical of Olympic runners, he compensates through intense, almost compulsive training driven by a fear of missing opportunities. He describes his training regimen, emphasizing his long hours and dedication. Dr. J supports this by mentioning examples of athletes with extreme endurance genes, contrasting them with power athletes who have trained to tap into both endurance and power circuits. The conversation highlights the case of a baseball pitcher who improves his performance throughout the game, suggesting that training can overcome genetic limitations to a certain extent. Andrea concludes by expressing her fascination with this dynamic.
Andrea and David's Differing Responses to Stress and Sex
00:40:29 - 00:42:50
Andrea describes her physical response to weightlifting, noting she can easily do several repetitions. She then contrasts her energy levels after sex, explaining that nighttime intimacy leaves her awake until very late, while morning sex energizes her. Dr. J introduces the topic of oxytocin receptors, pointing out a significant difference between Andrea and David's DNA profiles. Andrea shows no oxytocin receptor issues, while David's profile indicates he's less able to handle stress without sufficient oxytocin. Dr. J suggests that dark chocolate, which boosts oxytocin, could benefit David. The doctor mentions biohackers who inject oxytocin, though this is not recommended. The conversation concludes with Dr. J emphasizing that anything increasing oxytocin during stressful periods is beneficial, and David commenting on his generally good stress management.
Gluten's Impact on Alzheimer's Risk and Systemic Inflammation
00:42:58 - 00:44:53
Dr. J revisits the TATAP2 gene, an Alzheimer's risk gene linked to celiac disease and triggered by gluten. Gluten-induced gut inflammation potentially leads to brain inflammation due to inflammatory chemicals like TNFα, interleukin, and interferon circulating in the bloodstream. These chemicals signal the immune system to attack, even without infection, potentially causing it to attack the body's own cells. Dr. J explains this process using the example of a cut, where inflammatory chemicals attract the immune system to fight bacteria. However, without an infection, this process can lead to self-attacking inflammation. David expresses interest, noting he hadn't previously heard of this concept. Dr. J recommends the book "Grain Brain" by David Perlmutter as a further resource.
Gluten Sensitivity and Brain Health
00:44:55 - 00:46:58
Dr. J presents a strong argument for the connection between God issues, brain health, gluten sensitivities, and grain consumption, suggesting further research into "grain brain." David expresses interest. Dr. J notes Andrea's and her own gluten sensitivities, recommending a mostly grain-free diet for long-term brain health, though occasional consumption is acceptable. Andrea asks about implementing this with their children. Dr. J explains that both she and Andrea have a relevant gene (TAP2), impacting them differently (gut for Andrea, brain for David). Dr. J shares her experience with her children, noting a significant behavioral shift (tantrums, emotional outbursts) when they consume gluten or grains. The discussion highlights the potential impact of gluten and grains on brain health and behavior, particularly in individuals with relevant genetic predispositions.
Children's Health and Diet
00:46:58 - 00:48:20
Dr. J discusses the importance of exercise for children's well-being, noting its positive impact on their health. Andrea shares concerns about her older son's frequent headaches and relates her own childhood experiences to his current situation. The conversation then shifts to dietary habits, with Andrea mentioning her younger son's fondness for pizza and brownies. Dr. J reveals a personal gluten sensitivity despite enjoying pizza, leading to a discussion about the availability and quality of gluten-free pizza options. Dr. J mentions a favorite Korean pizza place in the Twin Cities known for its wood-fired pizzas.
Caffeine Metabolism and Individual Differences
00:48:20 - 00:49:05
Dr. J initiates a discussion about caffeine metabolism, clarifying the differences between Andrea and David's responses to caffeine. Andrea processes caffeine quickly, while David metabolizes it slowly. Dr. J explains this difference, noting that Andrea eliminates caffeine rapidly, whereas David retains it for a longer duration. David confirms this observation, sharing a personal anecdote about the lingering effects of caffeine from the previous night.
Caffeine and Supplement Intake Discussion
00:49:12 - 00:51:11
David describes his caffeine consumption, including margaritas and a pre-workout supplement called P4 (150mg caffeine per scoop). He usually takes one scoop and also uses "amino energy" (100mg caffeine) with amino acids and creatine, increasing his creatine intake based on nutritionist recommendations. Andrea mentions using the same P4 supplement. Dr. J inquires about the "plus plus" coding in their system, explaining that it indicates both fast and slow caffeine metabolism, neither inherently bad, but requiring personalized strategies. Dr. J reveals that he created software to categorize caffeine metabolism, with "plus plus" representing both extremes. He and Andrea share the same gene related to caffeine metabolism, coded as "plus plus".
Software Explanation and Lifespan Genes
00:51:13 - 00:53:14
Andrea inquires about distinguishing differences in metabolic rates between herself and another individual, both possessing a "plus plus" genetic marker. Dr. J explains that the distinction is due to software coding, using the difference in metabolic rates as a simple explanation. David compliments Dr. J's quick thinking. Dr. J then discusses the last category, lifespan, noting that both individuals possess excellent lifespan genes except for a deficiency in the SIRT gene. Dr. J recounts the excitement surrounding the discovery of the SIRT gene in the 1990s, when it was believed to hold the key to curing aging due to its impact on mice lifespan. However, Dr. J clarifies that while increasing SIRTuin levels does not cure aging, it does offer some lifespan benefits.
Supplement and Longevity Discussion
00:53:15 - 00:54:11
Dr. J explains that grape seed proanthocyanins are a good supplement for longevity and healthspan. Andrea asks if red wine helps, and Dr. J confirms it affects the same gene. David points out that red wine contains more sugar and can trigger inflammation, while Dr. J notes that a large quantity of red wine would be needed to match the benefits of grape seed extract. The conversation then shifts to a summary of the brain health section, with Dr. J asking if there are any further questions before moving on to the diet section. David expresses satisfaction with the clarity of the brain health section and summarizes his key takeaways: paying attention to gluten, working out, consuming dark chocolate when stressed, and incorporating grape seed extract into his diet.
Diet and Melatonin Discussion
00:54:11 - 00:55:25
The discussion moves to diet, with Dr. J inquiring about David's experience with melatonin. David mentions using it for sleep, generally taking half the recommended dose to avoid morning grogginess. He explains that his melatonin use is primarily to help him fall asleep. David then mentions that his wife, Andrea, has concerns about his sleep habits while on melatonin, specifically his snoring and tossing and turning. Andrea confirms this, describing his movements as being like "a fish out of water."
Melatonin Use and Sleep Quality
00:55:26 - 00:57:37
David describes his use of melatonin to improve sleep, noting it helps with restless legs syndrome and sleep disturbances caused by alcohol consumption or late workouts. He mentions that despite better sleep, he tosses and turns, snoring and moving around. Dr. J suggests that electrolytes, particularly magnesium, might help with the tossing and turning. Dr. J then points out a connection between David's melatonin receptor gene and a risk for higher blood sugar, noting that in David's case, melatonin use might actually help regulate blood sugar due to its link to insulin sensitivity. This is further discussed in relation to its positive effects on joints. The conversation is briefly interrupted by a UPS delivery.
Melatonin Dosage and Metabolism
00:57:40 - 00:59:07
Dr. J explains that David's body processes carbohydrates better with melatonin, regardless of sleep benefits. David discusses his melatonin usage, noting that taking it two hours before bed, as suggested (1-10mg), makes him fall asleep 30 minutes earlier than intended. Dr. J explains that melatonin production naturally increases two hours before sleep, and David's fast metabolism causes rapid absorption of the melatonin, leading to the early sleep onset. Dr. J confirms this is due to David's fast metabolism, not necessarily a negative aspect as long as he's aware of it. David agrees, stating that as long as he manages it, it's fine. Dr. J emphasizes the importance of exercise and the SLC38 gene, which indicates zinc's role in blood sugar regulation.
Zinc Intake and Red Meat Consumption
00:59:07 - 00:59:39
Dr. J recommends ensuring sufficient zinc intake, noting that red meat consumption usually provides enough. David confirms his high red meat consumption. Andrea inquires about specific zinc supplements, mentioning "zinc pickle" or a similar product.
Zinc Supplementation and Diet
00:59:40 - 01:01:17
Dr. J discusses zinc supplementation, noting some individuals experience acid reflux with certain zinc supplements. He recommends zinc carnitine due to better gut tolerance, clarifying it's not superior but easier on the digestive system. He mentions this information is available on his website. David mentions his red meat consumption isn't consistent, incorporating pork and chicken for dietary variety. He notes that when they do consume red meat, they eat significant amounts. Dr. J agrees with supplementing zinc on days when red meat isn't consumed. Dr. J adds that zinc is beneficial, especially in fighting viruses like COVID, referencing its importance in previous SARS outbreaks.
Vitamin D and Viral Immunity
01:01:17 - 01:01:46
Andrea interjects, mentioning vitamin D's role in fighting viruses, confirming its inclusion on Dr. J's list. Dr. J acknowledges this, indicating it's covered in the next section, playfully cautioning against jumping ahead.
Heart Disease Risk and Iron Levels
01:01:46 - 01:03:38
Dr. J briefly discusses intermittent fasting as a potential future consideration for David, contingent on any slowdown in his exercise regimen. The conversation then shifts to a heart disease gene, SOD2, and its connection to metformin and iron levels. Dr. J confirms that David doesn't possess a specific heart disease risk associated with this gene, but highlights that high blood iron significantly increases the risk of heart disease, specifically heart attacks. Dr. J emphasizes the importance of regularly checking iron levels during blood work. David inquires about lowering high iron levels, and Dr. J suggests blood donation as the most effective method, acknowledging it might be extreme for some. David expresses his dislike of needles but indicates a willingness to donate blood if necessary, prompting Dr. J to encourage him based on his perceived high pain tolerance.
Iron Levels and Health Recommendations
01:03:38 - 01:04:53
Dr. J discusses David's blood test results, focusing on high iron levels. Dr. J suggests reducing red meat consumption to lower iron, but notes that David's active lifestyle and metabolism might already be counteracting high iron. A specific gene is highlighted as a significant factor contributing to high iron levels. The potential risks associated with high iron are mentioned, and Dr. J emphasizes the importance of monitoring this specific gene due to its potential impact.
Hyaluronic Acid and Joint Health
01:04:53 - 01:05:31
Dr. J recommends hyaluronic acid supplements or bone broth to improve joint health, explaining that David possesses a rare gene (HABP2) linked to a higher risk of artery plaque. The conversation includes a brief exchange about bone broth preparation and its relation to hyaluronic acid. Dr. J clarifies the recommendation of hyaluronic acid supplementation due to the presence of the HABP2 gene.
Hyaluronic Acid and Joint Health
01:05:31 - 01:06:18
Dr. J explains that hyaluronic acid is a building block for soft tissues like the meniscus in the knee. It's also a component of arteries, contributing to their flexibility. While beneficial for joints, for David, the focus is on its role in arterial health, promoting flexibility and better blood flow. David expresses interest but notes their family isn't inclined towards making bone broth, and he'll research the supplement further.
Gut Health Analysis and NOD2 Genes
01:06:19 - 01:07:27
Dr. J mentions David's gut health report shows numerous genes lighting up, particularly NOD2 genes. While this initially seems concerning, Dr. J clarifies that these are "NOD2 minor" genes with minimal impact, despite the seemingly large number. This contrasts with another patient who had only two genes in this category, highlighting the relative nature of the findings. Dr. J also mentions ketosis in relation to David's gut health.
Keto Diet and Gut Health
01:07:33 - 01:09:26
Dr. J explains that inflammasomes in the gut contribute to inflammation, and ketones are effective in shutting them off. Ketones can be supplemented or achieved through ketosis, which may naturally occur during sleep for individuals with good blood sugar and high training volume. For gut issues, Dr. J recommends a ketogenic diet. David inquires about the keto diet's key aspects. Dr. J emphasizes that a common mistake is consuming too much protein, as the body can convert protein into sugar, unlike fat. The ideal protein intake is highly individual, depending on factors like body size and training intensity. Measuring ketone levels through breathalyzers or finger-prick tests can help monitor ketosis.
Ketone Testing and its Implications
01:09:27 - 01:10:15
Dr. J describes a blood ketone meter, comparing it to blood sugar meters used by diabetics. He explains that while he occasionally uses a ketone meter to monitor his ketosis levels and diet effectiveness, he finds the frequent finger pricking unpleasant. He notes that children with diabetes must do this regularly, highlighting the inconvenience.
Vitamin D Discussion and Arizona Lifestyle
01:10:18 - 01:10:57
Dr. J transitions to discussing vitamins, starting with vitamin D. He inquires about David's sun exposure in Arizona, given the state's sunny climate. David confirms significant sun exposure through various outdoor activities, including pool time, hiking, and dog walks, even actively seeking a tan. The conversation is cut short before David can fully explain his Florida activities.
Vitamin D Levels and Dietary Recommendations
01:10:58 - 01:12:37
Dr. J discusses David's vitamin D levels, suggesting that given his outdoor activities (paddle boarding, beach time), he should check his blood work for vitamin D levels. Dr. J notes that David's genes may present more challenges in this area than Andrea's, recommending supplementation to optimize levels, especially considering seasonal variations. The conversation then shifts to dietary oils, with Dr. J advising David to avoid seed oils like soybean and canola oil, and even grape seed oil, unlike Andrea. Dr. J suggests sticking to fruit-based oils such as avocado and coconut oil for cooking. David mentions his preference for avocado oil and that Andrea is the primary cook in the family.
Avocado Oil and Pesticide Exposure
01:12:38 - 01:14:45
This segment focuses on David's health concerns, specifically regarding pesticide exposure and its potential impact on his hormone levels. Dr. J suggests that avocado oil is a key factor in his diet. While not overly concerned about organic phosphate pesticides in David's diet, Dr. J mentions that public area spraying with these pesticides in Florida can affect the body's ability to clear them efficiently. The conversation then shifts to the FAM9B gene, which may lower testosterone levels, but lacks sufficient research. Dr. J explains the limited understanding of this gene and its effects, suggesting that monitoring testosterone levels as David ages might be necessary, and that maintaining muscle mass through training is preventative against low testosterone. David expresses his interest in understanding his testosterone levels, particularly given his professional baseball background and the need to avoid substances that could lead to doping violations. He highlights the careful approach he's always taken regarding supplements and medications, even after retiring from professional play.
Low Testosterone Levels in American Men
01:14:45 - 01:16:57
Andrea inquires about the low testosterone levels observed in American men and the adjustment of normal ranges to include suboptimally low levels. She mentions her use of both Eastern and Western medicine, noting discrepancies in normal ranges between the two approaches. Dr. J attributes the low testosterone levels to exposure to artificial estrogens, citing soy products, BPA from plastics, and other personal care chemicals as examples. Dr. J emphasizes that while the extent of their impact is debated, these substances act like estrogen. The conversation then shifts to a study on frogs exposed to atrazine, a herbicide. Dr. J highlights that even at 200 nanograms per liter, atrazine can transform male frogs into females, while the US allows 3000 nanograms per liter in drinking water. This leads to a discussion of "male feminization" as a consequence of high atrazine exposure and its connection to lowered testosterone levels.
Lowering Testosterone and Puberty Ranges
01:16:58 - 01:19:12
Dr. J discusses how cultural factors are leading to lower testosterone levels, particularly impacting puberty onset in girls. The lowering of normal ranges for testosterone and puberty is mentioned, citing research journals arguing for adjustments due to earlier puberty onset in girls, attributed to estrogen exposure. Andrea raises concerns about potential estrogen sources from plastics and rubber, referencing a study linking artificial grass to cancer in soccer players. Dr. J clarifies that cancer risks are generally separate from estrogen issues, except for breast cancer. Andrea asks about spelling and finding estrogen levels, leading Dr. J to recommend the website EWG.org for checking water levels and chemical contaminants in specific areas. Atrazine (A-T-R-A-Z-I-N-E) is mentioned as a specific chemical to look for. Dr. J uses Rochester, Minnesota as an example, highlighting seven chemicals exceeding government limits in their water supply, emphasizing widespread water contamination issues.
Water Fluoridation and its Effects
01:19:13 - 01:21:19
Dr. J expresses concern about high government limits on certain substances, noting that exceeding them is problematic. They mention using a whole-house water filter. Andrea agrees, but points out the counterargument regarding fluoride's role in preventing cavities. Dr. J counters that sufficient fluoride is obtained through a healthy diet, citing a Harvard researcher who has maintained excellent dental health for 20 years without fluoride, using only water and an electric toothbrush. Dr. J personally avoids high levels of fluoride due to potential thyroid issues, emphasizing that low levels from food are beneficial, while high levels present various problems. Dr. J criticizes the sketchy research from the 1980s that promoted water fluoridation, citing a study using cow teeth in acidic water with and without fluoride to illustrate questionable methodology. The study's conclusion that fluoride protected against degradation is questioned.
Questioning the Efficacy of Fluoride
01:21:20 - 01:23:17
Dr. J discusses a study used to advocate for widespread fluoride use, explaining that a more recent study using better technology and higher fluoride doses found fluoride's effectiveness questionable. Population-based studies comparing towns with and without fluoridated water show no significant difference in cavity rates. Dr. J notes that dentists often recommend fluoride treatments based on outdated information learned in dental school, similar to how doctors prescribe statins without fully understanding the potential side effects. Andrea expresses interest in the topic, and Dr. J mentions creating YouTube videos on fluoride research after investigating it due to concerns about his children's health.
Fluoride and Cavities
01:23:17 - 01:24:19
Dr. J shares their experience of never having cavities despite foregoing fluoride for five to ten years. Andrea mentions getting her first cavity recently, contrasting with her son's numerous cavities. The conversation then shifts to supplements, with Andrea noting she's preparing a list of supplements (zinc, magnesium, and others) for David.
Reliable Testosterone Testing
01:24:21 - 01:25:24
David expresses concern about finding a reputable place to get his testosterone tested, fearing bias towards unnecessary treatments. He worries that many clinics prioritize sales over patient well-being. Dr. J suggests using large testing corporations like Quest Diagnostics, emphasizing that a doctor's order is necessary for the test.
Blood Test Recommendations and Estrogen/Testosterone Discussion
01:25:24 - 01:27:33
Dr. J recommends getting both total and free testosterone blood tests, suggesting private mdlabs.com as an alternative to traditional doctor's offices and Quest Diagnostics. He notes that while the website allows users to select their desired tests, blood collection still requires a clinic visit. Dr. J then discusses David's estrogen gene results, noting a balance between genes indicating both high and low estrogen levels, suggesting they likely offset each other. He expresses less concern about David's estrogen levels, especially given his training regimen. David interjects, mentioning his high consumption of cruciferous vegetables like broccoli, cauliflower, Brussels sprouts, and kale, which Dr. J identifies as brassicas and credits with potentially contributing to maintaining high testosterone levels. David adds a comment about a previous experience, mentioning "Brent por," before the excerpt ends.
Training and Nutritional Guidance
01:27:33 - 01:29:38
David discusses his training regimen, emphasizing the importance of comprehensive nutritional intake. Dr. J commends a colleague for ensuring David's nutritional needs are met. They then review David's thyroid health, focusing on iodine levels. Dr. J suggests monitoring thyroid hormones alongside iodine levels. The conversation shifts to a gene analysis, specifically a B12 category on the following pages. Dr. J notes David's excellent B12 uptake, negating the need for supplementation. The discussion turns to David's multivitamin usage, which is inconsistent due to availability. Dr. J cautions against multivitamins containing tocopherols, a synthetic form of vitamin E, due to its potential to increase interleukin-6 levels. Dr. J advises David to check multivitamin labels for tocopherols and opt for alternative forms of vitamin E if available; otherwise, he recommends avoiding multivitamins altogether. David expresses interest in this information.
Multivitamin Considerations and Nutritional Gene Interactions
01:29:39 - 01:31:52
Dr. J discusses the challenges of finding multivitamins with good Vitamin E (specifically tocotrienols), noting the confusing terminology and suggesting a simple approach for consumers. He explains that some multivitamin studies show no overall benefit due to inflammation in some individuals, recommending avoidance for those susceptible. The conversation then shifts to fructose metabolism, highlighting a gene that predisposes individuals to store fructose as fat rather than burning it for energy. Dr. J cautions against excessive fructose consumption, using bananas as an example. David shares a personal anecdote about his changed preference for bananas, linking it to increased training intensity. Andrea briefly comments on fructose and children.
Pre-Sleep Snack Recommendations
01:31:56 - 01:33:57
David inquired about a suitable pre-sleep snack that wouldn't disrupt his sleep, given his late bedtime after gaming. Dr. J noted the high potassium content in bananas and its potential benefit for sleep due to David's ABC C9 gene, which is potassium-dependent. Andrea suggested sweet potatoes as an alternative, having higher potassium than bananas. Dr. J agreed, mentioning other potassium-rich foods like coconut and broccoli, while advising against high-fructose options. He recommended berries as a low-fructose alternative, with blueberries potentially having slightly higher fructose content than others like strawberries and blackberries. The discussion centered on finding potassium-rich, low-fructose foods to optimize sleep quality.
Fructose and Fatty Liver
01:33:58 - 01:35:23
Dr. J discusses a Romanian patient who, despite being slender, had a fatty liver due to high fruit consumption and a genetic predisposition to storing fructose as fat. The conversation highlights the potential negative impact of excessive fructose intake, even from seemingly healthy fruits like berries. Dr. J emphasizes that high fructose intake can lead to fat accumulation in the liver, which is undesirable. The discussion then transitions to the importance of potassium and magnesium supplementation, noting that many Americans are deficient in these minerals. Dr. J suggests that magnesium supplementation is beneficial based on individual symptoms.
Fruit Consumption and Dietary Recommendations
01:35:23 - 01:36:00
David asks for dietary advice regarding his morning routine of consuming an apple, banana, and protein bar before exercise. Dr. J suggests replacing the apple and banana with lower-fructose options such as apricots, cantaloupe, or berries, citing peaches as an example of a fruit with lower fructose content (two grams per peach). The discussion focuses on reducing fructose intake while maintaining a balanced diet.
Finalizing Recommendations and Individualized Approach
01:36:05 - 01:38:11
Dr. J suggests reviewing a website link for glucose-related information, highlighting various options available. Dr. J expresses satisfaction with the progress, offering to revisit any topics if needed. David expresses gratitude, noting he's taken detailed notes, focusing on 20 key areas. He emphasizes the importance of this individualized approach, contrasting it with a "one-size-fits-all" method. David highlights the value of this approach for his athletes, emphasizing the need to understand individual needs rather than applying a blanket approach to player care. He points out the limitations of a generalized approach, noting its ineffectiveness for some athletes. Dr. J agrees, criticizing the current medical system's broad approach and its limitations in providing truly individualized care.
Individualized Health Approach and System Optimization
01:38:13 - 01:40:25
Dr. J advocates for individualized medicine, suggesting it's a superior approach to a one-size-fits-all system, even within the medical field. David agrees, emphasizing the importance of personalized care to reduce strain on the healthcare system and ultimately lower individual costs. He argues that proactive personal health management reduces the need for extensive medical intervention. Andrea joins the discussion, sharing her experience of encouraging David to adopt a gluten-free diet to alleviate his nasal congestion. She notes his improved condition when consuming gluten-free beer, highlighting the potential impact of dietary changes. Dr. J concludes by observing that sensitivity to genetic factors increases with age, making personalized approaches increasingly relevant. Andrea expresses gratitude for participating in the discussion and looks forward to comparing her and David's health data to identify areas for improvement in their workouts and nutrition.
File Transfer and Podcast Discussion
40:25 - 01:42:41
David proposes sending a file via Gmail and Google Drive, citing past issues with Dropbox storage. He will notify Dr. J upon sending. Dr. J expresses gratitude for the time spent and highlights the importance and broad appeal of the discussed information. David emphasizes the podcast's universal relevance, extending beyond specific demographics like athletes, and asserts its value for anyone concerned about their health and well-being. He contrasts this with his previous baseball-focused podcast, which had a more niche audience. A second speaker agrees, emphasizing the importance of the information and its potential impact on listeners' lives, even if some might not find the specific details inherently interesting.
Addressing Concerns and Finding Solutions
01:42:42 - 01:44:11
SPEAKER_02 expresses relief at discovering the root cause of a problem, highlighting the importance of having the correct information. SPEAKER_01 discusses the cost-benefit analysis of a solution, emphasizing long-term savings and improved lifestyle. David emphasizes that certain issues are priceless and shouldn't be compromised for financial reasons. Dr. J agrees, expresses gratitude for the conversation, and offers continued support and contact. David reciprocates the gratitude, commits to staying in touch, and offers referrals if needed. The conversation concludes with mutual farewells and thanks.
00:00:00 - 00:01:48
Dr. J introduces his podcast on DNA consulting, highlighting unique client interactions and the insights gained. He mentions a recent conversation with an anti-poaching unit member in Africa. Dr. J emphasizes the power and limitations of DNA analysis, promoting his website (AJ consulting company dot com) and Patreon page (patreon.com/anthonyg) for podcast support. He also advertises a future podcast about fish and a free video on his Patreon page showcasing his family's fishing trip. He concludes the introduction by confirming readiness to begin the main discussion.
Lockdown Experiences and Location Clarification
00:01:50 - 00:02:28
Dr. J inquires about David's lockdown experience, learning that it's relatively relaxed compared to other areas. David describes spending quality time with his family. A brief clarification ensues regarding their locations: Dr. J is in Phoenix, Arizona, while David's location is not fully specified, but he mentions a more relaxed environment compared to other areas.
Dr. J's Mississippi Trip
00:02:33 - 00:04:23
Dr. J describes a family trip to Mississippi from Minnesota due to heavy April snowfall. The 18-hour drive was broken into two days with an overnight hotel stay. Most states en route were not under lockdown. They stayed in a beachfront Airbnb owned by a friend, who also owned a boat with twin 225 engines and a jetski. They spent time spear fishing for flounder at night, a technique called "gigging," using a sharpened stick. The family enjoyed fishing and sunshine. Dr. J also visited Covington, Louisiana, to see Brent Porcel at Top Velocity.
Facility Tour and Initial Impressions
00:04:23 - 00:05:37
Dr. J describes a positive experience meeting someone at a facility, noting impressive features like a display of autographed pro baseball jerseys. David corroborates the positive impression, mentioning multiple facility iterations over time and praising the current setup and the trainer, Brent Porcel, for his work with athletes. David credits Brent and Dr. J's podcasts for deepening his understanding of his body and training. The conversation highlights the facility as a supportive environment for athletic improvement.
DNA Report Comparison and Discussion
00:05:37 - 00:06:33
Dr. J acknowledges David's background as a pro baseball pitcher and mentions having analyzed both David's and Andrea's DNA reports. Dr. J notes significant differences in their athletic gene profiles. David expresses anticipation for a firsthand explanation of his DNA report, revealing he'd already checked one specific aspect.
Athleticism and Competitive Games
00:06:34 - 00:08:39
This segment begins with David and Andrea discussing pain tolerance and athletic abilities. David comments on Andrea's pain sensitivity, leading to a discussion about their athletic competitiveness in various sports. Andrea claims to have beaten David in most games they've played, excluding David's advantage in sports requiring significant power. David concedes that Andrea is a better athlete overall if power isn't a factor, but maintains an advantage when power is involved. Their discussion includes specific examples like basketball ("pop a shot"), golf, and pickleball, with Andrea pointing out recent wins in pickleball and tennis. Dr. J joins the conversation, expressing unfamiliarity with pickleball, prompting David to describe it as a game popular in Florida and Arizona. Andrea clarifies the rules, mentioning whiffle balls and paddles. Dr. J then mentions badminton, sharing a personal anecdote about playing it regularly in a swimming pool before marriage.
Discussion of a Rare Pain Sensitivity Gene
00:08:41 - 00:10:59
Andrea mentions pickleball. Dr. J reveals that Andrea and David share a rare gene linked to extremely low pain sensitivity, explaining their high pain tolerance. David confirms this observation, noting that both he and Andrea, as well as their children, exhibit this trait, although their children express pain differently emotionally. David describes his own experience with a major hip injury, attributing the severity to his delayed response to pain, and how this led him to seek further medical attention. He also mentions previous minor injuries and how he continued playing despite significant pain, worsening the damage.
David's Baseball Career and Family Life
00:10:59 - 00:12:56
Dr. J inquires about David's extensive baseball career, noting his Wikipedia page. David recounts playing professionally for 14 or 15 years with 14 different teams, listing them: Giants, Cubs, White Sox, Red Sox, Mariners, Yankees, Marlins, Indians, Orioles, Dodgers, Braves, Blue Jays, and one year in independent ball with the Long Island Ducks. He shares that his wife, Andrew, accompanied him throughout his career, experiencing various parts of the US with him, and that they have two sons born in Seattle and Phoenix. He mentions currently working in a front office and having a successful podcast, "The Bullpen with DA," with James Kudianos.
David's Podcast and Current Role
00:12:56 - 00:13:00
Dr. J asks about the duration of David's podcast, "The Bullpen with DA," which David states he ran for approximately a (the sentence cuts off here).
Transitioning from Podcast to Professional Baseball
00:13:01 - 00:13:59
David discusses his successful podcast experience and the reasons behind his decision to stop. He explains that his new job with the Blue Jays required him to cease podcasting due to potential conflicts of interest with the information he was privy to. While he enjoyed the podcast and collaboration with James, he understood the necessity of the decision, acknowledging the time commitment involved. He credits James for his significant contributions as a producer, highlighting the substantial time investment required from both of them. David reflects that neither he nor James would likely be able to manage the podcast's demands currently.
Discussing David's Athletic Genes and Pain Tolerance
00:14:04 - 00:14:56
Dr. J proposes starting the discussion with David's gym section within the pain tolerance section of the PDF, given his background as a professional baseball player. David expresses enthusiasm and acknowledges the extensive information presented. Dr. J briefly recaps the background information, noting that David and others were present during a previous discussion with Andrea. Dr. J explains the concept of having two copies of DNA in every cell, setting the stage for a deeper dive into the genetic aspects.
Genetic Analysis of Muscle Strength and Endurance
00:14:59 - 00:16:54
Dr. J explains that egg and sperm cells have only one copy of DNA, and when they fuse, the resulting offspring receives one copy from each parent. The discussion then shifts to the concept of "plus plus" and "plus minus," indicating the presence of good or bad gene versions inherited from both parents. Dr. J clarifies that the focus is on identifying bad genes to determine root causes and potential solutions. An exception is made for the ACVR1b gene, a good gene related to muscle strength, which is present in both individuals and their children. This gene provides increased muscle strength per volume, a trait common among professional athletes. The conversation then turns to the differences in muscle fiber types between the individuals' children, with one child possessing slow-twitch fiber types and additional rare endurance genes, while the other inherits the increased strength gene from both parents.
Joint Inflammation and Diet
00:16:55 - 00:19:04
Dr. J comments on David's impressive longevity despite genetic predisposition to joint inflammation, largely linked to carbohydrate intake. David reveals that he disregarded his diet until reaching peak velocity at age 15, attributing this to a fast metabolism. Later, he focused on reducing carbs, though not completely eliminating them. Dr. J explains that high insulin, triggered by many HLA genes, is the key factor in joint pain, not necessarily high blood sugar. He emphasizes that while high blood sugar often indicates high insulin, it's not always the case, depending on factors like muscle mass and activity level. Reducing carbs, especially simple carbs which spike insulin faster than complex carbs, is crucial for managing joint pain. David acknowledges his sweet tooth but notes that good muscle mass helps mitigate pain.
David's Joint Issues and Potential Underlying Causes
00:19:05 - 00:21:12
David discusses his history of joint problems, including a major hip surgery requiring reshaping of his femur head, and other surgeries. He attributes his recovery challenges to high sugar levels leading to inflammation. Dr. J agrees and suggests potential gluten sensitivity, noting that David's intense workout routine, even now, might exacerbate these issues. Dr. J mentions a surprising discovery of certain genes in David, potentially related to his condition, and highlights the "diO2 gene" related to the thyroid as an interesting finding.
Understanding Osteoarthritis and Rheumatoid Arthritis
00:21:14 - 00:23:19
Dr. J explains that the diO2 gene increases the risk of joint injuries, specifically osteoarthritis. David expresses unfamiliarity with the difference between osteoarthritis and rheumatoid arthritis. Dr. J clarifies that she learned the distinction while working with orthopedic surgeons at the Mayo Clinic. Rheumatoid arthritis is an autoimmune disease where the immune system attacks the joints, similar to the inflammatory response seen with carbs and insulin. Osteoarthritis, conversely, involves the degradation of soft tissue over time, leading to bone-on-bone friction and pain. Dr. J notes that suboptimal thyroid hormones increase the risk of osteoarthritis, especially with age, as thyroid hormone levels naturally decline. She recommends iodine supplementation for thyroid health, confirming that Andrea, who has Hashimoto's and takes selenium with iodine, is already following this advice. Dr. J concludes by recommending iodine supplementation to David as well to maintain healthy thyroid hormone levels.
Micronutrient Discussion and Joint Health
00:23:19 - 00:25:25
Dr. J suggests providing the body with building blocks for thyroid hormones to prevent bone-on-bone issues and osteoarthritis. David mentions selenium, and Dr. J notes that selenium supplementation is a matter of personal preference. The conversation shifts to chromium, a micronutrient that Dr. J relates to a sweet tooth; a chromium deficiency may manifest as a strong sweet craving, which disappears with supplementation. Dr. J suggests chromium supplementation for David's joint issues, given his high-intensity workout routine and potential for increased carb consumption. David explains his carb intake strategy, aiming for morning consumption before workouts and limiting intake on less active days. Dr. J affirms David's exercise routine as beneficial for joint health, noting the positive impact of increased blood flow.
Low Back Issues and Weightlifting
00:25:26 - 00:27:26
This segment discusses the participants' experiences with low back issues and weightlifting. Dr. J shares his personal experience of overcoming yearly back problems through deadlifting, contrasting it with the advice he initially received against it. David mentions his strong low back and reveals he recently started learning snatches, even practicing them before the call, aiming for Olympic participation in the future. Dr. J expresses excitement about David's new endeavor. Finally, Andrea shares that she incorporates deadlifts into her routine to alleviate back pain before performing clean and jerks and snatches.
Benefits and Experiences with Core Strengthening and Deadlifting
00:27:27 - 00:29:39
Andrea notes that core flexion throughout the day has been beneficial. Dr. J agrees, mentioning the importance of core strength to avoid excessive pressure on spinal discs. Dr. J shares their experience with deadlifting, highlighting its role in strengthening low back muscles, a skill they felt they'd missed out on earlier. They discuss the stigma surrounding deadlifting for women, with Dr. J emphasizing that it's beneficial for both genders and doesn't necessarily lead to excessive muscle growth. Andrea recounts her long-term experience with weight training, initially motivated by improving her performance in sports like softball, basketball, and volleyball. She mentions working out with David, who initially disliked leg workouts, and how he eventually started training with Keith at Physio or Pro Advantage. Andrea's training began in eighth grade, aiming to enhance her ability to spike volleyballs. Dr. J connects squatting to improved vertical jump and observes children naturally squatting, highlighting the natural movement pattern.
Early Childhood Fitness and Strength Training
00:29:41 - 00:31:48
Dr. J observes the impressive squatting ability of children, noting their naturally open hips. Dr. J emphasizes the importance of teaching proper lifting techniques, such as deadlifts, from a young age to prevent back injuries from improper bending. Andrea shares that she and her husband incorporate 15 push-ups and 15 squats into their children's daily routine as a condition for iPad use, after completing schoolwork and chores. Dr. J highlights the effectiveness of this approach, relating a story about her son's participation in a tractor pull competition. This event motivated her son and other children to increase their daily squats to approximately 100, leveraging the child's enthusiasm for the competition to improve their fitness. Dr. J finds it amusing to watch the children's exertion during these activities, noting the visible strain and increased blood pressure.
Blood Pressure and Genetic Predisposition
00:31:48 - 00:33:08
Dr. J expresses doubt about David having a gene linked to high blood pressure, noting David's history of low blood pressure despite inconsistent test results in spring training. Dr. J then highlights David's genetic predisposition to strong bones, suggesting a DEXA scan would likely reveal high bone density. The discussion shifts to the weighting of good versus bad genes, with Dr. J explaining the process of assessing their offsetting effects. Finally, Dr. J mentions David's pain sensitivity (previously discussed) and concludes that David's athletic genes are exceptional.
Dietary Recommendations and Aging
00:33:08 - 00:34:03
Dr. J emphasizes the importance of carb intake as David ages, referencing David's mention of the keto diet. The conversation touches upon the potential benefits of keto for joint pain. Dr. J shares his personal experience with intermittent keto diets, explaining that while beneficial for short periods (6 weeks), prolonged use disrupts sleep cycles due to increased brain activity.
Genetic Predisposition and Exercise Recommendations
00:34:03 - 00:36:12
Dr. J discusses the patient's genetic profile, highlighting genes related to inflammation (MEGF10) and their connection to both Alzheimer's risk and muscle development. Exercise, specifically muscle growth, is emphasized as crucial for mitigating potential risks associated with these genes. Dr. J explains that while exercise benefits everyone, it's particularly important for this patient due to their genetic makeup. The conversation then shifts to the BDNF gene and its role in brain health. Dr. J clarifies that while some individuals benefit from endurance exercise to increase BDNF levels, this patient's genetic profile suggests that building muscle mass is key for optimal brain function. The patient, David, seeks clarification on the type of exercise recommended, confirming his understanding that building muscle mass ("getting yoked") is the primary goal, considering his bone density.
The Effects of Exercise on Cognitive Function and Energy Levels
00:36:13 - 00:38:27
David discusses his need for a high-protein, high-carb diet to maintain optimal brain function, noting that neglecting exercise negatively impacts his cognitive abilities. Dr. J corroborates this, referencing Joe Rogan's similar experiences and highlighting the paradoxical perception of athletes as "meatheads" despite their intelligence. David confirms that while exercise initially causes fatigue, it ultimately boosts his energy and productivity later. Andrea, conversely, reports experiencing an immediate surge in energy after exercise, to the point of being overwhelming for David. Dr. J attributes Andrea's high energy levels to her endurance genes, common among elite athletes, further explaining the scientific literature supporting this observation.
Genetic Predisposition and Developed Mental Fortitude in Athletic Performance
00:38:29 - 00:40:28
This segment discusses the interplay between genetic predisposition and developed mental fortitude in athletic performance. David explains that while he lacks the endurance genes typical of Olympic runners, he compensates through intense, almost compulsive training driven by a fear of missing opportunities. He describes his training regimen, emphasizing his long hours and dedication. Dr. J supports this by mentioning examples of athletes with extreme endurance genes, contrasting them with power athletes who have trained to tap into both endurance and power circuits. The conversation highlights the case of a baseball pitcher who improves his performance throughout the game, suggesting that training can overcome genetic limitations to a certain extent. Andrea concludes by expressing her fascination with this dynamic.
Andrea and David's Differing Responses to Stress and Sex
00:40:29 - 00:42:50
Andrea describes her physical response to weightlifting, noting she can easily do several repetitions. She then contrasts her energy levels after sex, explaining that nighttime intimacy leaves her awake until very late, while morning sex energizes her. Dr. J introduces the topic of oxytocin receptors, pointing out a significant difference between Andrea and David's DNA profiles. Andrea shows no oxytocin receptor issues, while David's profile indicates he's less able to handle stress without sufficient oxytocin. Dr. J suggests that dark chocolate, which boosts oxytocin, could benefit David. The doctor mentions biohackers who inject oxytocin, though this is not recommended. The conversation concludes with Dr. J emphasizing that anything increasing oxytocin during stressful periods is beneficial, and David commenting on his generally good stress management.
Gluten's Impact on Alzheimer's Risk and Systemic Inflammation
00:42:58 - 00:44:53
Dr. J revisits the TATAP2 gene, an Alzheimer's risk gene linked to celiac disease and triggered by gluten. Gluten-induced gut inflammation potentially leads to brain inflammation due to inflammatory chemicals like TNFα, interleukin, and interferon circulating in the bloodstream. These chemicals signal the immune system to attack, even without infection, potentially causing it to attack the body's own cells. Dr. J explains this process using the example of a cut, where inflammatory chemicals attract the immune system to fight bacteria. However, without an infection, this process can lead to self-attacking inflammation. David expresses interest, noting he hadn't previously heard of this concept. Dr. J recommends the book "Grain Brain" by David Perlmutter as a further resource.
Gluten Sensitivity and Brain Health
00:44:55 - 00:46:58
Dr. J presents a strong argument for the connection between God issues, brain health, gluten sensitivities, and grain consumption, suggesting further research into "grain brain." David expresses interest. Dr. J notes Andrea's and her own gluten sensitivities, recommending a mostly grain-free diet for long-term brain health, though occasional consumption is acceptable. Andrea asks about implementing this with their children. Dr. J explains that both she and Andrea have a relevant gene (TAP2), impacting them differently (gut for Andrea, brain for David). Dr. J shares her experience with her children, noting a significant behavioral shift (tantrums, emotional outbursts) when they consume gluten or grains. The discussion highlights the potential impact of gluten and grains on brain health and behavior, particularly in individuals with relevant genetic predispositions.
Children's Health and Diet
00:46:58 - 00:48:20
Dr. J discusses the importance of exercise for children's well-being, noting its positive impact on their health. Andrea shares concerns about her older son's frequent headaches and relates her own childhood experiences to his current situation. The conversation then shifts to dietary habits, with Andrea mentioning her younger son's fondness for pizza and brownies. Dr. J reveals a personal gluten sensitivity despite enjoying pizza, leading to a discussion about the availability and quality of gluten-free pizza options. Dr. J mentions a favorite Korean pizza place in the Twin Cities known for its wood-fired pizzas.
Caffeine Metabolism and Individual Differences
00:48:20 - 00:49:05
Dr. J initiates a discussion about caffeine metabolism, clarifying the differences between Andrea and David's responses to caffeine. Andrea processes caffeine quickly, while David metabolizes it slowly. Dr. J explains this difference, noting that Andrea eliminates caffeine rapidly, whereas David retains it for a longer duration. David confirms this observation, sharing a personal anecdote about the lingering effects of caffeine from the previous night.
Caffeine and Supplement Intake Discussion
00:49:12 - 00:51:11
David describes his caffeine consumption, including margaritas and a pre-workout supplement called P4 (150mg caffeine per scoop). He usually takes one scoop and also uses "amino energy" (100mg caffeine) with amino acids and creatine, increasing his creatine intake based on nutritionist recommendations. Andrea mentions using the same P4 supplement. Dr. J inquires about the "plus plus" coding in their system, explaining that it indicates both fast and slow caffeine metabolism, neither inherently bad, but requiring personalized strategies. Dr. J reveals that he created software to categorize caffeine metabolism, with "plus plus" representing both extremes. He and Andrea share the same gene related to caffeine metabolism, coded as "plus plus".
Software Explanation and Lifespan Genes
00:51:13 - 00:53:14
Andrea inquires about distinguishing differences in metabolic rates between herself and another individual, both possessing a "plus plus" genetic marker. Dr. J explains that the distinction is due to software coding, using the difference in metabolic rates as a simple explanation. David compliments Dr. J's quick thinking. Dr. J then discusses the last category, lifespan, noting that both individuals possess excellent lifespan genes except for a deficiency in the SIRT gene. Dr. J recounts the excitement surrounding the discovery of the SIRT gene in the 1990s, when it was believed to hold the key to curing aging due to its impact on mice lifespan. However, Dr. J clarifies that while increasing SIRTuin levels does not cure aging, it does offer some lifespan benefits.
Supplement and Longevity Discussion
00:53:15 - 00:54:11
Dr. J explains that grape seed proanthocyanins are a good supplement for longevity and healthspan. Andrea asks if red wine helps, and Dr. J confirms it affects the same gene. David points out that red wine contains more sugar and can trigger inflammation, while Dr. J notes that a large quantity of red wine would be needed to match the benefits of grape seed extract. The conversation then shifts to a summary of the brain health section, with Dr. J asking if there are any further questions before moving on to the diet section. David expresses satisfaction with the clarity of the brain health section and summarizes his key takeaways: paying attention to gluten, working out, consuming dark chocolate when stressed, and incorporating grape seed extract into his diet.
Diet and Melatonin Discussion
00:54:11 - 00:55:25
The discussion moves to diet, with Dr. J inquiring about David's experience with melatonin. David mentions using it for sleep, generally taking half the recommended dose to avoid morning grogginess. He explains that his melatonin use is primarily to help him fall asleep. David then mentions that his wife, Andrea, has concerns about his sleep habits while on melatonin, specifically his snoring and tossing and turning. Andrea confirms this, describing his movements as being like "a fish out of water."
Melatonin Use and Sleep Quality
00:55:26 - 00:57:37
David describes his use of melatonin to improve sleep, noting it helps with restless legs syndrome and sleep disturbances caused by alcohol consumption or late workouts. He mentions that despite better sleep, he tosses and turns, snoring and moving around. Dr. J suggests that electrolytes, particularly magnesium, might help with the tossing and turning. Dr. J then points out a connection between David's melatonin receptor gene and a risk for higher blood sugar, noting that in David's case, melatonin use might actually help regulate blood sugar due to its link to insulin sensitivity. This is further discussed in relation to its positive effects on joints. The conversation is briefly interrupted by a UPS delivery.
Melatonin Dosage and Metabolism
00:57:40 - 00:59:07
Dr. J explains that David's body processes carbohydrates better with melatonin, regardless of sleep benefits. David discusses his melatonin usage, noting that taking it two hours before bed, as suggested (1-10mg), makes him fall asleep 30 minutes earlier than intended. Dr. J explains that melatonin production naturally increases two hours before sleep, and David's fast metabolism causes rapid absorption of the melatonin, leading to the early sleep onset. Dr. J confirms this is due to David's fast metabolism, not necessarily a negative aspect as long as he's aware of it. David agrees, stating that as long as he manages it, it's fine. Dr. J emphasizes the importance of exercise and the SLC38 gene, which indicates zinc's role in blood sugar regulation.
Zinc Intake and Red Meat Consumption
00:59:07 - 00:59:39
Dr. J recommends ensuring sufficient zinc intake, noting that red meat consumption usually provides enough. David confirms his high red meat consumption. Andrea inquires about specific zinc supplements, mentioning "zinc pickle" or a similar product.
Zinc Supplementation and Diet
00:59:40 - 01:01:17
Dr. J discusses zinc supplementation, noting some individuals experience acid reflux with certain zinc supplements. He recommends zinc carnitine due to better gut tolerance, clarifying it's not superior but easier on the digestive system. He mentions this information is available on his website. David mentions his red meat consumption isn't consistent, incorporating pork and chicken for dietary variety. He notes that when they do consume red meat, they eat significant amounts. Dr. J agrees with supplementing zinc on days when red meat isn't consumed. Dr. J adds that zinc is beneficial, especially in fighting viruses like COVID, referencing its importance in previous SARS outbreaks.
Vitamin D and Viral Immunity
01:01:17 - 01:01:46
Andrea interjects, mentioning vitamin D's role in fighting viruses, confirming its inclusion on Dr. J's list. Dr. J acknowledges this, indicating it's covered in the next section, playfully cautioning against jumping ahead.
Heart Disease Risk and Iron Levels
01:01:46 - 01:03:38
Dr. J briefly discusses intermittent fasting as a potential future consideration for David, contingent on any slowdown in his exercise regimen. The conversation then shifts to a heart disease gene, SOD2, and its connection to metformin and iron levels. Dr. J confirms that David doesn't possess a specific heart disease risk associated with this gene, but highlights that high blood iron significantly increases the risk of heart disease, specifically heart attacks. Dr. J emphasizes the importance of regularly checking iron levels during blood work. David inquires about lowering high iron levels, and Dr. J suggests blood donation as the most effective method, acknowledging it might be extreme for some. David expresses his dislike of needles but indicates a willingness to donate blood if necessary, prompting Dr. J to encourage him based on his perceived high pain tolerance.
Iron Levels and Health Recommendations
01:03:38 - 01:04:53
Dr. J discusses David's blood test results, focusing on high iron levels. Dr. J suggests reducing red meat consumption to lower iron, but notes that David's active lifestyle and metabolism might already be counteracting high iron. A specific gene is highlighted as a significant factor contributing to high iron levels. The potential risks associated with high iron are mentioned, and Dr. J emphasizes the importance of monitoring this specific gene due to its potential impact.
Hyaluronic Acid and Joint Health
01:04:53 - 01:05:31
Dr. J recommends hyaluronic acid supplements or bone broth to improve joint health, explaining that David possesses a rare gene (HABP2) linked to a higher risk of artery plaque. The conversation includes a brief exchange about bone broth preparation and its relation to hyaluronic acid. Dr. J clarifies the recommendation of hyaluronic acid supplementation due to the presence of the HABP2 gene.
Hyaluronic Acid and Joint Health
01:05:31 - 01:06:18
Dr. J explains that hyaluronic acid is a building block for soft tissues like the meniscus in the knee. It's also a component of arteries, contributing to their flexibility. While beneficial for joints, for David, the focus is on its role in arterial health, promoting flexibility and better blood flow. David expresses interest but notes their family isn't inclined towards making bone broth, and he'll research the supplement further.
Gut Health Analysis and NOD2 Genes
01:06:19 - 01:07:27
Dr. J mentions David's gut health report shows numerous genes lighting up, particularly NOD2 genes. While this initially seems concerning, Dr. J clarifies that these are "NOD2 minor" genes with minimal impact, despite the seemingly large number. This contrasts with another patient who had only two genes in this category, highlighting the relative nature of the findings. Dr. J also mentions ketosis in relation to David's gut health.
Keto Diet and Gut Health
01:07:33 - 01:09:26
Dr. J explains that inflammasomes in the gut contribute to inflammation, and ketones are effective in shutting them off. Ketones can be supplemented or achieved through ketosis, which may naturally occur during sleep for individuals with good blood sugar and high training volume. For gut issues, Dr. J recommends a ketogenic diet. David inquires about the keto diet's key aspects. Dr. J emphasizes that a common mistake is consuming too much protein, as the body can convert protein into sugar, unlike fat. The ideal protein intake is highly individual, depending on factors like body size and training intensity. Measuring ketone levels through breathalyzers or finger-prick tests can help monitor ketosis.
Ketone Testing and its Implications
01:09:27 - 01:10:15
Dr. J describes a blood ketone meter, comparing it to blood sugar meters used by diabetics. He explains that while he occasionally uses a ketone meter to monitor his ketosis levels and diet effectiveness, he finds the frequent finger pricking unpleasant. He notes that children with diabetes must do this regularly, highlighting the inconvenience.
Vitamin D Discussion and Arizona Lifestyle
01:10:18 - 01:10:57
Dr. J transitions to discussing vitamins, starting with vitamin D. He inquires about David's sun exposure in Arizona, given the state's sunny climate. David confirms significant sun exposure through various outdoor activities, including pool time, hiking, and dog walks, even actively seeking a tan. The conversation is cut short before David can fully explain his Florida activities.
Vitamin D Levels and Dietary Recommendations
01:10:58 - 01:12:37
Dr. J discusses David's vitamin D levels, suggesting that given his outdoor activities (paddle boarding, beach time), he should check his blood work for vitamin D levels. Dr. J notes that David's genes may present more challenges in this area than Andrea's, recommending supplementation to optimize levels, especially considering seasonal variations. The conversation then shifts to dietary oils, with Dr. J advising David to avoid seed oils like soybean and canola oil, and even grape seed oil, unlike Andrea. Dr. J suggests sticking to fruit-based oils such as avocado and coconut oil for cooking. David mentions his preference for avocado oil and that Andrea is the primary cook in the family.
Avocado Oil and Pesticide Exposure
01:12:38 - 01:14:45
This segment focuses on David's health concerns, specifically regarding pesticide exposure and its potential impact on his hormone levels. Dr. J suggests that avocado oil is a key factor in his diet. While not overly concerned about organic phosphate pesticides in David's diet, Dr. J mentions that public area spraying with these pesticides in Florida can affect the body's ability to clear them efficiently. The conversation then shifts to the FAM9B gene, which may lower testosterone levels, but lacks sufficient research. Dr. J explains the limited understanding of this gene and its effects, suggesting that monitoring testosterone levels as David ages might be necessary, and that maintaining muscle mass through training is preventative against low testosterone. David expresses his interest in understanding his testosterone levels, particularly given his professional baseball background and the need to avoid substances that could lead to doping violations. He highlights the careful approach he's always taken regarding supplements and medications, even after retiring from professional play.
Low Testosterone Levels in American Men
01:14:45 - 01:16:57
Andrea inquires about the low testosterone levels observed in American men and the adjustment of normal ranges to include suboptimally low levels. She mentions her use of both Eastern and Western medicine, noting discrepancies in normal ranges between the two approaches. Dr. J attributes the low testosterone levels to exposure to artificial estrogens, citing soy products, BPA from plastics, and other personal care chemicals as examples. Dr. J emphasizes that while the extent of their impact is debated, these substances act like estrogen. The conversation then shifts to a study on frogs exposed to atrazine, a herbicide. Dr. J highlights that even at 200 nanograms per liter, atrazine can transform male frogs into females, while the US allows 3000 nanograms per liter in drinking water. This leads to a discussion of "male feminization" as a consequence of high atrazine exposure and its connection to lowered testosterone levels.
Lowering Testosterone and Puberty Ranges
01:16:58 - 01:19:12
Dr. J discusses how cultural factors are leading to lower testosterone levels, particularly impacting puberty onset in girls. The lowering of normal ranges for testosterone and puberty is mentioned, citing research journals arguing for adjustments due to earlier puberty onset in girls, attributed to estrogen exposure. Andrea raises concerns about potential estrogen sources from plastics and rubber, referencing a study linking artificial grass to cancer in soccer players. Dr. J clarifies that cancer risks are generally separate from estrogen issues, except for breast cancer. Andrea asks about spelling and finding estrogen levels, leading Dr. J to recommend the website EWG.org for checking water levels and chemical contaminants in specific areas. Atrazine (A-T-R-A-Z-I-N-E) is mentioned as a specific chemical to look for. Dr. J uses Rochester, Minnesota as an example, highlighting seven chemicals exceeding government limits in their water supply, emphasizing widespread water contamination issues.
Water Fluoridation and its Effects
01:19:13 - 01:21:19
Dr. J expresses concern about high government limits on certain substances, noting that exceeding them is problematic. They mention using a whole-house water filter. Andrea agrees, but points out the counterargument regarding fluoride's role in preventing cavities. Dr. J counters that sufficient fluoride is obtained through a healthy diet, citing a Harvard researcher who has maintained excellent dental health for 20 years without fluoride, using only water and an electric toothbrush. Dr. J personally avoids high levels of fluoride due to potential thyroid issues, emphasizing that low levels from food are beneficial, while high levels present various problems. Dr. J criticizes the sketchy research from the 1980s that promoted water fluoridation, citing a study using cow teeth in acidic water with and without fluoride to illustrate questionable methodology. The study's conclusion that fluoride protected against degradation is questioned.
Questioning the Efficacy of Fluoride
01:21:20 - 01:23:17
Dr. J discusses a study used to advocate for widespread fluoride use, explaining that a more recent study using better technology and higher fluoride doses found fluoride's effectiveness questionable. Population-based studies comparing towns with and without fluoridated water show no significant difference in cavity rates. Dr. J notes that dentists often recommend fluoride treatments based on outdated information learned in dental school, similar to how doctors prescribe statins without fully understanding the potential side effects. Andrea expresses interest in the topic, and Dr. J mentions creating YouTube videos on fluoride research after investigating it due to concerns about his children's health.
Fluoride and Cavities
01:23:17 - 01:24:19
Dr. J shares their experience of never having cavities despite foregoing fluoride for five to ten years. Andrea mentions getting her first cavity recently, contrasting with her son's numerous cavities. The conversation then shifts to supplements, with Andrea noting she's preparing a list of supplements (zinc, magnesium, and others) for David.
Reliable Testosterone Testing
01:24:21 - 01:25:24
David expresses concern about finding a reputable place to get his testosterone tested, fearing bias towards unnecessary treatments. He worries that many clinics prioritize sales over patient well-being. Dr. J suggests using large testing corporations like Quest Diagnostics, emphasizing that a doctor's order is necessary for the test.
Blood Test Recommendations and Estrogen/Testosterone Discussion
01:25:24 - 01:27:33
Dr. J recommends getting both total and free testosterone blood tests, suggesting private mdlabs.com as an alternative to traditional doctor's offices and Quest Diagnostics. He notes that while the website allows users to select their desired tests, blood collection still requires a clinic visit. Dr. J then discusses David's estrogen gene results, noting a balance between genes indicating both high and low estrogen levels, suggesting they likely offset each other. He expresses less concern about David's estrogen levels, especially given his training regimen. David interjects, mentioning his high consumption of cruciferous vegetables like broccoli, cauliflower, Brussels sprouts, and kale, which Dr. J identifies as brassicas and credits with potentially contributing to maintaining high testosterone levels. David adds a comment about a previous experience, mentioning "Brent por," before the excerpt ends.
Training and Nutritional Guidance
01:27:33 - 01:29:38
David discusses his training regimen, emphasizing the importance of comprehensive nutritional intake. Dr. J commends a colleague for ensuring David's nutritional needs are met. They then review David's thyroid health, focusing on iodine levels. Dr. J suggests monitoring thyroid hormones alongside iodine levels. The conversation shifts to a gene analysis, specifically a B12 category on the following pages. Dr. J notes David's excellent B12 uptake, negating the need for supplementation. The discussion turns to David's multivitamin usage, which is inconsistent due to availability. Dr. J cautions against multivitamins containing tocopherols, a synthetic form of vitamin E, due to its potential to increase interleukin-6 levels. Dr. J advises David to check multivitamin labels for tocopherols and opt for alternative forms of vitamin E if available; otherwise, he recommends avoiding multivitamins altogether. David expresses interest in this information.
Multivitamin Considerations and Nutritional Gene Interactions
01:29:39 - 01:31:52
Dr. J discusses the challenges of finding multivitamins with good Vitamin E (specifically tocotrienols), noting the confusing terminology and suggesting a simple approach for consumers. He explains that some multivitamin studies show no overall benefit due to inflammation in some individuals, recommending avoidance for those susceptible. The conversation then shifts to fructose metabolism, highlighting a gene that predisposes individuals to store fructose as fat rather than burning it for energy. Dr. J cautions against excessive fructose consumption, using bananas as an example. David shares a personal anecdote about his changed preference for bananas, linking it to increased training intensity. Andrea briefly comments on fructose and children.
Pre-Sleep Snack Recommendations
01:31:56 - 01:33:57
David inquired about a suitable pre-sleep snack that wouldn't disrupt his sleep, given his late bedtime after gaming. Dr. J noted the high potassium content in bananas and its potential benefit for sleep due to David's ABC C9 gene, which is potassium-dependent. Andrea suggested sweet potatoes as an alternative, having higher potassium than bananas. Dr. J agreed, mentioning other potassium-rich foods like coconut and broccoli, while advising against high-fructose options. He recommended berries as a low-fructose alternative, with blueberries potentially having slightly higher fructose content than others like strawberries and blackberries. The discussion centered on finding potassium-rich, low-fructose foods to optimize sleep quality.
Fructose and Fatty Liver
01:33:58 - 01:35:23
Dr. J discusses a Romanian patient who, despite being slender, had a fatty liver due to high fruit consumption and a genetic predisposition to storing fructose as fat. The conversation highlights the potential negative impact of excessive fructose intake, even from seemingly healthy fruits like berries. Dr. J emphasizes that high fructose intake can lead to fat accumulation in the liver, which is undesirable. The discussion then transitions to the importance of potassium and magnesium supplementation, noting that many Americans are deficient in these minerals. Dr. J suggests that magnesium supplementation is beneficial based on individual symptoms.
Fruit Consumption and Dietary Recommendations
01:35:23 - 01:36:00
David asks for dietary advice regarding his morning routine of consuming an apple, banana, and protein bar before exercise. Dr. J suggests replacing the apple and banana with lower-fructose options such as apricots, cantaloupe, or berries, citing peaches as an example of a fruit with lower fructose content (two grams per peach). The discussion focuses on reducing fructose intake while maintaining a balanced diet.
Finalizing Recommendations and Individualized Approach
01:36:05 - 01:38:11
Dr. J suggests reviewing a website link for glucose-related information, highlighting various options available. Dr. J expresses satisfaction with the progress, offering to revisit any topics if needed. David expresses gratitude, noting he's taken detailed notes, focusing on 20 key areas. He emphasizes the importance of this individualized approach, contrasting it with a "one-size-fits-all" method. David highlights the value of this approach for his athletes, emphasizing the need to understand individual needs rather than applying a blanket approach to player care. He points out the limitations of a generalized approach, noting its ineffectiveness for some athletes. Dr. J agrees, criticizing the current medical system's broad approach and its limitations in providing truly individualized care.
Individualized Health Approach and System Optimization
01:38:13 - 01:40:25
Dr. J advocates for individualized medicine, suggesting it's a superior approach to a one-size-fits-all system, even within the medical field. David agrees, emphasizing the importance of personalized care to reduce strain on the healthcare system and ultimately lower individual costs. He argues that proactive personal health management reduces the need for extensive medical intervention. Andrea joins the discussion, sharing her experience of encouraging David to adopt a gluten-free diet to alleviate his nasal congestion. She notes his improved condition when consuming gluten-free beer, highlighting the potential impact of dietary changes. Dr. J concludes by observing that sensitivity to genetic factors increases with age, making personalized approaches increasingly relevant. Andrea expresses gratitude for participating in the discussion and looks forward to comparing her and David's health data to identify areas for improvement in their workouts and nutrition.
File Transfer and Podcast Discussion
40:25 - 01:42:41
David proposes sending a file via Gmail and Google Drive, citing past issues with Dropbox storage. He will notify Dr. J upon sending. Dr. J expresses gratitude for the time spent and highlights the importance and broad appeal of the discussed information. David emphasizes the podcast's universal relevance, extending beyond specific demographics like athletes, and asserts its value for anyone concerned about their health and well-being. He contrasts this with his previous baseball-focused podcast, which had a more niche audience. A second speaker agrees, emphasizing the importance of the information and its potential impact on listeners' lives, even if some might not find the specific details inherently interesting.
Addressing Concerns and Finding Solutions
01:42:42 - 01:44:11
SPEAKER_02 expresses relief at discovering the root cause of a problem, highlighting the importance of having the correct information. SPEAKER_01 discusses the cost-benefit analysis of a solution, emphasizing long-term savings and improved lifestyle. David emphasizes that certain issues are priceless and shouldn't be compromised for financial reasons. Dr. J agrees, expresses gratitude for the conversation, and offers continued support and contact. David reciprocates the gratitude, commits to staying in touch, and offers referrals if needed. The conversation concludes with mutual farewells and thanks.
DNA with Dr. Jay, Episode 02.
BASEBALL PITCHER Brent Pourciau (from LA)
BASEBALL PITCHER Brent Pourciau (from LA)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Podcast Overview
00:00:00 - 00:01:07
Dr. J introduces the podcast episode, mentioning it's a recycled episode featuring Brent Porcao, a baseball pitching coach from Covington, Louisiana. He notes the audio quality isn't ideal due to a Skype interview. Dr. J explains the episode showcases the evolution of his DNA consultations and highlights Brent's connection to a previous podcast guest, David Ardsma. The purpose of the interview is to discuss Brent's DNA analysis and potential partnership opportunities. Brent expresses his excitement.
Brent's DNA Analysis and 23andMe Discussion
00:01:08 - 00:01:51
Dr. J explains the process, referencing a summary report sent to Brent via Twitter. This report is based on Brent's 23andMe DNA test results. Brent comments on the lengthy processing time of the 23andMe test. Dr. J mentions 23andMe's popularity, noting it was the number one Christmas gift on Amazon that year, leading to a significant backlog in processing. Brent acknowledges the long processing time is understandable. Brent confirms he's reviewing the report.
Potential Partnership and Future Collaboration
00:01:52 - 00:02:02
Dr. J outlines his vision for a potential partnership with Brent, focusing on offering a free report to Brent's clients.
Marketing Strategy for Genetic Testing Services
00:02:02 - 00:03:26
Dr. J proposes a tiered approach to marketing genetic testing services. Initially, clients will receive a simplified version of the genetic analysis, assuming they've already done a 23andMe test. This simplified report will be accessible via a podcast link, explaining the process and results in detail. The podcast will cover the three-page report, focusing on the second and third pages which contain genetic code represented by "+" and "-" symbols. "+" indicates a "bad gene" inherited from one parent, while "-" represents a "good gene" from the other. Dr. J uses the example of the VDR gene (vitamin D receptor) to illustrate this, explaining that a "plus plus" result means inheriting a less efficient vitamin D receptor from both parents, potentially relating to Brent's pale skin. The discussion concludes with the understanding that clients can opt for a full consultation with Dr. J for a more in-depth analysis.
Vitamin D Supplementation and Sun Exposure
00:03:26 - 00:04:42
Dr. J and Brent discuss Brent's vitamin D levels. Brent mentions supplementing with vitamin D occasionally, prompting Dr. J to suggest more frequent supplementation unless Brent gets sufficient sun exposure. Brent expresses concern about burning easily in the sun. Dr. J explains that sun exposure up to the point of burning is beneficial for vitamin D production, but burning is excessive. Dr. J refers to page two of a report, which details Brent's specific VDR (vitamin D receptor) gene variant. Based on this variant, Dr. J recommends a daily vitamin D supplement of 5,000-10,000 IUs, contingent on limited sun exposure. Considering Brent lives in Louisiana, Dr. J suggests he likely receives adequate sun exposure, but emphasizes the need for direct sunlight for optimal vitamin D synthesis. Brent clarifies that while he's often indoors, some sunlight penetrates. Dr. J confirms that direct exposure is crucial.
Vitamin D Supplementation and Cholesterol Discussion
00:04:43 - 00:06:22
Dr. J and Brent discuss vitamin D supplementation. Brent questions the adequacy of government recommendations, and Dr. J confirms that supplementation is sufficient, especially considering sun exposure. Dr. J explains their approach to balancing supplementation with sun exposure. The conversation then shifts to vitamin D's role in recovery, with Brent mentioning case studies supporting its benefits. Dr. J clarifies that vitamin D is a hormone synthesized from cholesterol. This leads to a discussion about statins, with Brent revealing his father's long-term statin use and his own avoidance of them, a practice Dr. J approves of unless there's a genetic condition like familial hypercholesterolemia, which requires statin use. Dr. J reassures Brent that based on his DNA, he doesn't have this condition.
Cholesterol, Testosterone, and Vitamin D
00:06:22 - 00:08:04
Dr. J explains that cholesterol is overprescribed and is actually a building block for testosterone and vitamin D. He notes that the body needs cholesterol to produce vitamin D, even with sufficient sun exposure. Brent asks if this is common in redheads, mentioning his father and an ex-major leaguer friend with low testosterone. Dr. J confirms this is relevant and explains that the issue isn't necessarily vitamin D itself, but the receptor; the body isn't absorbing it efficiently. Higher bloodstream levels are suggested to improve absorption. Dr. J then highlights that Brent's only significant genetic plus is a positive gene, contrasting this with his typical screening of detox genes in high-performing individuals (including pro athletes), who usually show few gene mutations. Brent falls into this category of few mutations.
Genetic Predisposition to Empathy and Food Sensitivities
00:08:11 - 00:10:11
Dr. J discusses the lack of empathy some individuals exhibit towards those with food sensitivities, suggesting a correlation with genetic mutations. Brent shares his experience with anxiety and stress, attributing it to overwork and potentially low vitamin D levels. Dr. J reveals that Brent possesses a gene mutation in his oxytocin receptor, impacting his empathy levels. They discuss the implications of this mutation, with Dr. J suggesting it could be beneficial in business, while Brent admits that negative feedback still affects him despite the genetic predisposition. The conversation touches upon the prevalence of online negativity and its impact on individuals.
Caffeine Metabolism and Anxiety
00:10:18 - 00:11:55
Dr. J explains Brent's genetic predisposition to caffeine sensitivity. Brent's genetic report reveals four genes impacting caffeine metabolism, including the CYP1A2 gene with a 164A to C variation, slightly reducing caffeine breakdown. This results in caffeine remaining in Brent's system for approximately six hours. Additionally, other genes indicate increased stimulation and anxiety responses to caffeine. Brent connects this information to his experience of feeling unwell and experiencing heightened anxiety after daily consumption of a sports tea containing caffeine, a fact he was unaware of until reviewing the ingredients.
Caffeine Sensitivity and COMT Gene
00:11:56 - 00:13:43
Dr. J and Brent discuss Brent's caffeine sensitivity, linking it to the caffeine gene and the presence of multiple "plus-minus" genes in his COMT (catechol-O-methyltransferase) profile. Dr. J explains that Brent has two problematic copies of the COMT gene, resulting in potential issues with this gene's function. This genetic predisposition, according to Dr. J, explains Brent's history of dehydration issues, even to the point of near heat stroke. The discussion highlights the connection between genetic predispositions and personal experiences, with Brent's past health problems aligning with the identified genetic markers. Dr. J recommends increased salt and water intake to address the identified genetic issues.
Creatine, Dehydration, and Salt Sensitivity
00:13:43 - 00:15:28
Brent discusses his negative experiences with creatine, including dehydration and cramping. Dr. J explains that a specific gene can cause increased urination of water and salt, exacerbating the dehydrating effects of creatine. Dr. J also notes that salt is often demonized, but that some individuals are more sensitive to salt-induced hypertension than others. Dr. J reviews Brent's notes and confirms that Brent has a low risk for salt-induced hypertension, meaning his hypertension is not likely caused by salt intake. The conversation touches upon the conflicting research on salt and hypertension, attributing some of the discrepancies to genetic variations. Dr. J clarifies that while some individuals experience hypertension from high sodium intake, most do not. Brent then suggests that his hypertension might be related to caffeine consumption, describing a feeling of his body "nodding up" after caffeine intake, which he associates with hypertension.
Caffeine, Hypertension, and Salt Recommendations
00:15:29 - 00:16:50
Brent and Dr. J discuss Brent's hypertension and its potential link to caffeine consumption. Dr. J notes that Brent has a high number of caffeine-related genes, contributing to his condition. They explore the possibility that some of Brent's hypertension might be stress-related and suggest meditative practices. Dr. J recommends Redmond Sea Salt as a preferred salt option due to its affordability, purity (lack of microplastics and radioactivity, unlike some Himalayan salt batches), and iodine content sourced from ancient Utah seabeds. Brent mentions his usual use of Himalayan salt, and Dr. J confirms its general suitability while reiterating concerns about potential contaminants in some batches. The conversation concludes with Dr. J emphasizing the recommendation of Redmond Sea Salt.
COMT Gene, Adrenaline, and Gut Health
00:16:51 - 00:18:24
Dr. J and Brent discuss the COMT gene, its effect on adrenaline levels, and Brent's past experience with caffeine and adrenaline-induced gut issues. Dr. J explains that the COMT gene can lead to prolonged adrenaline presence in the body, increasing susceptibility to adrenaline addiction. Brent relates this to his past struggles with high adrenaline levels, fueled by caffeine consumption. He describes how this led to significant gut damage due to blood being pulled away from the digestive system. Brent details his recovery process, which involved rebuilding his gut health and managing his adrenaline levels. He mentions using probiotics and triphala to support gut detoxification. Dr. J inquires about Brent's use of probiotics and prebiotics, to which Brent confirms his extensive use of probiotics and triphala.
Brent's Dietary Habits and Adrenaline Management
00:18:24 - 00:19:41
Brent discusses his consumption of fermented foods like kombucha, noting its detoxifying and relaxing effects, although he sometimes overdoes it. He also enjoys a glass or two of wine in the evening to lower adrenaline levels, finding that excessive alcohol has the opposite effect. Dr. J agrees with the wine strategy and suggests magnesium supplementation. Brent reveals an allergy to most magnesium supplements, experiencing skin reactions, but finds a spinach-based magnesium supplement effective for managing hypertension and lowering adrenaline, particularly before bed. Dr. J confirms that magnesium is a good approach to counteracting adrenaline.
Estrogen's Effect on COMT Enzyme
00:19:44 - 00:21:13
Dr. J and Brent discuss the impact of estrogen on the COMT enzyme. Brent mentions his exposure to estrogen through his family. Dr. J clarifies that environmental exposure is unlikely to be significant, suggesting dietary sources like soy as more likely culprits. Brent reveals he avoids soy due to perceived estrogenic effects, leading to a discussion about avoiding soy and other estrogenic substances. Dr. J advises against soy and highlights lavender and flax as additional sources of estrogen to avoid, emphasizing their potential to further impair COMT enzyme function. Brent expresses surprise at the information regarding flax, a food he regularly consumes. Dr. J suggests he consider eliminating flax from his diet as well.
Plant Estrogen Levels in Food
00:21:16 - 00:22:14
Dr. J discusses a Canadian study on phytoestrogens in 200 plants. Almost all plants tested contained less than 1000 micrograms of estrogen per 100 grams of food, except soy (over 100,000 micrograms) and flax (300,000 micrograms). Brent mentions reports of men experiencing gynecomastia and lactation from soy consumption. Dr. J confirms this and adds that similar effects are now being linked to lavender.
Flax and Soy Consumption Risks for Athletes with Specific Genes
00:22:15 - 00:22:54
Brent asks about the estrogen content in flax seeds and oil. Dr. J explains that gut bacteria metabolize these estrogens, but advises against flax and soy consumption for Brent due to a specific gene and his athletic status. Brent inquires about testosterone enhancement strategies. Dr. J suggests it's not strictly necessary given Brent's gene but generally beneficial for health, although a personalized approach is needed.
Cholesterol, Inflammation, and Cardiovascular Health
00:22:56 - 00:24:24
Dr. J explains that while cholesterol can be used to enhance testosterone, the primary concern for Brent is inflammation, given his family history of cardiovascular disease (including multiple stints, a defective heart valve, and a heart attack). Dr. J notes that inflammation causes damage to blood vessels and arteries, and cholesterol acts as a repair mechanism, not the root cause. Brent expresses concern about his family history and asks how to combat inflammation. He mentions using good oils (excluding flax) and omega-3s, and asks about fish oil. Dr. J suggests sardines as a preferable source of omega-3s. The discussion then turns to the importance of exercise and the negative effects of overtraining, which contributes to inflammation. Brent adds that he's noticed kombucha helps reduce his acidity and inflammation, and asks Dr. J if this is accurate.
Gut Bacteria and Inflammation
00:24:25 - 00:25:55
Dr. J explains that feeding gut bacteria can reduce inflammation. Brent agrees, noting the link between bowel issues and inflammation. Dr. J mentions that approximately 10% of his patients have a genetic issue affecting the breakdown of tyramine and similar compounds in fermented or aged foods, causing problems like bloating. Brent shares that he benefits from kombucha, while his wife experiences negative effects, leading Dr. J to suggest she might have this genetic issue. Dr. J emphasizes the prevalence of this genetic issue and the importance of personalized approaches to diet and health, given the current trend of recommending fermented foods. The conversation transitions to the next topic on the list.
NAT2 Gene and Carcinogen Breakdown
00:25:55 - 00:26:13
Dr. J introduces NAT2 (N-acetyltransferase), a gene involved in carcinogen breakdown. The discussion begins to explore the role of this gene and its implications for health.
Cancer Risk and Antioxidant Intake
00:26:13 - 00:27:53
Dr. J and Brent discuss Brent's family history of cancer, including his father's cancer and his grandparents' deaths from colon and breast cancer at relatively young ages. Dr. J explains that this increases Brent's cancer risk. Brent mentions his regular vitamin C intake. Dr. J cautions against overconsumption of antioxidants, explaining that while they are important for eliminating carcinogens, excessive intake can protect cancer cells, allowing them to survive and proliferate. Dr. J suggests cycling antioxidant intake, emphasizing the importance of allowing the body to eliminate cancer cells naturally. Brent expresses concern about his daily consumption of antioxidants through smoothies and wine. Dr. J advises that this might be excessive and recommends cycling antioxidant intake to avoid potentially hindering the body's natural cancer-fighting mechanisms. Dr. J highlights vitamin C's unique role in producing hydrogen peroxide, which aids in eliminating cancer cells.
Cancer-Fighting Antioxidants and the Role of Viruses
00:27:58 - 00:29:57
Dr. J explains that some antioxidants, unlike most others, actively kill cancer cells. Brent mentions a belief that small amounts of food-grade hydrogen peroxide can help fight cancer, possibly due to the viral aspect of some cancers. Dr. J confirms that some viruses insert into DNA and accelerate cell reproduction, but stresses that anything eliminating these cells is beneficial, similar to how chemotherapy works by stressing all cells. Dr. J expresses dislike for chemotherapy, considering it a last resort, after Brent shares a story about a friend who died after two rounds of chemotherapy. The conversation shifts to the NAT2 gene, and Dr. J notes that garlic inhibits the function of this enzyme, which processes carcinogens. Brent, a daily garlic consumer, is advised to cycle garlic intake as it can reduce the body's ability to eliminate carcinogens. Brent mentions a new garlic product containing allicin, noting its positive effects on blood thinning and blood pressure.
Antioxidant Cycling and Cancer Treatment
00:29:57 - 00:31:50
Dr. J explains the concept of cycling antioxidants like garlic and blueberries, suggesting taking them every other day to allow the body to process them effectively and avoid inhibiting enzymes responsible for eliminating carcinogens. He cites a New England Journal of Medicine study from the 90s showing that giving smokers antioxidants increased lung cancer rates by 20%, highlighting the recent discovery that this is due to antioxidants protecting cancer cells. Brent shares an oncologist's concern about patients becoming "health freaks" after cancer diagnosis, questioning the approach. Dr. J strongly advocates for a "health freak" approach, emphasizing the importance of supporting the body's fight against cancer. He notes that many cancers burn sugar, making sugar elimination (through strategies like veganism) a crucial step. Brent mentions reading about this topic further.
Cancer Cell Metabolism and the Warburg Effect
00:31:50 - 00:33:35
Brent and Dr. J discuss the metabolic processes of cancer cells, focusing on the Warburg effect. Brent explains that cancer cells primarily burn glycogen and glucose, producing lactic acid, even when mitochondria are present. Dr. J elaborates, stating that mitochondria are the powerhouses of cells, but cancer cells bypass them, converting glucose to pyruvate and lactic acid outside the mitochondria, a less efficient energy production method. This inefficient process is known as the Warburg effect, and the reasons behind it remain unknown to scientists. Dr. J highlights that fat metabolism, unlike glucose, necessitates mitochondrial function. Therefore, a diet rich in fat and low in sugar could force cancer cells to utilize their mitochondria, potentially hindering their growth. Dr. J concludes that a high-fat diet could be a preventative measure against cancer, although this statement might not be endorsed by medical doctors.
Detoxification and Diet Strategies
00:33:36 - 00:34:09
Dr. J mentions Dr. Joseph Mercola's diet, which focuses on teaching the body to burn fat consistently. Brent notes the difficulty of eliminating sugar due to its addictive nature, even for those with cancer. The conversation then shifts to detoxification, with Brent acknowledging the need for a sugar detox. Dr. J confirms sugar's addictive properties and transitions the discussion to Brent's athletic profile.
Detoxification Methods and Exercise Recommendations
00:34:09 - 00:35:15
Brent asks about detoxifying carcinogens beyond garlic. Dr. J suggests stress reduction and exercise as beneficial methods, highlighting exercise's role in improving blood flow and system filtration. Brent clarifies whether weightlifting or vascular exercise is more effective. Dr. J explains that Brent's genetic profile, primarily that of a sprinter, makes high-intensity interval training (HIIT) optimal. Brent suggests CrossFit or circuit training as potential models, aiming for a balance between aerobic and anaerobic exercise.
High-Intensity Training and Central Nervous System Response
00:35:16 - 00:36:06
Dr. J describes sprint interval training, differentiating it from powerlifting and Olympic lifting. Brent shares his positive experience with Olympic lifting but notes that under high stress, combined with caffeine, the high-intensity training overstimulated his central nervous system, making it difficult to calm down and hindering his ability to manage his parasympathetic state. He explains that his central nervous system couldn't handle the combined effects of stress, caffeine, and high-intensity training.
Training, Caffeine, Adrenaline, and Genetic Predisposition
00:36:07 - 00:36:29
Dr. J acknowledges Brent's concerns. Brent summarizes his point: while training is beneficial, it negatively interacts with his caffeine and adrenaline issues, sometimes exacerbating them. Dr. J then mentions Brent's beneficial gene, nitric oxide synthase, common in power athletes.
Genetic Predisposition and Athletic Performance
00:36:32 - 00:38:08
Dr. J discusses Brent's genetic advantages for athletic performance, mentioning beneficial genes related to vasodilation (NAS3) and overall strength. Brent confirms his exceptional strength, high food intake to maintain muscle mass, and a family history of strength. However, Brent also describes challenges with joint tightness, particularly in his shoulders, leading to overwork and injury due to limited hip mobility. Dr. J notes Brent's low risk for lumbar disc issues, contrasting with the upper body joint problems. The conversation highlights the complex interplay between genetic advantages, physical limitations, and injury risk in high-performance athletes.
Athletic Profile and Dietary Review
00:38:08 - 00:39:37
Dr. J cautiously suggests a more careful approach to training for individuals at risk of low back problems, noting Brent's high response to amphetamines and the importance of monitoring stimulant intake. They discuss Brent's ability to digest dairy despite a past lactose intolerance. Dr. J highlights Brent's high HDL cholesterol, attributing it to several genes and emphasizing that the HDL/LDL ratio, along with particle size, is crucial for cholesterol assessment. Brent explains his previous high cholesterol readings and doctors' recommendations for statins, which are deemed unnecessary given his high HDL levels. Dr. J confirms the importance of the HDL/LDL ratio and particle size, noting that high bad particles often stem from inflammation, which needs to be addressed. Brent expresses his belief that he has inflammation.
The Impact of Age and Glutathione on Inflammation
00:39:41 - 00:41:21
Brent expresses his feeling of having a gene that doesn't help with inflammation, highlighting the need to manage stress and diet. Dr. J relates this to the body's decreasing ability to detoxify with age, using the example of hangovers being more severe in older age. Dr. J introduces glutathione, the body's main antioxidant, explaining that its production decreases with age and that its levels can be increased through supplementation. Specifically, Dr. J recommends liposomal glutathione, emphasizing that regular glutathione is destroyed by stomach acid. Liposomal glutathione is presented as a solution to increase glutathione levels and potentially reduce inflammation, a point confirmed by Dr. J in response to Brent's question.
Glutathione and Stress Management
00:41:21 - 00:41:38
Dr. J discusses the use of glutathione to reduce inflammation, noting its high cost and suggesting it be used only during periods of stress. While acknowledging that some individuals have genetic issues requiring its consistent use, Dr. J advises Brent, who doesn't have such issues, to cycle its use based on need due to the expense.
Genetic Predisposition to Sweet Foods and Colon Cancer Risk
00:41:38 - 00:42:12
Dr. J mentions Brent's sweet tooth gene, Fucosal transferase, and explains that Brent has a 17-fold increased risk of colon cancer from processed meats. The conversation touches upon Brent's high consumption of processed meats.
Processed Meats and Preservatives
00:42:12 - 00:42:57
Brent requests clarification on what constitutes "processed meat," leading Dr. J to explain that it includes items like bologna and salami, which contain preservatives and potentially expired meats. Dr. J emphasizes the masking effect of these additives, making it difficult to detect spoilage. Brent shares his reduced meat consumption due to past gut issues and difficulty digesting meat.
Dietary Recommendations and Health Profile
00:42:57 - 00:44:31
Dr. J advises Brent to limit processed meat consumption due to its potential health risks, citing the impact of colon cancer on Brent's grandfather. The discussion then shifts to Brent's health profile, revealing a surprising resistance to norovirus. Dr. J explains the severity of norovirus, contrasting it with Brent's immunity. Finally, the conversation turns to Brent's telomeres, which are longer than average. Dr. J explains that longer telomeres are associated with better health and longer lifespan, although testing telomere length is costly. Brent inquires about the length of his telomeres, and Dr. J confirms that his are long, which is positive.
The Effects of Space Radiation on DNA
00:44:31 - 00:45:49
This segment discusses the impact of space radiation, particularly cosmic radiation and iron particles, on DNA. Brent and Dr. J discuss a study on twins, where one spent a year in space, resulting in significant telomere lengthening. Dr. J explains that space radiation, worse than constant x-ray exposure, causes double-stranded DNA breaks. These breaks lead to mutations or cell death due to the body's imperfect repair mechanisms. Dr. J mentions a NASA presentation highlighting radiation as the biggest challenge for Mars missions, emphasizing that radiation penetrates even iron suits and spaceships.
Altitude and DCA Metabolism
00:45:49 - 00:47:09
Dr. J discusses Brent's DNA results, noting his slow metabolism of DCA, a chemical found in public pools and used as a chemotherapy drug. Brent mentions his master's studies on altitude, leading to a discussion about the human body's limitations at high altitudes. Dr. J explains that DCA can be absorbed through the skin and that while not a major concern for occasional exposure, frequent public pool use might be problematic due to Brent's slow metabolism. Dr. J suggests that using coconut oil might reduce skin absorption, but recommends limiting public pool exposure. Brent expresses concern about his children's frequent pool use. Dr. J reassures him that the slow metabolism won't cause significant problems, just a slower clearance rate. The conversation concludes with Dr. J stating that this information was gleaned from Brent's DNA analysis and Brent expressing his appreciation.
Athlete Optimization Through Genetic Insights
00:47:12 - 00:49:14
Brent and Dr. J discuss the application of genetic information to optimize athletic performance, specifically focusing on baseball. Brent raises the question of how genetic predispositions, such as those indicating suitability for sprinting versus endurance activities, can inform training and dietary recommendations for athletes. Dr. J emphasizes the importance of self-awareness in training and highlights the significant role of diet (protein, carbs, fats balance) in achieving optimal performance. He notes that while many athletes eventually learn these things through experience, genetic insights can significantly shorten this learning curve. Brent agrees, emphasizing the importance of body awareness and health in extending athletic careers, particularly in baseball, where the high volume of games often overshadows the need for holistic health management. Brent contrasts this with a prevalent baseball culture that prioritizes immediate performance output over long-term health.
The Impact of Genetics and Proactive Health Management on Athletic Longevity
00:49:14 - 00:51:18
Brent discusses the importance of early body optimization for a long professional athletic career, noting that without it, only those with exceptional genetics will succeed. Dr. J agrees, citing examples of high-end athletes who succeeded due to luck rather than proactive health management. The conversation shifts to the genetic advantages of some athletes, using Major League Baseball players as an example. Dr. J mentions Tom Brady as a counterpoint, highlighting his dedication to diet and training as key factors in his longevity, despite potential unknown genetic predispositions. Dr. J emphasizes that even with genetic challenges, understanding and mitigating them can lead to high performance levels. Brent uses Peyton Manning's career as an example, suggesting that early awareness of a family history of spinal degeneration could have potentially extended his career. Brent explains that Peyton's brother Cooper's inability to play football due to a similar spinal issue highlights the importance of proactive health management based on genetic predisposition. The conversation concludes with Dr. J thanking Brent for his time.
Initial Greetings and Collaboration
00:51:18 - 00:51:23
The speaker expresses enjoyment of the conversation and anticipates a positive working relationship with the team at Top Philosophy.
00:00:00 - 00:01:07
Dr. J introduces the podcast episode, mentioning it's a recycled episode featuring Brent Porcao, a baseball pitching coach from Covington, Louisiana. He notes the audio quality isn't ideal due to a Skype interview. Dr. J explains the episode showcases the evolution of his DNA consultations and highlights Brent's connection to a previous podcast guest, David Ardsma. The purpose of the interview is to discuss Brent's DNA analysis and potential partnership opportunities. Brent expresses his excitement.
Brent's DNA Analysis and 23andMe Discussion
00:01:08 - 00:01:51
Dr. J explains the process, referencing a summary report sent to Brent via Twitter. This report is based on Brent's 23andMe DNA test results. Brent comments on the lengthy processing time of the 23andMe test. Dr. J mentions 23andMe's popularity, noting it was the number one Christmas gift on Amazon that year, leading to a significant backlog in processing. Brent acknowledges the long processing time is understandable. Brent confirms he's reviewing the report.
Potential Partnership and Future Collaboration
00:01:52 - 00:02:02
Dr. J outlines his vision for a potential partnership with Brent, focusing on offering a free report to Brent's clients.
Marketing Strategy for Genetic Testing Services
00:02:02 - 00:03:26
Dr. J proposes a tiered approach to marketing genetic testing services. Initially, clients will receive a simplified version of the genetic analysis, assuming they've already done a 23andMe test. This simplified report will be accessible via a podcast link, explaining the process and results in detail. The podcast will cover the three-page report, focusing on the second and third pages which contain genetic code represented by "+" and "-" symbols. "+" indicates a "bad gene" inherited from one parent, while "-" represents a "good gene" from the other. Dr. J uses the example of the VDR gene (vitamin D receptor) to illustrate this, explaining that a "plus plus" result means inheriting a less efficient vitamin D receptor from both parents, potentially relating to Brent's pale skin. The discussion concludes with the understanding that clients can opt for a full consultation with Dr. J for a more in-depth analysis.
Vitamin D Supplementation and Sun Exposure
00:03:26 - 00:04:42
Dr. J and Brent discuss Brent's vitamin D levels. Brent mentions supplementing with vitamin D occasionally, prompting Dr. J to suggest more frequent supplementation unless Brent gets sufficient sun exposure. Brent expresses concern about burning easily in the sun. Dr. J explains that sun exposure up to the point of burning is beneficial for vitamin D production, but burning is excessive. Dr. J refers to page two of a report, which details Brent's specific VDR (vitamin D receptor) gene variant. Based on this variant, Dr. J recommends a daily vitamin D supplement of 5,000-10,000 IUs, contingent on limited sun exposure. Considering Brent lives in Louisiana, Dr. J suggests he likely receives adequate sun exposure, but emphasizes the need for direct sunlight for optimal vitamin D synthesis. Brent clarifies that while he's often indoors, some sunlight penetrates. Dr. J confirms that direct exposure is crucial.
Vitamin D Supplementation and Cholesterol Discussion
00:04:43 - 00:06:22
Dr. J and Brent discuss vitamin D supplementation. Brent questions the adequacy of government recommendations, and Dr. J confirms that supplementation is sufficient, especially considering sun exposure. Dr. J explains their approach to balancing supplementation with sun exposure. The conversation then shifts to vitamin D's role in recovery, with Brent mentioning case studies supporting its benefits. Dr. J clarifies that vitamin D is a hormone synthesized from cholesterol. This leads to a discussion about statins, with Brent revealing his father's long-term statin use and his own avoidance of them, a practice Dr. J approves of unless there's a genetic condition like familial hypercholesterolemia, which requires statin use. Dr. J reassures Brent that based on his DNA, he doesn't have this condition.
Cholesterol, Testosterone, and Vitamin D
00:06:22 - 00:08:04
Dr. J explains that cholesterol is overprescribed and is actually a building block for testosterone and vitamin D. He notes that the body needs cholesterol to produce vitamin D, even with sufficient sun exposure. Brent asks if this is common in redheads, mentioning his father and an ex-major leaguer friend with low testosterone. Dr. J confirms this is relevant and explains that the issue isn't necessarily vitamin D itself, but the receptor; the body isn't absorbing it efficiently. Higher bloodstream levels are suggested to improve absorption. Dr. J then highlights that Brent's only significant genetic plus is a positive gene, contrasting this with his typical screening of detox genes in high-performing individuals (including pro athletes), who usually show few gene mutations. Brent falls into this category of few mutations.
Genetic Predisposition to Empathy and Food Sensitivities
00:08:11 - 00:10:11
Dr. J discusses the lack of empathy some individuals exhibit towards those with food sensitivities, suggesting a correlation with genetic mutations. Brent shares his experience with anxiety and stress, attributing it to overwork and potentially low vitamin D levels. Dr. J reveals that Brent possesses a gene mutation in his oxytocin receptor, impacting his empathy levels. They discuss the implications of this mutation, with Dr. J suggesting it could be beneficial in business, while Brent admits that negative feedback still affects him despite the genetic predisposition. The conversation touches upon the prevalence of online negativity and its impact on individuals.
Caffeine Metabolism and Anxiety
00:10:18 - 00:11:55
Dr. J explains Brent's genetic predisposition to caffeine sensitivity. Brent's genetic report reveals four genes impacting caffeine metabolism, including the CYP1A2 gene with a 164A to C variation, slightly reducing caffeine breakdown. This results in caffeine remaining in Brent's system for approximately six hours. Additionally, other genes indicate increased stimulation and anxiety responses to caffeine. Brent connects this information to his experience of feeling unwell and experiencing heightened anxiety after daily consumption of a sports tea containing caffeine, a fact he was unaware of until reviewing the ingredients.
Caffeine Sensitivity and COMT Gene
00:11:56 - 00:13:43
Dr. J and Brent discuss Brent's caffeine sensitivity, linking it to the caffeine gene and the presence of multiple "plus-minus" genes in his COMT (catechol-O-methyltransferase) profile. Dr. J explains that Brent has two problematic copies of the COMT gene, resulting in potential issues with this gene's function. This genetic predisposition, according to Dr. J, explains Brent's history of dehydration issues, even to the point of near heat stroke. The discussion highlights the connection between genetic predispositions and personal experiences, with Brent's past health problems aligning with the identified genetic markers. Dr. J recommends increased salt and water intake to address the identified genetic issues.
Creatine, Dehydration, and Salt Sensitivity
00:13:43 - 00:15:28
Brent discusses his negative experiences with creatine, including dehydration and cramping. Dr. J explains that a specific gene can cause increased urination of water and salt, exacerbating the dehydrating effects of creatine. Dr. J also notes that salt is often demonized, but that some individuals are more sensitive to salt-induced hypertension than others. Dr. J reviews Brent's notes and confirms that Brent has a low risk for salt-induced hypertension, meaning his hypertension is not likely caused by salt intake. The conversation touches upon the conflicting research on salt and hypertension, attributing some of the discrepancies to genetic variations. Dr. J clarifies that while some individuals experience hypertension from high sodium intake, most do not. Brent then suggests that his hypertension might be related to caffeine consumption, describing a feeling of his body "nodding up" after caffeine intake, which he associates with hypertension.
Caffeine, Hypertension, and Salt Recommendations
00:15:29 - 00:16:50
Brent and Dr. J discuss Brent's hypertension and its potential link to caffeine consumption. Dr. J notes that Brent has a high number of caffeine-related genes, contributing to his condition. They explore the possibility that some of Brent's hypertension might be stress-related and suggest meditative practices. Dr. J recommends Redmond Sea Salt as a preferred salt option due to its affordability, purity (lack of microplastics and radioactivity, unlike some Himalayan salt batches), and iodine content sourced from ancient Utah seabeds. Brent mentions his usual use of Himalayan salt, and Dr. J confirms its general suitability while reiterating concerns about potential contaminants in some batches. The conversation concludes with Dr. J emphasizing the recommendation of Redmond Sea Salt.
COMT Gene, Adrenaline, and Gut Health
00:16:51 - 00:18:24
Dr. J and Brent discuss the COMT gene, its effect on adrenaline levels, and Brent's past experience with caffeine and adrenaline-induced gut issues. Dr. J explains that the COMT gene can lead to prolonged adrenaline presence in the body, increasing susceptibility to adrenaline addiction. Brent relates this to his past struggles with high adrenaline levels, fueled by caffeine consumption. He describes how this led to significant gut damage due to blood being pulled away from the digestive system. Brent details his recovery process, which involved rebuilding his gut health and managing his adrenaline levels. He mentions using probiotics and triphala to support gut detoxification. Dr. J inquires about Brent's use of probiotics and prebiotics, to which Brent confirms his extensive use of probiotics and triphala.
Brent's Dietary Habits and Adrenaline Management
00:18:24 - 00:19:41
Brent discusses his consumption of fermented foods like kombucha, noting its detoxifying and relaxing effects, although he sometimes overdoes it. He also enjoys a glass or two of wine in the evening to lower adrenaline levels, finding that excessive alcohol has the opposite effect. Dr. J agrees with the wine strategy and suggests magnesium supplementation. Brent reveals an allergy to most magnesium supplements, experiencing skin reactions, but finds a spinach-based magnesium supplement effective for managing hypertension and lowering adrenaline, particularly before bed. Dr. J confirms that magnesium is a good approach to counteracting adrenaline.
Estrogen's Effect on COMT Enzyme
00:19:44 - 00:21:13
Dr. J and Brent discuss the impact of estrogen on the COMT enzyme. Brent mentions his exposure to estrogen through his family. Dr. J clarifies that environmental exposure is unlikely to be significant, suggesting dietary sources like soy as more likely culprits. Brent reveals he avoids soy due to perceived estrogenic effects, leading to a discussion about avoiding soy and other estrogenic substances. Dr. J advises against soy and highlights lavender and flax as additional sources of estrogen to avoid, emphasizing their potential to further impair COMT enzyme function. Brent expresses surprise at the information regarding flax, a food he regularly consumes. Dr. J suggests he consider eliminating flax from his diet as well.
Plant Estrogen Levels in Food
00:21:16 - 00:22:14
Dr. J discusses a Canadian study on phytoestrogens in 200 plants. Almost all plants tested contained less than 1000 micrograms of estrogen per 100 grams of food, except soy (over 100,000 micrograms) and flax (300,000 micrograms). Brent mentions reports of men experiencing gynecomastia and lactation from soy consumption. Dr. J confirms this and adds that similar effects are now being linked to lavender.
Flax and Soy Consumption Risks for Athletes with Specific Genes
00:22:15 - 00:22:54
Brent asks about the estrogen content in flax seeds and oil. Dr. J explains that gut bacteria metabolize these estrogens, but advises against flax and soy consumption for Brent due to a specific gene and his athletic status. Brent inquires about testosterone enhancement strategies. Dr. J suggests it's not strictly necessary given Brent's gene but generally beneficial for health, although a personalized approach is needed.
Cholesterol, Inflammation, and Cardiovascular Health
00:22:56 - 00:24:24
Dr. J explains that while cholesterol can be used to enhance testosterone, the primary concern for Brent is inflammation, given his family history of cardiovascular disease (including multiple stints, a defective heart valve, and a heart attack). Dr. J notes that inflammation causes damage to blood vessels and arteries, and cholesterol acts as a repair mechanism, not the root cause. Brent expresses concern about his family history and asks how to combat inflammation. He mentions using good oils (excluding flax) and omega-3s, and asks about fish oil. Dr. J suggests sardines as a preferable source of omega-3s. The discussion then turns to the importance of exercise and the negative effects of overtraining, which contributes to inflammation. Brent adds that he's noticed kombucha helps reduce his acidity and inflammation, and asks Dr. J if this is accurate.
Gut Bacteria and Inflammation
00:24:25 - 00:25:55
Dr. J explains that feeding gut bacteria can reduce inflammation. Brent agrees, noting the link between bowel issues and inflammation. Dr. J mentions that approximately 10% of his patients have a genetic issue affecting the breakdown of tyramine and similar compounds in fermented or aged foods, causing problems like bloating. Brent shares that he benefits from kombucha, while his wife experiences negative effects, leading Dr. J to suggest she might have this genetic issue. Dr. J emphasizes the prevalence of this genetic issue and the importance of personalized approaches to diet and health, given the current trend of recommending fermented foods. The conversation transitions to the next topic on the list.
NAT2 Gene and Carcinogen Breakdown
00:25:55 - 00:26:13
Dr. J introduces NAT2 (N-acetyltransferase), a gene involved in carcinogen breakdown. The discussion begins to explore the role of this gene and its implications for health.
Cancer Risk and Antioxidant Intake
00:26:13 - 00:27:53
Dr. J and Brent discuss Brent's family history of cancer, including his father's cancer and his grandparents' deaths from colon and breast cancer at relatively young ages. Dr. J explains that this increases Brent's cancer risk. Brent mentions his regular vitamin C intake. Dr. J cautions against overconsumption of antioxidants, explaining that while they are important for eliminating carcinogens, excessive intake can protect cancer cells, allowing them to survive and proliferate. Dr. J suggests cycling antioxidant intake, emphasizing the importance of allowing the body to eliminate cancer cells naturally. Brent expresses concern about his daily consumption of antioxidants through smoothies and wine. Dr. J advises that this might be excessive and recommends cycling antioxidant intake to avoid potentially hindering the body's natural cancer-fighting mechanisms. Dr. J highlights vitamin C's unique role in producing hydrogen peroxide, which aids in eliminating cancer cells.
Cancer-Fighting Antioxidants and the Role of Viruses
00:27:58 - 00:29:57
Dr. J explains that some antioxidants, unlike most others, actively kill cancer cells. Brent mentions a belief that small amounts of food-grade hydrogen peroxide can help fight cancer, possibly due to the viral aspect of some cancers. Dr. J confirms that some viruses insert into DNA and accelerate cell reproduction, but stresses that anything eliminating these cells is beneficial, similar to how chemotherapy works by stressing all cells. Dr. J expresses dislike for chemotherapy, considering it a last resort, after Brent shares a story about a friend who died after two rounds of chemotherapy. The conversation shifts to the NAT2 gene, and Dr. J notes that garlic inhibits the function of this enzyme, which processes carcinogens. Brent, a daily garlic consumer, is advised to cycle garlic intake as it can reduce the body's ability to eliminate carcinogens. Brent mentions a new garlic product containing allicin, noting its positive effects on blood thinning and blood pressure.
Antioxidant Cycling and Cancer Treatment
00:29:57 - 00:31:50
Dr. J explains the concept of cycling antioxidants like garlic and blueberries, suggesting taking them every other day to allow the body to process them effectively and avoid inhibiting enzymes responsible for eliminating carcinogens. He cites a New England Journal of Medicine study from the 90s showing that giving smokers antioxidants increased lung cancer rates by 20%, highlighting the recent discovery that this is due to antioxidants protecting cancer cells. Brent shares an oncologist's concern about patients becoming "health freaks" after cancer diagnosis, questioning the approach. Dr. J strongly advocates for a "health freak" approach, emphasizing the importance of supporting the body's fight against cancer. He notes that many cancers burn sugar, making sugar elimination (through strategies like veganism) a crucial step. Brent mentions reading about this topic further.
Cancer Cell Metabolism and the Warburg Effect
00:31:50 - 00:33:35
Brent and Dr. J discuss the metabolic processes of cancer cells, focusing on the Warburg effect. Brent explains that cancer cells primarily burn glycogen and glucose, producing lactic acid, even when mitochondria are present. Dr. J elaborates, stating that mitochondria are the powerhouses of cells, but cancer cells bypass them, converting glucose to pyruvate and lactic acid outside the mitochondria, a less efficient energy production method. This inefficient process is known as the Warburg effect, and the reasons behind it remain unknown to scientists. Dr. J highlights that fat metabolism, unlike glucose, necessitates mitochondrial function. Therefore, a diet rich in fat and low in sugar could force cancer cells to utilize their mitochondria, potentially hindering their growth. Dr. J concludes that a high-fat diet could be a preventative measure against cancer, although this statement might not be endorsed by medical doctors.
Detoxification and Diet Strategies
00:33:36 - 00:34:09
Dr. J mentions Dr. Joseph Mercola's diet, which focuses on teaching the body to burn fat consistently. Brent notes the difficulty of eliminating sugar due to its addictive nature, even for those with cancer. The conversation then shifts to detoxification, with Brent acknowledging the need for a sugar detox. Dr. J confirms sugar's addictive properties and transitions the discussion to Brent's athletic profile.
Detoxification Methods and Exercise Recommendations
00:34:09 - 00:35:15
Brent asks about detoxifying carcinogens beyond garlic. Dr. J suggests stress reduction and exercise as beneficial methods, highlighting exercise's role in improving blood flow and system filtration. Brent clarifies whether weightlifting or vascular exercise is more effective. Dr. J explains that Brent's genetic profile, primarily that of a sprinter, makes high-intensity interval training (HIIT) optimal. Brent suggests CrossFit or circuit training as potential models, aiming for a balance between aerobic and anaerobic exercise.
High-Intensity Training and Central Nervous System Response
00:35:16 - 00:36:06
Dr. J describes sprint interval training, differentiating it from powerlifting and Olympic lifting. Brent shares his positive experience with Olympic lifting but notes that under high stress, combined with caffeine, the high-intensity training overstimulated his central nervous system, making it difficult to calm down and hindering his ability to manage his parasympathetic state. He explains that his central nervous system couldn't handle the combined effects of stress, caffeine, and high-intensity training.
Training, Caffeine, Adrenaline, and Genetic Predisposition
00:36:07 - 00:36:29
Dr. J acknowledges Brent's concerns. Brent summarizes his point: while training is beneficial, it negatively interacts with his caffeine and adrenaline issues, sometimes exacerbating them. Dr. J then mentions Brent's beneficial gene, nitric oxide synthase, common in power athletes.
Genetic Predisposition and Athletic Performance
00:36:32 - 00:38:08
Dr. J discusses Brent's genetic advantages for athletic performance, mentioning beneficial genes related to vasodilation (NAS3) and overall strength. Brent confirms his exceptional strength, high food intake to maintain muscle mass, and a family history of strength. However, Brent also describes challenges with joint tightness, particularly in his shoulders, leading to overwork and injury due to limited hip mobility. Dr. J notes Brent's low risk for lumbar disc issues, contrasting with the upper body joint problems. The conversation highlights the complex interplay between genetic advantages, physical limitations, and injury risk in high-performance athletes.
Athletic Profile and Dietary Review
00:38:08 - 00:39:37
Dr. J cautiously suggests a more careful approach to training for individuals at risk of low back problems, noting Brent's high response to amphetamines and the importance of monitoring stimulant intake. They discuss Brent's ability to digest dairy despite a past lactose intolerance. Dr. J highlights Brent's high HDL cholesterol, attributing it to several genes and emphasizing that the HDL/LDL ratio, along with particle size, is crucial for cholesterol assessment. Brent explains his previous high cholesterol readings and doctors' recommendations for statins, which are deemed unnecessary given his high HDL levels. Dr. J confirms the importance of the HDL/LDL ratio and particle size, noting that high bad particles often stem from inflammation, which needs to be addressed. Brent expresses his belief that he has inflammation.
The Impact of Age and Glutathione on Inflammation
00:39:41 - 00:41:21
Brent expresses his feeling of having a gene that doesn't help with inflammation, highlighting the need to manage stress and diet. Dr. J relates this to the body's decreasing ability to detoxify with age, using the example of hangovers being more severe in older age. Dr. J introduces glutathione, the body's main antioxidant, explaining that its production decreases with age and that its levels can be increased through supplementation. Specifically, Dr. J recommends liposomal glutathione, emphasizing that regular glutathione is destroyed by stomach acid. Liposomal glutathione is presented as a solution to increase glutathione levels and potentially reduce inflammation, a point confirmed by Dr. J in response to Brent's question.
Glutathione and Stress Management
00:41:21 - 00:41:38
Dr. J discusses the use of glutathione to reduce inflammation, noting its high cost and suggesting it be used only during periods of stress. While acknowledging that some individuals have genetic issues requiring its consistent use, Dr. J advises Brent, who doesn't have such issues, to cycle its use based on need due to the expense.
Genetic Predisposition to Sweet Foods and Colon Cancer Risk
00:41:38 - 00:42:12
Dr. J mentions Brent's sweet tooth gene, Fucosal transferase, and explains that Brent has a 17-fold increased risk of colon cancer from processed meats. The conversation touches upon Brent's high consumption of processed meats.
Processed Meats and Preservatives
00:42:12 - 00:42:57
Brent requests clarification on what constitutes "processed meat," leading Dr. J to explain that it includes items like bologna and salami, which contain preservatives and potentially expired meats. Dr. J emphasizes the masking effect of these additives, making it difficult to detect spoilage. Brent shares his reduced meat consumption due to past gut issues and difficulty digesting meat.
Dietary Recommendations and Health Profile
00:42:57 - 00:44:31
Dr. J advises Brent to limit processed meat consumption due to its potential health risks, citing the impact of colon cancer on Brent's grandfather. The discussion then shifts to Brent's health profile, revealing a surprising resistance to norovirus. Dr. J explains the severity of norovirus, contrasting it with Brent's immunity. Finally, the conversation turns to Brent's telomeres, which are longer than average. Dr. J explains that longer telomeres are associated with better health and longer lifespan, although testing telomere length is costly. Brent inquires about the length of his telomeres, and Dr. J confirms that his are long, which is positive.
The Effects of Space Radiation on DNA
00:44:31 - 00:45:49
This segment discusses the impact of space radiation, particularly cosmic radiation and iron particles, on DNA. Brent and Dr. J discuss a study on twins, where one spent a year in space, resulting in significant telomere lengthening. Dr. J explains that space radiation, worse than constant x-ray exposure, causes double-stranded DNA breaks. These breaks lead to mutations or cell death due to the body's imperfect repair mechanisms. Dr. J mentions a NASA presentation highlighting radiation as the biggest challenge for Mars missions, emphasizing that radiation penetrates even iron suits and spaceships.
Altitude and DCA Metabolism
00:45:49 - 00:47:09
Dr. J discusses Brent's DNA results, noting his slow metabolism of DCA, a chemical found in public pools and used as a chemotherapy drug. Brent mentions his master's studies on altitude, leading to a discussion about the human body's limitations at high altitudes. Dr. J explains that DCA can be absorbed through the skin and that while not a major concern for occasional exposure, frequent public pool use might be problematic due to Brent's slow metabolism. Dr. J suggests that using coconut oil might reduce skin absorption, but recommends limiting public pool exposure. Brent expresses concern about his children's frequent pool use. Dr. J reassures him that the slow metabolism won't cause significant problems, just a slower clearance rate. The conversation concludes with Dr. J stating that this information was gleaned from Brent's DNA analysis and Brent expressing his appreciation.
Athlete Optimization Through Genetic Insights
00:47:12 - 00:49:14
Brent and Dr. J discuss the application of genetic information to optimize athletic performance, specifically focusing on baseball. Brent raises the question of how genetic predispositions, such as those indicating suitability for sprinting versus endurance activities, can inform training and dietary recommendations for athletes. Dr. J emphasizes the importance of self-awareness in training and highlights the significant role of diet (protein, carbs, fats balance) in achieving optimal performance. He notes that while many athletes eventually learn these things through experience, genetic insights can significantly shorten this learning curve. Brent agrees, emphasizing the importance of body awareness and health in extending athletic careers, particularly in baseball, where the high volume of games often overshadows the need for holistic health management. Brent contrasts this with a prevalent baseball culture that prioritizes immediate performance output over long-term health.
The Impact of Genetics and Proactive Health Management on Athletic Longevity
00:49:14 - 00:51:18
Brent discusses the importance of early body optimization for a long professional athletic career, noting that without it, only those with exceptional genetics will succeed. Dr. J agrees, citing examples of high-end athletes who succeeded due to luck rather than proactive health management. The conversation shifts to the genetic advantages of some athletes, using Major League Baseball players as an example. Dr. J mentions Tom Brady as a counterpoint, highlighting his dedication to diet and training as key factors in his longevity, despite potential unknown genetic predispositions. Dr. J emphasizes that even with genetic challenges, understanding and mitigating them can lead to high performance levels. Brent uses Peyton Manning's career as an example, suggesting that early awareness of a family history of spinal degeneration could have potentially extended his career. Brent explains that Peyton's brother Cooper's inability to play football due to a similar spinal issue highlights the importance of proactive health management based on genetic predisposition. The conversation concludes with Dr. J thanking Brent for his time.
Initial Greetings and Collaboration
00:51:18 - 00:51:23
The speaker expresses enjoyment of the conversation and anticipates a positive working relationship with the team at Top Philosophy.
DNA with Dr. Jay, Episode 03.
FACTOR 5 LEIDEN with Stefani (from San Antonio)
FACTOR 5 LEIDEN with Stefani (from San Antonio)
Detailed A.I. Summary
**CLICK HERE TO READ
Podcast Introduction and Promotion
00:00:00 - 00:01:37
Dr. J introduces his unique DNA Consulting podcast, highlighting its focus on interesting conversations and case studies illustrating the power and limitations of DNA analysis. He mentions a recent conversation with an anti-poaching unit member in Africa and emphasizes the learning opportunities from diverse health issues discussed. Dr. J promotes his website, ajconsultingcompany.com, and his Patreon page, patreon.com/anthonygj, where he offers a free video of him and his family bow fishing. He also mentions plans for a future podcast about fish.
Initial Contact and Technical Check
00:01:42 - 00:02:10
Dr. J and Stephanie initiated contact, confirming audio setup for a podcast recording. Dr. J apologized for a delayed package and noted this was his first podcast interview, acknowledging a trial-and-error approach.
Location and Current Situation in San Antonio
00:02:10 - 00:03:05
Stephanie, located in San Antonio, Texas (despite her phone showing Missouri due to military relocation), discussed the impact of COVID-19 on the city, particularly the cancellation of Fiesta. She expressed concern about the planned reopening of the city. Dr. J briefly commented on San Antonio's attractions, including the Alamo.
Texas Experiences and Podcast Discussion
00:03:05 - 00:04:07
Dr. J and Stephanie discuss their experiences in Texas, specifically comparing Austin and San Antonio. Stephanie, a relatively new resident (two years), notes that Texas feels like its own country. Dr. J agrees, highlighting the distinct differences between the two cities; San Antonio feels more Spanish-influenced, while Austin has a more Californian vibe. They briefly discuss the culinary scenes, with Stephanie pointing out Austin's farm-to-table restaurant prevalence. The conversation then transitions to the podcast recording itself, with Dr. J expressing appreciation for Stephanie's participation and Stephanie reciprocating the sentiment.
Podcast Preparation and Genetic Analysis
00:04:07 - 00:04:32
Dr. J confirms receipt of a PDF document sent to Stephanie, slightly later than usual. Stephanie confirms she is reviewing it. Dr. J indicates they will go through the document together. Dr. J comments on Stephanie's good genes and suggests a correlation between the information in the PDF and Stephanie's health issues.
Meeting Agenda Review
00:04:32 - 00:05:05
Dr. J outlined the five sections of the meeting agenda: brain optimization, diet, detox and vitamins/hormones, gym/training, and sleep. Stephanie confirmed she was in the Central time zone, and it was 7:30 AM for her. Dr. J mentioned being out late the previous night.
Carp Bowfishing Discussion
00:05:06 - 00:05:52
Dr. J recounted a night spent bowfishing for carp. He explained that carp are invasive, destructive fish that harm native species like trout. He described the specialized equipment used: a fiberglass arrow with a 200-pound test string and barb, used to shoot the carp. Stephanie expressed unfamiliarity with this activity.
Carp Fishing Excursion
00:05:52 - 00:07:14
Dr. J recounts a carp fishing trip with his daughter. They encountered a large school of carp on a bike trail, leading to a several-hour fishing session where they caught approximately 70 carp using a spear gun with barbs for retrieval. Dr. J describes the experience as "insane," noting the excitement of his children who actively participated in catching and handling the fish, resulting in some blood splatter. The conversation touches upon the seasonal nature of finding such large schools of carp and the unusual nature of the event. Stephanie comments on her daughter's aversion to such activities, contrasting it with Dr. J's children's enthusiasm, which stems from their upbringing around hunting.
Childhood Experiences and Environmental Influences
00:07:15 - 00:07:53
Dr. J discusses the contrasting childhood experiences of his children, who were exposed to a lifestyle of outdoor activities and animal handling, unlike children exposed to Disney-like portrayals of animals. Stephanie comments that this upbringing might contribute to the family's resilience. Dr. J expresses hope that this isn't necessary for survival.
Understanding DNA Copies and Gene Reports
00:07:54 - 00:08:45
Dr. J explains that every cell in the body contains two copies of DNA, except for egg and sperm cells which have one. The fusion of egg and sperm results in one copy from each parent. Dr. J clarifies the "+, +" notation on the report, indicating that a particular gene version was inherited from both parents. He simplifies the interpretation by stating that "+" generally signifies a "bad" gene version in the context of the report, as the focus is on identifying potentially problematic genes rather than good ones.
Genetic Risk Factors and Mitigation Strategies
00:08:46 - 00:10:28
Dr. J explains the meaning of "plus plus" and "plus minus" in the context of gene variations, indicating that "plus plus" signifies inheriting a bad gene version from both parents, while "plus minus" means inheriting one bad and one good version. Dr. J clarifies that "plus minus" variations are less problematic due to the presence of a good gene copy, and that "minus minus" variations are not included in the report due to the extensive data involved. The discussion then focuses on the CETP gene, a cholesterol transporter linked to increased Alzheimer's risk, particularly when triglycerides are high. Dr. J recommends checking blood work for triglyceride levels; if above 125, increased cardio exercise is advised to lower them. The doctor notes that high triglyceride levels (e.g., 500) are often associated with sedentary lifestyles and emphasizes the importance of maintaining optimal levels, especially for the caller.
Blood Work and Factor V Leiden Discussion
00:10:29 - 00:12:04
Dr. J advises Stephanie to ensure her triglycerides are checked, differentiating them from LDL. Stephanie mentions needing to switch from military healthcare to get proper blood work done. Dr. J notes Stephanie's previous email mentioning Factor V Leiden. Stephanie explains her history of a DVT ten years ago, leading to Lovenox and Coumadin treatment. After genetic testing, she was diagnosed with Factor V Leiden and prescribed lifelong blood thinners. She expresses frustration with this, detailing inconsistent INR levels and what she perceived as poor medical advice regarding vitamin K and green vegetable consumption. She recounts switching doctors and stopping Coumadin about two to three years prior.
Stephanie's Medical History and Concerns
00:12:04 - 00:13:36
Stephanie discusses her current blood thinner medication, explaining that while it eliminates the need for constant INR monitoring, she feels it's not ideal long-term. She mentions her friend Justin Nault as her referral source and expresses her desire to find a personal medicine doctor to explore alternative solutions. She also reveals that her daughter has Factor V Leiden, prompting her to seek advice on managing both her own condition and her daughter's. Dr. J acknowledges the importance of identifying Factor V Leiden.
Family History and Further Questions
00:13:36 - 00:13:55
Dr. J inquires about family history of heart disease. Stephanie reports limited knowledge of her grandfather's heart issue, who passed away when she was young. The chapter ends mid-sentence.
Review of Genetic Screen Results and Heart Disease Risk
00:13:56 - 00:15:27
Dr. J discusses the caller's genetic screen results, focusing on Factor V Leiden (F5) and its link to heart disease. The caller mentions a family history of heart problems. Dr. J explains that the caller's F5 gene shows a "+/-" result, indicating a four-fold increased risk of thrombosis compared to someone with a normal gene. This increased risk is further exacerbated by pregnancy, due to hormonal changes. The caller explains that she was largely inactive during pregnancy due to severe migraines, which likely contributed to the increased risk.
Blood Thinning Supplements and Risks
00:15:27 - 00:17:20
Dr. J discusses the potential risks associated with blood-thinning supplements, including baby aspirin, grapeseed extract, curcumin, ginger, and ginkgo biloba. He recounts personal anecdotes of overdosing on curcumin and grapeseed extract, resulting in excessive bleeding. Dr. J emphasizes the importance of careful dosage and mentions a friend who experienced similar issues with curcumin. Stephanie shares her experience with prescribed blood thinners and the increased caution she exercises to avoid cuts while cooking. Dr. J highlights the increased risk of internal bleeding, particularly in contact sports like rugby, when blood is excessively thinned. He concludes by suggesting that a functional doctor's guidance is crucial for safe and effective supplementation.
Natural Blood Thinners and Medical System Challenges
00:17:20 - 00:18:51
Dr. J suggests natural blood thinners like curcumin and ginger for the caller, emphasizing the importance of using one at a high dose rather than stacking them. He mentions grapeseed extract as another option with increased lifespan as a side effect. While acknowledging the limited medical literature on dosage for these natural alternatives, Dr. J believes the risk is lower for the caller given their specific circumstances. Stephanie shares her experience with the reluctance of medical doctors, particularly military ones, to deviate from prescribed treatments, highlighting the pressure to comply to receive necessary care. Dr. J empathizes, citing his family's medical background and acknowledging flaws within the system due to its business-oriented nature and rushed patient interactions.
Concerns Regarding Medical Advice and Blind Following
00:18:51 - 00:19:29
Dr. J expresses concern about individuals who act as parental figures, dictating actions without allowing critical thinking. He emphasizes the availability of information online, enabling individuals to research and make informed decisions. He uses the example of a natural supplement potentially causing dangerously thin blood, leading to internal bleeding, as a cautionary tale against blindly following advice. He highlights the importance of critical evaluation of medical information.
Discussion of Specific Heart Disease Risk Genes
00:19:29 - 00:20:27
Dr. J continues by discussing Stephanie's genetic predispositions to heart disease. He reassures her that some risk factors are minor ("plus minus"). He details several genes, including LPA (related to triglycerides), and the SEL-E gene (related to lectins), explaining their impact on heart disease risk. He mentions that the SEL-E gene poses a significant risk, comparable to the factor five gene, increasing inflammation and the risk of plaque buildup in arteries. Stephanie mentions Justin's warnings about lectins, demonstrating some prior knowledge of the topic. Dr. J mentions a doctor who specializes in lectins.
Discussion of Dr. Gundry's "The Plant Paradox"
00:20:29 - 00:21:50
Dr. J and Stephanie discuss Dr. Steven Gundry's book, "The Plant Paradox." Dr. J mentions having discussed the book with Dr. Gundry, who gave a talk at the Mayo Clinic. Dr. J notes that the book's main thesis is that lectins are harmful, though he clarifies that this isn't necessarily true for everyone. He explains that lectins are plant toxins that act as a defense mechanism against predators, and that grains and seeds are significant sources of lectins. Dr. J observes that avoiding grains often leads to improved health, contrasting this with government dietary recommendations. He concludes by summarizing Dr. Gundry's perspective on lectins and their impact on health.
Lectin Impact on Health and Diet
00:00:50 - 00:23:19
Dr. J discusses the effects of lectins on health, referencing a colleague who has seen artery plaque reversal in patients after lectin removal from their diets. Dr. J explains that while this colleague is a strong proponent of strict lectin avoidance, Dr. J takes a more moderate approach. He suggests that the impact of lectins may depend on individual genetic factors, specifically mentioning lectin-binding genes that can increase inflammation. He advises paying closer attention to lectin intake if artery plaque is present, as evidenced by CT scans, but suggests less concern if plaque is absent. The conversation concludes with a caller expressing understanding and Dr. J acknowledging the varying impact of lectins on individuals.
Transition to Brain Health and Stress
00:23:19 - 00:23:48
Dr. J transitions the conversation from the discussion of lectins to the next topic: brain health. He acknowledges the importance of this topic and mentions that stress will be the following category of discussion, noting that the caller has a "plus-plus" in this area, implying a significant level of stress.
Oxytocin Receptor and Stress Management
00:23:49 - 00:25:37
Dr. J explains that the oxytocin receptor gene indicates the brain's ability to handle stress. A less efficient receptor means the individual is more susceptible to stress. Dr. J suggests increasing oxytocin levels to mitigate stress, referencing a Self-Hacked article listing 34 ways to do so, including consuming dark chocolate. Stephanie notes that her parents, both deceased, were highly stressed individuals, indicating a potential genetic predisposition. Dr. J adds that genetic predisposition (plus-plus, plus-minus) and upbringing significantly impact stress response, even with favorable genes.
Parental Reactions to Children's Distress
00:25:37 - 00:26:55
Dr. J discusses how parental reactions to minor childhood incidents can influence a child's behavior, noting that overreacting parents might inadvertently teach their children to overreact. Stephanie shares an anecdote about her husband's intervention when she tends to overreact to her daughter's minor injuries, highlighting the instinctive parental urge to feel a child's pain intensely. She emphasizes the difficulty of explaining this empathetic pain to those who haven't experienced it, particularly her husband. Dr. J agrees, using the analogy of parenthood itself being inexplicably difficult to understand until experienced firsthand.
Caffeine Metabolism and Anxiety Gene Discussion
00:26:55 - 00:28:58
Dr. J and Stephanie discuss Stephanie's genetic predisposition to caffeine metabolism and anxiety. Dr. J notes Stephanie's fast caffeine breakdown, as indicated by her 23andMe results, and that this isn't a major concern. They then shift focus to other genes related to anxiety, which Stephanie identifies as a long-term issue. Dr. J suggests targeting serotonin and oxytocin levels as potential solutions. The conversation veers into a discussion of individuals who experiment with biohacking techniques, including injecting oxytocin, with Stephanie mentioning Ben Greenfield and Justin as examples of people who explore these methods. Dr. J concludes by observing that tinkering with the body's systems can be both a hobby and a passion.
Post-Active Duty Plans and Diet Discussion
00:28:58 - 00:30:37
Stephanie explains that she delays exploring certain topics discussed by Justin until her husband's retirement from active military duty to maintain a sense of normalcy. Dr. J then transitions the conversation to diet, stating that most people possess genes indicating a risk for type 2 diabetes, suggesting that high-carb diets are likely detrimental. Dr. J asks Stephanie if she's checked her fasted blood sugar; Stephanie hasn't but intends to, though she's nervous. She mentions increased stress during quarantine and plans to utilize discounted blood work links provided by Justin, but needs to find a functional medicine doctor. Justin cautions her to fully commit to the Clovis diet before getting blood work done.
Blood Work and Diet Commitment
00:30:38 - 00:31:57
Stephanie discusses her doctor's advice to delay blood work until she's fully committed to a diet change, acknowledging her current numbers are likely not ideal. Dr. J confirms that her carb tolerance is better than average but emphasizes the importance of intense exercise to prevent fat storage, even for those with good carb metabolism. The concept of "skinny fat," where individuals appear thin but have high visceral fat, is introduced. Dr. J highlights the benefits of intense exercise and promises to discuss exercise routines later. Finally, Dr. J notes Stephanie's favorable genetic predisposition towards intermittent fasting.
Intermittent Fasting and Lifestyle
00:32:02 - 00:32:11
Stephanie shares her positive experience with intermittent fasting, relating it to her and her husband's military background and lifestyle. The chapter ends abruptly mid-sentence.
Intermittent Fasting and Blood Sugar
00:32:15 - 00:33:53
Stephanie describes her preference for later breakfasts, often not feeling hungry until 9 or 10 am, despite her partner advocating for early morning meals. Dr. J agrees, stating that breakfast might be the least important or even most detrimental meal for many, suggesting that waiting until noon for lunch might be better, especially if blood sugar is above 90. The importance of checking fasted blood sugar levels upon waking (below 90) is emphasized. Dr. J then explains the role of genetics, specifically mentioning intermittent fasting's importance and the ADIPOQ gene (adiponectin), a hormone aiding fat burning, which is produced in lower amounts in individuals with a specific genetic marker (implied to be Stephanie's "plus-plus" status). This lower production is identified as a potential negative aspect of this genetic marker.
Benefits and Debate Surrounding Intermittent Fasting
00:33:53 - 00:35:22
Dr. J explains that intermittent fasting increases the production of a hormone that helps burn fat, making it a strong argument for the practice. Stephanie mentions her husband's interest in the scientific basis for skipping breakfast. Dr. J recounts a recent talk given to Special Forces personnel where he mentioned intermittent fasting as beneficial for many, based on his genetic analysis of individuals. His casual mention sparked a lively debate among the 100+ attendees, highlighting the contentious nature of intermittent fasting within the nutrition community, particularly given the Special Forces' early-morning training routines and high-intensity physical demands. Dr. J acknowledges that there are arguments both for and against intermittent fasting in such high-demand situations.
Peak Human Performance and Training Cycles
00:35:22 - 00:37:00
Dr. J discusses the impact of training intensity and dietary practices like intermittent fasting on peak performance. He acknowledges that intense training, especially at the level of Special Forces, might lead to performance decrease. He mentions the difficulty of maintaining sufficient caloric intake to compensate for energy expenditure during intense training. However, he also points out that peak performance isn't sustainable and uses the example of Hafthor Julius Bjornsson, a strongman who recently broke a deadlift record, to illustrate the concept of training cycles. Dr. J explains that even elite athletes like Bjornsson require periods of rest and recovery after periods of extreme exertion to allow their bodies to recover and avoid injury. He emphasizes that the human body operates in cycles of peak performance followed by periods of deloading and recovery, and this applies even to individuals at the highest levels of physical training. Therefore, even for Special Forces personnel, there's a valid argument for incorporating intermittent fasting into their training regimen.
Military DNA Testing Concerns
00:37:00 - 00:38:03
Stephanie discusses her husband's military affiliation and the military's caution against DNA testing, citing potential security risks. Dr. J reveals involvement in discussions with higher-ups regarding widespread DNA testing within the military, ultimately resulting in a decision against it and subsequent public announcements discouraging 23andMe usage, particularly among special forces.
Ethical Concerns of Genetic Targeting
00:38:05 - 00:38:56
Dr. J explains the rationale behind the military's decision, highlighting the potential for genetic information to be exploited in designing targeted viruses. The discussion touches upon the coronavirus as a contrasting example, noting its broad impact despite potential contributing factors like smoking habits in certain populations. Dr. J mentions the ACE2 receptor as a binding site for the coronavirus.
Genetic Variations in Coronavirus Response
00:38:57 - 00:40:29
Dr. J explains that there are 15 different genetic versions of the ACE2 receptor, influencing how the coronavirus affects individuals. Some genetic versions result in minimal binding of the virus, leading to asymptomatic positive tests. Other versions cause strong binding, resulting in significant symptoms like coughing and fever. Dr. J then discusses the argument against the coronavirus being a bioweapon designed by China. The argument posits that if China intended to create a bioweapon, they would have designed it to target populations genetically different from their own, rather than affecting the largely homogenous Chinese population. The caller agrees, and Dr. J further elaborates that a targeted bioweapon could theoretically be designed to affect specific groups, like special forces operators, based on their DNA, while leaving the originating population unaffected.
Concerns Regarding Vaccine Heterogeneity and Data Collection
00:40:32 - 00:42:10
Dr. J expresses concern about the significant heterogeneity and variation among individuals, particularly within the diverse population of the U.S. special forces, making generalizations about potential vaccine side effects challenging. Stephanie shares an anecdote about her and her husband's numerous anthrax vaccinations, humorously speculating about potential long-term effects and contrasting the military's caution about such effects with the reality of receiving numerous vaccinations during active duty. Dr. J proposes a solution to overcome data collection obstacles: personally purchasing DNA kits, assigning random numbers to participants, collecting samples, and submitting them to 23andMe under his name to maintain anonymity and comply with regulations. This method would allow for genetic analysis without compromising the identities of the special forces personnel.
Understanding the Military's Stance on Genetic Testing
00:42:11 - 00:43:07
Dr. J explains that the military's reluctance towards genetic testing stems from a lack of understanding of genetics among many personnel. Fear of the unknown leads to a precautionary approach, even though Dr. J understands the science. Stephanie shares that her husband's inherent skepticism, coupled with the military's discouragement, makes genetic testing highly unlikely for them. They discuss the upcoming podcast and how Stephanie will share it with her husband, considering he might be listening. Dr. J notes the common occurrence of spouses listening in and confirms Stephanie's ability to hear both sides of the podcast recording clearly.
Podcast Recording and Technical Details
00:43:07 - 00:43:38
Dr. J explains the recording process, clarifying that he's using a headset and will merge both recordings (his and Stephanie's) after receiving her recording device to ensure high-quality audio for both participants. He points out a common issue with podcasts where guests using less professional equipment result in poor audio quality compared to the host.
Audio/Technical Difficulties and Metformin Discussion
00:43:38 - 00:45:11
Dr. J explains that the audio quality from a fuzzy Skype track is poor and irritating. They then transition to discussing metformin, a drug derived from a French lilac plant. Dr. J explains that metformin is currently a prescription drug in America, despite its natural origins, and that it's being studied for its potential lifespan-increasing effects in animals. The doctor notes that common side effects include diarrhea, particularly with high doses or poor genetics (which Stephanie does not have). Metformin's benefits include lowering blood sugar, increasing metabolism, and potentially increasing lifespan. Stephanie confirms that having "plus pluses" in both categories is positive, and Dr. J emphasizes that this is a good gene and a good solution for managing high blood sugar (above 90), suggesting it as a relatively inexpensive option.
Review of Heart Disease, Gut Health, and Genetic Predisposition
00:45:12 - 00:46:09
Dr. J reassures the caller about previously discussed heart disease, mentioning the CRP blood test as a factor to monitor but not overly worry about. The leaky gut section is also addressed, suggesting the caller follow recommendations if needed, while highlighting the caller's surprisingly phenomenal gut genes. Stephanie expresses surprise, given her past health issues. Dr. J clarifies that her anxiety may be more linked to brain genes than gut health, based on her 23andMe results, which are considered thorough. The conversation transitions to the next section.
Vitamins, Hormones, and Detox: Focus on Vitamin D Deficiency
00:46:11 - 00:46:46
The discussion moves to vitamins, hormones, and detox, with vitamin D highlighted as showing numerous positive indicators in the caller's results. Stephanie confirms past low vitamin D test results, explaining that while she hasn't had a recent test, she's been increasing her sun exposure due to the pandemic.
Vitamin D Dosage and Gut Health
00:46:46 - 00:48:22
Stephanie discusses the effects of stress on gut health, mood, and energy levels. She mentions taking 10,000 IU of Vitamin D daily based on previous recommendations from Justin. Dr. J confirms that 10,000 IU is on the higher end of the recommended range (2,000-10,000 IU), suggesting that it's likely sufficient. Dr. J emphasizes the importance of monitoring Vitamin D levels through blood tests, recommending a consistent dose for a month (e.g., in January or February), followed by a blood test to determine the optimal dosage. He explains that the necessary dosage can vary depending on sun exposure, suggesting a lower dose during sunnier months. The conversation concludes with Dr. J's humorous comment about the frequency of rain in San Antonio.
Vitamin D Supplementation and Timing
00:48:26 - 00:49:47
Dr. J and Stephanie discuss the challenges of tracking vitamin D levels due to inconsistent sunshine exposure. Stephanie reveals she was unaware of the advice against taking vitamin D3 in the evening, a practice Dr. J explains disrupts melatonin production and sleep. Dr. J recommends taking vitamin D3 in the morning with fat for better absorption, suggesting butter or MCT oil. The conversation touches upon Stephanie's caffeine intake from coffee and a protein powder, with Dr. J suggesting delaying caffeine consumption until noon to align with intermittent fasting. Finally, Dr. J reiterates the importance of taking vitamin D with fat for optimal absorption and mentions the significance of K2 alongside vitamin D.
Factor V Leiden and Estrogen's Role in Thrombosis
00:49:47 - 00:51:21
Dr. J explains how higher doses of medication help keep calcium out of arteries. The conversation then shifts to the caller's (Stephanie's) genetic predisposition towards higher estrogen levels, which Dr. J suggests is a significant contributor to her thrombosis, alongside her Factor V Leiden. Dr. J highlights the increased risk of thrombosis in individuals on birth control, particularly those with Factor V Leiden. Stephanie expresses concern about her 10-year-old daughter inheriting the Factor V Leiden gene and the potential implications for birth control use in the future. Dr. J confirms that the daughter will inherit at least one plus gene, but emphasizes the impossibility of determining which parent contributed which gene. The discussion concludes with Dr. J reiterating the combined risk of Factor V Leiden and high estrogen levels.
Sauna Benefits and Detoxification
00:51:22 - 00:52:49
Dr. J discusses the genetic inheritance of certain traits, using the example of "plus plus" and "plus minus" genes. The conversation then shifts to the benefits of saunas, with Stephanie expressing her desire to buy a personal sauna after previously using them regularly before the pandemic. Dr. J strongly supports this, highlighting the numerous health benefits of saunas. Dr. J cites a study involving skin patches that measured the absorption of chemicals like BPA, phthalates, oxybenzone, and artificial estrogens. The study showed that individuals who used saunas significantly reduced the absorption of these chemicals compared to those who did not, providing scientific evidence supporting the detoxifying effects of saunas. Stephanie expresses satisfaction at having scientific backing for her sauna purchase plans.
Estrogen, Environmental Estrogens, and Dr. J's Book
00:52:49 - 00:54:28
This segment discusses the findings of "BUS studies" (blood, urine, sweat) on estrogen levels, highlighting that artificial estrogens are far worse than natural ones. Dr. J explains that while natural estrogen is protective within a certain range, both high and low levels can cause problems. The conversation then shifts to Stephanie's experience reading Dr. J's book, which she finds highly scientific and challenging to understand. Dr. J suggests focusing on the book's top ten list of problematic substances, mentioning soy and flaxseed as examples. Stephanie shares her past consumption of flaxseed and expresses her intention to utilize the book's summary at the end for a more concise overview.
Thyroid Health and Iodine Supplementation
00:54:28 - 00:55:41
Dr. J recommends Stephanie implement a specific suggestion from his book, emphasizing its ease of use, especially given her sensitivity. The conversation then shifts to Stephanie's thyroid health, with Dr. J noting potential issues and recommending iodine supplementation as fundamental for improving metabolism due to potentially borderline thyroid hormone levels. Stephanie reveals a past diagnosis of thyroid issues, mentioning a previous prescription of Synthroid, which she took for several months without noticeable improvement. Dr. J acknowledges her experience.
Thyroid Hormone Conversion and Synthroid
00:55:41 - 00:57:15
Dr. J explains the complexities of thyroid hormones, starting with the fact that Synthroid is synthetic T4. The body uses iodine to produce T4, which is then converted to T3, crucial for fat burning and energy. Iodine deficiency leads to insufficient thyroid hormone production, impacting energy levels and weight. Dr. J highlights that while Synthroid provides T4, the caller's genetics (specifically the DIO1 gene) impair the conversion of T4 to T3. Therefore, despite having sufficient T4 from Synthroid, the caller's body doesn't efficiently utilize it for fat burning, resulting in excess T4. The conversation clarifies the confusion surrounding T4 and T3 naming and emphasizes the caller's inefficient T4-to-T3 conversion.
Thyroid Hormone Treatment Discussion
00:57:16 - 00:58:44
Dr. J explains why they generally avoid Synthroid, preferring to let the body naturally produce T3 from T4. However, due to Stephanie's specific genetics, this approach may not be effective. Dr. J suggests Armour Thyroid as a full-spectrum alternative, providing all thyroid hormones for the body to utilize as needed. The doctor also mentions that iodine and exercise could be beneficial, but given Stephanie's genetic predisposition, Armour Thyroid might be necessary. Dr. J emphasizes the potential benefits of Armour Thyroid, including increased energy and overall well-being, noting that many people experience significant improvements. The conversation concludes with Dr. J's opinion that thyroid optimization should be considered for aging individuals, as hormone levels naturally decline with age, and the current system waits too long to intervene.
ADHD and Low Energy
00:58:45 - 00:59:14
Stephanie discusses her experience with ADHD, noting that while her brain is hyperactive, she lacks the physical hyperactivity often associated with the condition. She expresses envy towards those with higher energy levels, contrasting her own low energy. Dr. J acknowledges that low energy is a common complaint.
Armor Thyroid and Carotene Gene Discussion
00:59:14 - 01:00:11
Dr. J explains that many doctors are hesitant about armor thyroid due to its pig-derived nature, despite its effectiveness and similarity to human thyroid hormones. Stephanie expresses enthusiasm for the treatment. Dr. J emphasizes the need for a prescription to avoid overdosing and potential heart problems. The conversation then shifts to the carotene gene, with Dr. J explaining the plus-minus variation and its impact on carotene-to-retinol conversion, stating that this particular variation is not a major concern. The discussion briefly touches upon AKT1.
Cannabis Use and the AKT1 Gene
01:00:11 - 01:01:51
This segment discusses Stephanie's interest in trying cannabis after retirement, prompting Dr. J to explain the effects of the AKT1 gene on cannabis experience. Dr. J explains that this gene can heighten feelings of paranoia, particularly with edibles or high doses, but doesn't pose a significant health risk. Stephanie shares her lack of experience with cannabis, recounting a single instance of secondhand exposure ("contact high") in high school, which led to anxiety about an upcoming military drug test. She describes her unusual attempt to detoxify by drinking a large quantity of pickle juice. Dr. J humorously relates this anecdote to his brothers' similar unusual habits involving pickle juice consumption.
Kombucha and Electrolytes
01:01:52 - 01:03:17
Dr. J discusses a person's kombucha consumption habits, noting that while it might seem unappealing, it's not unhealthy unless it contains artificial dyes. The conversation then shifts to the importance of electrolytes, particularly during intermittent fasting. Dr. J emphasizes the need for adequate hydration and electrolyte intake, advising against fear of salt and suggesting the use of electrolyte supplements, especially after activities like sauna use. Stephanie shares her experience with electrolyte drinks, describing her preference for a salty version and suggesting a higher daily intake than her current one. Dr. J concludes by mentioning that electrolytes can also be obtained through food and that the optimal intake depends on factors like exercise intensity and sweating.
Austin's Influx of Wellness Personalities
01:03:18 - 01:04:27
Dr. J and Stephanie discuss the relocation of several well-known personalities to Austin, Texas. The conversation begins with Dr. J mentioning that his friend Rob Wolf has moved to Austin. Stephanie agrees, noting the city's growing popularity as a residence for influencers, citing Rachel Hollis and Ben Greenfield as examples. Stephanie expresses some reservations about Greenfield's social media presence, specifically his frequent physique selfies. Dr. J defends Greenfield, stating he's a great guy and that it's simply his brand. The conversation then shifts to speculation about Ben Greenfield's actual residence, with Stephanie initially believing he lives in Austin based on a past Instagram post, but later admitting uncertainty. Dr. J, claiming familiarity with Greenfield, expresses surprise at the suggestion. The discussion concludes with both agreeing on the overall trend of people moving to Austin, with Dr. J adding Tim Ferriss to the list and giving a positive review of Rob Wolf's "element" products.
B9 Category Genetic Issues and MTHFR Gene
01:04:31 - 01:05:38
Dr. J discusses Stephanie's B9 category, noting potential genetic issues. The MTHFR gene is mentioned, explained as important in the wellness community, particularly among functional doctors. While acknowledging it's not the only relevant gene (mentioning mthfd1), Dr. J emphasizes that consuming leafy greens can mitigate potential issues. Stephanie mentions she's not a big vegetable eater, but her husband encourages her to eat more. Dr. J suggests supplements as an option alongside leafy greens, concluding that with sufficient leafy green consumption, her genes in this category aren't severely problematic, showing some positive and negative aspects. The overall takeaway is to not get overly concerned with the details.
Heavy Metals and CBS Gene
01:05:40 - 01:06:10
Dr. J moves on to the heavy metals category, highlighting some significant positive indicators. The CBS gene is identified as a key factor, increasing the risk of arsenic buildup. Dr. J advises paying attention to arsenic-containing foods, specifically listing Brussels sprouts, rice (less commonly), and mass-produced chicken due to the grains used in their feed.
Concerns about Chicken Sourcing and Quality
01:06:10 - 01:07:52
Dr. J mentions the potential buildup of arsenic in commercially raised chickens due to low-level exposure in feed. Stephanie shares her preference for free-range chicken from local farmers but notes her husband's reluctance due to his lifelong consumption of Tyson chicken. They discuss the challenges of finding high-quality ribeye steaks from local farms, with Stephanie noting that the tenderness isn't comparable to store-bought options from HEB. Dr. J suggests buying chicken only during summer months from a farmer who allows truly free-range chickens, contrasting this with the often misleading use of the term "free-range" for chickens kept in pens. Dr. J describes their free-range chickens as roaming freely in fields, highlighting the difference in quality and lifestyle compared to winter chickens raised indoors on grain.
Dietary Recommendations and Arsenic Avoidance
01:07:52 - 01:08:14
Dr. J advises stocking up on and freezing fruits in the summer. The main focus is avoiding arsenic, although Dr. J admits not being a super expert on the topic. The discussion then shifts to fructose, with Dr. J emphasizing caution due to its potential impact. Stephanie mentions sugar as a significant concern in her diet, prompting Dr. J to suggest fruits with lower fructose content, referencing a link on their website listing such fruits and their fructose levels.
Fructose Metabolism and PNPLA3 Gene
01:08:14 - 01:09:06
The conversation centers on the PNPLA3 gene (plus plus gene), its link to a higher risk of fatty liver, and its interaction with fructose. Dr. J explains that when fructose enters the body, it's either burned for energy or stored as fat in the liver, with the PNPLA3 gene predisposing individuals to storing it as fat. Stephanie agrees that this is not ideal.
Exercise Recommendations Based on Genetics
01:09:06 - 01:09:17
Dr. J transitions to discussing exercise recommendations, noting that the caller's genetics (ACTN3) suggest a mix of endurance and power training would be beneficial. The chapter ends mid-sentence.
Patient's Genetic Predisposition and Health Concerns
01:09:18 - 01:10:53
Dr. J discusses Stephanie's genetic predisposition for muscle fiber type, indicating flexibility in workout routines but also a potential joint risk for inflammation. Stephanie mentions a past fibromyalgia diagnosis but her aversion to medication due to a negative experience with a sister's heavy medication use. She explains that she chose not to seek medical intervention for her fibromyalgia. Dr. J agrees with her philosophy and explains that due to prolonged birth control use, resetting her system will be a slow process. The doctor highlights the importance of thyroid health, noting a correlation between low thyroid hormones and osteoarthritis risk, indicated by a gene related to joint tissue degradation. Dr. J emphasizes that improving thyroid hormone levels benefits both energy levels and joint health.
Joint Health and Genetic Predisposition
01:10:55 - 01:12:19
Dr. J discusses the caller's genetic predisposition to joint issues. Specific genes are mentioned, including HLA genes linked to arthritis (triggered by high insulin), and IL-2RA, which can be addressed with krill oil. The doctor emphasizes the importance of managing blood sugar levels (potentially through metformin and reduced carb intake or intermittent fasting) to mitigate arthritis risk. Additionally, maintaining healthy thyroid hormone levels through iodine intake is recommended. The ITGIV gene, common in many individuals, highlights the benefit of regular exercise for joint health. Finally, the doctor addresses gout risk, suggesting caution with fructose consumption due to the SLC2A9 gene's role in fructose transport.
Gout and Dietary Advice
01:12:19 - 01:13:02
Dr. J explains that uric acid buildup in joints causes gout, forming crystals like "glass shards." He notes that doctors commonly advise gout sufferers to avoid meat, which he finds humorous because the relevant gene is a fructose transporter, not related to meat consumption. He highlights the flawed advice given to patients, emphasizing that this is common medical practice. Stephanie shares that her husband, who is African-American, has received similar advice to lower sodium and avoid red meat for high blood pressure, despite being an athlete and not having consistently high blood pressure. She questions the validity of this advice.
Blood Pressure and Bone Strength
01:13:02 - 01:13:41
Stephanie mentions that she has never had blood pressure issues, even during stressful times caring for her sick parents. Dr. J is unsurprised, suggesting that exercise helps maintain good blood pressure. The conversation then shifts to bone strength, with Dr. J noting that Stephanie's genetic results show several "plus pluses" in this area.
Bone and Sleep Gene Analysis
01:13:42 - 01:14:40
Dr. J discusses Stephanie's genetic predispositions related to bone strength and sleep. Two genes affecting bone strength have opposing effects, one positive and one negative, likely offsetting each other. Dr. J advises that maintaining vitamin D intake, exercise, and K2 with vitamin D supplementation should mitigate concerns. Regarding sleep, Dr. J identifies a "plus-plus" clock gene as the likely source of sleep difficulties, explaining that this gene variant (along with ABCC9) is common but contributes to sleep disruptions and shorter sleep duration.
Oura Ring Sizing Issue
01:14:41 - 01:15:10
Stephanie mentions her difficulty in obtaining an Oura Ring due to her small ring size (4 and 1/4), which is smaller than the smallest size offered (size 6). She explores the possibility of wearing it on her thumb, but finds this impractical. She mentions receiving the ring as a retirement gift from her husband.
Retirement Gifts and Sleep Improvement
01:15:11 - 01:16:21
Stephanie expresses excitement about purchasing an eight sleep bed and a sauna upon retirement, citing issues with nighttime overheating. Dr. J affirms the importance of temperature regulation for sleep. The conversation shifts to sleep aids, with Dr. J suggesting a magnesium supplement before bed and advising against evening snacking to avoid disrupting sleep cycles. Dr. J shares their experience with the Oura Ring, mentioning wearing it only at night to prolong its lifespan and avoid damage from activities like weightlifting.
Sleep Disruption and Potential Solutions
01:16:31 - 01:18:05
Dr. J discusses the impact of even small amounts of food, including healthy options, on sleep quality, noting a significant negative effect on deep sleep. Stephanie mentions being a night snacker, highlighting the difficulty of breaking this habit. Dr. J suggests that overcoming this cycle takes approximately a week. Magnesium powder is recommended as a supplement for sleep improvement, and low-dose lithium (5mg per day) is also suggested, clarifying that this is a much lower dose than used for mental health treatments. The discussion emphasizes the importance of using a sleep tracker, such as an Oura Ring, to monitor the effectiveness of these strategies. Clinical studies supporting the use of lithium for individuals with specific gene variations affecting sleep are referenced.
Sleep Aids and Strategies
01:18:05 - 01:19:19
This segment discusses personal sleep habits and strategies for improving sleep quality. Stephanie shares her experience with sleep masks, noting that she sometimes misplaces them during the night. Dr. J agrees, relating a similar experience. Stephanie mentions her intention to purchase an Eight Sleep bed within the next year. Dr. J emphasizes the importance of blackout curtains, suggesting a practical in-store test to assess their effectiveness: putting the curtain over one's head to check for complete darkness. He contrasts the use of blackout curtains with sleep masks, advocating for the former as a more effective method for creating a dark sleep environment. Stephanie agrees and adds that she and her husband have different sleep habits, attributing her husband's sleep issues to his military experience.
Sleep Improvement Strategies
01:19:20 - 01:20:46
This segment focuses on improving Stephanie's sleep. A trial separation of sleeping arrangements is suggested, mirroring a trend of people currently doing so. Dr. J emphasizes the critical importance of sleep for overall health, even outweighing genetics. While mentioning the gene ABCC9 (a potassium channel), Dr. J downplays its significance in Stephanie's case, suggesting sufficient potassium intake. Dr. J notes Stephanie's increased blue light sensitivity, recommending caution with screens before bed and suggesting blue light blocking apps or glasses, although her sensitivity isn't considered extreme. Finally, Dr. J mentions a slightly increased risk of seasonal depression in winter, but deems it less of a concern given Stephanie's location in Texas.
Genetic Risk Assessment and Blood Thinning Alternatives
01:20:46 - 01:22:46
Dr. J reassures Stephanie about her genetic predisposition to blood clots, stating that her risk is relatively low due to her location and lifestyle. He mentions that individuals in colder climates with the same gene often face higher risks. The discussion then shifts to Stephanie's current blood-thinning medication. Stephanie expresses concern about the lack of monitoring for the effectiveness of her current treatment, relying solely on the absence of further incidents. Dr. J suggests working with a functional doctor to transition from prescription blood thinners to natural supplements, emphasizing that many of the recommended supplements offer additional health benefits. He advises trying various supplements at low doses to gauge their effects on her body, highlighting that these supplements are beneficial beyond addressing her specific genetic factor.
Post-23andMe Results Discussion and Breast Cancer Risk
01:22:46 - 01:24:50
Dr. J discusses the benefits of anti-inflammatory supplements, emphasizing the importance of individual response and dose adjustment under the guidance of a functional doctor, monitoring INR levels. Stephanie explains her motivations for taking the 23andMe test: her mother's death from breast cancer and interest in diet/lifestyle recommendations. She acknowledges the controversy surrounding the role of genetics versus lifestyle in breast cancer risk. She mentions her mother's death 25 years prior and that her mother's sisters are still alive without breast cancer. Dr. J confirms that Stephanie's genetic predisposition is related to higher estrogen levels, primarily linked to artificial estrogens. He highlights the significant increase in breast cancer rates since 1980, attributing it to environmental factors and chemicals in food rather than solely genetic changes. He suggests referring to the top ten list in his book for further information.
Addressing Caller's Health Concerns
01:24:55 - 01:26:34
Dr. J reassures the caller that their genetic predisposition to certain cancers isn't overly concerning, advising them to avoid specific chemicals. Sauna use is recommended as a method to reverse negative effects. While not overly worried, Dr. J suggests monitoring blood sugar levels, aiming for below 90, as a crucial preventative measure against cancer. The discussion then turns to the book "Tripping Over the Truth," which highlights the Warburg Effect – the observation that cancer cells primarily consume sugar. Dr. J emphasizes the significance of this discovery by Otto Warburg in the 1920s, stating that controlling blood sugar is a fundamental aspect of cancer prevention.
Sauna's Health Benefits and Actionable Steps
01:26:34 - 01:27:57
Dr. J highlights the significant impact of saunas, referencing a 20-year Scandinavian study showing decreased cancer, Alzheimer's, and heart disease rates. This leads to a discussion about the effectiveness of saunas compared to targeting estrogen. Stephanie expresses her relief and gratitude for the actionable steps provided, emphasizing her preference for practical applications. Dr. J reiterates the goal of providing easily applicable advice and appreciates Stephanie's decision to record the podcast for others to benefit. The conversation concludes with a mutual agreement on the value of the information shared and its practical implications.
Finding Financially Rewarding Ways to Help Others
01:27:57 - 01:28:25
Stephanie expresses her passion for helping others but desires to find a financially sustainable way to do so. Dr. J empathizes, relating it to the dissatisfaction of unfulfilling work. They briefly discuss the challenges of aligning passion with financial stability. The conversation concludes with Dr. J promising to follow up via email regarding a recorder and other unspecified matters. Stephanie expresses gratitude for Dr. J's time and assistance.
00:00:00 - 00:01:37
Dr. J introduces his unique DNA Consulting podcast, highlighting its focus on interesting conversations and case studies illustrating the power and limitations of DNA analysis. He mentions a recent conversation with an anti-poaching unit member in Africa and emphasizes the learning opportunities from diverse health issues discussed. Dr. J promotes his website, ajconsultingcompany.com, and his Patreon page, patreon.com/anthonygj, where he offers a free video of him and his family bow fishing. He also mentions plans for a future podcast about fish.
Initial Contact and Technical Check
00:01:42 - 00:02:10
Dr. J and Stephanie initiated contact, confirming audio setup for a podcast recording. Dr. J apologized for a delayed package and noted this was his first podcast interview, acknowledging a trial-and-error approach.
Location and Current Situation in San Antonio
00:02:10 - 00:03:05
Stephanie, located in San Antonio, Texas (despite her phone showing Missouri due to military relocation), discussed the impact of COVID-19 on the city, particularly the cancellation of Fiesta. She expressed concern about the planned reopening of the city. Dr. J briefly commented on San Antonio's attractions, including the Alamo.
Texas Experiences and Podcast Discussion
00:03:05 - 00:04:07
Dr. J and Stephanie discuss their experiences in Texas, specifically comparing Austin and San Antonio. Stephanie, a relatively new resident (two years), notes that Texas feels like its own country. Dr. J agrees, highlighting the distinct differences between the two cities; San Antonio feels more Spanish-influenced, while Austin has a more Californian vibe. They briefly discuss the culinary scenes, with Stephanie pointing out Austin's farm-to-table restaurant prevalence. The conversation then transitions to the podcast recording itself, with Dr. J expressing appreciation for Stephanie's participation and Stephanie reciprocating the sentiment.
Podcast Preparation and Genetic Analysis
00:04:07 - 00:04:32
Dr. J confirms receipt of a PDF document sent to Stephanie, slightly later than usual. Stephanie confirms she is reviewing it. Dr. J indicates they will go through the document together. Dr. J comments on Stephanie's good genes and suggests a correlation between the information in the PDF and Stephanie's health issues.
Meeting Agenda Review
00:04:32 - 00:05:05
Dr. J outlined the five sections of the meeting agenda: brain optimization, diet, detox and vitamins/hormones, gym/training, and sleep. Stephanie confirmed she was in the Central time zone, and it was 7:30 AM for her. Dr. J mentioned being out late the previous night.
Carp Bowfishing Discussion
00:05:06 - 00:05:52
Dr. J recounted a night spent bowfishing for carp. He explained that carp are invasive, destructive fish that harm native species like trout. He described the specialized equipment used: a fiberglass arrow with a 200-pound test string and barb, used to shoot the carp. Stephanie expressed unfamiliarity with this activity.
Carp Fishing Excursion
00:05:52 - 00:07:14
Dr. J recounts a carp fishing trip with his daughter. They encountered a large school of carp on a bike trail, leading to a several-hour fishing session where they caught approximately 70 carp using a spear gun with barbs for retrieval. Dr. J describes the experience as "insane," noting the excitement of his children who actively participated in catching and handling the fish, resulting in some blood splatter. The conversation touches upon the seasonal nature of finding such large schools of carp and the unusual nature of the event. Stephanie comments on her daughter's aversion to such activities, contrasting it with Dr. J's children's enthusiasm, which stems from their upbringing around hunting.
Childhood Experiences and Environmental Influences
00:07:15 - 00:07:53
Dr. J discusses the contrasting childhood experiences of his children, who were exposed to a lifestyle of outdoor activities and animal handling, unlike children exposed to Disney-like portrayals of animals. Stephanie comments that this upbringing might contribute to the family's resilience. Dr. J expresses hope that this isn't necessary for survival.
Understanding DNA Copies and Gene Reports
00:07:54 - 00:08:45
Dr. J explains that every cell in the body contains two copies of DNA, except for egg and sperm cells which have one. The fusion of egg and sperm results in one copy from each parent. Dr. J clarifies the "+, +" notation on the report, indicating that a particular gene version was inherited from both parents. He simplifies the interpretation by stating that "+" generally signifies a "bad" gene version in the context of the report, as the focus is on identifying potentially problematic genes rather than good ones.
Genetic Risk Factors and Mitigation Strategies
00:08:46 - 00:10:28
Dr. J explains the meaning of "plus plus" and "plus minus" in the context of gene variations, indicating that "plus plus" signifies inheriting a bad gene version from both parents, while "plus minus" means inheriting one bad and one good version. Dr. J clarifies that "plus minus" variations are less problematic due to the presence of a good gene copy, and that "minus minus" variations are not included in the report due to the extensive data involved. The discussion then focuses on the CETP gene, a cholesterol transporter linked to increased Alzheimer's risk, particularly when triglycerides are high. Dr. J recommends checking blood work for triglyceride levels; if above 125, increased cardio exercise is advised to lower them. The doctor notes that high triglyceride levels (e.g., 500) are often associated with sedentary lifestyles and emphasizes the importance of maintaining optimal levels, especially for the caller.
Blood Work and Factor V Leiden Discussion
00:10:29 - 00:12:04
Dr. J advises Stephanie to ensure her triglycerides are checked, differentiating them from LDL. Stephanie mentions needing to switch from military healthcare to get proper blood work done. Dr. J notes Stephanie's previous email mentioning Factor V Leiden. Stephanie explains her history of a DVT ten years ago, leading to Lovenox and Coumadin treatment. After genetic testing, she was diagnosed with Factor V Leiden and prescribed lifelong blood thinners. She expresses frustration with this, detailing inconsistent INR levels and what she perceived as poor medical advice regarding vitamin K and green vegetable consumption. She recounts switching doctors and stopping Coumadin about two to three years prior.
Stephanie's Medical History and Concerns
00:12:04 - 00:13:36
Stephanie discusses her current blood thinner medication, explaining that while it eliminates the need for constant INR monitoring, she feels it's not ideal long-term. She mentions her friend Justin Nault as her referral source and expresses her desire to find a personal medicine doctor to explore alternative solutions. She also reveals that her daughter has Factor V Leiden, prompting her to seek advice on managing both her own condition and her daughter's. Dr. J acknowledges the importance of identifying Factor V Leiden.
Family History and Further Questions
00:13:36 - 00:13:55
Dr. J inquires about family history of heart disease. Stephanie reports limited knowledge of her grandfather's heart issue, who passed away when she was young. The chapter ends mid-sentence.
Review of Genetic Screen Results and Heart Disease Risk
00:13:56 - 00:15:27
Dr. J discusses the caller's genetic screen results, focusing on Factor V Leiden (F5) and its link to heart disease. The caller mentions a family history of heart problems. Dr. J explains that the caller's F5 gene shows a "+/-" result, indicating a four-fold increased risk of thrombosis compared to someone with a normal gene. This increased risk is further exacerbated by pregnancy, due to hormonal changes. The caller explains that she was largely inactive during pregnancy due to severe migraines, which likely contributed to the increased risk.
Blood Thinning Supplements and Risks
00:15:27 - 00:17:20
Dr. J discusses the potential risks associated with blood-thinning supplements, including baby aspirin, grapeseed extract, curcumin, ginger, and ginkgo biloba. He recounts personal anecdotes of overdosing on curcumin and grapeseed extract, resulting in excessive bleeding. Dr. J emphasizes the importance of careful dosage and mentions a friend who experienced similar issues with curcumin. Stephanie shares her experience with prescribed blood thinners and the increased caution she exercises to avoid cuts while cooking. Dr. J highlights the increased risk of internal bleeding, particularly in contact sports like rugby, when blood is excessively thinned. He concludes by suggesting that a functional doctor's guidance is crucial for safe and effective supplementation.
Natural Blood Thinners and Medical System Challenges
00:17:20 - 00:18:51
Dr. J suggests natural blood thinners like curcumin and ginger for the caller, emphasizing the importance of using one at a high dose rather than stacking them. He mentions grapeseed extract as another option with increased lifespan as a side effect. While acknowledging the limited medical literature on dosage for these natural alternatives, Dr. J believes the risk is lower for the caller given their specific circumstances. Stephanie shares her experience with the reluctance of medical doctors, particularly military ones, to deviate from prescribed treatments, highlighting the pressure to comply to receive necessary care. Dr. J empathizes, citing his family's medical background and acknowledging flaws within the system due to its business-oriented nature and rushed patient interactions.
Concerns Regarding Medical Advice and Blind Following
00:18:51 - 00:19:29
Dr. J expresses concern about individuals who act as parental figures, dictating actions without allowing critical thinking. He emphasizes the availability of information online, enabling individuals to research and make informed decisions. He uses the example of a natural supplement potentially causing dangerously thin blood, leading to internal bleeding, as a cautionary tale against blindly following advice. He highlights the importance of critical evaluation of medical information.
Discussion of Specific Heart Disease Risk Genes
00:19:29 - 00:20:27
Dr. J continues by discussing Stephanie's genetic predispositions to heart disease. He reassures her that some risk factors are minor ("plus minus"). He details several genes, including LPA (related to triglycerides), and the SEL-E gene (related to lectins), explaining their impact on heart disease risk. He mentions that the SEL-E gene poses a significant risk, comparable to the factor five gene, increasing inflammation and the risk of plaque buildup in arteries. Stephanie mentions Justin's warnings about lectins, demonstrating some prior knowledge of the topic. Dr. J mentions a doctor who specializes in lectins.
Discussion of Dr. Gundry's "The Plant Paradox"
00:20:29 - 00:21:50
Dr. J and Stephanie discuss Dr. Steven Gundry's book, "The Plant Paradox." Dr. J mentions having discussed the book with Dr. Gundry, who gave a talk at the Mayo Clinic. Dr. J notes that the book's main thesis is that lectins are harmful, though he clarifies that this isn't necessarily true for everyone. He explains that lectins are plant toxins that act as a defense mechanism against predators, and that grains and seeds are significant sources of lectins. Dr. J observes that avoiding grains often leads to improved health, contrasting this with government dietary recommendations. He concludes by summarizing Dr. Gundry's perspective on lectins and their impact on health.
Lectin Impact on Health and Diet
00:00:50 - 00:23:19
Dr. J discusses the effects of lectins on health, referencing a colleague who has seen artery plaque reversal in patients after lectin removal from their diets. Dr. J explains that while this colleague is a strong proponent of strict lectin avoidance, Dr. J takes a more moderate approach. He suggests that the impact of lectins may depend on individual genetic factors, specifically mentioning lectin-binding genes that can increase inflammation. He advises paying closer attention to lectin intake if artery plaque is present, as evidenced by CT scans, but suggests less concern if plaque is absent. The conversation concludes with a caller expressing understanding and Dr. J acknowledging the varying impact of lectins on individuals.
Transition to Brain Health and Stress
00:23:19 - 00:23:48
Dr. J transitions the conversation from the discussion of lectins to the next topic: brain health. He acknowledges the importance of this topic and mentions that stress will be the following category of discussion, noting that the caller has a "plus-plus" in this area, implying a significant level of stress.
Oxytocin Receptor and Stress Management
00:23:49 - 00:25:37
Dr. J explains that the oxytocin receptor gene indicates the brain's ability to handle stress. A less efficient receptor means the individual is more susceptible to stress. Dr. J suggests increasing oxytocin levels to mitigate stress, referencing a Self-Hacked article listing 34 ways to do so, including consuming dark chocolate. Stephanie notes that her parents, both deceased, were highly stressed individuals, indicating a potential genetic predisposition. Dr. J adds that genetic predisposition (plus-plus, plus-minus) and upbringing significantly impact stress response, even with favorable genes.
Parental Reactions to Children's Distress
00:25:37 - 00:26:55
Dr. J discusses how parental reactions to minor childhood incidents can influence a child's behavior, noting that overreacting parents might inadvertently teach their children to overreact. Stephanie shares an anecdote about her husband's intervention when she tends to overreact to her daughter's minor injuries, highlighting the instinctive parental urge to feel a child's pain intensely. She emphasizes the difficulty of explaining this empathetic pain to those who haven't experienced it, particularly her husband. Dr. J agrees, using the analogy of parenthood itself being inexplicably difficult to understand until experienced firsthand.
Caffeine Metabolism and Anxiety Gene Discussion
00:26:55 - 00:28:58
Dr. J and Stephanie discuss Stephanie's genetic predisposition to caffeine metabolism and anxiety. Dr. J notes Stephanie's fast caffeine breakdown, as indicated by her 23andMe results, and that this isn't a major concern. They then shift focus to other genes related to anxiety, which Stephanie identifies as a long-term issue. Dr. J suggests targeting serotonin and oxytocin levels as potential solutions. The conversation veers into a discussion of individuals who experiment with biohacking techniques, including injecting oxytocin, with Stephanie mentioning Ben Greenfield and Justin as examples of people who explore these methods. Dr. J concludes by observing that tinkering with the body's systems can be both a hobby and a passion.
Post-Active Duty Plans and Diet Discussion
00:28:58 - 00:30:37
Stephanie explains that she delays exploring certain topics discussed by Justin until her husband's retirement from active military duty to maintain a sense of normalcy. Dr. J then transitions the conversation to diet, stating that most people possess genes indicating a risk for type 2 diabetes, suggesting that high-carb diets are likely detrimental. Dr. J asks Stephanie if she's checked her fasted blood sugar; Stephanie hasn't but intends to, though she's nervous. She mentions increased stress during quarantine and plans to utilize discounted blood work links provided by Justin, but needs to find a functional medicine doctor. Justin cautions her to fully commit to the Clovis diet before getting blood work done.
Blood Work and Diet Commitment
00:30:38 - 00:31:57
Stephanie discusses her doctor's advice to delay blood work until she's fully committed to a diet change, acknowledging her current numbers are likely not ideal. Dr. J confirms that her carb tolerance is better than average but emphasizes the importance of intense exercise to prevent fat storage, even for those with good carb metabolism. The concept of "skinny fat," where individuals appear thin but have high visceral fat, is introduced. Dr. J highlights the benefits of intense exercise and promises to discuss exercise routines later. Finally, Dr. J notes Stephanie's favorable genetic predisposition towards intermittent fasting.
Intermittent Fasting and Lifestyle
00:32:02 - 00:32:11
Stephanie shares her positive experience with intermittent fasting, relating it to her and her husband's military background and lifestyle. The chapter ends abruptly mid-sentence.
Intermittent Fasting and Blood Sugar
00:32:15 - 00:33:53
Stephanie describes her preference for later breakfasts, often not feeling hungry until 9 or 10 am, despite her partner advocating for early morning meals. Dr. J agrees, stating that breakfast might be the least important or even most detrimental meal for many, suggesting that waiting until noon for lunch might be better, especially if blood sugar is above 90. The importance of checking fasted blood sugar levels upon waking (below 90) is emphasized. Dr. J then explains the role of genetics, specifically mentioning intermittent fasting's importance and the ADIPOQ gene (adiponectin), a hormone aiding fat burning, which is produced in lower amounts in individuals with a specific genetic marker (implied to be Stephanie's "plus-plus" status). This lower production is identified as a potential negative aspect of this genetic marker.
Benefits and Debate Surrounding Intermittent Fasting
00:33:53 - 00:35:22
Dr. J explains that intermittent fasting increases the production of a hormone that helps burn fat, making it a strong argument for the practice. Stephanie mentions her husband's interest in the scientific basis for skipping breakfast. Dr. J recounts a recent talk given to Special Forces personnel where he mentioned intermittent fasting as beneficial for many, based on his genetic analysis of individuals. His casual mention sparked a lively debate among the 100+ attendees, highlighting the contentious nature of intermittent fasting within the nutrition community, particularly given the Special Forces' early-morning training routines and high-intensity physical demands. Dr. J acknowledges that there are arguments both for and against intermittent fasting in such high-demand situations.
Peak Human Performance and Training Cycles
00:35:22 - 00:37:00
Dr. J discusses the impact of training intensity and dietary practices like intermittent fasting on peak performance. He acknowledges that intense training, especially at the level of Special Forces, might lead to performance decrease. He mentions the difficulty of maintaining sufficient caloric intake to compensate for energy expenditure during intense training. However, he also points out that peak performance isn't sustainable and uses the example of Hafthor Julius Bjornsson, a strongman who recently broke a deadlift record, to illustrate the concept of training cycles. Dr. J explains that even elite athletes like Bjornsson require periods of rest and recovery after periods of extreme exertion to allow their bodies to recover and avoid injury. He emphasizes that the human body operates in cycles of peak performance followed by periods of deloading and recovery, and this applies even to individuals at the highest levels of physical training. Therefore, even for Special Forces personnel, there's a valid argument for incorporating intermittent fasting into their training regimen.
Military DNA Testing Concerns
00:37:00 - 00:38:03
Stephanie discusses her husband's military affiliation and the military's caution against DNA testing, citing potential security risks. Dr. J reveals involvement in discussions with higher-ups regarding widespread DNA testing within the military, ultimately resulting in a decision against it and subsequent public announcements discouraging 23andMe usage, particularly among special forces.
Ethical Concerns of Genetic Targeting
00:38:05 - 00:38:56
Dr. J explains the rationale behind the military's decision, highlighting the potential for genetic information to be exploited in designing targeted viruses. The discussion touches upon the coronavirus as a contrasting example, noting its broad impact despite potential contributing factors like smoking habits in certain populations. Dr. J mentions the ACE2 receptor as a binding site for the coronavirus.
Genetic Variations in Coronavirus Response
00:38:57 - 00:40:29
Dr. J explains that there are 15 different genetic versions of the ACE2 receptor, influencing how the coronavirus affects individuals. Some genetic versions result in minimal binding of the virus, leading to asymptomatic positive tests. Other versions cause strong binding, resulting in significant symptoms like coughing and fever. Dr. J then discusses the argument against the coronavirus being a bioweapon designed by China. The argument posits that if China intended to create a bioweapon, they would have designed it to target populations genetically different from their own, rather than affecting the largely homogenous Chinese population. The caller agrees, and Dr. J further elaborates that a targeted bioweapon could theoretically be designed to affect specific groups, like special forces operators, based on their DNA, while leaving the originating population unaffected.
Concerns Regarding Vaccine Heterogeneity and Data Collection
00:40:32 - 00:42:10
Dr. J expresses concern about the significant heterogeneity and variation among individuals, particularly within the diverse population of the U.S. special forces, making generalizations about potential vaccine side effects challenging. Stephanie shares an anecdote about her and her husband's numerous anthrax vaccinations, humorously speculating about potential long-term effects and contrasting the military's caution about such effects with the reality of receiving numerous vaccinations during active duty. Dr. J proposes a solution to overcome data collection obstacles: personally purchasing DNA kits, assigning random numbers to participants, collecting samples, and submitting them to 23andMe under his name to maintain anonymity and comply with regulations. This method would allow for genetic analysis without compromising the identities of the special forces personnel.
Understanding the Military's Stance on Genetic Testing
00:42:11 - 00:43:07
Dr. J explains that the military's reluctance towards genetic testing stems from a lack of understanding of genetics among many personnel. Fear of the unknown leads to a precautionary approach, even though Dr. J understands the science. Stephanie shares that her husband's inherent skepticism, coupled with the military's discouragement, makes genetic testing highly unlikely for them. They discuss the upcoming podcast and how Stephanie will share it with her husband, considering he might be listening. Dr. J notes the common occurrence of spouses listening in and confirms Stephanie's ability to hear both sides of the podcast recording clearly.
Podcast Recording and Technical Details
00:43:07 - 00:43:38
Dr. J explains the recording process, clarifying that he's using a headset and will merge both recordings (his and Stephanie's) after receiving her recording device to ensure high-quality audio for both participants. He points out a common issue with podcasts where guests using less professional equipment result in poor audio quality compared to the host.
Audio/Technical Difficulties and Metformin Discussion
00:43:38 - 00:45:11
Dr. J explains that the audio quality from a fuzzy Skype track is poor and irritating. They then transition to discussing metformin, a drug derived from a French lilac plant. Dr. J explains that metformin is currently a prescription drug in America, despite its natural origins, and that it's being studied for its potential lifespan-increasing effects in animals. The doctor notes that common side effects include diarrhea, particularly with high doses or poor genetics (which Stephanie does not have). Metformin's benefits include lowering blood sugar, increasing metabolism, and potentially increasing lifespan. Stephanie confirms that having "plus pluses" in both categories is positive, and Dr. J emphasizes that this is a good gene and a good solution for managing high blood sugar (above 90), suggesting it as a relatively inexpensive option.
Review of Heart Disease, Gut Health, and Genetic Predisposition
00:45:12 - 00:46:09
Dr. J reassures the caller about previously discussed heart disease, mentioning the CRP blood test as a factor to monitor but not overly worry about. The leaky gut section is also addressed, suggesting the caller follow recommendations if needed, while highlighting the caller's surprisingly phenomenal gut genes. Stephanie expresses surprise, given her past health issues. Dr. J clarifies that her anxiety may be more linked to brain genes than gut health, based on her 23andMe results, which are considered thorough. The conversation transitions to the next section.
Vitamins, Hormones, and Detox: Focus on Vitamin D Deficiency
00:46:11 - 00:46:46
The discussion moves to vitamins, hormones, and detox, with vitamin D highlighted as showing numerous positive indicators in the caller's results. Stephanie confirms past low vitamin D test results, explaining that while she hasn't had a recent test, she's been increasing her sun exposure due to the pandemic.
Vitamin D Dosage and Gut Health
00:46:46 - 00:48:22
Stephanie discusses the effects of stress on gut health, mood, and energy levels. She mentions taking 10,000 IU of Vitamin D daily based on previous recommendations from Justin. Dr. J confirms that 10,000 IU is on the higher end of the recommended range (2,000-10,000 IU), suggesting that it's likely sufficient. Dr. J emphasizes the importance of monitoring Vitamin D levels through blood tests, recommending a consistent dose for a month (e.g., in January or February), followed by a blood test to determine the optimal dosage. He explains that the necessary dosage can vary depending on sun exposure, suggesting a lower dose during sunnier months. The conversation concludes with Dr. J's humorous comment about the frequency of rain in San Antonio.
Vitamin D Supplementation and Timing
00:48:26 - 00:49:47
Dr. J and Stephanie discuss the challenges of tracking vitamin D levels due to inconsistent sunshine exposure. Stephanie reveals she was unaware of the advice against taking vitamin D3 in the evening, a practice Dr. J explains disrupts melatonin production and sleep. Dr. J recommends taking vitamin D3 in the morning with fat for better absorption, suggesting butter or MCT oil. The conversation touches upon Stephanie's caffeine intake from coffee and a protein powder, with Dr. J suggesting delaying caffeine consumption until noon to align with intermittent fasting. Finally, Dr. J reiterates the importance of taking vitamin D with fat for optimal absorption and mentions the significance of K2 alongside vitamin D.
Factor V Leiden and Estrogen's Role in Thrombosis
00:49:47 - 00:51:21
Dr. J explains how higher doses of medication help keep calcium out of arteries. The conversation then shifts to the caller's (Stephanie's) genetic predisposition towards higher estrogen levels, which Dr. J suggests is a significant contributor to her thrombosis, alongside her Factor V Leiden. Dr. J highlights the increased risk of thrombosis in individuals on birth control, particularly those with Factor V Leiden. Stephanie expresses concern about her 10-year-old daughter inheriting the Factor V Leiden gene and the potential implications for birth control use in the future. Dr. J confirms that the daughter will inherit at least one plus gene, but emphasizes the impossibility of determining which parent contributed which gene. The discussion concludes with Dr. J reiterating the combined risk of Factor V Leiden and high estrogen levels.
Sauna Benefits and Detoxification
00:51:22 - 00:52:49
Dr. J discusses the genetic inheritance of certain traits, using the example of "plus plus" and "plus minus" genes. The conversation then shifts to the benefits of saunas, with Stephanie expressing her desire to buy a personal sauna after previously using them regularly before the pandemic. Dr. J strongly supports this, highlighting the numerous health benefits of saunas. Dr. J cites a study involving skin patches that measured the absorption of chemicals like BPA, phthalates, oxybenzone, and artificial estrogens. The study showed that individuals who used saunas significantly reduced the absorption of these chemicals compared to those who did not, providing scientific evidence supporting the detoxifying effects of saunas. Stephanie expresses satisfaction at having scientific backing for her sauna purchase plans.
Estrogen, Environmental Estrogens, and Dr. J's Book
00:52:49 - 00:54:28
This segment discusses the findings of "BUS studies" (blood, urine, sweat) on estrogen levels, highlighting that artificial estrogens are far worse than natural ones. Dr. J explains that while natural estrogen is protective within a certain range, both high and low levels can cause problems. The conversation then shifts to Stephanie's experience reading Dr. J's book, which she finds highly scientific and challenging to understand. Dr. J suggests focusing on the book's top ten list of problematic substances, mentioning soy and flaxseed as examples. Stephanie shares her past consumption of flaxseed and expresses her intention to utilize the book's summary at the end for a more concise overview.
Thyroid Health and Iodine Supplementation
00:54:28 - 00:55:41
Dr. J recommends Stephanie implement a specific suggestion from his book, emphasizing its ease of use, especially given her sensitivity. The conversation then shifts to Stephanie's thyroid health, with Dr. J noting potential issues and recommending iodine supplementation as fundamental for improving metabolism due to potentially borderline thyroid hormone levels. Stephanie reveals a past diagnosis of thyroid issues, mentioning a previous prescription of Synthroid, which she took for several months without noticeable improvement. Dr. J acknowledges her experience.
Thyroid Hormone Conversion and Synthroid
00:55:41 - 00:57:15
Dr. J explains the complexities of thyroid hormones, starting with the fact that Synthroid is synthetic T4. The body uses iodine to produce T4, which is then converted to T3, crucial for fat burning and energy. Iodine deficiency leads to insufficient thyroid hormone production, impacting energy levels and weight. Dr. J highlights that while Synthroid provides T4, the caller's genetics (specifically the DIO1 gene) impair the conversion of T4 to T3. Therefore, despite having sufficient T4 from Synthroid, the caller's body doesn't efficiently utilize it for fat burning, resulting in excess T4. The conversation clarifies the confusion surrounding T4 and T3 naming and emphasizes the caller's inefficient T4-to-T3 conversion.
Thyroid Hormone Treatment Discussion
00:57:16 - 00:58:44
Dr. J explains why they generally avoid Synthroid, preferring to let the body naturally produce T3 from T4. However, due to Stephanie's specific genetics, this approach may not be effective. Dr. J suggests Armour Thyroid as a full-spectrum alternative, providing all thyroid hormones for the body to utilize as needed. The doctor also mentions that iodine and exercise could be beneficial, but given Stephanie's genetic predisposition, Armour Thyroid might be necessary. Dr. J emphasizes the potential benefits of Armour Thyroid, including increased energy and overall well-being, noting that many people experience significant improvements. The conversation concludes with Dr. J's opinion that thyroid optimization should be considered for aging individuals, as hormone levels naturally decline with age, and the current system waits too long to intervene.
ADHD and Low Energy
00:58:45 - 00:59:14
Stephanie discusses her experience with ADHD, noting that while her brain is hyperactive, she lacks the physical hyperactivity often associated with the condition. She expresses envy towards those with higher energy levels, contrasting her own low energy. Dr. J acknowledges that low energy is a common complaint.
Armor Thyroid and Carotene Gene Discussion
00:59:14 - 01:00:11
Dr. J explains that many doctors are hesitant about armor thyroid due to its pig-derived nature, despite its effectiveness and similarity to human thyroid hormones. Stephanie expresses enthusiasm for the treatment. Dr. J emphasizes the need for a prescription to avoid overdosing and potential heart problems. The conversation then shifts to the carotene gene, with Dr. J explaining the plus-minus variation and its impact on carotene-to-retinol conversion, stating that this particular variation is not a major concern. The discussion briefly touches upon AKT1.
Cannabis Use and the AKT1 Gene
01:00:11 - 01:01:51
This segment discusses Stephanie's interest in trying cannabis after retirement, prompting Dr. J to explain the effects of the AKT1 gene on cannabis experience. Dr. J explains that this gene can heighten feelings of paranoia, particularly with edibles or high doses, but doesn't pose a significant health risk. Stephanie shares her lack of experience with cannabis, recounting a single instance of secondhand exposure ("contact high") in high school, which led to anxiety about an upcoming military drug test. She describes her unusual attempt to detoxify by drinking a large quantity of pickle juice. Dr. J humorously relates this anecdote to his brothers' similar unusual habits involving pickle juice consumption.
Kombucha and Electrolytes
01:01:52 - 01:03:17
Dr. J discusses a person's kombucha consumption habits, noting that while it might seem unappealing, it's not unhealthy unless it contains artificial dyes. The conversation then shifts to the importance of electrolytes, particularly during intermittent fasting. Dr. J emphasizes the need for adequate hydration and electrolyte intake, advising against fear of salt and suggesting the use of electrolyte supplements, especially after activities like sauna use. Stephanie shares her experience with electrolyte drinks, describing her preference for a salty version and suggesting a higher daily intake than her current one. Dr. J concludes by mentioning that electrolytes can also be obtained through food and that the optimal intake depends on factors like exercise intensity and sweating.
Austin's Influx of Wellness Personalities
01:03:18 - 01:04:27
Dr. J and Stephanie discuss the relocation of several well-known personalities to Austin, Texas. The conversation begins with Dr. J mentioning that his friend Rob Wolf has moved to Austin. Stephanie agrees, noting the city's growing popularity as a residence for influencers, citing Rachel Hollis and Ben Greenfield as examples. Stephanie expresses some reservations about Greenfield's social media presence, specifically his frequent physique selfies. Dr. J defends Greenfield, stating he's a great guy and that it's simply his brand. The conversation then shifts to speculation about Ben Greenfield's actual residence, with Stephanie initially believing he lives in Austin based on a past Instagram post, but later admitting uncertainty. Dr. J, claiming familiarity with Greenfield, expresses surprise at the suggestion. The discussion concludes with both agreeing on the overall trend of people moving to Austin, with Dr. J adding Tim Ferriss to the list and giving a positive review of Rob Wolf's "element" products.
B9 Category Genetic Issues and MTHFR Gene
01:04:31 - 01:05:38
Dr. J discusses Stephanie's B9 category, noting potential genetic issues. The MTHFR gene is mentioned, explained as important in the wellness community, particularly among functional doctors. While acknowledging it's not the only relevant gene (mentioning mthfd1), Dr. J emphasizes that consuming leafy greens can mitigate potential issues. Stephanie mentions she's not a big vegetable eater, but her husband encourages her to eat more. Dr. J suggests supplements as an option alongside leafy greens, concluding that with sufficient leafy green consumption, her genes in this category aren't severely problematic, showing some positive and negative aspects. The overall takeaway is to not get overly concerned with the details.
Heavy Metals and CBS Gene
01:05:40 - 01:06:10
Dr. J moves on to the heavy metals category, highlighting some significant positive indicators. The CBS gene is identified as a key factor, increasing the risk of arsenic buildup. Dr. J advises paying attention to arsenic-containing foods, specifically listing Brussels sprouts, rice (less commonly), and mass-produced chicken due to the grains used in their feed.
Concerns about Chicken Sourcing and Quality
01:06:10 - 01:07:52
Dr. J mentions the potential buildup of arsenic in commercially raised chickens due to low-level exposure in feed. Stephanie shares her preference for free-range chicken from local farmers but notes her husband's reluctance due to his lifelong consumption of Tyson chicken. They discuss the challenges of finding high-quality ribeye steaks from local farms, with Stephanie noting that the tenderness isn't comparable to store-bought options from HEB. Dr. J suggests buying chicken only during summer months from a farmer who allows truly free-range chickens, contrasting this with the often misleading use of the term "free-range" for chickens kept in pens. Dr. J describes their free-range chickens as roaming freely in fields, highlighting the difference in quality and lifestyle compared to winter chickens raised indoors on grain.
Dietary Recommendations and Arsenic Avoidance
01:07:52 - 01:08:14
Dr. J advises stocking up on and freezing fruits in the summer. The main focus is avoiding arsenic, although Dr. J admits not being a super expert on the topic. The discussion then shifts to fructose, with Dr. J emphasizing caution due to its potential impact. Stephanie mentions sugar as a significant concern in her diet, prompting Dr. J to suggest fruits with lower fructose content, referencing a link on their website listing such fruits and their fructose levels.
Fructose Metabolism and PNPLA3 Gene
01:08:14 - 01:09:06
The conversation centers on the PNPLA3 gene (plus plus gene), its link to a higher risk of fatty liver, and its interaction with fructose. Dr. J explains that when fructose enters the body, it's either burned for energy or stored as fat in the liver, with the PNPLA3 gene predisposing individuals to storing it as fat. Stephanie agrees that this is not ideal.
Exercise Recommendations Based on Genetics
01:09:06 - 01:09:17
Dr. J transitions to discussing exercise recommendations, noting that the caller's genetics (ACTN3) suggest a mix of endurance and power training would be beneficial. The chapter ends mid-sentence.
Patient's Genetic Predisposition and Health Concerns
01:09:18 - 01:10:53
Dr. J discusses Stephanie's genetic predisposition for muscle fiber type, indicating flexibility in workout routines but also a potential joint risk for inflammation. Stephanie mentions a past fibromyalgia diagnosis but her aversion to medication due to a negative experience with a sister's heavy medication use. She explains that she chose not to seek medical intervention for her fibromyalgia. Dr. J agrees with her philosophy and explains that due to prolonged birth control use, resetting her system will be a slow process. The doctor highlights the importance of thyroid health, noting a correlation between low thyroid hormones and osteoarthritis risk, indicated by a gene related to joint tissue degradation. Dr. J emphasizes that improving thyroid hormone levels benefits both energy levels and joint health.
Joint Health and Genetic Predisposition
01:10:55 - 01:12:19
Dr. J discusses the caller's genetic predisposition to joint issues. Specific genes are mentioned, including HLA genes linked to arthritis (triggered by high insulin), and IL-2RA, which can be addressed with krill oil. The doctor emphasizes the importance of managing blood sugar levels (potentially through metformin and reduced carb intake or intermittent fasting) to mitigate arthritis risk. Additionally, maintaining healthy thyroid hormone levels through iodine intake is recommended. The ITGIV gene, common in many individuals, highlights the benefit of regular exercise for joint health. Finally, the doctor addresses gout risk, suggesting caution with fructose consumption due to the SLC2A9 gene's role in fructose transport.
Gout and Dietary Advice
01:12:19 - 01:13:02
Dr. J explains that uric acid buildup in joints causes gout, forming crystals like "glass shards." He notes that doctors commonly advise gout sufferers to avoid meat, which he finds humorous because the relevant gene is a fructose transporter, not related to meat consumption. He highlights the flawed advice given to patients, emphasizing that this is common medical practice. Stephanie shares that her husband, who is African-American, has received similar advice to lower sodium and avoid red meat for high blood pressure, despite being an athlete and not having consistently high blood pressure. She questions the validity of this advice.
Blood Pressure and Bone Strength
01:13:02 - 01:13:41
Stephanie mentions that she has never had blood pressure issues, even during stressful times caring for her sick parents. Dr. J is unsurprised, suggesting that exercise helps maintain good blood pressure. The conversation then shifts to bone strength, with Dr. J noting that Stephanie's genetic results show several "plus pluses" in this area.
Bone and Sleep Gene Analysis
01:13:42 - 01:14:40
Dr. J discusses Stephanie's genetic predispositions related to bone strength and sleep. Two genes affecting bone strength have opposing effects, one positive and one negative, likely offsetting each other. Dr. J advises that maintaining vitamin D intake, exercise, and K2 with vitamin D supplementation should mitigate concerns. Regarding sleep, Dr. J identifies a "plus-plus" clock gene as the likely source of sleep difficulties, explaining that this gene variant (along with ABCC9) is common but contributes to sleep disruptions and shorter sleep duration.
Oura Ring Sizing Issue
01:14:41 - 01:15:10
Stephanie mentions her difficulty in obtaining an Oura Ring due to her small ring size (4 and 1/4), which is smaller than the smallest size offered (size 6). She explores the possibility of wearing it on her thumb, but finds this impractical. She mentions receiving the ring as a retirement gift from her husband.
Retirement Gifts and Sleep Improvement
01:15:11 - 01:16:21
Stephanie expresses excitement about purchasing an eight sleep bed and a sauna upon retirement, citing issues with nighttime overheating. Dr. J affirms the importance of temperature regulation for sleep. The conversation shifts to sleep aids, with Dr. J suggesting a magnesium supplement before bed and advising against evening snacking to avoid disrupting sleep cycles. Dr. J shares their experience with the Oura Ring, mentioning wearing it only at night to prolong its lifespan and avoid damage from activities like weightlifting.
Sleep Disruption and Potential Solutions
01:16:31 - 01:18:05
Dr. J discusses the impact of even small amounts of food, including healthy options, on sleep quality, noting a significant negative effect on deep sleep. Stephanie mentions being a night snacker, highlighting the difficulty of breaking this habit. Dr. J suggests that overcoming this cycle takes approximately a week. Magnesium powder is recommended as a supplement for sleep improvement, and low-dose lithium (5mg per day) is also suggested, clarifying that this is a much lower dose than used for mental health treatments. The discussion emphasizes the importance of using a sleep tracker, such as an Oura Ring, to monitor the effectiveness of these strategies. Clinical studies supporting the use of lithium for individuals with specific gene variations affecting sleep are referenced.
Sleep Aids and Strategies
01:18:05 - 01:19:19
This segment discusses personal sleep habits and strategies for improving sleep quality. Stephanie shares her experience with sleep masks, noting that she sometimes misplaces them during the night. Dr. J agrees, relating a similar experience. Stephanie mentions her intention to purchase an Eight Sleep bed within the next year. Dr. J emphasizes the importance of blackout curtains, suggesting a practical in-store test to assess their effectiveness: putting the curtain over one's head to check for complete darkness. He contrasts the use of blackout curtains with sleep masks, advocating for the former as a more effective method for creating a dark sleep environment. Stephanie agrees and adds that she and her husband have different sleep habits, attributing her husband's sleep issues to his military experience.
Sleep Improvement Strategies
01:19:20 - 01:20:46
This segment focuses on improving Stephanie's sleep. A trial separation of sleeping arrangements is suggested, mirroring a trend of people currently doing so. Dr. J emphasizes the critical importance of sleep for overall health, even outweighing genetics. While mentioning the gene ABCC9 (a potassium channel), Dr. J downplays its significance in Stephanie's case, suggesting sufficient potassium intake. Dr. J notes Stephanie's increased blue light sensitivity, recommending caution with screens before bed and suggesting blue light blocking apps or glasses, although her sensitivity isn't considered extreme. Finally, Dr. J mentions a slightly increased risk of seasonal depression in winter, but deems it less of a concern given Stephanie's location in Texas.
Genetic Risk Assessment and Blood Thinning Alternatives
01:20:46 - 01:22:46
Dr. J reassures Stephanie about her genetic predisposition to blood clots, stating that her risk is relatively low due to her location and lifestyle. He mentions that individuals in colder climates with the same gene often face higher risks. The discussion then shifts to Stephanie's current blood-thinning medication. Stephanie expresses concern about the lack of monitoring for the effectiveness of her current treatment, relying solely on the absence of further incidents. Dr. J suggests working with a functional doctor to transition from prescription blood thinners to natural supplements, emphasizing that many of the recommended supplements offer additional health benefits. He advises trying various supplements at low doses to gauge their effects on her body, highlighting that these supplements are beneficial beyond addressing her specific genetic factor.
Post-23andMe Results Discussion and Breast Cancer Risk
01:22:46 - 01:24:50
Dr. J discusses the benefits of anti-inflammatory supplements, emphasizing the importance of individual response and dose adjustment under the guidance of a functional doctor, monitoring INR levels. Stephanie explains her motivations for taking the 23andMe test: her mother's death from breast cancer and interest in diet/lifestyle recommendations. She acknowledges the controversy surrounding the role of genetics versus lifestyle in breast cancer risk. She mentions her mother's death 25 years prior and that her mother's sisters are still alive without breast cancer. Dr. J confirms that Stephanie's genetic predisposition is related to higher estrogen levels, primarily linked to artificial estrogens. He highlights the significant increase in breast cancer rates since 1980, attributing it to environmental factors and chemicals in food rather than solely genetic changes. He suggests referring to the top ten list in his book for further information.
Addressing Caller's Health Concerns
01:24:55 - 01:26:34
Dr. J reassures the caller that their genetic predisposition to certain cancers isn't overly concerning, advising them to avoid specific chemicals. Sauna use is recommended as a method to reverse negative effects. While not overly worried, Dr. J suggests monitoring blood sugar levels, aiming for below 90, as a crucial preventative measure against cancer. The discussion then turns to the book "Tripping Over the Truth," which highlights the Warburg Effect – the observation that cancer cells primarily consume sugar. Dr. J emphasizes the significance of this discovery by Otto Warburg in the 1920s, stating that controlling blood sugar is a fundamental aspect of cancer prevention.
Sauna's Health Benefits and Actionable Steps
01:26:34 - 01:27:57
Dr. J highlights the significant impact of saunas, referencing a 20-year Scandinavian study showing decreased cancer, Alzheimer's, and heart disease rates. This leads to a discussion about the effectiveness of saunas compared to targeting estrogen. Stephanie expresses her relief and gratitude for the actionable steps provided, emphasizing her preference for practical applications. Dr. J reiterates the goal of providing easily applicable advice and appreciates Stephanie's decision to record the podcast for others to benefit. The conversation concludes with a mutual agreement on the value of the information shared and its practical implications.
Finding Financially Rewarding Ways to Help Others
01:27:57 - 01:28:25
Stephanie expresses her passion for helping others but desires to find a financially sustainable way to do so. Dr. J empathizes, relating it to the dissatisfaction of unfulfilling work. They briefly discuss the challenges of aligning passion with financial stability. The conversation concludes with Dr. J promising to follow up via email regarding a recorder and other unspecified matters. Stephanie expresses gratitude for Dr. J's time and assistance.
DNA with Dr. Jay, Episode 04.
CLOVIS CULTURE Justin Nault (from Nashville)
CLOVIS CULTURE Justin Nault (from Nashville)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Podcast Overview
00:00:00 - 00:01:07
Anthony J introduces the podcast episode featuring Justin Alt, mentioning previous interactions and the podcast's audio quality. He promotes his consulting company. The podcast host, Justin Alt, introduces the episode's topic: genetics testing and the human genome, with Dr. Anthony J as the guest.
Discussion of DNA Sequencing Companies and Data Access
00:01:07 - 00:02:28
Anthony J and Justin Alt discuss the accessibility of raw data from DNA sequencing companies like 23andMe. Anthony J highlights that not all companies provide access to this data, emphasizing the importance of choosing companies that do. He explains that the raw data is extensive (thousands of pages of code) and may not be easily understandable to most people, but free online software can help analyze it.
Anthony J's Background and Consulting Work
00:02:28 - 00:04:06
Anthony J describes his custom-written crypt software that generates reports. He mentions his past work as a virus designer for the government, briefly touched upon in a previous conversation. He subsequently started a consulting company, focusing on designing newer devices that utilize DNA to produce viruses in a liquid. He explains the process of designing DNA, inserting it into human cells, and harvesting the resulting viruses. He notes that this work, undertaken in the mid-2020s, faced challenges with the FDA, leading to the shutdown of his operations. Consequently, individuals began seeking his expertise to analyze their DNA code, referencing 23andMe.
Discussion on 23andMe and DNA Reports
00:04:06 - 00:05:32
Anthony J discusses his experiences with people coming to him for help interpreting DNA reports from services like 23andMe. He notes that these reports often provide seemingly trivial information, such as eye color or cilantro preferences, while deeper health information is also present but requires expertise to interpret. The Podcast Host expresses excitement about exploring their own DNA information, mentioning previous experiences with DNA analysis services like Prometheus and DNAfit, highlighting the cost and the need for specialized knowledge to fully understand the results. Justin Alt agrees that the quality of information provided needs to be considered.
The Challenges of Interpreting Complex Scientific Data
00:05:32 - 00:07:23
This segment discusses the difficulties in interpreting scientific reports, particularly those related to genetic associations and cancer risk. The conversation begins with the hosts expressing their initial confusion when faced with overwhelming amounts of data from sources like Prometheus. Anthony J explains that there's a spectrum of issues: some reports are superficial and meaningless, while others provide an excessive amount of information. He points out that many studies report small fold increases (e.g., 1.3-fold, 1.5-fold) in cancer risk associated with specific genes. While these studies might generate hundreds of online results, Anthony J notes that these small associations often don't hold up in larger, more rigorous studies. He emphasizes that the sheer volume of data can be more confusing than helpful, especially considering the numerous potential risk factors involved. The hosts clarify the meaning of fold increases (e.g., a twofold increase being equivalent to a 100% increase), and Anthony J explains that the interpretation of these increases can vary depending on the specific gene and biological context.
Genetic Predisposition and Care Team Efficacy
00:07:23 - 00:08:42
Anthony J uses the example of "care team" to illustrate how genetic studies can show varying efficacy (e.g., 70%). He explains that while "care team" is often perceived as beneficial (like vitamin A from carrots improving eyesight), some individuals have a genetic inability (up to 80% reduction) to convert it into retinol, the actual usable form. Therefore, for those with this genetic issue, consuming carrots is less effective than consuming retinol-rich foods like liver, highlighting the importance of considering individual genetic factors when assessing the effectiveness of treatments or interventions. Justin Alt briefly agrees with this assessment of the limitations of the conversion process.
Genetic Factors and Health Risks
00:08:42 - 00:10:59
Anthony J discusses the complexities of genetic associations with health issues, using retinol and iron as examples. He highlights the limitations of studies that only look at associations without considering the actual biological mechanisms. He emphasizes the significance of individual genetic variations, particularly focusing on the impact of a problematic iron gene, which can lead to risky situations like liver overload. He mentions knowing many people who trust in this information and references a two-hour talk on the subject, further emphasizing the importance of understanding individual genetic predispositions in health management. The conversation also touches upon the value of networking within the health community.
Liver Consumption and High Iron Levels
00:10:59 - 00:12:17
Anthony J discusses the prevalence of liver consumption within a particular group, suggesting it's almost a requirement for membership. He then shifts to discussing high iron levels, expressing more concern about individuals with high iron than low iron. The Podcast Host interjects, mentioning a discussion with Paul Saladino about their own high iron levels resulting from consuming four ounces of liver daily, sourced from local regenerative agriculture farms. The host details their high ferritin levels revealed by blood work and mentions Paul Saladino's analysis of their 23andMe data, suggesting a potential genetic predisposition like hemochromatosis. The host concludes by mentioning Angelina Jolie as a prominent example of someone who utilized 23andMe data to make preventative health decisions.
Concerns about Misinformation in Healthcare
00:12:17 - 00:13:41
The discussion begins with a concern about the potential dangers of misinformation in healthcare, specifically mentioning examples of companies offering simplified, potentially inaccurate health advice for a low price. The conversation then shifts to the importance of in-depth discussion and understanding of complex medical cases, highlighting that while not every intricacy needs to be discussed, certain crucial details are essential. The speakers then transition to a related anecdote about a podcast discussion involving Joe Rogan, Chris Presser, and a documentary featuring Emma Fighter, where the amount of research done was jokingly compared to PhD-level work. This leads to a critique of the idea that extensive online research alone should equate to a PhD, emphasizing the need for a more rigorous process to achieve such an academic qualification.
The Importance of Thorough Understanding in Healthcare
00:13:41 - 00:14:07
This chapter focuses on the necessity of a comprehensive understanding of medical information. The conversation continues from the previous chapter, highlighting the problem of individuals possessing information without a true understanding of its implications. The speakers underscore the importance of a deeper level of comprehension beyond simply accumulating data.
The Misinterpretation of Scientific Studies and Expertise
00:14:08 - 00:15:23
The Podcast Host discusses the common misconception of interpreting scientific studies solely based on conclusions, highlighting the need for deeper understanding. They emphasize the complexity of fields like biochemistry, drawing a parallel to their own expertise in music. Simply reading textbooks doesn't equate to expertise; years of dedicated practice and study are necessary. The host uses the example of reading biochemistry textbooks without achieving expert-level understanding. Anthony J. reinforces this point, using the analogy of someone reading about music without playing an instrument claiming a PhD in music. The host further illustrates their point by mentioning reaching 10,000 hours of stage time by age 18, highlighting the dedication required for true expertise. Anthony J. mentions Chris Johnson, implying further discussion on the topic of expertise and experience.
A Musician's Unique Approach to Performance
00:15:23 - 00:16:03
Anthony J describes a musician who incorporates audience participation into his performances, playing the harmonica and drums simultaneously and inviting others to join him. The Podcast Host expresses enthusiasm for this approach and its relevance to serious musicians. The Host then transitions to the main topic, a report, and plans to share relevant blood work and a list of participants in the show notes. The Host wants to provide context for listeners unfamiliar with the subject matter before diving into the report's details.
Introduction to Genetic Terminology
00:16:03 - 00:16:48
The Podcast Host requests a brief explanation of genetic terms like "genome," "snips," "heterozygous," and "homozygous" for the benefit of listeners new to the topic. Justin Alt agrees to provide this explanation. Anthony J begins by simplifying the concept of DNA, explaining that most cells contain two copies of DNA, one from each parent, except for egg and sperm cells which have only one copy. The discussion briefly touches upon the fusion of egg and sperm cells to form a complete set of DNA.
Genetic Predisposition and Epigenetics
00:16:48 - 00:18:45
Anthony J discusses the concept of gene pairs and their potential impact. He explains that having two copies of a gene means there's a possibility of inheriting a "bad" gene from one or both parents. He simplifies the discussion by focusing on the impact of inheriting two "bad" genes, acknowledging that the presence of one "bad" gene and one "good" gene is a different scenario. He mentions that while thousands of genes might have variations, he focuses on the significant ones. He clarifies that the classification of genes as "good" or "bad" is somewhat arbitrary, as some gene variations might not be detrimental but still hold importance. The conversation then shifts to the role of epigenetics, with the Podcast Host highlighting that genetic predisposition doesn't necessarily determine one's fate. Justin Alt emphasizes the importance of understanding genetic inheritance in parents. Anthony J uses the analogy of a house blueprint with a flawed bathroom to illustrate how a problematic genetic blueprint can lead to issues, but also emphasizes that these issues can be addressed, referencing the example of beta-carotene conversion to retinol as a fixable problem.
The Challenges of Genetic Analogy and the Importance of Context
00:18:45 - 00:20:30
Anthony J discusses the difficulty of directly translating genetic information into easily understandable metrics like exercise or other lifestyle factors. He uses the analogy of adding a bathroom to a house to illustrate the complexity of modifying genetic predispositions. While acknowledging that some genetic traits are hard-wired and unchangeable (like eye color), he emphasizes that many genetic differences can be modified through lifestyle and environmental factors. He highlights the importance of considering the context and the interplay of multiple genes, using the example of the Foxo gene and its impact on brain optimism. He mentions that he uses five categories (brain, diet, etc.) when analyzing genetic information.
Alzheimer's Risk Gene Categories
00:20:32 - 00:22:15
Anthony J discusses Alzheimer's risk gene categories, explaining that there are five categories. He notes that even if someone develops Alzheimer's, it's often the extreme end of a spectrum, and early intervention can be preventative. He details that one category involves chronic inflammation specifically in the brain, which differs from inflammation in other parts of the body and is not easily detectable through standard blood tests. He points out that researchers don't typically check spinal fluid for inflammatory chemicals in the brain due to the invasive nature of the procedure.
Risk Factors for Alzheimer's and the Role of Heavy Metals
00:22:15 - 00:24:07
Anthony J discusses additional risk factors for Alzheimer's, focusing on heavy metals. He emphasizes the importance of proactive heavy metal checks and reduction if elevated levels (cobalt, chromium) are detected. He notes that individual responses to carbohydrates vary significantly, with some experiencing positive brain function while others experience negative liver or body responses. He advises caution with carbohydrate intake, particularly during training, suggesting a need for careful monitoring of individual responses to dietary choices.
Concerns Regarding Head Trauma and Brain Optimization
00:24:07 - 00:25:30
The Podcast Host shares a concern about head trauma after consulting a functional medicine doctor who, upon reviewing the Host's raw data, inquired about past concussions. The Host, a former boxer, acknowledges numerous instances of potential head trauma, leading the doctor to advise against further boxing and emphasize caution. The Host then asks Anthony J if this is a significant concern, particularly given the focus on brain optimization. Anthony J agrees, highlighting the importance of personalized recommendations based on genetics, contrasting this approach with the common practice of providing generalized advice. He uses the example of professional athletes like Julian Edelman, who endure repeated head impacts, to illustrate the need for tailored strategies in brain health.
Examples of Anger and its Consequences
00:25:30 - 00:26:52
The conversation shifts to examples of individuals who exhibited extreme anger, leading to negative consequences. The Podcast Host mentions Chris Henry, a Cincinnati Bengals player, who was involved in a domestic dispute resulting in an accident and his death. The Host also cites Chris Benoit, a WWE superstar, who committed a murder-suicide. Anthony J interjects, revealing his past experience performing autopsies, specifically on NFL players and military personnel, during his Alzheimer's research in Boston. He describes finding plaques in the brains of these individuals, linking them to conditions like Alzheimer's disease and mentioning different types of plaques, including amyloid and tau.
Discussion on Genetic Predisposition to Neurological Conditions
00:26:52 - 00:28:23
Anthony J discusses the complexities of genetic predisposition to neurological conditions like Alzheimer's and brain injuries. He highlights that while certain genes might be associated with increased risk, the actual manifestation and severity of the condition are not always straightforward. He mentions the concept of "plus plus" and "plus minus" genes, explaining that "plus plus" genes are easier to predict in their effect, while "plus minus" genes are more complex and harder to predict their impact on the individual. He emphasizes that the body's compensatory mechanisms can also influence the outcome, making it difficult to establish a direct correlation between specific genes and the severity of neurological conditions. The discussion touches upon the importance of considering individual factors and the limitations of solely relying on genetic information for prognosis. Justin Alt briefly interjects, but the main focus remains on Anthony J's explanation of genetic complexities in neurological diseases.
Risk Factors and Supplements
00:28:24 - 00:30:17
This segment discusses risk factors related to exercise and supplements. Anthony J explains a scenario involving "plus" and "minus" factors, highlighting that while something might seem positive, it could increase the risk of falls. Justin Alt emphasizes the importance of considering the type of exercise performed. The conversation then shifts to supplements, with Anthony J mentioning the impact of various factors like thyroid hormones and sex hormones on overall health. He notes that "beat the enough" is crucial, and the discussion touches upon the chicken-and-egg dilemma of certain health issues. Curcumin is mentioned as a relevant supplement. The conversation concludes with a brief discussion about individual cases and the complexities involved in assessing health risks and benefits.
Localized Gut Inflammation and Blood Markers
00:30:29 - 00:31:21
The Podcast Host discusses the results of their Genova Diagnostics tests, including a neutral valve and GI map. Despite having blood markers like homocysteine and C-reactive protein within the normal reference range, the GI map revealed localized gut inflammation. This discrepancy between blood markers and gut inflammation is noted as strange, with the inflammation seemingly not affecting the bloodstream. Anthony J and Justin Alt offer brief comments of agreement and surprise. The Podcast Host suggests this might be a built-in defense mechanism.
Discussion of Brain Genes and Anxiety
00:31:21 - 00:31:55
Anthony J suggests they could delve into the details of brain genes, mentioning that most of the results are positive except for a couple of anxiety-related markers. He notes that many people exhibit these markers. The conversation briefly touches upon the topic of avoiding the introduction of bacteria. The Podcast Host expresses interest in the "melancholy and anxiety" section of the results, which will be available to listeners in the show notes. An unidentified speaker makes a brief, non-specific comment.
Serotonin and Supplement Discussion
00:31:57 - 00:32:48
Anthony J discusses increasing serotonin levels, suggesting 5HTP alongside tryptophan, an amino acid and building block for serotonin. He explains that providing the body with building blocks and then triggering serotonin production is beneficial, although individual responses vary. He notes that serotonin is complex. Justin Alt briefly adds to the conversation.
Caffeine Metabolism and Test Results Interpretation
00:32:48 - 00:33:22
The Podcast Host raises a question about caffeine metabolism, noting a "plus plus" result indicating faster-than-average elimination. The discussion clarifies that a "plus plus" result doesn't automatically signify a negative outcome; it simply reflects the test's specific measurement. Anthony J confirms this interpretation.
Caffeine's Impact on Individuals with Anxiety
00:33:23 - 00:34:55
This segment discusses the varying effects of caffeine, particularly highlighting its potential negative impact on individuals with anxiety. Anthony J shares an anecdote about a professional baseball player with three anxiety genes linked to caffeine sensitivity, emphasizing that the blanket statement of caffeine being universally beneficial is inaccurate. He explains that for some, caffeine's effects can last for days, exacerbating anxiety symptoms. The conversation underscores the importance of individual responses to caffeine and the need to consider genetic predispositions and how the body processes it. The Podcast Host corroborates this by mentioning clients who experience prolonged sleep disruption even after a single morning cup of coffee, further illustrating the significant individual variability in caffeine sensitivity and its potential to negatively affect those with anxiety.
The Individualized Effects of Caffeine and Diet
00:34:55 - 00:36:18
Anthony J discusses how some people experience significant anxiety from caffeine, a reaction that many doctors dismiss. He notes that while the anxiety might seem "mental," it's rooted in the physiological effects of caffeine, lasting longer than its typical half-life. The Podcast Host agrees, highlighting the highly individualized nature of caffeine's impact. The Host points out the potential for misinformation in the health and wellness space, citing the example of Dave Asprey's promotion of coffee, which might lead individuals to overlook negative personal reactions. The conversation expands to encompass the broader issue of individualized dietary responses, with Anthony J noting that diets effective for some may be detrimental to others, and the dangers of promoting a single diet as universally beneficial.
The Spread and Impact of a Fitness Trend
00:36:18 - 00:38:00
Anthony J discusses how a fitness trend initially struggles to gain traction, with many people abandoning it due to difficulty. However, a few successful individuals create a "club," inspiring others and leading to wider adoption. The conversation then shifts to the potentially egotistical nature of such trends, where individuals may judge others based on their body type. Anthony J explains that this often stems from a misunderstanding of hormonal influences, particularly estrogen. He mentions his book on estrogen and details how it uniquely interacts with the body, penetrating cell and nuclear membranes to directly affect DNA and potentially influencing future generations through epigenetic changes. The Podcast Host acknowledges this point, highlighting the scary implications of this hormonal impact on inherited traits. The discussion concludes with Anthony J emphasizing how parental dietary choices can have lasting effects on their offspring's health.
Diet Optimization Genes and Intermittent Fasting
00:38:00 - 00:39:38
This section discusses diet optimization genes, specifically focusing on intermittent fasting. Anthony J. notes that while intermittent fasting is optimal for almost everyone, exceptions exist for professional athletes or individuals focused on muscle gain. He suggests that while such individuals might benefit from consistent eating, they may experience a shorter lifespan as a consequence. The Podcast Host agrees, stating that high-level athletic performance often comes at the cost of longevity. Anthony J. further elaborates that while it's difficult to definitively prove this correlation, some individuals are willing to accept this trade-off for peak athletic performance. He suggests that athletes might reverse this approach around age 50 to prioritize longevity.
Concerns Regarding Oversimplification in Health Advice
00:39:38 - 00:40:57
Anthony J expresses concern about oversimplified health advice found in books and other media. He points out the complexity of factors contributing to conditions like Alzheimer's, mentioning the influence of genetics (at least 100 genes involved), heavy metals, and other categories. He criticizes the tendency to offer generalized solutions like ketosis, arguing that these approaches might only be effective for a small percentage of people due to individual variations in genetic predispositions and other health factors. He uses the example of lectins, noting that while eliminating them might benefit some, it's not a universal solution. The discussion highlights the need for a more nuanced and personalized approach to health advice, rather than relying on blanket recommendations.
Genetic Predisposition to Liver Damage from Boxing
00:40:57 - 00:42:09
Anthony J discusses a gene, possibly "super ox," linked to higher iron levels and a significantly increased risk of liver damage in boxers. He explains that individuals with high iron levels face a substantially greater risk (tenfold increase mentioned), while those with normal iron levels have minimal risk. He notes that this is a significant issue, particularly in America, where a substantial portion of the population is affected. The conversation briefly touches upon a referral to Nicole, possibly a specialist, following a previous podcast. Justin Alt acknowledges this referral and expresses gratitude for the information received.
Different Ways to Measure Heart Disease Risk
00:42:09 - 00:43:11
Anthony J discusses the various methods of measuring heart disease risk, highlighting the complexity and the lack of a single, universally accepted approach. He mentions the existence of books dedicated to specific categories of heart disease, but criticizes their limited scope. The Podcast Host interjects, suggesting that different approaches might exist, implying a degree of subjectivity. Anthony J agrees, emphasizing that the main risk for the Podcast Host seems to stem from triglycerides. He expresses doubt about high triglyceride levels but suggests checking the Podcast Host's blood work for confirmation. The Podcast Host confirms having the blood work available and proceeds to check it.
Triglycerides and Exercise
00:43:11 - 00:44:05
Anthony J discusses triglyceride levels, emphasizing that levels below 125 are ideal, even with some trial participants having levels as high as 500. He highlights the ease of lowering triglycerides through exercise, explaining that it improves blood flow through the liver. He contrasts this with individuals who are sedentary, have high triglycerides, and may consider medication as a solution. The Podcast Host agrees, stating that high triglycerides indicate lifestyle issues. The conversation then shifts to the Podcast Host's interest in lean mass hyperresponders.
Lean Mass Hyperresponders and Family History
00:44:05 - 00:44:53
The Podcast Host expresses his obsession with lean mass hyperresponders, mentioning a previous podcast discussion and identifying himself as a textbook example. Justin Alt interjects, mentioning high LDL cholesterol. Anthony J recalls this, noting that the Podcast Host doesn't possess the necessary genes for this response, suggesting it's an epigenetic phenomenon. The Podcast Host then shares his family history of heart attacks, expressing concern and his intention to get a calcium score to assess his heart health. He reiterates his interest in the lean mass hyperresponder phenomenon.
LDL Cholesterol and its Association with Health
00:44:57 - 00:46:43
This segment discusses the complexities surrounding LDL cholesterol and its relationship to health. The conversation begins with a mention of variations in LDL levels between individuals and an article suggesting a positive association between higher LDL levels and longevity. Anthony J, who has a PhD in cholesterol and hormones, challenges the dogmatic approach to LDL reduction, highlighting that simply decreasing LDL doesn't automatically equate to better health. He points out the lack of evidence supporting the automatic benefits of LDL reduction. The discussion then shifts to the "lean mass hyperresponder" phenomenon and the possibility of LDL becoming problematic in cases of insulin resistance, high Lp(a) levels, systemic inflammation, or high C-reactive protein. Anthony J emphasizes the importance of considering individual genetic factors and the influence of environmental factors like sleep and chemical exposure when assessing LDL levels and their impact on health. The conversation concludes with a focus on the need for a more nuanced understanding of LDL cholesterol, moving beyond simplistic interpretations of its role in health.
Unexpected Heart Attack Risk
00:46:45 - 00:48:29
The conversation begins with a discussion about heart disease risk factors, prompted by the Podcast Host's anecdote about his uncle's unexpected heart attack despite a healthy lifestyle. Anthony J mentions a recent Instagram post about a study showing a U-shaped relationship between total cholesterol and all-cause mortality in a cohort of 12 million adults. The study indicated that having very low cholesterol (below 200) is associated with a significantly higher risk of mortality than having moderately high cholesterol. Anthony J emphasizes the existence of an optimal cholesterol range, highlighting that extremely low cholesterol is unexpectedly riskier than moderately high cholesterol in terms of all-cause mortality. The Podcast Host expresses interest in this finding, intending to discuss it further with Anthony J.
High Cholesterol and Treatment Options
00:48:29 - 00:50:04
The Podcast Host expresses concern over a U-shaped curve related to cholesterol levels. They share a listener's experience of having a cholesterol level of 220 and a doctor recommending statins. The Host then reveals their own significantly elevated cholesterol levels: a total cholesterol of 545 and an LDL particle number greater than 3500, which is outside the reference range. Anthony J suggests a calcium CT scan and acknowledges the various factors influencing cholesterol, mentioning the existence of CDK genes that regulate cholesterol production. The conversation touches upon the complexities of cholesterol management and the need for further investigation.
Concerns about Blood Test Results and Carnivore Diet
00:50:04 - 00:51:37
Anthony J expresses concerns about the reliability of blood tests, mentioning difficulties in getting them done and the existence of numerous other tests that could provide a more comprehensive picture. He also mentions flavonoids and other factors that might influence results. Justin Alt agrees with the need for thorough checks. Anthony J expresses nervousness about potentially diluting or misinterpreting the results. The Podcast Host confirms the desire for accurate and reliable data, revealing that the blood work discussed was conducted by Paul Saladino after a six-week strict carnivore diet consisting primarily of red meat, liver, and eggs. The Host emphasizes that despite this restrictive diet, their blood test results were unusually high, a point Anthony J acknowledges.
Concerns Regarding Low Cholesterol Levels on a Vegan Diet
00:51:37 - 00:53:22
Anthony J discusses a case where a person on a vegan diet had dangerously low cholesterol levels. He mentions his experience as a special operator in the military, requiring him to sign paperwork related to health. He emphasizes the significantly low cholesterol levels, contrasting with the doctors' assessments. The conversation briefly touches upon the difficulty in assessing health information, with Anthony J mentioning the existence of genes like HLA as another form of information. The discussion concludes with a brief check of the Podcast Host's blood sugar level, which is reported as 91.
Zinc Supplementation and Carnivore Diet
00:53:23 - 00:54:42
This segment discusses the Podcast Host's zinc levels and the potential benefits of zinc supplementation, particularly within the context of a carnivore diet. The conversation begins with a brief exchange about coffee, then shifts to the Podcast Host's zinc intake and a review of their data. Anthony J notes a trend in the data indicating the Podcast Host's zinc levels might be low. The discussion then centers on the difficulty of obtaining sufficient zinc through diet alone, even with a high red meat consumption. Anthony J suggests that supplementation is necessary, highlighting its potential benefits. The Podcast Host mentions hearing similar observations from Dave Feldman's mass hyper-responder group, particularly among individuals following carnivore diets. The conversation concludes with Anthony J mentioning that those on carnivore diets often experience rapid blood glucose responses.
Cholesterol Levels and Lean Mass Hyperresponder
00:54:44 - 00:56:10
Anthony J notes that a cholesterol level of 91 is good, but might decrease slightly. He suggests taking zinc. The Podcast Host expresses concern about cholesterol levels, particularly given family history, and mentions discussions with Rob Wolf and others about lean mass hyperresponders. The possibility of low-level hypothyroidism as a contributing factor to the lean mass hyperresponder phenomenon is raised, prompting the Podcast Host to review their blood work.
Diagnosing Low T3 Levels
00:56:10 - 00:57:48
Anthony J discusses a case where low T3 levels were identified. He notes that this is consistent with a specific scenario and suggests investigating the possibility of reduced conversion of T4 to T3. The conversation then shifts to the importance of iodine as a fundamental building block for thyroid hormone production, emphasizing that insufficient iodine intake can hinder this process. Anthony J proposes an experiment involving iodine supplementation, suggesting a gradual increase in dosage rather than immediately taking a large amount (two grams), to avoid potential adverse effects. Justin Alt expresses concern about exceeding safe iodine levels. The discussion concludes with a decision to proceed cautiously with iodine supplementation.
Discussion on Intermittent Fasting and Genes
00:57:48 - 00:59:09
Anthony J discusses the potential benefits of intermittent fasting, particularly in relation to genes called FOXE1. He explains that studies have shown a correlation between variations in these genes and thyroid healing; individuals with the "good" version healed well, while those with the "bad" version struggled. He connects this to autophagy, the process of cellular self-cleaning, suggesting that intermittent fasting is a way to increase autophagy and improve thyroid health. He mentions a recent discovery related to this and briefly touches upon potential implications, though the details are unclear. The conversation concludes with a brief agreement between Anthony J and the Podcast Host.
Leaky Gut Genes and Dietary Strategies
00:59:11 - 01:02:00
This segment focuses on a discussion about leaky gut genes and dietary strategies to manage them. Anthony J suggests pulling out of a weekend diet for a month as a short-term strategy. The conversation then shifts to specific leaky gut genes, with a focus on one gene that causes problems for individuals who possess it. The role of plant foods, particularly in relation to this gene, is debated, with Anthony J noting the difficulty of managing this gene while consuming plant-based foods. The discussion touches upon the relationship between this gene and autophagy, and the potential ineffectiveness of intermittent fasting and grain consumption for individuals with this gene. Another gene, IBD-5, is mentioned, along with its association with inflammatory bowel disease and the potential role of ergothioneine and interferon. The discussion also includes a mention of mushrooms and their potential impact, with the podcast host indicating they consume mushrooms regularly without issue. Finally, Anthony J mentions an article and Joe Cohen's website, noting that while he finds the website helpful, it contains pro-soy content, which he is not a fan of.
Ergothioneine and its Benefits
01:02:06 - 01:03:43
Anthony J discusses ergothioneine, a vitamin the body needs but cannot produce. He notes that many people have ergothioneine deficiencies and that even doctors are often unfamiliar with it. He explains that issues with transporting ergothioneine to the gut can prevent its benefits from being realized, emphasizing the importance of addressing this problem. He mentions that studies on related issues often focus on averages, which may not accurately reflect individual needs.
Discussion on Genetic Predisposition to Injury and Recovery
01:03:45 - 01:05:21
The Podcast Host shares results from a DNA Fit test, revealing a high risk (10/10) for soft tissue injury and slow recovery from intense exercise. Anthony J explains that the test's scoring system likely uses a plus/minus scale for gene variations, meaning a 10/10 score with plus/minus variations might be even higher (e.g., 10/15) if all variations were positive. He mentions specific genes like ILB and collagen genes as examples.
Back Problems and Treatment
01:05:21 - 01:08:33
Anthony J discusses his history of back problems, noting that plus/minus predictions are harder for back issues. He describes his own severe back pain, rating himself a 15/10, and explains how he used to throw his back out annually since age 12. He details his recovery journey, mentioning that learning to deadlift correctly and using a specific (unnamed) treatment helped him significantly. He emphasizes the importance of addressing the root cause, suggesting that a doctor's check-up, particularly regarding interlude (possibly referring to a specific medical condition or treatment), is crucial. He also touches upon blood sugar levels and joint issues, highlighting that these factors should be considered when dealing with back pain. He concludes by pointing out the lack of holistic approach from orthopedic surgeons, who rarely check thyroid hormones before recommending joint replacements.
Genetic Predisposition and Joint Health
01:08:33 - 01:10:32
Anthony J discusses a gene linked to joint issues and its relation to serotonin, noting that orthopedic surgeons typically don't consider this genetic factor. He mentions the potential impact of diet on joint health, contrasting it with the limited perspective of traditional medical approaches. The conversation shifts to the Podcast Host's experience with blood tests and dietary changes, specifically mentioning the effects of a carnivore diet and a modified ketogenic diet on cholesterol levels. Anthony J adds his perspective on the impact of vegan diets on testosterone levels and energy, highlighting the short-term benefits and long-term drawbacks. He concludes by noting the popularity and unpopularity of different dietary approaches, particularly the carnivore diet.
Plant Sterols and Cholesterol Discussion
01:10:32 - 01:12:02
Anthony J discusses plant sterols, specifically phytosterols (like sitosterol), and their impact on health. He explains that while plants contain cholesterol, it's different from human cholesterol (LDL, HDL). He notes that approximately 5% of people have difficulty clearing plant sterols, leading to a buildup in the body. Oxidized cholesterol, whether from plant or animal sources, is inflammatory. Anthony J highlights that doctors rarely test for phytosterol levels, despite their potential health implications. The podcast host reveals that their blood work shows elevated levels of cytosterol and campesterol.
LDL Cholesterol and Plant Sterols
01:12:02 - 01:14:06
The discussion centers on oxidized LDL cholesterol levels (35), and the impact of genetic predisposition to poor plant sterol clearance. Anthony J highlights his unique experience in having patients with cytosterol blood work available, emphasizing the rarity of this data. He strongly advises individuals with genes impacting plant sterol clearance to significantly reduce or eliminate plant consumption, even suggesting a carnivore diet as an option. While acknowledging the potential benefits of plant sterol supplements like Reservatrol, he expresses reservations about their efficacy. The Podcast Host introduces a counterpoint, suggesting that increasing plant sterols might be beneficial for individuals with problematic genes, creating a debate on the optimal approach to managing cholesterol levels in individuals with specific genetic predispositions.
The Impact of Dietary Changes on the Body
01:14:08 - 01:15:48
Anthony J discusses the body's reaction to sudden dietary shifts, using the example of a vegan switching to a carnivore diet or vice versa. He explains that a drastic change can overwhelm the body, causing a spike in cytosterols as the body struggles to adapt. He compares this to a factory switching production from airplanes to semi-trucks – a process requiring adjustments and time, not an immediate switch. He emphasizes the importance of gradual transitions to allow the body to adjust and avoid negative consequences. The Podcast Host agrees, highlighting the modern human tendency towards instant gratification and the resulting anxieties about dietary changes, particularly when transitioning from a standard American diet to a more restrictive one like the carnivore diet.
The Importance of Self-Knowledge and Dietary Experimentation
01:15:50 - 01:17:06
The Podcast Host emphasizes that drastic dietary changes, like a Twinkie-only diet, won't necessarily lead to death, encouraging experimentation. Anthony J agrees, highlighting the importance of self-knowledge and understanding one's body, referencing Socrates' emphasis on self-knowledge as a key to wisdom. The Podcast Host reiterates the importance of experimentation and not being afraid to try different approaches, even if they contradict previously held beliefs or protocols. The conversation concludes with the Podcast Host mentioning obtaining a connection for peptides following a previous discussion with Anthony J.
Genetic Factors and Athletic Performance
01:17:07 - 01:18:31
Anthony J discusses the impact of genetics on athletic performance. He notes that while some genes might not significantly affect performance, others can have a substantial impact. The conversation then shifts to sleep genes, although time constraints are acknowledged. Anthony J highlights the importance of pain sensitivity, explaining that individuals with low pain sensitivity might not feel pain as acutely, increasing the risk of injury (e.g., blowing a knee during a run). Conversely, those with high pain sensitivity might experience pain excessively, requiring them to work through discomfort. The discussion touches upon the varying degrees of pain tolerance and its implications for athletic performance and injury prevention.
Personal Health and Biohacking Discussion
01:18:32 - 01:20:07
This segment focuses on a discussion between Anthony J and the Podcast Host about personal health and biohacking. Anthony J mentions that gut pain indicates a significant issue. The Podcast Host shares their personal experience with self-inflicted physical punishment, expressing curiosity about this tendency. Anthony J then discusses the Podcast Host's sleep patterns, noting good sleep quality but also sensitivity. He mentions circadian rhythm and potentially delayed sleep, suggesting the use of Aura to track sleep. The Podcast Host confirms getting at least an hour of sleep and mentions their biohacking efforts, referencing Dave Asprey's work on achieving deep sleep even with limited sleep hours. The conversation concludes with Anthony J mentioning peptides for deep sleep.
Sleep and its Impact on Daily Life
01:20:07 - 01:21:26
Anthony J shares an anecdote about his wife's ability to consistently get three hours of deep sleep, regardless of circumstances. He contrasts this with his own sleep challenges, highlighting the impact of evening eating on his sleep quality. He emphasizes the importance of addressing fundamental factors like diet when dealing with sleep issues. The Podcast Host then interjects, mentioning alcohol and THC as significant factors impacting deep sleep, based on personal experimentation. The Host's experience with THC vaping resulted in a complete lack of deep sleep. Anthony J confirms this observation, suggesting it's unsurprising given prior research. The Host further discusses the common misconception that marijuana helps people sleep, clarifying that while it might aid in falling asleep, it negatively impacts deep sleep.
Discussion on Sleep and Melatonin
01:21:28 - 01:22:50
Anthony J discusses the gene AKT and its relation to sleep. He mentions that melatonin can be helpful for sleep, suggesting it as a biohack to test. The conversation then shifts to the Podcast Host's experiences with sleep remedies, including Doc Parsley sleep remedy, which contains vitamin D and may lower melatonin levels. The Podcast Host notes that Doc Parsley hasn't significantly improved their deep sleep, and they primarily use melatonin when traveling. They also mention using a melatonin spray, but haven't observed astronomically higher deep sleep levels with it.
Melatonin, Blue Light, and Lithium Effects on Sleep
01:22:50 - 01:24:15
Podcast Host inquires about the impact of sleep environment on deep sleep, prompting Anthony J to discuss the variable effects of melatonin. He notes that while often beneficial, it can have the opposite effect on some individuals. Blue light exposure is identified as a potential culprit affecting sleep. Anthony J then mentions lithium, specifically lithium orotate, citing studies suggesting its potential benefits. However, he cautions about the risks associated with lithium, explaining that when it separates from orotate, it releases orotic acid, a substance used in animal studies to induce liver cancer. He clarifies that even low levels can be problematic. The discussion shifts to magnesium orotate, another supplement gaining popularity. Anthony J explains that studies indicate its effectiveness in cases of mineral deficiency, where it facilitates the absorption of minerals like lithium into the brain, albeit at a slower rate.
Lithium Orotate and its Effects
01:24:15 - 01:25:08
Anthony J discusses lithium orotate, noting its rapid absorption into the brain and popularity among biohackers. He explains that its benefits are most pronounced in individuals with significant deficiencies. However, for those consistently taking it, the impact diminishes as levels are already maintained. The conversation then shifts to actionable steps for health optimization, with the Podcast Host emphasizing lifestyle factors like diet, sleep, exercise, and environmental factors as having the greatest impact (95%), while genetic optimization is considered a smaller, final step (5%).
Genetic Optimization vs. Lifestyle Factors
01:25:08 - 01:25:29
The Podcast Host reiterates that lifestyle choices are paramount for health, with genetic factors playing a smaller role in optimization. Anthony J agrees, suggesting that even with optimal genes, the difference in outcome might only be around 5%.
Complexities of Genetic Analysis and Personalized Health
01:25:30 - 01:27:09
Anthony J discusses the intricacies of genetic analysis, citing the example of liver health and the interplay of factors like iron and retinol levels. He highlights the challenges in considering multiple risk factors simultaneously. The Podcast Host then points out the importance of understanding less obvious connections, such as caffeine sensitivity and anxiety. The host recommends listeners consult Anthony J's services at ajconsultingcompany.com, requiring 23andMe raw data. Anthony J mentions his long waitlist, previously requiring price increases to manage demand. He expresses his desire to serve a broader clientele beyond high-profile athletes, aiming to help individuals with various health concerns. The Podcast Host expresses interest in Anthony J's training.
Closing Remarks and Call to Action
01:27:10 - 01:27:20
The Podcast Host expresses gratitude to Justin for participating in the podcast. The Host confirms that Justin's contact information and relevant links will be included in the show notes to facilitate connections between listeners and Justin for potential collaborations.
00:00:00 - 00:01:07
Anthony J introduces the podcast episode featuring Justin Alt, mentioning previous interactions and the podcast's audio quality. He promotes his consulting company. The podcast host, Justin Alt, introduces the episode's topic: genetics testing and the human genome, with Dr. Anthony J as the guest.
Discussion of DNA Sequencing Companies and Data Access
00:01:07 - 00:02:28
Anthony J and Justin Alt discuss the accessibility of raw data from DNA sequencing companies like 23andMe. Anthony J highlights that not all companies provide access to this data, emphasizing the importance of choosing companies that do. He explains that the raw data is extensive (thousands of pages of code) and may not be easily understandable to most people, but free online software can help analyze it.
Anthony J's Background and Consulting Work
00:02:28 - 00:04:06
Anthony J describes his custom-written crypt software that generates reports. He mentions his past work as a virus designer for the government, briefly touched upon in a previous conversation. He subsequently started a consulting company, focusing on designing newer devices that utilize DNA to produce viruses in a liquid. He explains the process of designing DNA, inserting it into human cells, and harvesting the resulting viruses. He notes that this work, undertaken in the mid-2020s, faced challenges with the FDA, leading to the shutdown of his operations. Consequently, individuals began seeking his expertise to analyze their DNA code, referencing 23andMe.
Discussion on 23andMe and DNA Reports
00:04:06 - 00:05:32
Anthony J discusses his experiences with people coming to him for help interpreting DNA reports from services like 23andMe. He notes that these reports often provide seemingly trivial information, such as eye color or cilantro preferences, while deeper health information is also present but requires expertise to interpret. The Podcast Host expresses excitement about exploring their own DNA information, mentioning previous experiences with DNA analysis services like Prometheus and DNAfit, highlighting the cost and the need for specialized knowledge to fully understand the results. Justin Alt agrees that the quality of information provided needs to be considered.
The Challenges of Interpreting Complex Scientific Data
00:05:32 - 00:07:23
This segment discusses the difficulties in interpreting scientific reports, particularly those related to genetic associations and cancer risk. The conversation begins with the hosts expressing their initial confusion when faced with overwhelming amounts of data from sources like Prometheus. Anthony J explains that there's a spectrum of issues: some reports are superficial and meaningless, while others provide an excessive amount of information. He points out that many studies report small fold increases (e.g., 1.3-fold, 1.5-fold) in cancer risk associated with specific genes. While these studies might generate hundreds of online results, Anthony J notes that these small associations often don't hold up in larger, more rigorous studies. He emphasizes that the sheer volume of data can be more confusing than helpful, especially considering the numerous potential risk factors involved. The hosts clarify the meaning of fold increases (e.g., a twofold increase being equivalent to a 100% increase), and Anthony J explains that the interpretation of these increases can vary depending on the specific gene and biological context.
Genetic Predisposition and Care Team Efficacy
00:07:23 - 00:08:42
Anthony J uses the example of "care team" to illustrate how genetic studies can show varying efficacy (e.g., 70%). He explains that while "care team" is often perceived as beneficial (like vitamin A from carrots improving eyesight), some individuals have a genetic inability (up to 80% reduction) to convert it into retinol, the actual usable form. Therefore, for those with this genetic issue, consuming carrots is less effective than consuming retinol-rich foods like liver, highlighting the importance of considering individual genetic factors when assessing the effectiveness of treatments or interventions. Justin Alt briefly agrees with this assessment of the limitations of the conversion process.
Genetic Factors and Health Risks
00:08:42 - 00:10:59
Anthony J discusses the complexities of genetic associations with health issues, using retinol and iron as examples. He highlights the limitations of studies that only look at associations without considering the actual biological mechanisms. He emphasizes the significance of individual genetic variations, particularly focusing on the impact of a problematic iron gene, which can lead to risky situations like liver overload. He mentions knowing many people who trust in this information and references a two-hour talk on the subject, further emphasizing the importance of understanding individual genetic predispositions in health management. The conversation also touches upon the value of networking within the health community.
Liver Consumption and High Iron Levels
00:10:59 - 00:12:17
Anthony J discusses the prevalence of liver consumption within a particular group, suggesting it's almost a requirement for membership. He then shifts to discussing high iron levels, expressing more concern about individuals with high iron than low iron. The Podcast Host interjects, mentioning a discussion with Paul Saladino about their own high iron levels resulting from consuming four ounces of liver daily, sourced from local regenerative agriculture farms. The host details their high ferritin levels revealed by blood work and mentions Paul Saladino's analysis of their 23andMe data, suggesting a potential genetic predisposition like hemochromatosis. The host concludes by mentioning Angelina Jolie as a prominent example of someone who utilized 23andMe data to make preventative health decisions.
Concerns about Misinformation in Healthcare
00:12:17 - 00:13:41
The discussion begins with a concern about the potential dangers of misinformation in healthcare, specifically mentioning examples of companies offering simplified, potentially inaccurate health advice for a low price. The conversation then shifts to the importance of in-depth discussion and understanding of complex medical cases, highlighting that while not every intricacy needs to be discussed, certain crucial details are essential. The speakers then transition to a related anecdote about a podcast discussion involving Joe Rogan, Chris Presser, and a documentary featuring Emma Fighter, where the amount of research done was jokingly compared to PhD-level work. This leads to a critique of the idea that extensive online research alone should equate to a PhD, emphasizing the need for a more rigorous process to achieve such an academic qualification.
The Importance of Thorough Understanding in Healthcare
00:13:41 - 00:14:07
This chapter focuses on the necessity of a comprehensive understanding of medical information. The conversation continues from the previous chapter, highlighting the problem of individuals possessing information without a true understanding of its implications. The speakers underscore the importance of a deeper level of comprehension beyond simply accumulating data.
The Misinterpretation of Scientific Studies and Expertise
00:14:08 - 00:15:23
The Podcast Host discusses the common misconception of interpreting scientific studies solely based on conclusions, highlighting the need for deeper understanding. They emphasize the complexity of fields like biochemistry, drawing a parallel to their own expertise in music. Simply reading textbooks doesn't equate to expertise; years of dedicated practice and study are necessary. The host uses the example of reading biochemistry textbooks without achieving expert-level understanding. Anthony J. reinforces this point, using the analogy of someone reading about music without playing an instrument claiming a PhD in music. The host further illustrates their point by mentioning reaching 10,000 hours of stage time by age 18, highlighting the dedication required for true expertise. Anthony J. mentions Chris Johnson, implying further discussion on the topic of expertise and experience.
A Musician's Unique Approach to Performance
00:15:23 - 00:16:03
Anthony J describes a musician who incorporates audience participation into his performances, playing the harmonica and drums simultaneously and inviting others to join him. The Podcast Host expresses enthusiasm for this approach and its relevance to serious musicians. The Host then transitions to the main topic, a report, and plans to share relevant blood work and a list of participants in the show notes. The Host wants to provide context for listeners unfamiliar with the subject matter before diving into the report's details.
Introduction to Genetic Terminology
00:16:03 - 00:16:48
The Podcast Host requests a brief explanation of genetic terms like "genome," "snips," "heterozygous," and "homozygous" for the benefit of listeners new to the topic. Justin Alt agrees to provide this explanation. Anthony J begins by simplifying the concept of DNA, explaining that most cells contain two copies of DNA, one from each parent, except for egg and sperm cells which have only one copy. The discussion briefly touches upon the fusion of egg and sperm cells to form a complete set of DNA.
Genetic Predisposition and Epigenetics
00:16:48 - 00:18:45
Anthony J discusses the concept of gene pairs and their potential impact. He explains that having two copies of a gene means there's a possibility of inheriting a "bad" gene from one or both parents. He simplifies the discussion by focusing on the impact of inheriting two "bad" genes, acknowledging that the presence of one "bad" gene and one "good" gene is a different scenario. He mentions that while thousands of genes might have variations, he focuses on the significant ones. He clarifies that the classification of genes as "good" or "bad" is somewhat arbitrary, as some gene variations might not be detrimental but still hold importance. The conversation then shifts to the role of epigenetics, with the Podcast Host highlighting that genetic predisposition doesn't necessarily determine one's fate. Justin Alt emphasizes the importance of understanding genetic inheritance in parents. Anthony J uses the analogy of a house blueprint with a flawed bathroom to illustrate how a problematic genetic blueprint can lead to issues, but also emphasizes that these issues can be addressed, referencing the example of beta-carotene conversion to retinol as a fixable problem.
The Challenges of Genetic Analogy and the Importance of Context
00:18:45 - 00:20:30
Anthony J discusses the difficulty of directly translating genetic information into easily understandable metrics like exercise or other lifestyle factors. He uses the analogy of adding a bathroom to a house to illustrate the complexity of modifying genetic predispositions. While acknowledging that some genetic traits are hard-wired and unchangeable (like eye color), he emphasizes that many genetic differences can be modified through lifestyle and environmental factors. He highlights the importance of considering the context and the interplay of multiple genes, using the example of the Foxo gene and its impact on brain optimism. He mentions that he uses five categories (brain, diet, etc.) when analyzing genetic information.
Alzheimer's Risk Gene Categories
00:20:32 - 00:22:15
Anthony J discusses Alzheimer's risk gene categories, explaining that there are five categories. He notes that even if someone develops Alzheimer's, it's often the extreme end of a spectrum, and early intervention can be preventative. He details that one category involves chronic inflammation specifically in the brain, which differs from inflammation in other parts of the body and is not easily detectable through standard blood tests. He points out that researchers don't typically check spinal fluid for inflammatory chemicals in the brain due to the invasive nature of the procedure.
Risk Factors for Alzheimer's and the Role of Heavy Metals
00:22:15 - 00:24:07
Anthony J discusses additional risk factors for Alzheimer's, focusing on heavy metals. He emphasizes the importance of proactive heavy metal checks and reduction if elevated levels (cobalt, chromium) are detected. He notes that individual responses to carbohydrates vary significantly, with some experiencing positive brain function while others experience negative liver or body responses. He advises caution with carbohydrate intake, particularly during training, suggesting a need for careful monitoring of individual responses to dietary choices.
Concerns Regarding Head Trauma and Brain Optimization
00:24:07 - 00:25:30
The Podcast Host shares a concern about head trauma after consulting a functional medicine doctor who, upon reviewing the Host's raw data, inquired about past concussions. The Host, a former boxer, acknowledges numerous instances of potential head trauma, leading the doctor to advise against further boxing and emphasize caution. The Host then asks Anthony J if this is a significant concern, particularly given the focus on brain optimization. Anthony J agrees, highlighting the importance of personalized recommendations based on genetics, contrasting this approach with the common practice of providing generalized advice. He uses the example of professional athletes like Julian Edelman, who endure repeated head impacts, to illustrate the need for tailored strategies in brain health.
Examples of Anger and its Consequences
00:25:30 - 00:26:52
The conversation shifts to examples of individuals who exhibited extreme anger, leading to negative consequences. The Podcast Host mentions Chris Henry, a Cincinnati Bengals player, who was involved in a domestic dispute resulting in an accident and his death. The Host also cites Chris Benoit, a WWE superstar, who committed a murder-suicide. Anthony J interjects, revealing his past experience performing autopsies, specifically on NFL players and military personnel, during his Alzheimer's research in Boston. He describes finding plaques in the brains of these individuals, linking them to conditions like Alzheimer's disease and mentioning different types of plaques, including amyloid and tau.
Discussion on Genetic Predisposition to Neurological Conditions
00:26:52 - 00:28:23
Anthony J discusses the complexities of genetic predisposition to neurological conditions like Alzheimer's and brain injuries. He highlights that while certain genes might be associated with increased risk, the actual manifestation and severity of the condition are not always straightforward. He mentions the concept of "plus plus" and "plus minus" genes, explaining that "plus plus" genes are easier to predict in their effect, while "plus minus" genes are more complex and harder to predict their impact on the individual. He emphasizes that the body's compensatory mechanisms can also influence the outcome, making it difficult to establish a direct correlation between specific genes and the severity of neurological conditions. The discussion touches upon the importance of considering individual factors and the limitations of solely relying on genetic information for prognosis. Justin Alt briefly interjects, but the main focus remains on Anthony J's explanation of genetic complexities in neurological diseases.
Risk Factors and Supplements
00:28:24 - 00:30:17
This segment discusses risk factors related to exercise and supplements. Anthony J explains a scenario involving "plus" and "minus" factors, highlighting that while something might seem positive, it could increase the risk of falls. Justin Alt emphasizes the importance of considering the type of exercise performed. The conversation then shifts to supplements, with Anthony J mentioning the impact of various factors like thyroid hormones and sex hormones on overall health. He notes that "beat the enough" is crucial, and the discussion touches upon the chicken-and-egg dilemma of certain health issues. Curcumin is mentioned as a relevant supplement. The conversation concludes with a brief discussion about individual cases and the complexities involved in assessing health risks and benefits.
Localized Gut Inflammation and Blood Markers
00:30:29 - 00:31:21
The Podcast Host discusses the results of their Genova Diagnostics tests, including a neutral valve and GI map. Despite having blood markers like homocysteine and C-reactive protein within the normal reference range, the GI map revealed localized gut inflammation. This discrepancy between blood markers and gut inflammation is noted as strange, with the inflammation seemingly not affecting the bloodstream. Anthony J and Justin Alt offer brief comments of agreement and surprise. The Podcast Host suggests this might be a built-in defense mechanism.
Discussion of Brain Genes and Anxiety
00:31:21 - 00:31:55
Anthony J suggests they could delve into the details of brain genes, mentioning that most of the results are positive except for a couple of anxiety-related markers. He notes that many people exhibit these markers. The conversation briefly touches upon the topic of avoiding the introduction of bacteria. The Podcast Host expresses interest in the "melancholy and anxiety" section of the results, which will be available to listeners in the show notes. An unidentified speaker makes a brief, non-specific comment.
Serotonin and Supplement Discussion
00:31:57 - 00:32:48
Anthony J discusses increasing serotonin levels, suggesting 5HTP alongside tryptophan, an amino acid and building block for serotonin. He explains that providing the body with building blocks and then triggering serotonin production is beneficial, although individual responses vary. He notes that serotonin is complex. Justin Alt briefly adds to the conversation.
Caffeine Metabolism and Test Results Interpretation
00:32:48 - 00:33:22
The Podcast Host raises a question about caffeine metabolism, noting a "plus plus" result indicating faster-than-average elimination. The discussion clarifies that a "plus plus" result doesn't automatically signify a negative outcome; it simply reflects the test's specific measurement. Anthony J confirms this interpretation.
Caffeine's Impact on Individuals with Anxiety
00:33:23 - 00:34:55
This segment discusses the varying effects of caffeine, particularly highlighting its potential negative impact on individuals with anxiety. Anthony J shares an anecdote about a professional baseball player with three anxiety genes linked to caffeine sensitivity, emphasizing that the blanket statement of caffeine being universally beneficial is inaccurate. He explains that for some, caffeine's effects can last for days, exacerbating anxiety symptoms. The conversation underscores the importance of individual responses to caffeine and the need to consider genetic predispositions and how the body processes it. The Podcast Host corroborates this by mentioning clients who experience prolonged sleep disruption even after a single morning cup of coffee, further illustrating the significant individual variability in caffeine sensitivity and its potential to negatively affect those with anxiety.
The Individualized Effects of Caffeine and Diet
00:34:55 - 00:36:18
Anthony J discusses how some people experience significant anxiety from caffeine, a reaction that many doctors dismiss. He notes that while the anxiety might seem "mental," it's rooted in the physiological effects of caffeine, lasting longer than its typical half-life. The Podcast Host agrees, highlighting the highly individualized nature of caffeine's impact. The Host points out the potential for misinformation in the health and wellness space, citing the example of Dave Asprey's promotion of coffee, which might lead individuals to overlook negative personal reactions. The conversation expands to encompass the broader issue of individualized dietary responses, with Anthony J noting that diets effective for some may be detrimental to others, and the dangers of promoting a single diet as universally beneficial.
The Spread and Impact of a Fitness Trend
00:36:18 - 00:38:00
Anthony J discusses how a fitness trend initially struggles to gain traction, with many people abandoning it due to difficulty. However, a few successful individuals create a "club," inspiring others and leading to wider adoption. The conversation then shifts to the potentially egotistical nature of such trends, where individuals may judge others based on their body type. Anthony J explains that this often stems from a misunderstanding of hormonal influences, particularly estrogen. He mentions his book on estrogen and details how it uniquely interacts with the body, penetrating cell and nuclear membranes to directly affect DNA and potentially influencing future generations through epigenetic changes. The Podcast Host acknowledges this point, highlighting the scary implications of this hormonal impact on inherited traits. The discussion concludes with Anthony J emphasizing how parental dietary choices can have lasting effects on their offspring's health.
Diet Optimization Genes and Intermittent Fasting
00:38:00 - 00:39:38
This section discusses diet optimization genes, specifically focusing on intermittent fasting. Anthony J. notes that while intermittent fasting is optimal for almost everyone, exceptions exist for professional athletes or individuals focused on muscle gain. He suggests that while such individuals might benefit from consistent eating, they may experience a shorter lifespan as a consequence. The Podcast Host agrees, stating that high-level athletic performance often comes at the cost of longevity. Anthony J. further elaborates that while it's difficult to definitively prove this correlation, some individuals are willing to accept this trade-off for peak athletic performance. He suggests that athletes might reverse this approach around age 50 to prioritize longevity.
Concerns Regarding Oversimplification in Health Advice
00:39:38 - 00:40:57
Anthony J expresses concern about oversimplified health advice found in books and other media. He points out the complexity of factors contributing to conditions like Alzheimer's, mentioning the influence of genetics (at least 100 genes involved), heavy metals, and other categories. He criticizes the tendency to offer generalized solutions like ketosis, arguing that these approaches might only be effective for a small percentage of people due to individual variations in genetic predispositions and other health factors. He uses the example of lectins, noting that while eliminating them might benefit some, it's not a universal solution. The discussion highlights the need for a more nuanced and personalized approach to health advice, rather than relying on blanket recommendations.
Genetic Predisposition to Liver Damage from Boxing
00:40:57 - 00:42:09
Anthony J discusses a gene, possibly "super ox," linked to higher iron levels and a significantly increased risk of liver damage in boxers. He explains that individuals with high iron levels face a substantially greater risk (tenfold increase mentioned), while those with normal iron levels have minimal risk. He notes that this is a significant issue, particularly in America, where a substantial portion of the population is affected. The conversation briefly touches upon a referral to Nicole, possibly a specialist, following a previous podcast. Justin Alt acknowledges this referral and expresses gratitude for the information received.
Different Ways to Measure Heart Disease Risk
00:42:09 - 00:43:11
Anthony J discusses the various methods of measuring heart disease risk, highlighting the complexity and the lack of a single, universally accepted approach. He mentions the existence of books dedicated to specific categories of heart disease, but criticizes their limited scope. The Podcast Host interjects, suggesting that different approaches might exist, implying a degree of subjectivity. Anthony J agrees, emphasizing that the main risk for the Podcast Host seems to stem from triglycerides. He expresses doubt about high triglyceride levels but suggests checking the Podcast Host's blood work for confirmation. The Podcast Host confirms having the blood work available and proceeds to check it.
Triglycerides and Exercise
00:43:11 - 00:44:05
Anthony J discusses triglyceride levels, emphasizing that levels below 125 are ideal, even with some trial participants having levels as high as 500. He highlights the ease of lowering triglycerides through exercise, explaining that it improves blood flow through the liver. He contrasts this with individuals who are sedentary, have high triglycerides, and may consider medication as a solution. The Podcast Host agrees, stating that high triglycerides indicate lifestyle issues. The conversation then shifts to the Podcast Host's interest in lean mass hyperresponders.
Lean Mass Hyperresponders and Family History
00:44:05 - 00:44:53
The Podcast Host expresses his obsession with lean mass hyperresponders, mentioning a previous podcast discussion and identifying himself as a textbook example. Justin Alt interjects, mentioning high LDL cholesterol. Anthony J recalls this, noting that the Podcast Host doesn't possess the necessary genes for this response, suggesting it's an epigenetic phenomenon. The Podcast Host then shares his family history of heart attacks, expressing concern and his intention to get a calcium score to assess his heart health. He reiterates his interest in the lean mass hyperresponder phenomenon.
LDL Cholesterol and its Association with Health
00:44:57 - 00:46:43
This segment discusses the complexities surrounding LDL cholesterol and its relationship to health. The conversation begins with a mention of variations in LDL levels between individuals and an article suggesting a positive association between higher LDL levels and longevity. Anthony J, who has a PhD in cholesterol and hormones, challenges the dogmatic approach to LDL reduction, highlighting that simply decreasing LDL doesn't automatically equate to better health. He points out the lack of evidence supporting the automatic benefits of LDL reduction. The discussion then shifts to the "lean mass hyperresponder" phenomenon and the possibility of LDL becoming problematic in cases of insulin resistance, high Lp(a) levels, systemic inflammation, or high C-reactive protein. Anthony J emphasizes the importance of considering individual genetic factors and the influence of environmental factors like sleep and chemical exposure when assessing LDL levels and their impact on health. The conversation concludes with a focus on the need for a more nuanced understanding of LDL cholesterol, moving beyond simplistic interpretations of its role in health.
Unexpected Heart Attack Risk
00:46:45 - 00:48:29
The conversation begins with a discussion about heart disease risk factors, prompted by the Podcast Host's anecdote about his uncle's unexpected heart attack despite a healthy lifestyle. Anthony J mentions a recent Instagram post about a study showing a U-shaped relationship between total cholesterol and all-cause mortality in a cohort of 12 million adults. The study indicated that having very low cholesterol (below 200) is associated with a significantly higher risk of mortality than having moderately high cholesterol. Anthony J emphasizes the existence of an optimal cholesterol range, highlighting that extremely low cholesterol is unexpectedly riskier than moderately high cholesterol in terms of all-cause mortality. The Podcast Host expresses interest in this finding, intending to discuss it further with Anthony J.
High Cholesterol and Treatment Options
00:48:29 - 00:50:04
The Podcast Host expresses concern over a U-shaped curve related to cholesterol levels. They share a listener's experience of having a cholesterol level of 220 and a doctor recommending statins. The Host then reveals their own significantly elevated cholesterol levels: a total cholesterol of 545 and an LDL particle number greater than 3500, which is outside the reference range. Anthony J suggests a calcium CT scan and acknowledges the various factors influencing cholesterol, mentioning the existence of CDK genes that regulate cholesterol production. The conversation touches upon the complexities of cholesterol management and the need for further investigation.
Concerns about Blood Test Results and Carnivore Diet
00:50:04 - 00:51:37
Anthony J expresses concerns about the reliability of blood tests, mentioning difficulties in getting them done and the existence of numerous other tests that could provide a more comprehensive picture. He also mentions flavonoids and other factors that might influence results. Justin Alt agrees with the need for thorough checks. Anthony J expresses nervousness about potentially diluting or misinterpreting the results. The Podcast Host confirms the desire for accurate and reliable data, revealing that the blood work discussed was conducted by Paul Saladino after a six-week strict carnivore diet consisting primarily of red meat, liver, and eggs. The Host emphasizes that despite this restrictive diet, their blood test results were unusually high, a point Anthony J acknowledges.
Concerns Regarding Low Cholesterol Levels on a Vegan Diet
00:51:37 - 00:53:22
Anthony J discusses a case where a person on a vegan diet had dangerously low cholesterol levels. He mentions his experience as a special operator in the military, requiring him to sign paperwork related to health. He emphasizes the significantly low cholesterol levels, contrasting with the doctors' assessments. The conversation briefly touches upon the difficulty in assessing health information, with Anthony J mentioning the existence of genes like HLA as another form of information. The discussion concludes with a brief check of the Podcast Host's blood sugar level, which is reported as 91.
Zinc Supplementation and Carnivore Diet
00:53:23 - 00:54:42
This segment discusses the Podcast Host's zinc levels and the potential benefits of zinc supplementation, particularly within the context of a carnivore diet. The conversation begins with a brief exchange about coffee, then shifts to the Podcast Host's zinc intake and a review of their data. Anthony J notes a trend in the data indicating the Podcast Host's zinc levels might be low. The discussion then centers on the difficulty of obtaining sufficient zinc through diet alone, even with a high red meat consumption. Anthony J suggests that supplementation is necessary, highlighting its potential benefits. The Podcast Host mentions hearing similar observations from Dave Feldman's mass hyper-responder group, particularly among individuals following carnivore diets. The conversation concludes with Anthony J mentioning that those on carnivore diets often experience rapid blood glucose responses.
Cholesterol Levels and Lean Mass Hyperresponder
00:54:44 - 00:56:10
Anthony J notes that a cholesterol level of 91 is good, but might decrease slightly. He suggests taking zinc. The Podcast Host expresses concern about cholesterol levels, particularly given family history, and mentions discussions with Rob Wolf and others about lean mass hyperresponders. The possibility of low-level hypothyroidism as a contributing factor to the lean mass hyperresponder phenomenon is raised, prompting the Podcast Host to review their blood work.
Diagnosing Low T3 Levels
00:56:10 - 00:57:48
Anthony J discusses a case where low T3 levels were identified. He notes that this is consistent with a specific scenario and suggests investigating the possibility of reduced conversion of T4 to T3. The conversation then shifts to the importance of iodine as a fundamental building block for thyroid hormone production, emphasizing that insufficient iodine intake can hinder this process. Anthony J proposes an experiment involving iodine supplementation, suggesting a gradual increase in dosage rather than immediately taking a large amount (two grams), to avoid potential adverse effects. Justin Alt expresses concern about exceeding safe iodine levels. The discussion concludes with a decision to proceed cautiously with iodine supplementation.
Discussion on Intermittent Fasting and Genes
00:57:48 - 00:59:09
Anthony J discusses the potential benefits of intermittent fasting, particularly in relation to genes called FOXE1. He explains that studies have shown a correlation between variations in these genes and thyroid healing; individuals with the "good" version healed well, while those with the "bad" version struggled. He connects this to autophagy, the process of cellular self-cleaning, suggesting that intermittent fasting is a way to increase autophagy and improve thyroid health. He mentions a recent discovery related to this and briefly touches upon potential implications, though the details are unclear. The conversation concludes with a brief agreement between Anthony J and the Podcast Host.
Leaky Gut Genes and Dietary Strategies
00:59:11 - 01:02:00
This segment focuses on a discussion about leaky gut genes and dietary strategies to manage them. Anthony J suggests pulling out of a weekend diet for a month as a short-term strategy. The conversation then shifts to specific leaky gut genes, with a focus on one gene that causes problems for individuals who possess it. The role of plant foods, particularly in relation to this gene, is debated, with Anthony J noting the difficulty of managing this gene while consuming plant-based foods. The discussion touches upon the relationship between this gene and autophagy, and the potential ineffectiveness of intermittent fasting and grain consumption for individuals with this gene. Another gene, IBD-5, is mentioned, along with its association with inflammatory bowel disease and the potential role of ergothioneine and interferon. The discussion also includes a mention of mushrooms and their potential impact, with the podcast host indicating they consume mushrooms regularly without issue. Finally, Anthony J mentions an article and Joe Cohen's website, noting that while he finds the website helpful, it contains pro-soy content, which he is not a fan of.
Ergothioneine and its Benefits
01:02:06 - 01:03:43
Anthony J discusses ergothioneine, a vitamin the body needs but cannot produce. He notes that many people have ergothioneine deficiencies and that even doctors are often unfamiliar with it. He explains that issues with transporting ergothioneine to the gut can prevent its benefits from being realized, emphasizing the importance of addressing this problem. He mentions that studies on related issues often focus on averages, which may not accurately reflect individual needs.
Discussion on Genetic Predisposition to Injury and Recovery
01:03:45 - 01:05:21
The Podcast Host shares results from a DNA Fit test, revealing a high risk (10/10) for soft tissue injury and slow recovery from intense exercise. Anthony J explains that the test's scoring system likely uses a plus/minus scale for gene variations, meaning a 10/10 score with plus/minus variations might be even higher (e.g., 10/15) if all variations were positive. He mentions specific genes like ILB and collagen genes as examples.
Back Problems and Treatment
01:05:21 - 01:08:33
Anthony J discusses his history of back problems, noting that plus/minus predictions are harder for back issues. He describes his own severe back pain, rating himself a 15/10, and explains how he used to throw his back out annually since age 12. He details his recovery journey, mentioning that learning to deadlift correctly and using a specific (unnamed) treatment helped him significantly. He emphasizes the importance of addressing the root cause, suggesting that a doctor's check-up, particularly regarding interlude (possibly referring to a specific medical condition or treatment), is crucial. He also touches upon blood sugar levels and joint issues, highlighting that these factors should be considered when dealing with back pain. He concludes by pointing out the lack of holistic approach from orthopedic surgeons, who rarely check thyroid hormones before recommending joint replacements.
Genetic Predisposition and Joint Health
01:08:33 - 01:10:32
Anthony J discusses a gene linked to joint issues and its relation to serotonin, noting that orthopedic surgeons typically don't consider this genetic factor. He mentions the potential impact of diet on joint health, contrasting it with the limited perspective of traditional medical approaches. The conversation shifts to the Podcast Host's experience with blood tests and dietary changes, specifically mentioning the effects of a carnivore diet and a modified ketogenic diet on cholesterol levels. Anthony J adds his perspective on the impact of vegan diets on testosterone levels and energy, highlighting the short-term benefits and long-term drawbacks. He concludes by noting the popularity and unpopularity of different dietary approaches, particularly the carnivore diet.
Plant Sterols and Cholesterol Discussion
01:10:32 - 01:12:02
Anthony J discusses plant sterols, specifically phytosterols (like sitosterol), and their impact on health. He explains that while plants contain cholesterol, it's different from human cholesterol (LDL, HDL). He notes that approximately 5% of people have difficulty clearing plant sterols, leading to a buildup in the body. Oxidized cholesterol, whether from plant or animal sources, is inflammatory. Anthony J highlights that doctors rarely test for phytosterol levels, despite their potential health implications. The podcast host reveals that their blood work shows elevated levels of cytosterol and campesterol.
LDL Cholesterol and Plant Sterols
01:12:02 - 01:14:06
The discussion centers on oxidized LDL cholesterol levels (35), and the impact of genetic predisposition to poor plant sterol clearance. Anthony J highlights his unique experience in having patients with cytosterol blood work available, emphasizing the rarity of this data. He strongly advises individuals with genes impacting plant sterol clearance to significantly reduce or eliminate plant consumption, even suggesting a carnivore diet as an option. While acknowledging the potential benefits of plant sterol supplements like Reservatrol, he expresses reservations about their efficacy. The Podcast Host introduces a counterpoint, suggesting that increasing plant sterols might be beneficial for individuals with problematic genes, creating a debate on the optimal approach to managing cholesterol levels in individuals with specific genetic predispositions.
The Impact of Dietary Changes on the Body
01:14:08 - 01:15:48
Anthony J discusses the body's reaction to sudden dietary shifts, using the example of a vegan switching to a carnivore diet or vice versa. He explains that a drastic change can overwhelm the body, causing a spike in cytosterols as the body struggles to adapt. He compares this to a factory switching production from airplanes to semi-trucks – a process requiring adjustments and time, not an immediate switch. He emphasizes the importance of gradual transitions to allow the body to adjust and avoid negative consequences. The Podcast Host agrees, highlighting the modern human tendency towards instant gratification and the resulting anxieties about dietary changes, particularly when transitioning from a standard American diet to a more restrictive one like the carnivore diet.
The Importance of Self-Knowledge and Dietary Experimentation
01:15:50 - 01:17:06
The Podcast Host emphasizes that drastic dietary changes, like a Twinkie-only diet, won't necessarily lead to death, encouraging experimentation. Anthony J agrees, highlighting the importance of self-knowledge and understanding one's body, referencing Socrates' emphasis on self-knowledge as a key to wisdom. The Podcast Host reiterates the importance of experimentation and not being afraid to try different approaches, even if they contradict previously held beliefs or protocols. The conversation concludes with the Podcast Host mentioning obtaining a connection for peptides following a previous discussion with Anthony J.
Genetic Factors and Athletic Performance
01:17:07 - 01:18:31
Anthony J discusses the impact of genetics on athletic performance. He notes that while some genes might not significantly affect performance, others can have a substantial impact. The conversation then shifts to sleep genes, although time constraints are acknowledged. Anthony J highlights the importance of pain sensitivity, explaining that individuals with low pain sensitivity might not feel pain as acutely, increasing the risk of injury (e.g., blowing a knee during a run). Conversely, those with high pain sensitivity might experience pain excessively, requiring them to work through discomfort. The discussion touches upon the varying degrees of pain tolerance and its implications for athletic performance and injury prevention.
Personal Health and Biohacking Discussion
01:18:32 - 01:20:07
This segment focuses on a discussion between Anthony J and the Podcast Host about personal health and biohacking. Anthony J mentions that gut pain indicates a significant issue. The Podcast Host shares their personal experience with self-inflicted physical punishment, expressing curiosity about this tendency. Anthony J then discusses the Podcast Host's sleep patterns, noting good sleep quality but also sensitivity. He mentions circadian rhythm and potentially delayed sleep, suggesting the use of Aura to track sleep. The Podcast Host confirms getting at least an hour of sleep and mentions their biohacking efforts, referencing Dave Asprey's work on achieving deep sleep even with limited sleep hours. The conversation concludes with Anthony J mentioning peptides for deep sleep.
Sleep and its Impact on Daily Life
01:20:07 - 01:21:26
Anthony J shares an anecdote about his wife's ability to consistently get three hours of deep sleep, regardless of circumstances. He contrasts this with his own sleep challenges, highlighting the impact of evening eating on his sleep quality. He emphasizes the importance of addressing fundamental factors like diet when dealing with sleep issues. The Podcast Host then interjects, mentioning alcohol and THC as significant factors impacting deep sleep, based on personal experimentation. The Host's experience with THC vaping resulted in a complete lack of deep sleep. Anthony J confirms this observation, suggesting it's unsurprising given prior research. The Host further discusses the common misconception that marijuana helps people sleep, clarifying that while it might aid in falling asleep, it negatively impacts deep sleep.
Discussion on Sleep and Melatonin
01:21:28 - 01:22:50
Anthony J discusses the gene AKT and its relation to sleep. He mentions that melatonin can be helpful for sleep, suggesting it as a biohack to test. The conversation then shifts to the Podcast Host's experiences with sleep remedies, including Doc Parsley sleep remedy, which contains vitamin D and may lower melatonin levels. The Podcast Host notes that Doc Parsley hasn't significantly improved their deep sleep, and they primarily use melatonin when traveling. They also mention using a melatonin spray, but haven't observed astronomically higher deep sleep levels with it.
Melatonin, Blue Light, and Lithium Effects on Sleep
01:22:50 - 01:24:15
Podcast Host inquires about the impact of sleep environment on deep sleep, prompting Anthony J to discuss the variable effects of melatonin. He notes that while often beneficial, it can have the opposite effect on some individuals. Blue light exposure is identified as a potential culprit affecting sleep. Anthony J then mentions lithium, specifically lithium orotate, citing studies suggesting its potential benefits. However, he cautions about the risks associated with lithium, explaining that when it separates from orotate, it releases orotic acid, a substance used in animal studies to induce liver cancer. He clarifies that even low levels can be problematic. The discussion shifts to magnesium orotate, another supplement gaining popularity. Anthony J explains that studies indicate its effectiveness in cases of mineral deficiency, where it facilitates the absorption of minerals like lithium into the brain, albeit at a slower rate.
Lithium Orotate and its Effects
01:24:15 - 01:25:08
Anthony J discusses lithium orotate, noting its rapid absorption into the brain and popularity among biohackers. He explains that its benefits are most pronounced in individuals with significant deficiencies. However, for those consistently taking it, the impact diminishes as levels are already maintained. The conversation then shifts to actionable steps for health optimization, with the Podcast Host emphasizing lifestyle factors like diet, sleep, exercise, and environmental factors as having the greatest impact (95%), while genetic optimization is considered a smaller, final step (5%).
Genetic Optimization vs. Lifestyle Factors
01:25:08 - 01:25:29
The Podcast Host reiterates that lifestyle choices are paramount for health, with genetic factors playing a smaller role in optimization. Anthony J agrees, suggesting that even with optimal genes, the difference in outcome might only be around 5%.
Complexities of Genetic Analysis and Personalized Health
01:25:30 - 01:27:09
Anthony J discusses the intricacies of genetic analysis, citing the example of liver health and the interplay of factors like iron and retinol levels. He highlights the challenges in considering multiple risk factors simultaneously. The Podcast Host then points out the importance of understanding less obvious connections, such as caffeine sensitivity and anxiety. The host recommends listeners consult Anthony J's services at ajconsultingcompany.com, requiring 23andMe raw data. Anthony J mentions his long waitlist, previously requiring price increases to manage demand. He expresses his desire to serve a broader clientele beyond high-profile athletes, aiming to help individuals with various health concerns. The Podcast Host expresses interest in Anthony J's training.
Closing Remarks and Call to Action
01:27:10 - 01:27:20
The Podcast Host expresses gratitude to Justin for participating in the podcast. The Host confirms that Justin's contact information and relevant links will be included in the show notes to facilitate connections between listeners and Justin for potential collaborations.
DNA with Dr. Jay, Episode 05.
MARK IRON (from Australia)
MARK IRON (from Australia)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Podcast Overview
00:00:00 - 00:01:02
The podcast episode begins with an introduction by the host, who mentions a collaboration with Mark Iron, an Australian Instagram influencer (@School for Success) with around half a million followers. The host explains that Mark shared a podcast episode he recorded, focusing on a discussion about his DNA analysis. The host briefly mentions the episode's slightly less structured format than usual but highlights interesting points and perspectives. He promotes his own services (ajconsultingcompany.com for DNA analysis) and Patreon page (patreon.com/anthonygjay), showcasing a recent video about shooting fish.
Discussion of Mark Iron's DNA Analysis: Vitamin E and Inflammation
00:01:02 - 00:01:52
The conversation shifts to a discussion of Mark Iron's DNA analysis report. The host and Mark discuss a surprising finding: Mark's genes indicate that synthetic vitamin E (tocopherol), commonly found in multivitamins, causes inflammation in his body. They contrast this with the natural form of vitamin E, tocotrienols, which is beneficial. The difficulty in readily accessing tocotrienols is also noted.
Multivitamin Concerns and Inflammation Markers
00:01:52 - 00:03:54
The discussion begins with a question about tocopherols in multivitamins and their potential effects on the body, specifically whether they cause gut or systemic inflammation. The conversation then shifts to a DNA report, specifically page five focusing on heart disease. The report highlights elevated CRP blood levels and an IL-6 receptor gene, indicating higher-than-average interleukin-6 levels. Interleukin-6 is explained as a type of inflammation, similar to CRP and TNF-alpha, which activates immune cells. The individual's history of five shoulder surgeries due to severe arthritis is mentioned as a relevant factor. The high IL-6 level is identified as a genetic predisposition, which also triggers higher CRP levels, although CRP is more commonly measured clinically than IL-6.
Inflammatory Markers and Vitamin E
00:03:58 - 00:05:46
This segment discusses the relationship between CRP levels, IL-6, and dietary factors, particularly focusing on the impact of different forms of Vitamin E. The conversation begins by establishing CRP as a proxy for IL-6, noting that lifestyle choices like healthy eating and exercise can lower CRP. The role of omega-3 fatty acids, including EPA and DHA, in lowering CRP is also mentioned. The discussion then shifts to the gene GSTP1 and its interaction with tocopherols (a form of Vitamin E). It's explained that supplementing with tocopherols can trigger the release of IL-6, which is problematic for individuals with a genetic predisposition to higher IL-6 levels, as it exacerbates inflammation. The speaker highlights that avoiding tocopherols is crucial, especially for those with the mentioned genetic predisposition, and points out that tocopherols are often found in common supplements like fish oil.
High-Dose Vitamin E and Cancer Risk
00:05:46 - 00:07:37
The discussion begins with the speaker explaining that high doses of vitamin E, found in multivitamins and supplements, can increase cancer risk, particularly for smokers. This finding, published in the New England Journal of Medicine, was initially surprising. The speaker explains that chronic antioxidant intake, unlike vitamin C which is an exception due to its conversion to hydrogen peroxide, can help cancer cells survive. The conversation then shifts to the use of spices, which are high in antioxidants. While spices could potentially contribute to this problem, the speaker notes that they also contain other anti-cancer properties, unlike isolated antioxidant supplements. Therefore, the risk associated with spice consumption is likely mitigated by these additional beneficial components.
The Importance of Personalized Nutrition Based on Genetics
00:07:38 - 00:09:29
This segment discusses the limitations of generic vitamin and supplement recommendations and emphasizes the crucial role of personalized nutrition based on individual genetics. Speakers highlight that studies showing no benefit from multivitamins often fail to account for genetic variations. They explain that certain vitamins, beneficial for some individuals, can cause inflammation and negative effects in others due to genetic differences. The speakers warn against the "one-size-fits-all" approach to diet and supplementation, emphasizing that a diet or supplement regimen that works for one person may be detrimental to another. They conclude that research on vitamins and supplements is often rendered useless without considering individual genetic factors (SNPs). The speakers agree that claims of perfect diets for everyone should be viewed with skepticism.
The Importance of Personalized Medicine Based on Genetics
00:09:30 - 00:10:31
The discussion highlights the limitations of generalized research studies that don't account for individual genetic variations when studying the effects of drugs or treatments. It's emphasized that personalized medicine, considering individual genetic variants, is crucial for effective treatment, particularly in cases like cancer. The speakers discuss how most doctors are behind the curve in utilizing this technology and the importance of patients seeking out doctors who can analyze their genes to make informed decisions about their health and performance. The need for patients to understand and absorb this information to make educated choices about their health is stressed.
Specific Nutritional Considerations Based on Genetics
00:10:31 - 00:11:29
The conversation shifts to specific nutritional advice based on genetic predispositions. A discount link for genetic testing is offered to be shared later. The example of vitamin B12 is discussed, highlighting the difficulty of absorption through the gut and the importance of supplementation or a diet rich in meat to ensure sufficient intake. One speaker mentions their dietary habits, incorporating a mix of meat-heavy days and other days, suggesting a balanced approach to meet nutritional needs.
Dietary Approaches and Genetic Predisposition
00:11:29 - 00:12:36
The discussion centers on the speaker's current diet, incorporating elements of keto and paleo. The importance of B12 supplementation for non-meat eaters is highlighted, emphasizing the potential long-term consequences of dietary choices on gene expression. The speaker stresses the significance of genetic testing in optimizing diet, citing fibromyalgia as an example where understanding genetic predispositions to inflammation can inform dietary and lifestyle choices to mitigate symptoms like fatigue, mood swings, and anxiety. The conversation concludes this section by noting the speaker's favorable genetic profile regarding heavy metals and transitioning to a discussion of brain health.
Brain Optimization Genes and Anxiety
00:12:36 - 00:13:21
The conversation shifts to analyzing brain optimization genes, specifically focusing on anxiety and its potential link to inflammation. The speaker's genetic report reveals a positive outlook regarding Alzheimer's risk and overall brain performance. The absence of entries in certain categories is explained as indicating no identified gene-related issues in those areas. The speaker contrasts their approach of focusing on key findings with the more extensive reports some providers offer, preferring a concise summary of significant genetic insights.
Focusing on Problematic Genes
00:13:21 - 00:15:18
This segment focuses on identifying and addressing problematic genes, specifically those linked to mental health issues like anxiety and depression. The speakers express a desire to focus on "bad genes" rather than the numerous "good genes," arguing that this approach is more efficient. The discussion centers on the HTR2A gene, which affects serotonin receptor function and can contribute to depression and anxiety. The speakers highlight the importance of gut health in serotonin production, emphasizing that a healthy gut is crucial for mental well-being. They criticize the widespread use of SSRIs like Zoloft, Prozac, Paxil, Lexapro, and Selexa, suggesting that these drugs often mask underlying issues like inflammation rather than addressing the root cause. One speaker shares a personal experience with anxiety and panic attacks, noting that medication altered their brain chemistry and that inflammation was the primary underlying issue.
Serotonin, Sleep, and Supplements
00:15:18 - 00:17:18
This segment discusses the relationship between serotonin, sleep, and various supplements. The speakers mention that a healthy gut contributes to serotonin production, alongside factors like sunshine. They explore supplements like 5-HTP and tryptophan, noting tryptophan's role as a serotonin building block found in protein-rich foods. The discussion touches upon the debated link between tryptophan in turkey and sleepiness, suggesting carbohydrate consumption might be a more significant factor. Genetic issues impacting sleep are linked to serotonin levels. Two studies are referenced: one highlighting the inverse relationship between serotonin, sulfur amino acids, and dopamine (excess of one depletes the other), leading one speaker to stop supplementing tyrosine and L-tryptophan; and another showing that light therapy (30 minutes) counteracts acute tryptophan depletion, preventing it from crossing the blood-brain barrier. The speaker personally uses light therapy in the mornings.
Dopamine Levels and Motivation
00:17:21 - 00:18:02
The discussion begins with a comment on the interesting interplay between genetics and dopamine levels, specifically noting lower dopamine levels in the context of the speaker's genetics. The conversation then shifts to the COMT gene and its influence on dopamine, acknowledging a jump in topics due to the podcast format. The importance of optimal dopamine levels for motivation is highlighted, contrasting it with fluctuating levels that lead to distraction and inconsistency. The speakers then transition to a section on Cannabis in a document (page nine), relating it to the ongoing discussion of motivation.
Locating the Cannabis Section
00:18:03 - 00:18:41
The speakers attempt to locate the "Cannabis" section on page nine of a document. One speaker guides the other through the document, providing directions to navigate to the correct section. There is a brief exchange of confirmations and directions to find the section, which is located near the B9 and vitamin E section.
Cannabis and Catecholomethyl Transferase
00:18:41 - 00:18:58
Once the "Cannabis" section is located, the discussion focuses on Catecholomethyl transferase (COMT) and its relevance to cannabis use. The speaker mentions the specific version of COMT the individual possesses and explains the connection between cannabis use and the potential impact on the intestines.
Cannabis Use and Genetic Predisposition
00:18:58 - 00:20:54
The discussion centers on the potential negative impact of cannabis use, particularly concerning a specific gene variant. The speaker explains that this gene variant can lead to lower dopamine levels, further decreasing motivation, especially in individuals already predisposed to lower levels. While lifestyle adjustments like sunshine, high-protein diets, caffeine, and music can help boost dopamine, cannabis use is highlighted as particularly detrimental, potentially hindering recovery and even triggering schizophrenia in susceptible individuals. The speaker emphasizes the risks associated with cannabis use for those with this gene variant, advising against it. The conversation then shifts to the individual's lower serotonin levels, not due to low amounts but rather due to the serotonin not binding to receptors as effectively. This further emphasizes the importance of addressing both dopamine and serotonin levels.
Receptor Binding and Pain Sensitivity
00:20:54 - 00:22:40
This segment discusses the impact of receptor binding on medication effectiveness and its correlation with pain sensitivity. The speakers note that when a medication binds to a receptor less effectively, a higher dose is needed to achieve the same result. The conversation then shifts to the relationship between the COMT gene and pain sensitivity, referencing a section on page 13 of a document detailing genetic influences on pain perception. A specific gene, SCN9A, is highlighted as a rare gene variant associated with extremely low pain sensitivity, potentially leading to injuries due to delayed pain recognition. Conversely, individuals with high pain sensitivity are discussed, emphasizing the challenges they face in managing pain and the need to push through discomfort. The speakers share personal anecdotes, illustrating the consequences of ignoring pain signals, particularly in the context of weightlifting and potential injuries.
Analyzing Genetic Predisposition to Powerlifting and Injury
00:22:40 - 00:24:27
This segment focuses on analyzing the individual's genetic predisposition towards powerlifting and the increased risk of injuries. The discussion begins with the importance of being in tune with one's pain levels during workouts, contrasting the common bodybuilding advice of "pushing through the pain" which is deemed detrimental in this case. The individual's genetic makeup is then examined, revealing an extreme fast-twitch muscle fiber type (ACTN3 gene), ideal for sprinting and powerlifting, but not endurance activities. The ACVR1B gene is also highlighted, indicating higher muscle strength per muscle volume. This combination suggests a phenomenal genetic predisposition for heavy weightlifting. However, the conversation shifts to the individual's past experience of injuries sustained from heavy weightlifting, leading to cessation of this activity six years prior. The potential difficulties of recovering from such injuries due to scar tissue are mentioned. Finally, the individual's adherence to a ketogenic diet is linked to their HLA DRB1 and DRB9 genes, suggesting a potential benefit in mitigating inflammation and injury risk.
Arthritis Risk and Insulin Resistance
00:24:27 - 00:26:06
The discussion centers on the link between specific genes (DRV9 and others), shoulder surgeries, and the increased risk of arthritis. A speaker notes a four-fold increased risk with the first two surgeries and a two-fold increase with the third. However, the key point is that these genes are triggered by high insulin levels. Maintaining low or optimized blood sugar and insulin levels protects the joints. The importance of this for listeners is emphasized, connecting high insulin to arthritis and AGEs (Advanced Glycation End Products). The speaker suggests that morning joint pain could be linked to this. Another speaker agrees and highlights the significance of AGEs as a neglected area of research, now linked to inflammation from high-carb diets. A study suggesting 80% of the world's population has some insulin resistance, leading to AGE buildup, is mentioned.
The Impact of Genetics and Age on Joint Pain
00:26:09 - 00:27:34
This segment discusses the connection between age, genetics, and joint pain. The speakers note that chronic, low-grade inflammation from conditions like leaky gut or anxiety, often linked to specific genes, can manifest as joint pain, especially as people age. Younger individuals may not notice these symptoms initially, but the speakers emphasize the predictive power of genetic testing in identifying potential future health issues. A speaker shares a personal anecdote about ignoring early symptoms due to a high pain tolerance, eventually leading to severe arthritis that significantly impacted their sleep. The conversation highlights the importance of proactive health management based on genetic predispositions to prevent or mitigate the severity of age-related joint problems.
Joint Pain and Treatment Options
00:27:34 - 00:29:24
This segment focuses on the speaker's joint pain issues, specifically mentioning shoulder surgeries due to a low pain tolerance and the importance of blood flow for joint health. The discussion highlights the role of synovial fluid and limited blood vessels in joints, emphasizing the need for movement to facilitate nutrient delivery and toxin removal. The speaker's genetic predisposition, including the ITGIV gene, is noted, suggesting a higher responsiveness to infrared light therapy as a potential treatment. The conversation also touches upon previous disc issues in the back, the limitations imposed on weightlifting due to these issues, and the delayed onset of pain as a consequence of heavy lifting. The speaker's CILP gene, related to collagen production, is mentioned, and the importance of maintaining collagen levels through diet (bone broth) and supplements (glycine) is discussed as a means to manage existing disc problems and support joint health.
Glycine and Magnesium for Sleep Improvement
00:29:26 - 00:31:08
The discussion centers on the use of glycine and magnesium to improve sleep. One speaker mentions research by Dr. James Donicolantonio suggesting that three grams of glycine before bed can improve sleep. Another speaker notes that while they don't possess certain genes where glycine is crucial for sleep improvement, they still find it beneficial. The conversation then shifts to magnesium, highlighting a common clock gene that indicates a higher responsiveness to magnesium. It's noted that magnesium is anti-inflammatory and that many people are deficient or suboptimal in magnesium, contributing to poor sleep. A statistic is cited indicating that 70% of Americans are suboptimal or deficient in magnesium.
Micronutrient Deficiencies and the Need for Supplementation
00:31:11 - 00:33:07
The discussion centers on magnesium deficiency and its widespread impact on health and energy levels. Speakers highlight magnesium's crucial role in various bodily functions, including ATP production and DNA repair. The significant percentage of the population (70%) deficient in magnesium is linked to energy issues. The depletion of micronutrients in modern soil due to over-reliance on phosphorus and nitrogen fertilizers is identified as a primary cause. This deficiency is argued to lead to long-term health problems often overlooked. The speakers express skepticism towards the notion that supplementation is unnecessary, contrasting the nutrient-rich soil of ancestral times with the depleted soil of today. The increasing global population and its food demands further exacerbate the problem, making supplementation, particularly for maintaining energy levels and productivity, a necessity. The financial benefits of increased energy and productivity resulting from supplementation are also emphasized, countering the idea that low energy levels are acceptable.
Supplementing for Genetic Predispositions
00:33:07 - 00:33:50
The discussion begins with exploring supplements to address genetic predispositions. Magnesium and lithium are mentioned as potentially beneficial supplements, with the speaker noting that lithium, in low doses, has shown improvements in clinical studies related to a specific clock gene. The ease and affordability of magnesium supplementation are highlighted. The conversation then shifts towards focusing on testosterone, acknowledging the breadth of topics and time constraints.
Prioritizing Testosterone, Vitamin D, and Histamines
00:33:50 - 00:34:45
The speakers decide to prioritize discussion on testosterone, vitamin D, and histamines. The importance of vitamin D is emphasized, particularly given the individual's genetic profile indicating a higher-than-normal requirement. The speaker notes the difference in blood test units between Australia and the US, recommending a minimum vitamin D level of 50 nanograms per milliliter (ng/mL) for Americans, contrasting this with the average American level of 30 ng/mL. The conversation ends mid-sentence, indicating further discussion on this topic.
Optimal Health and Performance Levels
00:34:45 - 00:35:39
The discussion centers on achieving optimal health levels beyond what doctors consider "average." The speaker emphasizes the importance of exceeding average energy and overall well-being to reach elite performance. They cite hunter-gatherer tribes as an example, noting their vitamin D levels consistently range between 70 and 100 (American units), contrasting sharply with the lower levels often seen in modern populations. The speaker stresses that vitamin D levels below 50 are associated with various health problems, urging individuals to maintain levels above 50 to avoid these issues, despite doctors sometimes dismissing these associations as merely correlational. The speaker highlights the need to address this as a crucial factor for optimal performance.
Addressing Low Testosterone and the FAM9B Gene
00:35:39 - 00:36:54
The conversation shifts to addressing low testosterone levels, specifically focusing on the FAM9B gene, whose function is poorly understood. The speaker explains that the gene's only known effect is causing lower testosterone, but the underlying mechanism remains unclear. Therefore, no specific solutions are offered for this gene. However, the speaker recommends focusing on fundamental strategies to improve testosterone levels, including zinc supplementation, regular exercise (especially weightlifting), sufficient sleep, magnesium intake, and boron supplementation. These basic approaches are presented as essential steps for overall health and performance enhancement.
Testosterone, Estrogen, and Genetic Factors
00:36:56 - 00:38:47
This segment discusses the interplay between testosterone, estrogen, and genetic factors in aging men. The speakers discuss the possibility of testosterone replacement therapy (TRT), noting that natural increases are possible with a healthy lifestyle and avoidance of artificial estrogens. One speaker shares their personal experience with TRT, having been on and off it for several years. The conversation then shifts to the impact of genetics, specifically mentioning the IRS 10 list and its potential influence on low testosterone. Higher SHBG levels and the ESR1 gene (estrogen receptor alpha) are highlighted as factors that can increase the sensitivity to estrogen, regardless of the actual estrogen levels. The discussion concludes with a question about the potential benefits of DIM supplementation, with a speaker expressing a preference to avoid it due to potential drawbacks.
Optimizing Testosterone Levels Naturally
00:38:47 - 00:40:44
This segment focuses on natural ways to increase testosterone levels. The discussion begins with a cautionary note about the potential negative effects of excessive dim supplementation, including increased estrogen and prostate cancer risk, emphasizing the importance of precise dosing and monitoring. The conversation then shifts to alternative methods, highlighting the benefits of consuming cruciferous vegetables like broccoli and Brussels sprouts due to their dindylmethane (DIM) content, which aids in estrogen clearance. Sweating, through exercise or sauna use, is presented as the most effective way to eliminate estrogen. The speakers also mention other factors contributing to higher testosterone, such as maintaining high thyroid function, DHA intake, and fasting to boost growth hormone. A sauna study is referenced, showing that sauna use significantly reduces the presence of artificial estrogens (BPA, phthalates) on the skin, suggesting that sweating effectively removes these toxins from the body. The study also indicated that neither sauna users nor the control group excreted significant amounts of estrogen in their urine.
Benefits of Sweating for Testosterone Levels
00:40:44 - 00:41:17
The discussion centers on the positive effects of daily sweating on testosterone levels. Sweating helps eliminate estrogens and lower sex hormone-binding globulin, contributing to higher testosterone. The process also clears heavy metals, further boosting testosterone. The speakers emphasize the importance of daily sweating as a key factor in achieving higher testosterone levels. A brief aside mentions someone's family having "a kind of crap genus" but good genetics regarding Alzheimer's.
Alzheimer's Disease and Medical Industry Practices
00:41:17 - 00:42:28
The conversation shifts to Alzheimer's disease and the medical industry's approach to it. One speaker expresses frustration with the industry's tendency to treat all forms of Alzheimer's as a single entity, similar to the past practice of broadly categorizing all cancers as "cancer" without specifying the type. The speaker advocates for a more precise approach, emphasizing the importance of considering genetic factors and the role of various elements like fats and glucose in the disease's development. The discussion highlights the need for a more nuanced understanding and treatment of Alzheimer's, mirroring the advancements made in cancer treatment through precise categorization.
The Heterogeneity of Diseases
00:42:29 - 00:44:19
The discussion centers on the diverse nature of diseases, highlighting the inability to group them together based on a single cause. The speaker uses the examples of B-cell lymphoma, liver cancer, and Alzheimer's disease to illustrate this point, emphasizing that the underlying causes can vary significantly. For instance, Alzheimer's can stem from issues with heavy metal clearance or carbohydrate metabolism, depending on individual genetic predispositions. The speaker intends to write a book detailing these diverse categories, anticipating it will challenge the current industry perspective.
Thyroid Issues and Genetic Predisposition
00:43:08 - 00:44:19
The conversation shifts to thyroid issues, noting the prevalence of problems and the role of artificial estrogens in exacerbating them. The speaker mentions having bad genes related to thyroid function. The importance of iodine intake is stressed, as iodine deficiency can lead to thyroid hormone deficiency, since iodine is a crucial building block for thyroid hormones. The speaker's genetic predisposition makes them more susceptible to this issue. The discussion touches upon the FOXE1 gene, discovered after the Chernobyl accident, where individuals with the "good" version of this gene showed no thyroid problems, unlike those with the "bad" version.
Thyroid Health and Autophagy
00:44:26 - 00:46:04
This segment discusses the connection between a specific gene, autophagy, and thyroid health. The speaker explains that a malfunction in this gene impairs the thyroid's ability to perform autophagy ("taking out the trash"). Intermittent fasting is identified as a method to increase autophagy. One speaker mentions their daily fasting routine (until 5:30 PM, consuming only black coffee and herbal teas), highlighting the importance of avoiding black and green teas due to their fluoride content, which interferes with iodine transport and negatively impacts thyroid function. The potential negative health consequences of excessive green tea consumption are also noted, emphasizing the critical role of iodine intake and the benefits of intermittent fasting for individuals with similar genetic predispositions.
Extended Fasting and Autophagy
00:46:06 - 00:47:05
This segment discusses the speakers' experiences with extended fasting, with one speaker detailing their eating schedule (5:30 PM on weekdays, 1:00 PM on weekends). The speaker emphasizes the benefits of not having to think about food and the process of autophagy, describing it as a cellular process that scans for and metabolizes damaged cells, providing energy and building materials. The speaker shares their personal experience of fasting until noon and then again until 6 PM, and another speaker mentions a similar schedule, noting that some individuals may have better autophagy genes.
Age, Thyroid Hormones, and Health
00:47:05 - 00:47:51
The conversation shifts to the impact of age on thyroid hormones, with a speaker suggesting that 80-year-olds should consider thyroid replacement therapy to maintain energy levels. The importance of working with a doctor to determine appropriate dosage is highlighted to avoid potential side effects like heart palpitations. The discussion concludes with a brief acknowledgment of the variability in medical professionals' approaches to thyroid replacement.
Thyroid Function and Low Testosterone
00:47:51 - 00:49:58
This segment discusses the importance of optimal thyroid function and its connection to low testosterone levels in men. The speakers highlight how standard thyroid tests might not reveal underlying issues, emphasizing the need for more comprehensive assessment. They relate low testosterone to poor lifestyle choices, including diet and lack of exercise. The consumption of grocery store milk is cited as a potential contributor to low testosterone due to natural and artificial estrogens. Low testosterone is linked to feelings of apathy, lack of confidence, and reduced motivation, potentially impacting engagement in societal issues. The speakers connect low testosterone to a decreased sense of agency and increased receptivity, suggesting a potential link to societal apathy and the acceptance of restrictions on freedoms. The conversation concludes with a reflection on personal experiences with low testosterone and its impact.
Personal Experiences and Lab Testing Discrepancies
00:49:59 - 00:51:06
A discussion unfolds regarding personal experiences with testosterone levels and the discrepancies found in lab testing results. One speaker expresses frustration with a classically trained doctor who dismissed their concerns despite feeling unwell, even though their levels were within the "normal" range. The speaker emphasizes the significant difference in feeling and functioning at higher testosterone levels. Another speaker points out the inconsistencies between different lab testing companies, with some considering zero testosterone as normal, while others have different ranges. The speakers agree that this highlights the need to be critical of lab results and potentially switch testing companies or self-educate.
Benefits of Optimal Testosterone Levels
00:51:06 - 00:51:37
The conversation shifts to the numerous benefits of maintaining optimal testosterone levels. These benefits include improved physical health, such as stronger bones and muscles, a leaner physique, and enhanced glucose transport to muscles. Beyond the physical, the speakers highlight the positive impact on mental well-being, including increased confidence, optimism, and reduced anxiety and fear. The speakers conclude that high testosterone levels are crucial for peak performance, using the example of an elite soldier.
Proactive Healthcare and Optimization
00:51:40 - 00:53:14
The discussion centers on the importance of proactive healthcare and optimizing one's health before issues arise. Speakers express frustration with the healthcare system's tendency to only address problems after they become serious. They emphasize the benefits of personalized approaches, such as DNA analysis, to identify and address potential health problems early. The speakers highlight the impact of factors like inflammation and low testosterone on energy levels, and suggest that addressing these issues through lifestyle changes and targeted interventions can significantly improve overall health and well-being. One speaker shares a personal anecdote about experiencing a significant improvement in energy levels and overall health after making lifestyle changes, emphasizing the transformative potential of proactive health management.
Personal Anecdotes and Transformations
00:53:14 - 00:53:31
This section features a personal anecdote from one speaker about their experience during their PhD studies. They describe a period of stress, unhealthy eating habits, and a resulting decline in energy levels and overall well-being. This anecdote serves to illustrate the negative consequences of neglecting one's health and the potential for significant improvement through proactive measures. The speaker's experience contrasts with the previous discussion of proactive health optimization, highlighting the importance of prioritizing health and well-being.
Personal Health Journey and Genetic Testing
00:53:31 - 00:55:16
The speaker discusses their personal experience with developing acid reflux and other health issues after years of neglecting their health. They describe how adopting a healthier lifestyle, including exercise and diet changes (specifically addressing gluten sensitivity), significantly improved their well-being. This experience led them to question the scientific consensus on certain health issues, particularly gluten sensitivity, and to consider the possibility of inaccuracies or biases in scientific claims. The speaker emphasizes the importance of personalized health approaches, advocating for genetic testing to identify individual needs and optimize health outcomes through targeted interventions like vitamin supplementation. They highlight the benefits of such testing in achieving optimal energy levels, testosterone levels, thyroid function, and growth hormone production, concluding that this personalized approach is crucial for achieving peak health.
Personal Empowerment and DNA Analysis
00:55:16 - 00:57:12
This segment begins with a discussion about personal empowerment, emphasizing the potential power individuals possess and the importance of self-investment. The conversation then shifts to the use of DNA analysis for personalized health insights, specifically mentioning the speaker's experience using 23andMe kits for their children. The speaker details using the results to address retinol deficiencies in their children's diets, leading them to incorporate liver into their meals. The discussion connects this modern approach to ancestral diets, highlighting the nutritional benefits of consuming whole animals and the higher nutrient content of soil in the past. The importance of retinol conversion to vitamin A for children's health and overall well-being is also stressed, concluding with the speaker's positive experience and the assertion that it's never too early to utilize such analysis for children.
Homeschooling and its Advantages
00:57:12 - 00:59:23
The discussion begins with a consideration of the advantages of preparing children for school, focusing on managing dopamine levels for improved focus and faster learning. The conversation then shifts to the topic of homeschooling, specifically its legality and prevalence in Australia. One participant shares their experience homeschooling their 17-year-old child, utilizing Zoom for online learning. Another participant recounts their own experience of being homeschooled from seventh grade, highlighting the benefits of flexible scheduling and the ability to prioritize exercise and physical activity. The importance of physical activity for brain development is emphasized, advocating for incorporating activities like deadlifts and squats into a child's routine. The discussion concludes with a personal anecdote about golfing as a positive physical activity during homeschooling years.
Genetic Predisposition to Obesity and Fat Storage
00:59:23 - 01:00:29
The discussion centers on the impact of genetics, specifically the FTO gene, on obesity. One participant shares their experience of having "the worst obesity genes," including three pluses on the FTO gene, which predisposes individuals to store fat more readily than others and makes burning fat as energy difficult. The conversation touches upon the influence of "fake oestrogens" stored in fat cells, further exacerbating fat growth. The overall sentiment is that several factors, including genetics, contributed to the individual's weight challenges.
Strategies for Fat Conversion and Cold Exposure
01:00:31 - 01:01:02
The conversation shifts to practical strategies for addressing fat conversion issues. The difficulty of consistent cold shower practices is acknowledged, but the combination of sauna use followed immediately by a cold shower is presented as a more manageable and effective alternative for improving fat metabolism. The speaker highlights that this approach is often more achievable for individuals struggling with fat conversion.
Personal Experience with Genetics and Weight Management
01:01:02 - 01:03:11
The speaker, who is nearing 49 years old and currently maintains 10% body fat, discusses their personal experience with genetics and weight management. They emphasize that their low body fat percentage is achievable for others, highlighting the effectiveness of intermittent fasting and autophagy. The speaker criticizes a BBC documentary, "Why Are We Getting So Fat," for identifying a problematic gene without offering practical solutions beyond portion control, which they deem ineffective. Instead, they advocate for selecting a dietary approach (keto, carnivore, or paleo) and combining it with genetic testing, autophagy, and fasting. The speaker stresses the simplicity of this approach, emphasizing the importance of consistency over time. They acknowledge the desire for quick fixes like fat loss pills but mention a peptide, MOTS-C, specifically targeting the FTO gene, while noting their personal negative experience with it.
Peptide Side Effects and Lifestyle Choices
01:03:11 - 01:04:09
The conversation begins with a discussion of peptide side effects, specifically lightheadedness. The speakers note that this side effect is being investigated. The discussion then shifts to the speaker's continued practice of intermittent fasting, emphasizing that it's not a quick fix for unhealthy eating habits. The detrimental effects of fast food are highlighted, including its high levels of artificial estrogens, which negatively impact testosterone, DHEA, thyroid function, and energy levels, while increasing inflammation and stress hormones. The speakers agree that consuming such foods leads to weight gain, decreased motivation, reduced energy, and a cessation of exercise, creating a negative feedback loop.
The Addictive Nature of Processed Foods
01:04:10 - 01:04:38
The conversation continues by discussing the addictive nature of gluten, which affects the opioid receptor, and the presence of soy in processed foods, further contributing to this addictive cycle. The speakers also mention the addictive properties of cappuccinos, highlighting how many commercially available products are designed to be addictive. This reinforces the vicious cycle of unhealthy eating habits, lack of motivation, and decreased energy levels.
Conclusion and Next Appointment
01:04:40 - 01:04:50
The conversation concludes with a reminder of an upcoming client appointment.
Podcast Wrap-up and Contact Information
01:04:50 - 01:05:59
The podcast concludes with a discussion on how listeners can contact Dr. Anthony. Dr. Anthony mentions his website, ajconsultingcompany.com, noting that the name is not ideal but is unable to change it. He also mentions a discount offered to listeners who contact him through a specific intermediary (Mark). The hosts express their gratitude for Dr. Anthony's time and insights, highlighting the value provided to listeners. The conversation ends with pleasantries and closing remarks.
00:00:00 - 00:01:02
The podcast episode begins with an introduction by the host, who mentions a collaboration with Mark Iron, an Australian Instagram influencer (@School for Success) with around half a million followers. The host explains that Mark shared a podcast episode he recorded, focusing on a discussion about his DNA analysis. The host briefly mentions the episode's slightly less structured format than usual but highlights interesting points and perspectives. He promotes his own services (ajconsultingcompany.com for DNA analysis) and Patreon page (patreon.com/anthonygjay), showcasing a recent video about shooting fish.
Discussion of Mark Iron's DNA Analysis: Vitamin E and Inflammation
00:01:02 - 00:01:52
The conversation shifts to a discussion of Mark Iron's DNA analysis report. The host and Mark discuss a surprising finding: Mark's genes indicate that synthetic vitamin E (tocopherol), commonly found in multivitamins, causes inflammation in his body. They contrast this with the natural form of vitamin E, tocotrienols, which is beneficial. The difficulty in readily accessing tocotrienols is also noted.
Multivitamin Concerns and Inflammation Markers
00:01:52 - 00:03:54
The discussion begins with a question about tocopherols in multivitamins and their potential effects on the body, specifically whether they cause gut or systemic inflammation. The conversation then shifts to a DNA report, specifically page five focusing on heart disease. The report highlights elevated CRP blood levels and an IL-6 receptor gene, indicating higher-than-average interleukin-6 levels. Interleukin-6 is explained as a type of inflammation, similar to CRP and TNF-alpha, which activates immune cells. The individual's history of five shoulder surgeries due to severe arthritis is mentioned as a relevant factor. The high IL-6 level is identified as a genetic predisposition, which also triggers higher CRP levels, although CRP is more commonly measured clinically than IL-6.
Inflammatory Markers and Vitamin E
00:03:58 - 00:05:46
This segment discusses the relationship between CRP levels, IL-6, and dietary factors, particularly focusing on the impact of different forms of Vitamin E. The conversation begins by establishing CRP as a proxy for IL-6, noting that lifestyle choices like healthy eating and exercise can lower CRP. The role of omega-3 fatty acids, including EPA and DHA, in lowering CRP is also mentioned. The discussion then shifts to the gene GSTP1 and its interaction with tocopherols (a form of Vitamin E). It's explained that supplementing with tocopherols can trigger the release of IL-6, which is problematic for individuals with a genetic predisposition to higher IL-6 levels, as it exacerbates inflammation. The speaker highlights that avoiding tocopherols is crucial, especially for those with the mentioned genetic predisposition, and points out that tocopherols are often found in common supplements like fish oil.
High-Dose Vitamin E and Cancer Risk
00:05:46 - 00:07:37
The discussion begins with the speaker explaining that high doses of vitamin E, found in multivitamins and supplements, can increase cancer risk, particularly for smokers. This finding, published in the New England Journal of Medicine, was initially surprising. The speaker explains that chronic antioxidant intake, unlike vitamin C which is an exception due to its conversion to hydrogen peroxide, can help cancer cells survive. The conversation then shifts to the use of spices, which are high in antioxidants. While spices could potentially contribute to this problem, the speaker notes that they also contain other anti-cancer properties, unlike isolated antioxidant supplements. Therefore, the risk associated with spice consumption is likely mitigated by these additional beneficial components.
The Importance of Personalized Nutrition Based on Genetics
00:07:38 - 00:09:29
This segment discusses the limitations of generic vitamin and supplement recommendations and emphasizes the crucial role of personalized nutrition based on individual genetics. Speakers highlight that studies showing no benefit from multivitamins often fail to account for genetic variations. They explain that certain vitamins, beneficial for some individuals, can cause inflammation and negative effects in others due to genetic differences. The speakers warn against the "one-size-fits-all" approach to diet and supplementation, emphasizing that a diet or supplement regimen that works for one person may be detrimental to another. They conclude that research on vitamins and supplements is often rendered useless without considering individual genetic factors (SNPs). The speakers agree that claims of perfect diets for everyone should be viewed with skepticism.
The Importance of Personalized Medicine Based on Genetics
00:09:30 - 00:10:31
The discussion highlights the limitations of generalized research studies that don't account for individual genetic variations when studying the effects of drugs or treatments. It's emphasized that personalized medicine, considering individual genetic variants, is crucial for effective treatment, particularly in cases like cancer. The speakers discuss how most doctors are behind the curve in utilizing this technology and the importance of patients seeking out doctors who can analyze their genes to make informed decisions about their health and performance. The need for patients to understand and absorb this information to make educated choices about their health is stressed.
Specific Nutritional Considerations Based on Genetics
00:10:31 - 00:11:29
The conversation shifts to specific nutritional advice based on genetic predispositions. A discount link for genetic testing is offered to be shared later. The example of vitamin B12 is discussed, highlighting the difficulty of absorption through the gut and the importance of supplementation or a diet rich in meat to ensure sufficient intake. One speaker mentions their dietary habits, incorporating a mix of meat-heavy days and other days, suggesting a balanced approach to meet nutritional needs.
Dietary Approaches and Genetic Predisposition
00:11:29 - 00:12:36
The discussion centers on the speaker's current diet, incorporating elements of keto and paleo. The importance of B12 supplementation for non-meat eaters is highlighted, emphasizing the potential long-term consequences of dietary choices on gene expression. The speaker stresses the significance of genetic testing in optimizing diet, citing fibromyalgia as an example where understanding genetic predispositions to inflammation can inform dietary and lifestyle choices to mitigate symptoms like fatigue, mood swings, and anxiety. The conversation concludes this section by noting the speaker's favorable genetic profile regarding heavy metals and transitioning to a discussion of brain health.
Brain Optimization Genes and Anxiety
00:12:36 - 00:13:21
The conversation shifts to analyzing brain optimization genes, specifically focusing on anxiety and its potential link to inflammation. The speaker's genetic report reveals a positive outlook regarding Alzheimer's risk and overall brain performance. The absence of entries in certain categories is explained as indicating no identified gene-related issues in those areas. The speaker contrasts their approach of focusing on key findings with the more extensive reports some providers offer, preferring a concise summary of significant genetic insights.
Focusing on Problematic Genes
00:13:21 - 00:15:18
This segment focuses on identifying and addressing problematic genes, specifically those linked to mental health issues like anxiety and depression. The speakers express a desire to focus on "bad genes" rather than the numerous "good genes," arguing that this approach is more efficient. The discussion centers on the HTR2A gene, which affects serotonin receptor function and can contribute to depression and anxiety. The speakers highlight the importance of gut health in serotonin production, emphasizing that a healthy gut is crucial for mental well-being. They criticize the widespread use of SSRIs like Zoloft, Prozac, Paxil, Lexapro, and Selexa, suggesting that these drugs often mask underlying issues like inflammation rather than addressing the root cause. One speaker shares a personal experience with anxiety and panic attacks, noting that medication altered their brain chemistry and that inflammation was the primary underlying issue.
Serotonin, Sleep, and Supplements
00:15:18 - 00:17:18
This segment discusses the relationship between serotonin, sleep, and various supplements. The speakers mention that a healthy gut contributes to serotonin production, alongside factors like sunshine. They explore supplements like 5-HTP and tryptophan, noting tryptophan's role as a serotonin building block found in protein-rich foods. The discussion touches upon the debated link between tryptophan in turkey and sleepiness, suggesting carbohydrate consumption might be a more significant factor. Genetic issues impacting sleep are linked to serotonin levels. Two studies are referenced: one highlighting the inverse relationship between serotonin, sulfur amino acids, and dopamine (excess of one depletes the other), leading one speaker to stop supplementing tyrosine and L-tryptophan; and another showing that light therapy (30 minutes) counteracts acute tryptophan depletion, preventing it from crossing the blood-brain barrier. The speaker personally uses light therapy in the mornings.
Dopamine Levels and Motivation
00:17:21 - 00:18:02
The discussion begins with a comment on the interesting interplay between genetics and dopamine levels, specifically noting lower dopamine levels in the context of the speaker's genetics. The conversation then shifts to the COMT gene and its influence on dopamine, acknowledging a jump in topics due to the podcast format. The importance of optimal dopamine levels for motivation is highlighted, contrasting it with fluctuating levels that lead to distraction and inconsistency. The speakers then transition to a section on Cannabis in a document (page nine), relating it to the ongoing discussion of motivation.
Locating the Cannabis Section
00:18:03 - 00:18:41
The speakers attempt to locate the "Cannabis" section on page nine of a document. One speaker guides the other through the document, providing directions to navigate to the correct section. There is a brief exchange of confirmations and directions to find the section, which is located near the B9 and vitamin E section.
Cannabis and Catecholomethyl Transferase
00:18:41 - 00:18:58
Once the "Cannabis" section is located, the discussion focuses on Catecholomethyl transferase (COMT) and its relevance to cannabis use. The speaker mentions the specific version of COMT the individual possesses and explains the connection between cannabis use and the potential impact on the intestines.
Cannabis Use and Genetic Predisposition
00:18:58 - 00:20:54
The discussion centers on the potential negative impact of cannabis use, particularly concerning a specific gene variant. The speaker explains that this gene variant can lead to lower dopamine levels, further decreasing motivation, especially in individuals already predisposed to lower levels. While lifestyle adjustments like sunshine, high-protein diets, caffeine, and music can help boost dopamine, cannabis use is highlighted as particularly detrimental, potentially hindering recovery and even triggering schizophrenia in susceptible individuals. The speaker emphasizes the risks associated with cannabis use for those with this gene variant, advising against it. The conversation then shifts to the individual's lower serotonin levels, not due to low amounts but rather due to the serotonin not binding to receptors as effectively. This further emphasizes the importance of addressing both dopamine and serotonin levels.
Receptor Binding and Pain Sensitivity
00:20:54 - 00:22:40
This segment discusses the impact of receptor binding on medication effectiveness and its correlation with pain sensitivity. The speakers note that when a medication binds to a receptor less effectively, a higher dose is needed to achieve the same result. The conversation then shifts to the relationship between the COMT gene and pain sensitivity, referencing a section on page 13 of a document detailing genetic influences on pain perception. A specific gene, SCN9A, is highlighted as a rare gene variant associated with extremely low pain sensitivity, potentially leading to injuries due to delayed pain recognition. Conversely, individuals with high pain sensitivity are discussed, emphasizing the challenges they face in managing pain and the need to push through discomfort. The speakers share personal anecdotes, illustrating the consequences of ignoring pain signals, particularly in the context of weightlifting and potential injuries.
Analyzing Genetic Predisposition to Powerlifting and Injury
00:22:40 - 00:24:27
This segment focuses on analyzing the individual's genetic predisposition towards powerlifting and the increased risk of injuries. The discussion begins with the importance of being in tune with one's pain levels during workouts, contrasting the common bodybuilding advice of "pushing through the pain" which is deemed detrimental in this case. The individual's genetic makeup is then examined, revealing an extreme fast-twitch muscle fiber type (ACTN3 gene), ideal for sprinting and powerlifting, but not endurance activities. The ACVR1B gene is also highlighted, indicating higher muscle strength per muscle volume. This combination suggests a phenomenal genetic predisposition for heavy weightlifting. However, the conversation shifts to the individual's past experience of injuries sustained from heavy weightlifting, leading to cessation of this activity six years prior. The potential difficulties of recovering from such injuries due to scar tissue are mentioned. Finally, the individual's adherence to a ketogenic diet is linked to their HLA DRB1 and DRB9 genes, suggesting a potential benefit in mitigating inflammation and injury risk.
Arthritis Risk and Insulin Resistance
00:24:27 - 00:26:06
The discussion centers on the link between specific genes (DRV9 and others), shoulder surgeries, and the increased risk of arthritis. A speaker notes a four-fold increased risk with the first two surgeries and a two-fold increase with the third. However, the key point is that these genes are triggered by high insulin levels. Maintaining low or optimized blood sugar and insulin levels protects the joints. The importance of this for listeners is emphasized, connecting high insulin to arthritis and AGEs (Advanced Glycation End Products). The speaker suggests that morning joint pain could be linked to this. Another speaker agrees and highlights the significance of AGEs as a neglected area of research, now linked to inflammation from high-carb diets. A study suggesting 80% of the world's population has some insulin resistance, leading to AGE buildup, is mentioned.
The Impact of Genetics and Age on Joint Pain
00:26:09 - 00:27:34
This segment discusses the connection between age, genetics, and joint pain. The speakers note that chronic, low-grade inflammation from conditions like leaky gut or anxiety, often linked to specific genes, can manifest as joint pain, especially as people age. Younger individuals may not notice these symptoms initially, but the speakers emphasize the predictive power of genetic testing in identifying potential future health issues. A speaker shares a personal anecdote about ignoring early symptoms due to a high pain tolerance, eventually leading to severe arthritis that significantly impacted their sleep. The conversation highlights the importance of proactive health management based on genetic predispositions to prevent or mitigate the severity of age-related joint problems.
Joint Pain and Treatment Options
00:27:34 - 00:29:24
This segment focuses on the speaker's joint pain issues, specifically mentioning shoulder surgeries due to a low pain tolerance and the importance of blood flow for joint health. The discussion highlights the role of synovial fluid and limited blood vessels in joints, emphasizing the need for movement to facilitate nutrient delivery and toxin removal. The speaker's genetic predisposition, including the ITGIV gene, is noted, suggesting a higher responsiveness to infrared light therapy as a potential treatment. The conversation also touches upon previous disc issues in the back, the limitations imposed on weightlifting due to these issues, and the delayed onset of pain as a consequence of heavy lifting. The speaker's CILP gene, related to collagen production, is mentioned, and the importance of maintaining collagen levels through diet (bone broth) and supplements (glycine) is discussed as a means to manage existing disc problems and support joint health.
Glycine and Magnesium for Sleep Improvement
00:29:26 - 00:31:08
The discussion centers on the use of glycine and magnesium to improve sleep. One speaker mentions research by Dr. James Donicolantonio suggesting that three grams of glycine before bed can improve sleep. Another speaker notes that while they don't possess certain genes where glycine is crucial for sleep improvement, they still find it beneficial. The conversation then shifts to magnesium, highlighting a common clock gene that indicates a higher responsiveness to magnesium. It's noted that magnesium is anti-inflammatory and that many people are deficient or suboptimal in magnesium, contributing to poor sleep. A statistic is cited indicating that 70% of Americans are suboptimal or deficient in magnesium.
Micronutrient Deficiencies and the Need for Supplementation
00:31:11 - 00:33:07
The discussion centers on magnesium deficiency and its widespread impact on health and energy levels. Speakers highlight magnesium's crucial role in various bodily functions, including ATP production and DNA repair. The significant percentage of the population (70%) deficient in magnesium is linked to energy issues. The depletion of micronutrients in modern soil due to over-reliance on phosphorus and nitrogen fertilizers is identified as a primary cause. This deficiency is argued to lead to long-term health problems often overlooked. The speakers express skepticism towards the notion that supplementation is unnecessary, contrasting the nutrient-rich soil of ancestral times with the depleted soil of today. The increasing global population and its food demands further exacerbate the problem, making supplementation, particularly for maintaining energy levels and productivity, a necessity. The financial benefits of increased energy and productivity resulting from supplementation are also emphasized, countering the idea that low energy levels are acceptable.
Supplementing for Genetic Predispositions
00:33:07 - 00:33:50
The discussion begins with exploring supplements to address genetic predispositions. Magnesium and lithium are mentioned as potentially beneficial supplements, with the speaker noting that lithium, in low doses, has shown improvements in clinical studies related to a specific clock gene. The ease and affordability of magnesium supplementation are highlighted. The conversation then shifts towards focusing on testosterone, acknowledging the breadth of topics and time constraints.
Prioritizing Testosterone, Vitamin D, and Histamines
00:33:50 - 00:34:45
The speakers decide to prioritize discussion on testosterone, vitamin D, and histamines. The importance of vitamin D is emphasized, particularly given the individual's genetic profile indicating a higher-than-normal requirement. The speaker notes the difference in blood test units between Australia and the US, recommending a minimum vitamin D level of 50 nanograms per milliliter (ng/mL) for Americans, contrasting this with the average American level of 30 ng/mL. The conversation ends mid-sentence, indicating further discussion on this topic.
Optimal Health and Performance Levels
00:34:45 - 00:35:39
The discussion centers on achieving optimal health levels beyond what doctors consider "average." The speaker emphasizes the importance of exceeding average energy and overall well-being to reach elite performance. They cite hunter-gatherer tribes as an example, noting their vitamin D levels consistently range between 70 and 100 (American units), contrasting sharply with the lower levels often seen in modern populations. The speaker stresses that vitamin D levels below 50 are associated with various health problems, urging individuals to maintain levels above 50 to avoid these issues, despite doctors sometimes dismissing these associations as merely correlational. The speaker highlights the need to address this as a crucial factor for optimal performance.
Addressing Low Testosterone and the FAM9B Gene
00:35:39 - 00:36:54
The conversation shifts to addressing low testosterone levels, specifically focusing on the FAM9B gene, whose function is poorly understood. The speaker explains that the gene's only known effect is causing lower testosterone, but the underlying mechanism remains unclear. Therefore, no specific solutions are offered for this gene. However, the speaker recommends focusing on fundamental strategies to improve testosterone levels, including zinc supplementation, regular exercise (especially weightlifting), sufficient sleep, magnesium intake, and boron supplementation. These basic approaches are presented as essential steps for overall health and performance enhancement.
Testosterone, Estrogen, and Genetic Factors
00:36:56 - 00:38:47
This segment discusses the interplay between testosterone, estrogen, and genetic factors in aging men. The speakers discuss the possibility of testosterone replacement therapy (TRT), noting that natural increases are possible with a healthy lifestyle and avoidance of artificial estrogens. One speaker shares their personal experience with TRT, having been on and off it for several years. The conversation then shifts to the impact of genetics, specifically mentioning the IRS 10 list and its potential influence on low testosterone. Higher SHBG levels and the ESR1 gene (estrogen receptor alpha) are highlighted as factors that can increase the sensitivity to estrogen, regardless of the actual estrogen levels. The discussion concludes with a question about the potential benefits of DIM supplementation, with a speaker expressing a preference to avoid it due to potential drawbacks.
Optimizing Testosterone Levels Naturally
00:38:47 - 00:40:44
This segment focuses on natural ways to increase testosterone levels. The discussion begins with a cautionary note about the potential negative effects of excessive dim supplementation, including increased estrogen and prostate cancer risk, emphasizing the importance of precise dosing and monitoring. The conversation then shifts to alternative methods, highlighting the benefits of consuming cruciferous vegetables like broccoli and Brussels sprouts due to their dindylmethane (DIM) content, which aids in estrogen clearance. Sweating, through exercise or sauna use, is presented as the most effective way to eliminate estrogen. The speakers also mention other factors contributing to higher testosterone, such as maintaining high thyroid function, DHA intake, and fasting to boost growth hormone. A sauna study is referenced, showing that sauna use significantly reduces the presence of artificial estrogens (BPA, phthalates) on the skin, suggesting that sweating effectively removes these toxins from the body. The study also indicated that neither sauna users nor the control group excreted significant amounts of estrogen in their urine.
Benefits of Sweating for Testosterone Levels
00:40:44 - 00:41:17
The discussion centers on the positive effects of daily sweating on testosterone levels. Sweating helps eliminate estrogens and lower sex hormone-binding globulin, contributing to higher testosterone. The process also clears heavy metals, further boosting testosterone. The speakers emphasize the importance of daily sweating as a key factor in achieving higher testosterone levels. A brief aside mentions someone's family having "a kind of crap genus" but good genetics regarding Alzheimer's.
Alzheimer's Disease and Medical Industry Practices
00:41:17 - 00:42:28
The conversation shifts to Alzheimer's disease and the medical industry's approach to it. One speaker expresses frustration with the industry's tendency to treat all forms of Alzheimer's as a single entity, similar to the past practice of broadly categorizing all cancers as "cancer" without specifying the type. The speaker advocates for a more precise approach, emphasizing the importance of considering genetic factors and the role of various elements like fats and glucose in the disease's development. The discussion highlights the need for a more nuanced understanding and treatment of Alzheimer's, mirroring the advancements made in cancer treatment through precise categorization.
The Heterogeneity of Diseases
00:42:29 - 00:44:19
The discussion centers on the diverse nature of diseases, highlighting the inability to group them together based on a single cause. The speaker uses the examples of B-cell lymphoma, liver cancer, and Alzheimer's disease to illustrate this point, emphasizing that the underlying causes can vary significantly. For instance, Alzheimer's can stem from issues with heavy metal clearance or carbohydrate metabolism, depending on individual genetic predispositions. The speaker intends to write a book detailing these diverse categories, anticipating it will challenge the current industry perspective.
Thyroid Issues and Genetic Predisposition
00:43:08 - 00:44:19
The conversation shifts to thyroid issues, noting the prevalence of problems and the role of artificial estrogens in exacerbating them. The speaker mentions having bad genes related to thyroid function. The importance of iodine intake is stressed, as iodine deficiency can lead to thyroid hormone deficiency, since iodine is a crucial building block for thyroid hormones. The speaker's genetic predisposition makes them more susceptible to this issue. The discussion touches upon the FOXE1 gene, discovered after the Chernobyl accident, where individuals with the "good" version of this gene showed no thyroid problems, unlike those with the "bad" version.
Thyroid Health and Autophagy
00:44:26 - 00:46:04
This segment discusses the connection between a specific gene, autophagy, and thyroid health. The speaker explains that a malfunction in this gene impairs the thyroid's ability to perform autophagy ("taking out the trash"). Intermittent fasting is identified as a method to increase autophagy. One speaker mentions their daily fasting routine (until 5:30 PM, consuming only black coffee and herbal teas), highlighting the importance of avoiding black and green teas due to their fluoride content, which interferes with iodine transport and negatively impacts thyroid function. The potential negative health consequences of excessive green tea consumption are also noted, emphasizing the critical role of iodine intake and the benefits of intermittent fasting for individuals with similar genetic predispositions.
Extended Fasting and Autophagy
00:46:06 - 00:47:05
This segment discusses the speakers' experiences with extended fasting, with one speaker detailing their eating schedule (5:30 PM on weekdays, 1:00 PM on weekends). The speaker emphasizes the benefits of not having to think about food and the process of autophagy, describing it as a cellular process that scans for and metabolizes damaged cells, providing energy and building materials. The speaker shares their personal experience of fasting until noon and then again until 6 PM, and another speaker mentions a similar schedule, noting that some individuals may have better autophagy genes.
Age, Thyroid Hormones, and Health
00:47:05 - 00:47:51
The conversation shifts to the impact of age on thyroid hormones, with a speaker suggesting that 80-year-olds should consider thyroid replacement therapy to maintain energy levels. The importance of working with a doctor to determine appropriate dosage is highlighted to avoid potential side effects like heart palpitations. The discussion concludes with a brief acknowledgment of the variability in medical professionals' approaches to thyroid replacement.
Thyroid Function and Low Testosterone
00:47:51 - 00:49:58
This segment discusses the importance of optimal thyroid function and its connection to low testosterone levels in men. The speakers highlight how standard thyroid tests might not reveal underlying issues, emphasizing the need for more comprehensive assessment. They relate low testosterone to poor lifestyle choices, including diet and lack of exercise. The consumption of grocery store milk is cited as a potential contributor to low testosterone due to natural and artificial estrogens. Low testosterone is linked to feelings of apathy, lack of confidence, and reduced motivation, potentially impacting engagement in societal issues. The speakers connect low testosterone to a decreased sense of agency and increased receptivity, suggesting a potential link to societal apathy and the acceptance of restrictions on freedoms. The conversation concludes with a reflection on personal experiences with low testosterone and its impact.
Personal Experiences and Lab Testing Discrepancies
00:49:59 - 00:51:06
A discussion unfolds regarding personal experiences with testosterone levels and the discrepancies found in lab testing results. One speaker expresses frustration with a classically trained doctor who dismissed their concerns despite feeling unwell, even though their levels were within the "normal" range. The speaker emphasizes the significant difference in feeling and functioning at higher testosterone levels. Another speaker points out the inconsistencies between different lab testing companies, with some considering zero testosterone as normal, while others have different ranges. The speakers agree that this highlights the need to be critical of lab results and potentially switch testing companies or self-educate.
Benefits of Optimal Testosterone Levels
00:51:06 - 00:51:37
The conversation shifts to the numerous benefits of maintaining optimal testosterone levels. These benefits include improved physical health, such as stronger bones and muscles, a leaner physique, and enhanced glucose transport to muscles. Beyond the physical, the speakers highlight the positive impact on mental well-being, including increased confidence, optimism, and reduced anxiety and fear. The speakers conclude that high testosterone levels are crucial for peak performance, using the example of an elite soldier.
Proactive Healthcare and Optimization
00:51:40 - 00:53:14
The discussion centers on the importance of proactive healthcare and optimizing one's health before issues arise. Speakers express frustration with the healthcare system's tendency to only address problems after they become serious. They emphasize the benefits of personalized approaches, such as DNA analysis, to identify and address potential health problems early. The speakers highlight the impact of factors like inflammation and low testosterone on energy levels, and suggest that addressing these issues through lifestyle changes and targeted interventions can significantly improve overall health and well-being. One speaker shares a personal anecdote about experiencing a significant improvement in energy levels and overall health after making lifestyle changes, emphasizing the transformative potential of proactive health management.
Personal Anecdotes and Transformations
00:53:14 - 00:53:31
This section features a personal anecdote from one speaker about their experience during their PhD studies. They describe a period of stress, unhealthy eating habits, and a resulting decline in energy levels and overall well-being. This anecdote serves to illustrate the negative consequences of neglecting one's health and the potential for significant improvement through proactive measures. The speaker's experience contrasts with the previous discussion of proactive health optimization, highlighting the importance of prioritizing health and well-being.
Personal Health Journey and Genetic Testing
00:53:31 - 00:55:16
The speaker discusses their personal experience with developing acid reflux and other health issues after years of neglecting their health. They describe how adopting a healthier lifestyle, including exercise and diet changes (specifically addressing gluten sensitivity), significantly improved their well-being. This experience led them to question the scientific consensus on certain health issues, particularly gluten sensitivity, and to consider the possibility of inaccuracies or biases in scientific claims. The speaker emphasizes the importance of personalized health approaches, advocating for genetic testing to identify individual needs and optimize health outcomes through targeted interventions like vitamin supplementation. They highlight the benefits of such testing in achieving optimal energy levels, testosterone levels, thyroid function, and growth hormone production, concluding that this personalized approach is crucial for achieving peak health.
Personal Empowerment and DNA Analysis
00:55:16 - 00:57:12
This segment begins with a discussion about personal empowerment, emphasizing the potential power individuals possess and the importance of self-investment. The conversation then shifts to the use of DNA analysis for personalized health insights, specifically mentioning the speaker's experience using 23andMe kits for their children. The speaker details using the results to address retinol deficiencies in their children's diets, leading them to incorporate liver into their meals. The discussion connects this modern approach to ancestral diets, highlighting the nutritional benefits of consuming whole animals and the higher nutrient content of soil in the past. The importance of retinol conversion to vitamin A for children's health and overall well-being is also stressed, concluding with the speaker's positive experience and the assertion that it's never too early to utilize such analysis for children.
Homeschooling and its Advantages
00:57:12 - 00:59:23
The discussion begins with a consideration of the advantages of preparing children for school, focusing on managing dopamine levels for improved focus and faster learning. The conversation then shifts to the topic of homeschooling, specifically its legality and prevalence in Australia. One participant shares their experience homeschooling their 17-year-old child, utilizing Zoom for online learning. Another participant recounts their own experience of being homeschooled from seventh grade, highlighting the benefits of flexible scheduling and the ability to prioritize exercise and physical activity. The importance of physical activity for brain development is emphasized, advocating for incorporating activities like deadlifts and squats into a child's routine. The discussion concludes with a personal anecdote about golfing as a positive physical activity during homeschooling years.
Genetic Predisposition to Obesity and Fat Storage
00:59:23 - 01:00:29
The discussion centers on the impact of genetics, specifically the FTO gene, on obesity. One participant shares their experience of having "the worst obesity genes," including three pluses on the FTO gene, which predisposes individuals to store fat more readily than others and makes burning fat as energy difficult. The conversation touches upon the influence of "fake oestrogens" stored in fat cells, further exacerbating fat growth. The overall sentiment is that several factors, including genetics, contributed to the individual's weight challenges.
Strategies for Fat Conversion and Cold Exposure
01:00:31 - 01:01:02
The conversation shifts to practical strategies for addressing fat conversion issues. The difficulty of consistent cold shower practices is acknowledged, but the combination of sauna use followed immediately by a cold shower is presented as a more manageable and effective alternative for improving fat metabolism. The speaker highlights that this approach is often more achievable for individuals struggling with fat conversion.
Personal Experience with Genetics and Weight Management
01:01:02 - 01:03:11
The speaker, who is nearing 49 years old and currently maintains 10% body fat, discusses their personal experience with genetics and weight management. They emphasize that their low body fat percentage is achievable for others, highlighting the effectiveness of intermittent fasting and autophagy. The speaker criticizes a BBC documentary, "Why Are We Getting So Fat," for identifying a problematic gene without offering practical solutions beyond portion control, which they deem ineffective. Instead, they advocate for selecting a dietary approach (keto, carnivore, or paleo) and combining it with genetic testing, autophagy, and fasting. The speaker stresses the simplicity of this approach, emphasizing the importance of consistency over time. They acknowledge the desire for quick fixes like fat loss pills but mention a peptide, MOTS-C, specifically targeting the FTO gene, while noting their personal negative experience with it.
Peptide Side Effects and Lifestyle Choices
01:03:11 - 01:04:09
The conversation begins with a discussion of peptide side effects, specifically lightheadedness. The speakers note that this side effect is being investigated. The discussion then shifts to the speaker's continued practice of intermittent fasting, emphasizing that it's not a quick fix for unhealthy eating habits. The detrimental effects of fast food are highlighted, including its high levels of artificial estrogens, which negatively impact testosterone, DHEA, thyroid function, and energy levels, while increasing inflammation and stress hormones. The speakers agree that consuming such foods leads to weight gain, decreased motivation, reduced energy, and a cessation of exercise, creating a negative feedback loop.
The Addictive Nature of Processed Foods
01:04:10 - 01:04:38
The conversation continues by discussing the addictive nature of gluten, which affects the opioid receptor, and the presence of soy in processed foods, further contributing to this addictive cycle. The speakers also mention the addictive properties of cappuccinos, highlighting how many commercially available products are designed to be addictive. This reinforces the vicious cycle of unhealthy eating habits, lack of motivation, and decreased energy levels.
Conclusion and Next Appointment
01:04:40 - 01:04:50
The conversation concludes with a reminder of an upcoming client appointment.
Podcast Wrap-up and Contact Information
01:04:50 - 01:05:59
The podcast concludes with a discussion on how listeners can contact Dr. Anthony. Dr. Anthony mentions his website, ajconsultingcompany.com, noting that the name is not ideal but is unable to change it. He also mentions a discount offered to listeners who contact him through a specific intermediary (Mark). The hosts express their gratitude for Dr. Anthony's time and insights, highlighting the value provided to listeners. The conversation ends with pleasantries and closing remarks.
DNA with Dr. Jay, Episode 06.
CARNIVORE WOMAN Susan (from Minnesota)
CARNIVORE WOMAN Susan (from Minnesota)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Podcast Overview
00:00:00 - 00:01:15
The speaker introduces himself as a Mayo Clinic scientist, DNA consultant, and YouTuber with two channels: Anthony J. Cast (scientific content) and Anthony J. Family Cast (family adventures). He mentions a Patreon page for supporting his YouTube channels and promotes his DNA consulting services at ajconsultingcompany.com, offering both public and private DNA analysis. The podcast will feature a conversation with Susan from Minnesota, primarily focusing on the carnivore diet, with future episodes also covering this topic.
Pre-Podcast Preparations and Initial Chat
00:01:16 - 00:01:49
The podcast begins with greetings between the host and Susan. They confirm the recording is active. The host mentions his dogs are excluded from the room to avoid disruptions, sharing an anecdote about a previous podcast with a dog reacting to a UPS delivery. The conversation briefly touches upon the breed of Susan's dogs, identified as Basenjis.
Book Club Venue and Upcoming Discussion
00:01:49 - 00:02:50
The conversation begins with a discussion about the quietness of the recording environment, with one speaker mentioning two dogs who might make noise. The speakers then transition to discussing the location of a previous book club meeting, held at Crater Space in downtown St. Paul, Minnesota. They praise the venue, noting its accessibility, amenities (a coffee shop), and ease of access. One speaker mentions having used the space previously for an event. The conversation concludes with confirmation that a PDF has been received and readiness to proceed with the main topic.
Anticipation and Intrigue Regarding Medical History
00:02:51 - 00:03:20
The speakers express excitement about the upcoming discussion, focusing on the speaker's personal interest in learning about their medical history, given their adoption. The speaker expresses intrigue about potentially uncovering unknown aspects of their family's medical history. The other speaker comments on the predictive nature of the information to be discussed.
Genetic Report Review and Interpretation
00:03:20 - 00:05:05
The discussion begins with a speaker sharing their experience of identifying certain genes and informing individuals about potential familial genetic predispositions, often met with confirmation from those individuals. A brief aside follows regarding the logistics of the meeting, with speakers addressing potential noise from drinks. The conversation then shifts to a review of a genetic report. A question arises about the meaning of certain categories in the report, specifically whether the presence or absence of sub-categories indicates prioritized concerns or only significant abnormalities. The speaker clarifies that the absence of gene issues in a category means no substantial findings were identified. The discussion concludes with a speaker expressing their interest in identifying only "bad genes" – those indicating potential problems – because understanding the specific problem allows for targeted solutions, rather than relying on guesswork. An example is given of a book categorizing genes, starting with those related to the brain.
Alzheimer's Risk Assessment and Genetic Factors
00:05:06 - 00:06:53
This segment discusses Alzheimer's risk assessment, referencing Dale Bredesen's book "The End of Alzheimer's." The speaker explains that Bredesen's approach assumes the presence of every potential genetic risk factor, advocating for extreme measures like avoiding heavy metals, exercising, reducing inflammation and carbohydrates, and taking numerous supplements. However, the speaker argues this is overly cautious and not necessary for everyone. They emphasize a more precise approach, noting that the individual being discussed has a very low Alzheimer's risk. The conversation then shifts to a basic explanation of human genetics, clarifying that every cell (except egg and sperm cells) contains two copies of DNA, one from each parent. The speaker explains the significance of "plus plus" and "plus minus" notations in genetic reports, indicating the inheritance of good or bad gene versions from both parents or one parent, respectively, impacting the severity of potential genetic risks.
Genetic Predisposition and Anxiety
00:06:53 - 00:08:21
The discussion begins with an assessment of genetic markers, focusing on the significance of "pluses" in the report. While minor genetic variations are deemed less concerning due to the presence of a good gene copy, the speakers prioritize the more substantial "pluses." The first gene identified is a common anxiety gene present in 60% of the population, considered a less significant risk factor. However, the current cultural climate of stress and anxiety, exacerbated by lockdowns, is acknowledged as a contributing factor. The second gene discussed is TPH2, a serotonin transporter crucial for serotonin uptake in the brain. The importance of gut health is highlighted, as 90% of serotonin is produced in the gut. The speakers emphasize that sufficient gut serotonin production can mitigate the impact of poor serotonin transport to the brain. The conversation concludes this section by noting the individual's use of probiotics.
Probiotic Selection and Weight Gain
00:08:21 - 00:09:02
The conversation shifts to the individual's probiotic choice and the underlying reason for exploring genetic testing and health optimization. The individual explains their decision to explore various health avenues stemmed from a significant weight gain (10kg in two months) ten years prior. Their journey involved consultations with various healthcare professionals, including traditional medical doctors, nutritionists, and functional medicine doctors. The narrative ends mid-sentence, indicating a continuation of the story in the subsequent part of the transcript.
Probiotic Use and Gut Health Assessment
00:09:02 - 00:10:34
The conversation centers on the speaker's experience with probiotics prescribed by a functional medicine doctor. The speaker mentions using a specific probiotic brand recommended by their doctor to address detoxification issues identified in previous functional medicine consultations. Despite consistent use and a generally healthy diet (including being grain-free), the speaker reports no noticeable difference in their health after a week without the probiotic. The possibility of other underlying factors influencing their health is acknowledged. The discussion then shifts to the speaker's genetic predisposition to gut issues, specifically mentioning "leaky gut," "GI distress," and several "bad genes" identified in their genetic testing. The significant genetic risk for gut problems is highlighted as a priority area for further discussion.
Understanding a Specific Gene and its Relation to Inflammation
00:10:34 - 00:12:27
The discussion centers on a specific gene, CDK, linked to inflammation. A particular version of this gene doesn't effectively shut off inflammation, but flavonoids found in colorful plants and supplements like grapeseed proanthocyanidins can mitigate this. Proanthocyanidins, while having a complex name, are highlighted as a potentially superior supplement to resveratrol for addressing this type of inflammation, beneficial for gut health and potentially increasing lifespan based on animal studies. The conversation then clarifies that "colorful plants" refers to those rich in flavonoids, the pigments protecting plants from sun damage, exemplified by red tomatoes and bell peppers.
Flavonoid Sources and Dietary Preferences
00:12:27 - 00:13:05
The discussion centers on obtaining flavonoids through diet. Purple carrots are suggested as a better source than orange carrots due to their higher flavonoid content. The speakers express a preference for obtaining nutrients from food, mentioning grapeseed as an alternative source if dietary intake is uncertain. The conversation then shifts to a specific gene, ATG-16L1.
ATG-16L1 Gene and Health Implications
00:13:05 - 00:14:01
The speakers discuss the ATG-16L1 gene, noting that having two pluses signifies a high risk (three-fold higher) of leaky gut issues. A second related gene increases the risk further (another two-fold). The presence of even one of these genes is associated with gluten sensitivity, although genetics alone cannot definitively predict it. One speaker mentions having reduced grain and bread consumption, which is considered beneficial given the gene discussion. The connection between the gene (autophagy related 16l1) and intermittent fasting is briefly mentioned, relating to cellular cleanup processes ("cells taking out the trash").
Intermittent Fasting Experiences and Strategies
00:14:01 - 00:15:37
This segment details personal experiences with intermittent fasting. The speaker discusses the benefits of intermittent fasting for autophagy, mentioning their initial regimen of two 24-hour fasts per week (20 hours fasting, 4 hours eating). They then describe participating in a 72-hour fasting challenge, unexpectedly extending it to 82 hours due to a late dinner before starting the fast. The speaker reflects on the difficulty of extended fasting and their current strategy of a single 36-hour fast weekly, typically starting Sunday night and concluding Tuesday morning. The speaker notes their success with this adjusted approach.
Intermittent Fasting and Keto-ish Diet
00:15:37 - 00:17:55
The speaker discusses their experience with intermittent fasting, noting struggles when approaching 24-hour fasts but feeling fine after a night's sleep. They've been trying to eat within a shorter window since the beginning of the year, acknowledging challenges due to social commitments and a sales job requiring client meetings that may extend past their fasting window. They find not eating in the morning relatively easy. They also describe adding collagen and cream to their morning coffee, questioning whether this breaks their fast. The response explains that the impact depends on the strictness of the fast, with water and electrolytes being the strictest, followed by fats, then proteins, and finally carbs which significantly impact ketosis. While protein can affect autophagy pathways, the amount, exercise level, and fast duration are also factors. The advice given is not to overthink minor details but to focus on the overall intermittent fasting practice and listen to how the body feels.
Personal Experiences with Extended Fasting
00:17:55 - 00:19:05
The conversation begins with a discussion of extended fasting, including a 20-day fast mentioned by one participant. Concerns are raised about the potential risks of such extreme fasts, but the benefits are also acknowledged if done carefully and with attention to the body's signals. One participant describes their own intermittent fasting practices, including three-day fasts done a couple of times a year, noting that their metabolism slows and they get cold during these longer fasts. Another participant shares their experience with a single extended fast, reporting feeling cold only on the last day. The discussion concludes with the second participant expressing their intention to continue with weekly 36-hour fasts due to positive experiences.
Modifying Fasting Practices and Coffee's Impact
00:19:06 - 00:19:39
The conversation shifts to modifications in fasting routines. One participant describes their attempt to modify their Monday morning routine by omitting cream from their coffee while retaining collagen. The use of heavy whipping cream for added fat is mentioned. The discussion then touches upon the technical aspects of fasting, with a participant pointing out that coffee, even without cream, can disrupt a fast due to its effect on blood sugar levels. The conversation ends mid-sentence.
The Effects of Coffee During Extended Fasting
00:19:40 - 00:20:15
This segment discusses the impact of coffee consumption during extended fasting. While some individuals justify coffee intake due to preference or addiction, it's noted that coffee can elevate blood sugar levels, potentially interfering with blood sugar monitoring. This is because coffee triggers a fight-or-flight response, increasing adrenaline. The speakers acknowledge that coffee isn't necessarily prohibited during fasting but suggest that completely eliminating it represents a more advanced level of fasting. The necessity of this depends on individual goals.
Personal Experiences and Strategies for Managing Fasting
00:20:15 - 00:21:22
This section details personal experiences and strategies related to fasting. One speaker shares their approach to limiting coffee intake to one cup daily, attributing improvements in energy levels to this change, along with other lifestyle adjustments. The importance of electrolytes is highlighted, with the speaker mentioning headaches experienced during extended fasts due to electrolyte deficiencies. The use of electrolyte supplements like Fino or Redmond salt in water is discussed as a solution to prevent these headaches, particularly during the later stages of a 36-hour fast.
Personal Experiences with Fasting
00:21:22 - 00:23:17
This section details personal experiences with different types of fasting. The speaker discusses a three-day fast, noting that low electrolytes exacerbated headaches. Electrolyte pills were used to mitigate this. A 24-hour dry fast is then described, where initial thirst was the main challenge, but this subsided. Interestingly, the speaker went musky fishing during this fast, noting the irony of being asked about their water bottle while abstaining from fluids. The experience was ultimately positive, despite the lack of water. While not eager to repeat the dry fast, the speaker plans to repeat the three-day fast, potentially modifying it by omitting coffee. The use of both regular and mineral water during fasting is also mentioned to combat boredom.
Dealing with Food Cravings and Leaky Gut
00:23:18 - 00:24:19
The speaker discusses their struggles with food cravings, particularly for carbs, and uses hot sauce as a distraction technique. They mention doing three-day fasts to curb these cravings. The conversation then shifts to leaky gut and the IBD-5 gene, its association with inflammatory bowel disease (IBD), and the debate surrounding its exact causal mechanism. The speaker shares personal experiences with sudden urges to use the bathroom, a hallmark symptom of IBD. Another speaker also mentions having gut issues.
Suggestions for Gut Health and Mushroom Supplements
00:24:22 - 00:25:17
The speaker suggests looking into interferons, another form of inflammation, as a possible connection to the gut issues. They mention an article with more information. The conversation then turns to mushroom supplements, with the speaker mentioning using Four Sigmatic coffee in the past but now looking for a clean and good mushroom supplement powder. Another speaker recommends using bulk supplement powders like reishi, cordyceps, and lion's mane.
Lion's Mane Mushroom Supplement Discussion
00:25:17 - 00:26:55
A discussion unfolds regarding lion's mane mushroom supplements. One participant mentions trying a liquid extract brand called Lifecycle, recommended due to reported sleep improvement. Another participant inquires about purchasing in bulk, leading to the mention of "Bulk Supplements" as a brand offering large quantities at lower cost. The conversation touches upon the taste variations between brands and the possibility of mixing lion's mane with other supplements like collagen powder. Concerns are raised about potential interactions between different supplements, highlighting the importance of spacing out consumption and conducting research to avoid counteracting effects. The participants agree that further research is needed to ensure optimal supplement timing and avoid negative interactions.
Supplement Timing and Cycling
00:26:55 - 00:28:07
The discussion centers on the importance of taking certain supplements with fats for optimal absorption, citing examples like vitamin D and tocotrienol. The speakers note that during strict fasting periods without fat intake, supplement absorption may be compromised, making it acceptable to skip supplements during a fast. The conversation then shifts to the concept of supplement cycling, mirroring the cyclical nature of seasonal eating. This is justified by the body's natural ability to store many vitamins, as evidenced by the high vitamin content in organs like the liver. The speakers suggest that cycling supplements mimics the dietary patterns of ancestors and is a viable approach for many vitamins.
Interleukin and IBS Risk
00:28:10 - 00:28:29
The conversation concludes by mentioning interleukin-1 beta (IL1B), an interleukin gene identified as a threefold risk factor for irritable bowel syndrome (IBS).
Gut Health and Gene Expression
00:28:29 - 00:29:52
Discussion focuses on the implications of specific gene variations. A gene related to inflammation is mentioned, with curcumin suggested as a potential aid. Another gene, DEFB1, shows a two-fold increased risk of leaky gut issues due to reduced production of beta-defensin, a peptide that combats bad gut bacteria. The advice given is to avoid processed foods and sugar, and consider probiotics, but only if dietary changes don't suffice. The conversation then shifts back to caffeine and serotonin.
Serotonin and Caffeine
00:29:53 - 00:30:12
The discussion returns to the topic of caffeine and its impact, specifically in relation to serotonin levels. The individual reports occasional feelings of overwhelm, despite not generally experiencing excessive anxiety. An example is provided of feeling overwhelmed while working from home.
Overwhelmed Feelings and Serotonin
00:30:13 - 00:30:57
The conversation begins with the individual describing feelings of being overwhelmed while juggling work, online courses, and household tasks. They question if these feelings might be linked to a specific gene. The other participant confirms a potential connection and suggests that poor sleep, impacting serotonin levels, could exacerbate anxiety. As a solution, they recommend using serotonin-boosting supplements strategically during periods of heightened stress.
Caffeine Metabolism and Gene Analysis
00:30:58 - 00:31:51
The discussion shifts to caffeine metabolism. The individual's rapid caffeine breakdown, with a four-hour half-life, is highlighted. Despite a "double-double bad gene" designation in the report, it's clarified that this isn't necessarily negative in this context. The discussion emphasizes that the report doesn't solely focus on negative gene markers; some genes, like those related to muscle fiber types (e.g., fast-twitch muscles for sprinting), are noted for their positive implications even if labeled as "plus-plus". The caffeine gene is presented as a similar example, where the "bad" designation doesn't automatically equate to a negative health outcome.
Diet and Genetic Predisposition to Type 2 Diabetes
00:31:53 - 00:33:48
The conversation shifts to dietary recommendations based on the individual's genetic profile. The speaker praises the individual's brain health markers. The discussion then turns to genes associated with type 2 diabetes, noting that many people possess these genes but that their impact depends heavily on carbohydrate intake. Zinc is highlighted as a crucial element, particularly due to the individual's genetic predisposition (plus-plus on the zinc transporter SLC 30A8). Red meat is suggested as an excellent zinc source, but other options are also considered. The individual's regular red meat consumption (at least four days a week) is noted. The question of zinc supplementation is raised, and the speaker suggests it might be beneficial, especially considering the current COVID-19 situation and zinc's role in combating viruses. The speaker mentions zinc carnosine as a preferred supplement.
Zinc Supplement Discussion
00:33:48 - 00:34:05
The conversation begins with a discussion about the side effects of different zinc supplements. The speaker notes that some forms can cause acid reflux and stomach discomfort. As an alternative, carnosine is suggested as a gentler option. Ultimately, the speaker advises choosing a zinc supplement based on personal tolerance and comfort level.
Adiponectin and Metformin Genes
00:34:06 - 00:35:27
The discussion shifts to genetic predispositions related to adiponectin and metformin. The speaker mentions that the patient's adiponectin gene is linked to intermittent fasting, which the patient is already practicing. The patient's metformin gene indicates a higher-than-average response to metformin, a prescription drug derived from a natural plant. Metformin's benefits, including increased lifespan in animal studies, are highlighted, along with the common side effect of diarrhea. The speaker shares their personal experience with metformin, describing their usage pattern, which involves cycling the drug and using it strategically when consuming high-carb meals. The speaker also notes that metformin lowers blood sugar and increases metabolism.
Blood Glucose Monitoring and Metformin
00:35:29 - 00:37:02
This segment discusses methods for monitoring blood glucose levels and the potential use of metformin. One participant mentions owning a finger-pricking glucose and ketone monitor but hasn't used it yet. The conversation clarifies that self-monitoring fasted blood glucose is easier and less stressful than doctor visits. The use of a Keto Mojo-like device is mentioned. The high cost of test strips is noted, but one participant still has unused strips. The discussion then shifts to the use of metformin to lower blood sugar levels above 90 mg/dL, even without a diabetes diagnosis. The difficulty of obtaining a metformin prescription without a diabetes diagnosis is highlighted, with a suggestion to frame the request by mentioning research on metformin's lifespan-extending effects.
Doctor's Visit Discussion
00:37:03 - 00:38:36
The conversation centers on a patient's discussion with their doctor regarding various health aspects. The patient expresses a good relationship with their GP, who is open to alternative approaches like different diets and natural remedies. The discussion then shifts to metformin, a drug gaining popularity for potential lifespan increase, but the doctor advises against it for individuals with poor responder genes, while noting the patient is a high responder. The final topic is skin health, specifically mentioning the filaggrin gene (FLG) which can cause seasonal, dry skin issues. The patient mentions their proactive approach to skincare with moisturizing lotions. The doctor offers further recommendations for skin issues if needed.
Skin Condition Discussion
00:38:45 - 00:40:06
A patient describes a recurring eczema-like condition on their right thigh, approximately three inches in diameter. The patient notes a history of scratching the area raw as a child and wonders if the condition is related to stem cell activity and a specific gene. The doctor suggests perilla seed oil as a topical treatment, noting its effectiveness for similar issues. The doctor also mentions studies showing histidine, an amino acid, can increase filagrin, a skin barrier protein, which may be deficient in the patient. The doctor recommends trying perilla seed oil topically first, and possibly supplementing with histidine if needed, due to its potential to improve skin barrier function.
Dietary Sensitivities and Genetic Predisposition
00:40:10 - 00:41:23
A discussion ensues regarding a previous spit test for food sensitivities, revealing a mild dairy reaction. While the test showed minimal reactions (mostly level 1), the speaker experienced phlegm in their throat after consuming dairy. The conversation clarifies that the absence of strong reactions on the test doesn't rule out a sensitivity; it simply indicates no genetic predisposition to dairy intolerance. The speaker's experience is attributed to epigenetics, meaning acquired sensitivities that can develop and potentially resolve over time, regardless of genetic factors. The conclusion is that while the genetic component is clear, a dairy sensitivity might still exist.
Vitamin and Hormone Detox
00:41:23 - 00:41:37
The conversation transitions to the "vitamin hormone detox" section, marked as a high priority ("plus plus"). The exact nature of this section and the following discussion is cut off at the end of the provided transcript.
Vitamin D Deficiency and CYP2R1 Gene
00:41:37 - 00:43:27
The conversation focuses on vitamin D deficiency, particularly relevant for individuals in Minnesota due to limited sunlight exposure. The importance of maintaining vitamin D levels above 50 nanograms per milliliter is emphasized. A previous blood test is recommended to check current levels. The discussion then turns to the CYP2R1 gene, a liver enzyme that converts D3 (colcalciferol) into its active form, calcitriol. A deficiency in this gene's function can impair the conversion process, leading to lower levels of active vitamin D, even with supplementation. The speaker notes that they previously took vitamin D supplements but recently stopped, highlighting the need to resume supplementation and monitor levels. The complex nomenclature of vitamin D forms (D3, colcalciferol, calcitriol) is also mentioned.
Vitamin D Levels and Testing
00:43:27 - 00:44:56
This segment focuses on optimizing Vitamin D levels, specifically the relationship between D3 and D4. The speaker explains that while supplementing D3 is common and sufficient for many, it's crucial to ensure adequate conversion to D4, as D4 is the more important form. The recommendation is to maintain higher-than-average, but still within the normal range, D3 levels to facilitate better conversion. A blood test is necessary to determine individual D3 levels. The speaker suggests a strategy of taking 5,000 IUs of Vitamin D and retesting after a month to fine-tune the dosage. The affordability and wide availability of D3 supplements are also mentioned.
Vitamin D and Joint Issues
00:44:57 - 00:45:48
A discussion about a person in Boston experiencing joint issues in winter, linked to low vitamin D levels. The individual waited for a doctor's prescription for vitamin D, despite the readily available over-the-counter option. The speakers discuss the cost-effectiveness of buying vitamin D supplements directly, and the preference for vitamin D supplements containing K2.
Genetic Predisposition to Pesticide/Chemical Sensitivity
00:45:49 - 00:46:22
A gene affecting the breakdown of oxidized fats and seed oils is mentioned. Approximately 20% of the population possesses this gene, with a high prevalence among podcast participants. The gene's association with sensitivity to pesticides and cleaning chemicals is highlighted, emphasizing the importance of avoiding seed oils like canola and soybean. The use of sesame oil for oil pulling is mentioned, but its consumption is distinguished from the discussion of seed oil avoidance.
Cooking Oils and Fat Consumption
00:46:22 - 00:47:05
The conversation shifts to the types of cooking oils and fats. The speakers discuss the negative effects of seed oils due to their proneness to oxidation. They express a preference for cooking with saturated fats like butter, MCT oil, and coconut oil, noting that butter is dairy and coconut is a fruit, while also mentioning olive oil and avocados as acceptable alternatives. The use of sesame oil is questioned, and the speakers conclude that avoiding its use in cooking is advisable.
Pesticide Breakdown and Sex Hormones
00:47:05 - 00:48:14
The discussion moves to organophosphate pesticides, explaining that they are broken down by the same gene that processes other toxins. The speakers acknowledge regional differences in pesticide exposure, particularly mentioning mosquito sprays in Florida. The conversation then turns to sex hormones, specifically highlighting sex hormone-binding globulin (SHBG) as a significant factor. SHBG is described as a "limo service" for sex hormones, transporting estrogen and testosterone through the bloodstream. The speakers explain that an overproduction of SHBG can be problematic.
Hormone Levels and Supplements
00:48:14 - 00:50:14
The conversation focuses on the impact of high SHBG (sex hormone-binding globulin) levels, where testosterone and estrogen get trapped and are not utilized by the body. Supplements like boron, zinc (obtained from meat), and Tongkat Ali are suggested to help free up these hormones. The speaker emphasizes the importance of checking SHBG levels alongside vitamin D, noting that while normal ranges for testosterone and vitamin D are often unreliable, the normal range for SHBG is more trustworthy. High SHBG, even within the normal range, is considered potentially problematic, especially in relation to unexplained weight gain. Tongkat Ali is recommended as a way to lower high SHBG. The conversation concludes with the speaker sharing a personal anecdote about a past medical issue involving endometriosis, a large mass removed from their lower area, and the subsequent removal of an ovary and fallopian tubes.
Menopause and Liver Enzyme Function
00:50:14 - 00:52:08
The conversation begins with the speaker discussing the impact of ovary removal surgery on her menstrual cycle and subsequent menopause. The weight gain experienced post-surgery is noted, followed by the onset of irregular cycles and eventual menopause a year later. The speaker questions whether this hormonal disruption might influence the discussion's topic. The conversation then shifts to the CYP1B1 gene, a liver enzyme involved in breaking down artificial estrogens. The speaker explains that a less efficient breakdown of these estrogens due to this gene can lead to conditions like gynecomastia in men. The speaker highlights the widespread exposure to artificial estrogens through various sources, including personal care products, plastics (BPAs and phthalates), sunscreens, and drinking water. The speaker emphasizes that individuals with the CYP1B1 gene variant are at increased risk due to their impaired ability to clear these chemicals, citing endometriosis as a well-established example supported by animal studies.
Sauna Use for Detoxification
00:52:09 - 00:53:58
This segment discusses the benefits of sauna use for detoxification, particularly in eliminating artificial estrogens like BPA and phthalates. A study is mentioned where individuals using saunas showed significantly higher levels of these chemicals in sweat patches compared to a control group, indicating that sweating effectively removes these toxins. The discussion notes that these chemicals weren't significantly excreted through urine, highlighting the sauna's unique role in detoxification. The speakers then discuss the choice between infrared and traditional saunas, with a preference expressed for a hot sauna, regardless of type. One speaker mentions considering Sauna Space as a brand.
Comparing EMF Solutions and Heat Therapy
00:53:59 - 00:55:22
The discussion centers on comparing two low-EMF solutions: one from Brian Hoyer and Kre-Tex solutions. The speaker notes that while both aim to generate heat, the Kre-Tex solution gets hotter and is larger. The speaker expresses uncertainty about which is superior, stating that the key benefit lies in achieving high heat. The conversation then shifts to the benefits of heat and infrared, highlighting that heat increases heat shock proteins, a benefit not solely provided by infrared. Infrared's ability to heat from the inside is also mentioned. The speaker concludes that both heat and infrared are important, but heat is prioritized due to the speaker's difficulty eliminating it, relating this to a gene linked to man boobs, suggesting that while not everyone with the gene has man boobs, virtually everyone with man boobs has the gene. This gene is considered problematic due to modern environmental exposures absent in ancestral populations.
Autoimmune Thyroid Risk Assessment
00:55:22 - 00:56:58
The conversation focuses on a patient's genetic predisposition to autoimmune thyroid issues, specifically mentioning a "thyroglobulin gene (TG)" with "plus pluses," indicating a tenfold increased risk. The discussion acknowledges other autoimmune risk factors and emphasizes the importance of a non-inflammatory diet, gut health, exercise, and consistent healthy habits to mitigate this risk. While acknowledging the elevated risk, the speaker suggests not excessive worry, but recommends iodine supplementation due to its role in thyroid hormone production. The patient's seafood consumption (once or twice weekly) is deemed likely sufficient for iodine intake. Finally, the patient mentions having their thyroid hormone levels (T4, T3, reverse T3, and TSH) checked twice.
Thyroid Concerns and Supplementation
00:56:58 - 00:58:53
The conversation centers on an individual's fluctuating thyroid levels, which remain within the normal range (0.5-4) despite repeated testing showing values of 0.55 and later 0.8. The individual expresses frustration and considers iodine supplementation due to a family history of thyroid issues and the understanding that the thyroglobulin gene plays a crucial role in iodine utilization for T4 and T3 production. The speaker suggests that fluctuating thyroid levels might be linked to intermittent inflammation caused by stress or lack of sleep, making it difficult to capture abnormal levels through standard blood tests, especially for T3. The speaker supports the idea of iodine supplementation as a precautionary measure given the individual's genetic predisposition and recommends tyrosine as another potentially helpful supplement.
Thyroid Health and Genetic Predisposition
00:58:54 - 01:00:34
This segment discusses the importance of tyrosine as a building block for thyroid hormones and the difficulty in diagnosing thyroid issues. The speaker mentions that some individuals take years to receive a diagnosis for conditions like Hashimoto's. Given the listener's genetic predisposition, the speaker suggests that addressing thyroid health might be more beneficial than focusing solely on sex hormones, noting that high SHBG levels can lower effective sex hormone levels. The speaker recommends exploring thyroid optimization or replacement therapy, such as Armour thyroid, but emphasizes the importance of working with a doctor to determine the correct dosage to avoid potential heart-related side effects like palpitations. The bio-identical nature of Armour thyroid, derived from pigs, is also clarified.
Thyroid Hormone Supplementation Discussion
01:00:35 - 01:02:07
The conversation centers around thyroid hormone supplementation. The speaker discusses the advantages of using porcine-derived thyroid hormone (Armor Thyroid) due to its full-spectrum T4 and T3 balance, unlike some artificial alternatives. The possibility of supplementing with iodine and tyrosine as a preliminary step before Armor Thyroid is raised. The speaker clarifies that they already possess iodine and explains the safe dosage, emphasizing that overdosing is difficult. Tyrosine supplementation is also discussed, noting its role as an amino acid and its benefit in boosting thyroid hormone production when taken with fats. Finally, the speaker questions the necessity of frequent lab tests given their past results consistently showed thyroid hormone levels within the normal range, although low within that range is still a concern.
Heart Rate and Fat Burning
01:02:07 - 01:02:27
Discussion on the relationship between heart rate and fat burning, particularly relevant for bodybuilders. Higher heart rate helps burn more fat, but exceeding a certain limit can be detrimental. Monitoring heart rate and other indicators like sweating helps determine the optimal range.
Thyroid Optimization and Aging
01:02:29 - 01:03:09
A speaker advocates for thyroid optimization as people age due to declining thyroid hormones. They suggest that even small doses of thyroid medication (like a quarter of a pill) can be beneficial and inexpensive, starting as early as 30s or 40s depending on genetics. Armor thyroid is mentioned as a specific medication option.
Treatment Plan and Further Investigation
01:03:10 - 01:03:47
A plan is outlined to start with tyrosine and iodine supplements, followed by blood work. The possibility that previous misdiagnosis of thyroid issues might be related to other underlying conditions, specifically a histamine intolerance risk linked to the AOC1 gene (amine oxidase copper containing one), is discussed.
Histamine, Copper, and Weight Gain
01:03:48 - 01:05:15
The discussion centers on the connection between histamine, copper, and weight gain. A copper-dependent gene's role in histamine clearance is highlighted, emphasizing copper's importance. High histamine levels are linked to inflammation, potentially causing disrupted sleep, allergies, and weight gain. While eliminating histamine from the diet is nearly impossible due to its widespread presence in foods, increasing copper intake is suggested as a solution. The conversation then shifts to practical ways of increasing copper intake, including copper supplements and consuming liver, with a personal anecdote about preparing and enjoying liver pate shared. The speaker mentions a preference for liver pate over other liver preparations.
Liver Pâté Recipe and Storage
01:05:22 - 01:06:40
The conversation begins with a discussion about a liver pâté recipe. One participant mentions their children's fondness for the pâté, and another expresses interest in obtaining the recipe. The possibility of using a Vitamix instead of a food processor is considered. The question of whether the type of liver (beef, goose, etc.) matters is raised and answered in the negative. One participant mentions having a large quantity of frozen livers and seeks advice on processing them. Another suggests processing all at once, sharing their own experience of deer hunting and their wife's method of preparing and freezing the livers in smaller portions for easier thawing and use over time. The conversation concludes with a brief, somewhat tangential discussion about histamine, associating it with nasal sprays, and questioning the accuracy of that association.
Histamine and Inflammation
01:06:40 - 01:07:30
The discussion begins with a question about histamine and inflammation. It's clarified that histamine is an amine, a building block for proteins, and an inflammatory molecule triggering the immune system. While beneficial for healing cuts by attracting immune cells to fight bacteria, excessive histamine leads to symptoms like runny noses, as the immune system attacks non-threatening substances.
Rare Genes and Dietary Implications
01:07:30 - 01:08:39
The conversation shifts to rare ABCG5 and ABCG8 genes. Less than 1% of the population possesses the "plus-plus" variant on both genes, a characteristic the speaker possesses. This genetic makeup suggests ancestors had a carnivorous diet, as the genes are linked to cytosterolemia and plant sensitivities. The speaker recommends trying a carnivore diet due to the gene's association with plant sterols, gallstones, and other plant-related health risks. The discussion explains that plants contain cytosterols, a type of cholesterol, which individuals with this gene variant may struggle to process efficiently.
Plant Cholesterol and Genetic Predisposition
01:08:39 - 01:10:26
This segment discusses the impact of plant cholesterol on individuals with rare genes (ABC, G5, and 8). The speakers explain that while most people can process plant cholesterol without issue, individuals with these genes have difficulty breaking it down, leading to potential health problems. The conversation highlights a case study of a person with two "plus plus" genes, emphasizing the need for caution with plant consumption. The effect of cooking versus raw consumption is addressed, concluding that it makes no difference. A blood test to check cytosterol levels is suggested as a way to quantify the issue. The speakers conclude that animal products, lacking cytosterols, might be a better dietary option for individuals with this genetic predisposition, and suggest a carnivore diet as an experiment to explore.
Supplement Considerations for a Rare Gene
01:10:26 - 01:12:49
This segment discusses the suitability of various supplements for an individual with a rare gene affecting cholesterol metabolism. The conversation begins by clarifying that purified supplements like resveratrol and vitamin C do not contain plant cholesterol. Tyrosine and other previously discussed supplements are deemed acceptable. However, mushrooms are identified as a potential concern due to their sterol content (specifically ergosterol in shiitake mushrooms). Further research is recommended to determine the impact of mushroom consumption on this specific genetic condition. The speaker notes that this gene is rare, and individuals with it often thrive on carnivore diets. The discussion concludes with a reflection on how dietary habits change over time, using bread and potato chips as examples of foods that were once staples but are now easily avoided due to changed preferences and dietary needs.
Carnivore Diet Discussion and COMT Gene
01:12:49 - 01:13:55
The conversation begins with a discussion on the benefits of adopting good habits, specifically mentioning the need to commit to a new habit for 90 days to determine its effectiveness, citing Sean Baker's advice. The discussion then shifts to the carnivore diet, noting its increasing popularity and the availability of resources like cookbooks by authors such as Maria Emmerich. The speakers share their experiences with the diet and its accessibility.
COMT Gene and Electrolyte Importance
01:13:55 - 01:14:26
The conversation transitions to the COMT gene and its impact on electrolyte balance. The speaker explains that individuals with a 2++ genotype for COMT may experience increased electrolyte excretion due to the gene's influence on catecholamine breakdown. This results in the kidneys receiving signals to excrete more water and electrolytes than necessary, highlighting the importance of electrolyte supplementation for those with this genotype.
Electrolyte Replacement During Fasting
01:14:27 - 01:15:48
This segment focuses on the importance of electrolyte replacement, particularly during intermittent fasting. The speakers discuss the necessity of replacing water and electrolytes lost during fasting to avoid headaches and other symptoms. The use of electrolyte pills is mentioned, with a specific concern raised about the typical high sodium and low potassium content in many commercially available options. One speaker emphasizes their efforts to find electrolyte pills without sugar and with a balanced potassium-sodium ratio. The conversation also touches upon a long list of supplements, including less common ones like phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, which are noted as being necessary for some individuals but not for most. The speaker clarifies that while a comprehensive list is available on their website, most people don't require these less common supplements.
Methionine, Amino Acids, and Ancestral Diet
01:15:48 - 01:16:23
The discussion begins with the MTRR gene's role in methionine production. A ++ genotype indicates reduced methionine production, necessitating dietary intake, particularly from sources like chicken and fish. This leads to a broader conversation about the body's need for various amino acids, electrolytes, and the implication of a high-meat ancestral diet. The speakers consider the potential benefits of incorporating more meat into their current diet.
Supplementing on a Carnivore Diet
01:16:23 - 01:17:28
The conversation shifts to the question of supplementation during a planned 90-day carnivore trial. The consensus is that supplementation remains an option, even with a carnivore diet, as none of the supplements pose a risk of exceeding safe levels. The discussion then focuses on specific vitamins. B12 supplementation is deemed unnecessary due to efficient gut absorption, further supporting the theory of a high-meat ancestral diet. However, due to the methylfolate gene (MTHFR), supplementation with 5-MTHF (methylfolate) is recommended.
Supplement Recommendations and Heavy Metal Testing
01:17:28 - 01:19:06
The conversation centers on supplement recommendations and the necessity of heavy metal testing. The speaker explains that methylfolate (5-MTHF) is a key supplement. The question of a heavy metals test arises, but the speaker advises against it due to the patient's genetic profile showing no significant concerns regarding heavy metal accumulation. The cost of the test ($150 without insurance) is mentioned. The speaker clarifies that the test might be considered if the patient experiences symptoms similar to those from 2010. Concerns about vitamin E are dismissed as the patient isn't using a multivitamin or a synthetic form of vitamin E. Finally, the discussion turns to fructose intolerance, indicated by a specific gene. The patient's preference for berries in their keto diet is noted, but the speaker advises caution with high-fructose fruits like melons.
Dietary Changes and Website Feedback
01:19:06 - 01:19:37
The conversation begins with a suggestion to try a new approach and reintroduce certain foods. A website link providing information on fructose levels in fruits is mentioned. The speaker reports positive changes in their diet, eliminating corn syrup and soda pop for years, opting for Zevia instead when consuming soda. The speaker confirms making dietary changes and the discussion moves to the next topic.
Joint Health Analysis: Inflammation, Insulin, Thyroid, and Blood Flow
01:19:38 - 01:21:00
The discussion shifts to the speaker's joint health, identifying four key factors: inflammation (interleukin genes like IL2RA and IL1B), high insulin levels triggering HLA genes, thyroid optimization (with iodine playing a crucial role), and the importance of blood flow through exercise to remove toxins. The speaker notes that high blood sugar and subsequently high insulin levels put joints at risk. The importance of maintaining good blood flow to the joints through exercise is emphasized. The discussion concludes with a mention of SLC-2A19 and its connection to sugar, indicating a continuation of the sugar discussion in the next section.
Gout and Fructose Intolerance
01:21:01 - 01:22:46
The discussion centers on the speaker's health concerns, particularly regarding gout and food sensitivities. High fructose consumption, from sources like fruits and soda, is linked to increased uric acid levels, leading to gout. The speaker mentions avoiding fructose and not experiencing gout. The conversation then shifts to other potential health issues, including a possible thyroid problem and hip/knee pain. The speaker reveals a past sensitivity to egg yolks, which caused knee inflammation when consuming multiple hard-boiled eggs daily. Muscle testing indicated this sensitivity, although it seems to have improved. The other speaker notes that egg white sensitivity is more common. The possibility of reintroducing egg yolks into a carnivore diet is considered, with the speaker indicating periodic consumption of egg yolks.
Dietary Changes and Health Issues
01:22:46 - 01:23:29
The speaker discusses a significant increase in hard-boiled egg consumption (2-6 per day) which coincided with the onset of health problems. They also mention a potential link to the ABCG5 gene and the possibility of additional dietary factors contributing to the issue. The conversation then shifts to bone health, with the speaker emphasizing the importance of bone broth and collagen, noting their own daily consumption of bone broth and suggesting that collagen intake might mitigate concerns.
Back Problems and Genetic Predisposition
01:23:31 - 01:24:28
The speaker shares a personal anecdote about back problems experienced in their early 30s, stemming from past sports injuries. A doctor diagnosed them with the L5 of an 80-year-old, attributing it to "bad genes." Despite this diagnosis, the speaker found relief through yoga and acupuncture, significantly improving their back condition. They conclude by wondering if this back issue might be related to the previously discussed health problems, questioning the role of genetics in both instances.
Genetic Predisposition and Pain Sensitivity
01:24:28 - 01:26:12
The discussion centers on the patient's genetic predisposition to low back issues, specifically related to the L5 vertebra. A positive finding is noted regarding good bone density, counteracting some risks. The patient also possesses a gene indicating low pain sensitivity, which is generally positive but carries the risk of undetected injuries. The patient confirms frequently experiencing this, often surprising doctors with their resilience to pain. The conversation shifts to the patient's nighttime bathroom trips, linked to their high water intake. It's suggested that adjusting the timing of water consumption, rather than the quantity, and incorporating more electrolytes might alleviate this. The presence of two CLMT genes, particularly relevant in men, is highlighted as a potential contributor to frequent nighttime urination.
Sleep Genes and Cognitive Performance
01:26:14 - 01:27:54
The discussion centers on the impact of a gene (WWC1) on sleep and memory recall. Poor sleep, potentially influenced by this gene, reduces memory recall by approximately 25%. While nicotine might offer some benefit, adequate sleep is emphasized as the key to optimal cognitive performance. The conversation then shifts to biohacking techniques involving methylene blue and nicotine, with mention of Ben Greenfield's work. However, the use of methylene blue is cautioned against due to its complex effects and potential risks if overdosed; low doses have opposite effects to high doses on mitochondria, involving redox reactions. The speakers advise against using methylene blue without expert guidance on dosage.
Blue Light Sensitivity and Eye Protection
01:27:55 - 01:28:58
Discussion on personal experiences with blue light sensitivity. Participants share their use of blue light blocking glasses, noting varying effectiveness depending on the brand and quality. Concerns are raised about the reliability of cheaper glasses, particularly those from online marketplaces like Amazon, highlighting the importance of verifying the actual blue light blocking capabilities.
Addressing Acid Reflux and Hiatal Hernia
01:28:58 - 01:29:38
A participant describes a past experience with painful symptoms initially attributed to acid reflux, later diagnosed as a hiatal hernia successfully treated by a chiropractor. The participant questions a potential link between histamine and the recurrence of these symptoms, noting ongoing efforts to track potential triggers and better understand the connection.
Throat Irritation and Supplement Discussion
01:29:39 - 01:31:17
A discussion ensues regarding throat irritation experienced after consuming a Spotted Cow beer. The speaker notes a raw and inflamed feeling in their upper throat, even after only drinking water. The possibility of this being linked to genes or histamine is explored, with a potential connection acknowledged but not definitively confirmed. The conversation then shifts to supplements for managing carb intake. Berberine is mentioned as a supplement to potentially help with blood sugar, but the speaker is advised that since they are highly responsive to metformin, prioritizing metformin is recommended due to its extensive research. Berberine is considered a viable option to explore alongside metformin, particularly if blood glucose levels exceed 90, but not a high priority given the effectiveness of metformin.
Discussion of Metformin and Alternative Approaches
01:31:18 - 01:32:41
Susan expresses concerns about the inconvenience of needing a prescription for metformin. The conversation then shifts to the Burberry diet, noted for not requiring a prescription. Susan thanks Dr. J for the provided PDF and notes she's made extensive notes. While intrigued by the carnivore diet, Susan expresses a need for further research before committing to such a significant lifestyle change. She emphasizes her desire for a healthy weight without excessive gym workouts, citing snoring as a weight-related concern. The high motivation for a 90-day trial is highlighted, and the possibility of working with Paul Saladino for consultation is mentioned.
Carnivore Diet Expert Recommendation and Return Shipping
01:32:45 - 01:33:19
Dr. J recommends consulting Paul Saladino, a carnivore diet expert in California, particularly for clients with the ABCD5 gene. Saladino has recently published a book on the subject and is a valuable resource for understanding the nuances of the carnivore diet. Many of Dr. J's clients, especially those with the ABCD5 gene, find his expertise beneficial.
Return Shipping Instructions
01:33:20 - 01:33:58
Following the discussion about Paul Saladino, the conversation shifts to the return shipping of a recorder. The original recorder was sent in a box, but a flat envelope was provided for return. Dr. J instructs to repackage the recorder securely in bubble wrap and tape it, then use the provided flat rate prepaid envelope for return shipping. The flat rate envelope ensures consistent pricing regardless of the package's size.
Meeting Conclusion and Closing Remarks
01:33:58 - 01:34:25
The meeting concluded with the speaker expressing hope that there would be no issues with the new system, acknowledging that it was still being refined. A participant expressed gratitude for the information shared, noting the amount of information presented, and requested access to the provided PDF for later review. The conversation ended with mutual thank yous and goodbyes.
00:00:00 - 00:01:15
The speaker introduces himself as a Mayo Clinic scientist, DNA consultant, and YouTuber with two channels: Anthony J. Cast (scientific content) and Anthony J. Family Cast (family adventures). He mentions a Patreon page for supporting his YouTube channels and promotes his DNA consulting services at ajconsultingcompany.com, offering both public and private DNA analysis. The podcast will feature a conversation with Susan from Minnesota, primarily focusing on the carnivore diet, with future episodes also covering this topic.
Pre-Podcast Preparations and Initial Chat
00:01:16 - 00:01:49
The podcast begins with greetings between the host and Susan. They confirm the recording is active. The host mentions his dogs are excluded from the room to avoid disruptions, sharing an anecdote about a previous podcast with a dog reacting to a UPS delivery. The conversation briefly touches upon the breed of Susan's dogs, identified as Basenjis.
Book Club Venue and Upcoming Discussion
00:01:49 - 00:02:50
The conversation begins with a discussion about the quietness of the recording environment, with one speaker mentioning two dogs who might make noise. The speakers then transition to discussing the location of a previous book club meeting, held at Crater Space in downtown St. Paul, Minnesota. They praise the venue, noting its accessibility, amenities (a coffee shop), and ease of access. One speaker mentions having used the space previously for an event. The conversation concludes with confirmation that a PDF has been received and readiness to proceed with the main topic.
Anticipation and Intrigue Regarding Medical History
00:02:51 - 00:03:20
The speakers express excitement about the upcoming discussion, focusing on the speaker's personal interest in learning about their medical history, given their adoption. The speaker expresses intrigue about potentially uncovering unknown aspects of their family's medical history. The other speaker comments on the predictive nature of the information to be discussed.
Genetic Report Review and Interpretation
00:03:20 - 00:05:05
The discussion begins with a speaker sharing their experience of identifying certain genes and informing individuals about potential familial genetic predispositions, often met with confirmation from those individuals. A brief aside follows regarding the logistics of the meeting, with speakers addressing potential noise from drinks. The conversation then shifts to a review of a genetic report. A question arises about the meaning of certain categories in the report, specifically whether the presence or absence of sub-categories indicates prioritized concerns or only significant abnormalities. The speaker clarifies that the absence of gene issues in a category means no substantial findings were identified. The discussion concludes with a speaker expressing their interest in identifying only "bad genes" – those indicating potential problems – because understanding the specific problem allows for targeted solutions, rather than relying on guesswork. An example is given of a book categorizing genes, starting with those related to the brain.
Alzheimer's Risk Assessment and Genetic Factors
00:05:06 - 00:06:53
This segment discusses Alzheimer's risk assessment, referencing Dale Bredesen's book "The End of Alzheimer's." The speaker explains that Bredesen's approach assumes the presence of every potential genetic risk factor, advocating for extreme measures like avoiding heavy metals, exercising, reducing inflammation and carbohydrates, and taking numerous supplements. However, the speaker argues this is overly cautious and not necessary for everyone. They emphasize a more precise approach, noting that the individual being discussed has a very low Alzheimer's risk. The conversation then shifts to a basic explanation of human genetics, clarifying that every cell (except egg and sperm cells) contains two copies of DNA, one from each parent. The speaker explains the significance of "plus plus" and "plus minus" notations in genetic reports, indicating the inheritance of good or bad gene versions from both parents or one parent, respectively, impacting the severity of potential genetic risks.
Genetic Predisposition and Anxiety
00:06:53 - 00:08:21
The discussion begins with an assessment of genetic markers, focusing on the significance of "pluses" in the report. While minor genetic variations are deemed less concerning due to the presence of a good gene copy, the speakers prioritize the more substantial "pluses." The first gene identified is a common anxiety gene present in 60% of the population, considered a less significant risk factor. However, the current cultural climate of stress and anxiety, exacerbated by lockdowns, is acknowledged as a contributing factor. The second gene discussed is TPH2, a serotonin transporter crucial for serotonin uptake in the brain. The importance of gut health is highlighted, as 90% of serotonin is produced in the gut. The speakers emphasize that sufficient gut serotonin production can mitigate the impact of poor serotonin transport to the brain. The conversation concludes this section by noting the individual's use of probiotics.
Probiotic Selection and Weight Gain
00:08:21 - 00:09:02
The conversation shifts to the individual's probiotic choice and the underlying reason for exploring genetic testing and health optimization. The individual explains their decision to explore various health avenues stemmed from a significant weight gain (10kg in two months) ten years prior. Their journey involved consultations with various healthcare professionals, including traditional medical doctors, nutritionists, and functional medicine doctors. The narrative ends mid-sentence, indicating a continuation of the story in the subsequent part of the transcript.
Probiotic Use and Gut Health Assessment
00:09:02 - 00:10:34
The conversation centers on the speaker's experience with probiotics prescribed by a functional medicine doctor. The speaker mentions using a specific probiotic brand recommended by their doctor to address detoxification issues identified in previous functional medicine consultations. Despite consistent use and a generally healthy diet (including being grain-free), the speaker reports no noticeable difference in their health after a week without the probiotic. The possibility of other underlying factors influencing their health is acknowledged. The discussion then shifts to the speaker's genetic predisposition to gut issues, specifically mentioning "leaky gut," "GI distress," and several "bad genes" identified in their genetic testing. The significant genetic risk for gut problems is highlighted as a priority area for further discussion.
Understanding a Specific Gene and its Relation to Inflammation
00:10:34 - 00:12:27
The discussion centers on a specific gene, CDK, linked to inflammation. A particular version of this gene doesn't effectively shut off inflammation, but flavonoids found in colorful plants and supplements like grapeseed proanthocyanidins can mitigate this. Proanthocyanidins, while having a complex name, are highlighted as a potentially superior supplement to resveratrol for addressing this type of inflammation, beneficial for gut health and potentially increasing lifespan based on animal studies. The conversation then clarifies that "colorful plants" refers to those rich in flavonoids, the pigments protecting plants from sun damage, exemplified by red tomatoes and bell peppers.
Flavonoid Sources and Dietary Preferences
00:12:27 - 00:13:05
The discussion centers on obtaining flavonoids through diet. Purple carrots are suggested as a better source than orange carrots due to their higher flavonoid content. The speakers express a preference for obtaining nutrients from food, mentioning grapeseed as an alternative source if dietary intake is uncertain. The conversation then shifts to a specific gene, ATG-16L1.
ATG-16L1 Gene and Health Implications
00:13:05 - 00:14:01
The speakers discuss the ATG-16L1 gene, noting that having two pluses signifies a high risk (three-fold higher) of leaky gut issues. A second related gene increases the risk further (another two-fold). The presence of even one of these genes is associated with gluten sensitivity, although genetics alone cannot definitively predict it. One speaker mentions having reduced grain and bread consumption, which is considered beneficial given the gene discussion. The connection between the gene (autophagy related 16l1) and intermittent fasting is briefly mentioned, relating to cellular cleanup processes ("cells taking out the trash").
Intermittent Fasting Experiences and Strategies
00:14:01 - 00:15:37
This segment details personal experiences with intermittent fasting. The speaker discusses the benefits of intermittent fasting for autophagy, mentioning their initial regimen of two 24-hour fasts per week (20 hours fasting, 4 hours eating). They then describe participating in a 72-hour fasting challenge, unexpectedly extending it to 82 hours due to a late dinner before starting the fast. The speaker reflects on the difficulty of extended fasting and their current strategy of a single 36-hour fast weekly, typically starting Sunday night and concluding Tuesday morning. The speaker notes their success with this adjusted approach.
Intermittent Fasting and Keto-ish Diet
00:15:37 - 00:17:55
The speaker discusses their experience with intermittent fasting, noting struggles when approaching 24-hour fasts but feeling fine after a night's sleep. They've been trying to eat within a shorter window since the beginning of the year, acknowledging challenges due to social commitments and a sales job requiring client meetings that may extend past their fasting window. They find not eating in the morning relatively easy. They also describe adding collagen and cream to their morning coffee, questioning whether this breaks their fast. The response explains that the impact depends on the strictness of the fast, with water and electrolytes being the strictest, followed by fats, then proteins, and finally carbs which significantly impact ketosis. While protein can affect autophagy pathways, the amount, exercise level, and fast duration are also factors. The advice given is not to overthink minor details but to focus on the overall intermittent fasting practice and listen to how the body feels.
Personal Experiences with Extended Fasting
00:17:55 - 00:19:05
The conversation begins with a discussion of extended fasting, including a 20-day fast mentioned by one participant. Concerns are raised about the potential risks of such extreme fasts, but the benefits are also acknowledged if done carefully and with attention to the body's signals. One participant describes their own intermittent fasting practices, including three-day fasts done a couple of times a year, noting that their metabolism slows and they get cold during these longer fasts. Another participant shares their experience with a single extended fast, reporting feeling cold only on the last day. The discussion concludes with the second participant expressing their intention to continue with weekly 36-hour fasts due to positive experiences.
Modifying Fasting Practices and Coffee's Impact
00:19:06 - 00:19:39
The conversation shifts to modifications in fasting routines. One participant describes their attempt to modify their Monday morning routine by omitting cream from their coffee while retaining collagen. The use of heavy whipping cream for added fat is mentioned. The discussion then touches upon the technical aspects of fasting, with a participant pointing out that coffee, even without cream, can disrupt a fast due to its effect on blood sugar levels. The conversation ends mid-sentence.
The Effects of Coffee During Extended Fasting
00:19:40 - 00:20:15
This segment discusses the impact of coffee consumption during extended fasting. While some individuals justify coffee intake due to preference or addiction, it's noted that coffee can elevate blood sugar levels, potentially interfering with blood sugar monitoring. This is because coffee triggers a fight-or-flight response, increasing adrenaline. The speakers acknowledge that coffee isn't necessarily prohibited during fasting but suggest that completely eliminating it represents a more advanced level of fasting. The necessity of this depends on individual goals.
Personal Experiences and Strategies for Managing Fasting
00:20:15 - 00:21:22
This section details personal experiences and strategies related to fasting. One speaker shares their approach to limiting coffee intake to one cup daily, attributing improvements in energy levels to this change, along with other lifestyle adjustments. The importance of electrolytes is highlighted, with the speaker mentioning headaches experienced during extended fasts due to electrolyte deficiencies. The use of electrolyte supplements like Fino or Redmond salt in water is discussed as a solution to prevent these headaches, particularly during the later stages of a 36-hour fast.
Personal Experiences with Fasting
00:21:22 - 00:23:17
This section details personal experiences with different types of fasting. The speaker discusses a three-day fast, noting that low electrolytes exacerbated headaches. Electrolyte pills were used to mitigate this. A 24-hour dry fast is then described, where initial thirst was the main challenge, but this subsided. Interestingly, the speaker went musky fishing during this fast, noting the irony of being asked about their water bottle while abstaining from fluids. The experience was ultimately positive, despite the lack of water. While not eager to repeat the dry fast, the speaker plans to repeat the three-day fast, potentially modifying it by omitting coffee. The use of both regular and mineral water during fasting is also mentioned to combat boredom.
Dealing with Food Cravings and Leaky Gut
00:23:18 - 00:24:19
The speaker discusses their struggles with food cravings, particularly for carbs, and uses hot sauce as a distraction technique. They mention doing three-day fasts to curb these cravings. The conversation then shifts to leaky gut and the IBD-5 gene, its association with inflammatory bowel disease (IBD), and the debate surrounding its exact causal mechanism. The speaker shares personal experiences with sudden urges to use the bathroom, a hallmark symptom of IBD. Another speaker also mentions having gut issues.
Suggestions for Gut Health and Mushroom Supplements
00:24:22 - 00:25:17
The speaker suggests looking into interferons, another form of inflammation, as a possible connection to the gut issues. They mention an article with more information. The conversation then turns to mushroom supplements, with the speaker mentioning using Four Sigmatic coffee in the past but now looking for a clean and good mushroom supplement powder. Another speaker recommends using bulk supplement powders like reishi, cordyceps, and lion's mane.
Lion's Mane Mushroom Supplement Discussion
00:25:17 - 00:26:55
A discussion unfolds regarding lion's mane mushroom supplements. One participant mentions trying a liquid extract brand called Lifecycle, recommended due to reported sleep improvement. Another participant inquires about purchasing in bulk, leading to the mention of "Bulk Supplements" as a brand offering large quantities at lower cost. The conversation touches upon the taste variations between brands and the possibility of mixing lion's mane with other supplements like collagen powder. Concerns are raised about potential interactions between different supplements, highlighting the importance of spacing out consumption and conducting research to avoid counteracting effects. The participants agree that further research is needed to ensure optimal supplement timing and avoid negative interactions.
Supplement Timing and Cycling
00:26:55 - 00:28:07
The discussion centers on the importance of taking certain supplements with fats for optimal absorption, citing examples like vitamin D and tocotrienol. The speakers note that during strict fasting periods without fat intake, supplement absorption may be compromised, making it acceptable to skip supplements during a fast. The conversation then shifts to the concept of supplement cycling, mirroring the cyclical nature of seasonal eating. This is justified by the body's natural ability to store many vitamins, as evidenced by the high vitamin content in organs like the liver. The speakers suggest that cycling supplements mimics the dietary patterns of ancestors and is a viable approach for many vitamins.
Interleukin and IBS Risk
00:28:10 - 00:28:29
The conversation concludes by mentioning interleukin-1 beta (IL1B), an interleukin gene identified as a threefold risk factor for irritable bowel syndrome (IBS).
Gut Health and Gene Expression
00:28:29 - 00:29:52
Discussion focuses on the implications of specific gene variations. A gene related to inflammation is mentioned, with curcumin suggested as a potential aid. Another gene, DEFB1, shows a two-fold increased risk of leaky gut issues due to reduced production of beta-defensin, a peptide that combats bad gut bacteria. The advice given is to avoid processed foods and sugar, and consider probiotics, but only if dietary changes don't suffice. The conversation then shifts back to caffeine and serotonin.
Serotonin and Caffeine
00:29:53 - 00:30:12
The discussion returns to the topic of caffeine and its impact, specifically in relation to serotonin levels. The individual reports occasional feelings of overwhelm, despite not generally experiencing excessive anxiety. An example is provided of feeling overwhelmed while working from home.
Overwhelmed Feelings and Serotonin
00:30:13 - 00:30:57
The conversation begins with the individual describing feelings of being overwhelmed while juggling work, online courses, and household tasks. They question if these feelings might be linked to a specific gene. The other participant confirms a potential connection and suggests that poor sleep, impacting serotonin levels, could exacerbate anxiety. As a solution, they recommend using serotonin-boosting supplements strategically during periods of heightened stress.
Caffeine Metabolism and Gene Analysis
00:30:58 - 00:31:51
The discussion shifts to caffeine metabolism. The individual's rapid caffeine breakdown, with a four-hour half-life, is highlighted. Despite a "double-double bad gene" designation in the report, it's clarified that this isn't necessarily negative in this context. The discussion emphasizes that the report doesn't solely focus on negative gene markers; some genes, like those related to muscle fiber types (e.g., fast-twitch muscles for sprinting), are noted for their positive implications even if labeled as "plus-plus". The caffeine gene is presented as a similar example, where the "bad" designation doesn't automatically equate to a negative health outcome.
Diet and Genetic Predisposition to Type 2 Diabetes
00:31:53 - 00:33:48
The conversation shifts to dietary recommendations based on the individual's genetic profile. The speaker praises the individual's brain health markers. The discussion then turns to genes associated with type 2 diabetes, noting that many people possess these genes but that their impact depends heavily on carbohydrate intake. Zinc is highlighted as a crucial element, particularly due to the individual's genetic predisposition (plus-plus on the zinc transporter SLC 30A8). Red meat is suggested as an excellent zinc source, but other options are also considered. The individual's regular red meat consumption (at least four days a week) is noted. The question of zinc supplementation is raised, and the speaker suggests it might be beneficial, especially considering the current COVID-19 situation and zinc's role in combating viruses. The speaker mentions zinc carnosine as a preferred supplement.
Zinc Supplement Discussion
00:33:48 - 00:34:05
The conversation begins with a discussion about the side effects of different zinc supplements. The speaker notes that some forms can cause acid reflux and stomach discomfort. As an alternative, carnosine is suggested as a gentler option. Ultimately, the speaker advises choosing a zinc supplement based on personal tolerance and comfort level.
Adiponectin and Metformin Genes
00:34:06 - 00:35:27
The discussion shifts to genetic predispositions related to adiponectin and metformin. The speaker mentions that the patient's adiponectin gene is linked to intermittent fasting, which the patient is already practicing. The patient's metformin gene indicates a higher-than-average response to metformin, a prescription drug derived from a natural plant. Metformin's benefits, including increased lifespan in animal studies, are highlighted, along with the common side effect of diarrhea. The speaker shares their personal experience with metformin, describing their usage pattern, which involves cycling the drug and using it strategically when consuming high-carb meals. The speaker also notes that metformin lowers blood sugar and increases metabolism.
Blood Glucose Monitoring and Metformin
00:35:29 - 00:37:02
This segment discusses methods for monitoring blood glucose levels and the potential use of metformin. One participant mentions owning a finger-pricking glucose and ketone monitor but hasn't used it yet. The conversation clarifies that self-monitoring fasted blood glucose is easier and less stressful than doctor visits. The use of a Keto Mojo-like device is mentioned. The high cost of test strips is noted, but one participant still has unused strips. The discussion then shifts to the use of metformin to lower blood sugar levels above 90 mg/dL, even without a diabetes diagnosis. The difficulty of obtaining a metformin prescription without a diabetes diagnosis is highlighted, with a suggestion to frame the request by mentioning research on metformin's lifespan-extending effects.
Doctor's Visit Discussion
00:37:03 - 00:38:36
The conversation centers on a patient's discussion with their doctor regarding various health aspects. The patient expresses a good relationship with their GP, who is open to alternative approaches like different diets and natural remedies. The discussion then shifts to metformin, a drug gaining popularity for potential lifespan increase, but the doctor advises against it for individuals with poor responder genes, while noting the patient is a high responder. The final topic is skin health, specifically mentioning the filaggrin gene (FLG) which can cause seasonal, dry skin issues. The patient mentions their proactive approach to skincare with moisturizing lotions. The doctor offers further recommendations for skin issues if needed.
Skin Condition Discussion
00:38:45 - 00:40:06
A patient describes a recurring eczema-like condition on their right thigh, approximately three inches in diameter. The patient notes a history of scratching the area raw as a child and wonders if the condition is related to stem cell activity and a specific gene. The doctor suggests perilla seed oil as a topical treatment, noting its effectiveness for similar issues. The doctor also mentions studies showing histidine, an amino acid, can increase filagrin, a skin barrier protein, which may be deficient in the patient. The doctor recommends trying perilla seed oil topically first, and possibly supplementing with histidine if needed, due to its potential to improve skin barrier function.
Dietary Sensitivities and Genetic Predisposition
00:40:10 - 00:41:23
A discussion ensues regarding a previous spit test for food sensitivities, revealing a mild dairy reaction. While the test showed minimal reactions (mostly level 1), the speaker experienced phlegm in their throat after consuming dairy. The conversation clarifies that the absence of strong reactions on the test doesn't rule out a sensitivity; it simply indicates no genetic predisposition to dairy intolerance. The speaker's experience is attributed to epigenetics, meaning acquired sensitivities that can develop and potentially resolve over time, regardless of genetic factors. The conclusion is that while the genetic component is clear, a dairy sensitivity might still exist.
Vitamin and Hormone Detox
00:41:23 - 00:41:37
The conversation transitions to the "vitamin hormone detox" section, marked as a high priority ("plus plus"). The exact nature of this section and the following discussion is cut off at the end of the provided transcript.
Vitamin D Deficiency and CYP2R1 Gene
00:41:37 - 00:43:27
The conversation focuses on vitamin D deficiency, particularly relevant for individuals in Minnesota due to limited sunlight exposure. The importance of maintaining vitamin D levels above 50 nanograms per milliliter is emphasized. A previous blood test is recommended to check current levels. The discussion then turns to the CYP2R1 gene, a liver enzyme that converts D3 (colcalciferol) into its active form, calcitriol. A deficiency in this gene's function can impair the conversion process, leading to lower levels of active vitamin D, even with supplementation. The speaker notes that they previously took vitamin D supplements but recently stopped, highlighting the need to resume supplementation and monitor levels. The complex nomenclature of vitamin D forms (D3, colcalciferol, calcitriol) is also mentioned.
Vitamin D Levels and Testing
00:43:27 - 00:44:56
This segment focuses on optimizing Vitamin D levels, specifically the relationship between D3 and D4. The speaker explains that while supplementing D3 is common and sufficient for many, it's crucial to ensure adequate conversion to D4, as D4 is the more important form. The recommendation is to maintain higher-than-average, but still within the normal range, D3 levels to facilitate better conversion. A blood test is necessary to determine individual D3 levels. The speaker suggests a strategy of taking 5,000 IUs of Vitamin D and retesting after a month to fine-tune the dosage. The affordability and wide availability of D3 supplements are also mentioned.
Vitamin D and Joint Issues
00:44:57 - 00:45:48
A discussion about a person in Boston experiencing joint issues in winter, linked to low vitamin D levels. The individual waited for a doctor's prescription for vitamin D, despite the readily available over-the-counter option. The speakers discuss the cost-effectiveness of buying vitamin D supplements directly, and the preference for vitamin D supplements containing K2.
Genetic Predisposition to Pesticide/Chemical Sensitivity
00:45:49 - 00:46:22
A gene affecting the breakdown of oxidized fats and seed oils is mentioned. Approximately 20% of the population possesses this gene, with a high prevalence among podcast participants. The gene's association with sensitivity to pesticides and cleaning chemicals is highlighted, emphasizing the importance of avoiding seed oils like canola and soybean. The use of sesame oil for oil pulling is mentioned, but its consumption is distinguished from the discussion of seed oil avoidance.
Cooking Oils and Fat Consumption
00:46:22 - 00:47:05
The conversation shifts to the types of cooking oils and fats. The speakers discuss the negative effects of seed oils due to their proneness to oxidation. They express a preference for cooking with saturated fats like butter, MCT oil, and coconut oil, noting that butter is dairy and coconut is a fruit, while also mentioning olive oil and avocados as acceptable alternatives. The use of sesame oil is questioned, and the speakers conclude that avoiding its use in cooking is advisable.
Pesticide Breakdown and Sex Hormones
00:47:05 - 00:48:14
The discussion moves to organophosphate pesticides, explaining that they are broken down by the same gene that processes other toxins. The speakers acknowledge regional differences in pesticide exposure, particularly mentioning mosquito sprays in Florida. The conversation then turns to sex hormones, specifically highlighting sex hormone-binding globulin (SHBG) as a significant factor. SHBG is described as a "limo service" for sex hormones, transporting estrogen and testosterone through the bloodstream. The speakers explain that an overproduction of SHBG can be problematic.
Hormone Levels and Supplements
00:48:14 - 00:50:14
The conversation focuses on the impact of high SHBG (sex hormone-binding globulin) levels, where testosterone and estrogen get trapped and are not utilized by the body. Supplements like boron, zinc (obtained from meat), and Tongkat Ali are suggested to help free up these hormones. The speaker emphasizes the importance of checking SHBG levels alongside vitamin D, noting that while normal ranges for testosterone and vitamin D are often unreliable, the normal range for SHBG is more trustworthy. High SHBG, even within the normal range, is considered potentially problematic, especially in relation to unexplained weight gain. Tongkat Ali is recommended as a way to lower high SHBG. The conversation concludes with the speaker sharing a personal anecdote about a past medical issue involving endometriosis, a large mass removed from their lower area, and the subsequent removal of an ovary and fallopian tubes.
Menopause and Liver Enzyme Function
00:50:14 - 00:52:08
The conversation begins with the speaker discussing the impact of ovary removal surgery on her menstrual cycle and subsequent menopause. The weight gain experienced post-surgery is noted, followed by the onset of irregular cycles and eventual menopause a year later. The speaker questions whether this hormonal disruption might influence the discussion's topic. The conversation then shifts to the CYP1B1 gene, a liver enzyme involved in breaking down artificial estrogens. The speaker explains that a less efficient breakdown of these estrogens due to this gene can lead to conditions like gynecomastia in men. The speaker highlights the widespread exposure to artificial estrogens through various sources, including personal care products, plastics (BPAs and phthalates), sunscreens, and drinking water. The speaker emphasizes that individuals with the CYP1B1 gene variant are at increased risk due to their impaired ability to clear these chemicals, citing endometriosis as a well-established example supported by animal studies.
Sauna Use for Detoxification
00:52:09 - 00:53:58
This segment discusses the benefits of sauna use for detoxification, particularly in eliminating artificial estrogens like BPA and phthalates. A study is mentioned where individuals using saunas showed significantly higher levels of these chemicals in sweat patches compared to a control group, indicating that sweating effectively removes these toxins. The discussion notes that these chemicals weren't significantly excreted through urine, highlighting the sauna's unique role in detoxification. The speakers then discuss the choice between infrared and traditional saunas, with a preference expressed for a hot sauna, regardless of type. One speaker mentions considering Sauna Space as a brand.
Comparing EMF Solutions and Heat Therapy
00:53:59 - 00:55:22
The discussion centers on comparing two low-EMF solutions: one from Brian Hoyer and Kre-Tex solutions. The speaker notes that while both aim to generate heat, the Kre-Tex solution gets hotter and is larger. The speaker expresses uncertainty about which is superior, stating that the key benefit lies in achieving high heat. The conversation then shifts to the benefits of heat and infrared, highlighting that heat increases heat shock proteins, a benefit not solely provided by infrared. Infrared's ability to heat from the inside is also mentioned. The speaker concludes that both heat and infrared are important, but heat is prioritized due to the speaker's difficulty eliminating it, relating this to a gene linked to man boobs, suggesting that while not everyone with the gene has man boobs, virtually everyone with man boobs has the gene. This gene is considered problematic due to modern environmental exposures absent in ancestral populations.
Autoimmune Thyroid Risk Assessment
00:55:22 - 00:56:58
The conversation focuses on a patient's genetic predisposition to autoimmune thyroid issues, specifically mentioning a "thyroglobulin gene (TG)" with "plus pluses," indicating a tenfold increased risk. The discussion acknowledges other autoimmune risk factors and emphasizes the importance of a non-inflammatory diet, gut health, exercise, and consistent healthy habits to mitigate this risk. While acknowledging the elevated risk, the speaker suggests not excessive worry, but recommends iodine supplementation due to its role in thyroid hormone production. The patient's seafood consumption (once or twice weekly) is deemed likely sufficient for iodine intake. Finally, the patient mentions having their thyroid hormone levels (T4, T3, reverse T3, and TSH) checked twice.
Thyroid Concerns and Supplementation
00:56:58 - 00:58:53
The conversation centers on an individual's fluctuating thyroid levels, which remain within the normal range (0.5-4) despite repeated testing showing values of 0.55 and later 0.8. The individual expresses frustration and considers iodine supplementation due to a family history of thyroid issues and the understanding that the thyroglobulin gene plays a crucial role in iodine utilization for T4 and T3 production. The speaker suggests that fluctuating thyroid levels might be linked to intermittent inflammation caused by stress or lack of sleep, making it difficult to capture abnormal levels through standard blood tests, especially for T3. The speaker supports the idea of iodine supplementation as a precautionary measure given the individual's genetic predisposition and recommends tyrosine as another potentially helpful supplement.
Thyroid Health and Genetic Predisposition
00:58:54 - 01:00:34
This segment discusses the importance of tyrosine as a building block for thyroid hormones and the difficulty in diagnosing thyroid issues. The speaker mentions that some individuals take years to receive a diagnosis for conditions like Hashimoto's. Given the listener's genetic predisposition, the speaker suggests that addressing thyroid health might be more beneficial than focusing solely on sex hormones, noting that high SHBG levels can lower effective sex hormone levels. The speaker recommends exploring thyroid optimization or replacement therapy, such as Armour thyroid, but emphasizes the importance of working with a doctor to determine the correct dosage to avoid potential heart-related side effects like palpitations. The bio-identical nature of Armour thyroid, derived from pigs, is also clarified.
Thyroid Hormone Supplementation Discussion
01:00:35 - 01:02:07
The conversation centers around thyroid hormone supplementation. The speaker discusses the advantages of using porcine-derived thyroid hormone (Armor Thyroid) due to its full-spectrum T4 and T3 balance, unlike some artificial alternatives. The possibility of supplementing with iodine and tyrosine as a preliminary step before Armor Thyroid is raised. The speaker clarifies that they already possess iodine and explains the safe dosage, emphasizing that overdosing is difficult. Tyrosine supplementation is also discussed, noting its role as an amino acid and its benefit in boosting thyroid hormone production when taken with fats. Finally, the speaker questions the necessity of frequent lab tests given their past results consistently showed thyroid hormone levels within the normal range, although low within that range is still a concern.
Heart Rate and Fat Burning
01:02:07 - 01:02:27
Discussion on the relationship between heart rate and fat burning, particularly relevant for bodybuilders. Higher heart rate helps burn more fat, but exceeding a certain limit can be detrimental. Monitoring heart rate and other indicators like sweating helps determine the optimal range.
Thyroid Optimization and Aging
01:02:29 - 01:03:09
A speaker advocates for thyroid optimization as people age due to declining thyroid hormones. They suggest that even small doses of thyroid medication (like a quarter of a pill) can be beneficial and inexpensive, starting as early as 30s or 40s depending on genetics. Armor thyroid is mentioned as a specific medication option.
Treatment Plan and Further Investigation
01:03:10 - 01:03:47
A plan is outlined to start with tyrosine and iodine supplements, followed by blood work. The possibility that previous misdiagnosis of thyroid issues might be related to other underlying conditions, specifically a histamine intolerance risk linked to the AOC1 gene (amine oxidase copper containing one), is discussed.
Histamine, Copper, and Weight Gain
01:03:48 - 01:05:15
The discussion centers on the connection between histamine, copper, and weight gain. A copper-dependent gene's role in histamine clearance is highlighted, emphasizing copper's importance. High histamine levels are linked to inflammation, potentially causing disrupted sleep, allergies, and weight gain. While eliminating histamine from the diet is nearly impossible due to its widespread presence in foods, increasing copper intake is suggested as a solution. The conversation then shifts to practical ways of increasing copper intake, including copper supplements and consuming liver, with a personal anecdote about preparing and enjoying liver pate shared. The speaker mentions a preference for liver pate over other liver preparations.
Liver Pâté Recipe and Storage
01:05:22 - 01:06:40
The conversation begins with a discussion about a liver pâté recipe. One participant mentions their children's fondness for the pâté, and another expresses interest in obtaining the recipe. The possibility of using a Vitamix instead of a food processor is considered. The question of whether the type of liver (beef, goose, etc.) matters is raised and answered in the negative. One participant mentions having a large quantity of frozen livers and seeks advice on processing them. Another suggests processing all at once, sharing their own experience of deer hunting and their wife's method of preparing and freezing the livers in smaller portions for easier thawing and use over time. The conversation concludes with a brief, somewhat tangential discussion about histamine, associating it with nasal sprays, and questioning the accuracy of that association.
Histamine and Inflammation
01:06:40 - 01:07:30
The discussion begins with a question about histamine and inflammation. It's clarified that histamine is an amine, a building block for proteins, and an inflammatory molecule triggering the immune system. While beneficial for healing cuts by attracting immune cells to fight bacteria, excessive histamine leads to symptoms like runny noses, as the immune system attacks non-threatening substances.
Rare Genes and Dietary Implications
01:07:30 - 01:08:39
The conversation shifts to rare ABCG5 and ABCG8 genes. Less than 1% of the population possesses the "plus-plus" variant on both genes, a characteristic the speaker possesses. This genetic makeup suggests ancestors had a carnivorous diet, as the genes are linked to cytosterolemia and plant sensitivities. The speaker recommends trying a carnivore diet due to the gene's association with plant sterols, gallstones, and other plant-related health risks. The discussion explains that plants contain cytosterols, a type of cholesterol, which individuals with this gene variant may struggle to process efficiently.
Plant Cholesterol and Genetic Predisposition
01:08:39 - 01:10:26
This segment discusses the impact of plant cholesterol on individuals with rare genes (ABC, G5, and 8). The speakers explain that while most people can process plant cholesterol without issue, individuals with these genes have difficulty breaking it down, leading to potential health problems. The conversation highlights a case study of a person with two "plus plus" genes, emphasizing the need for caution with plant consumption. The effect of cooking versus raw consumption is addressed, concluding that it makes no difference. A blood test to check cytosterol levels is suggested as a way to quantify the issue. The speakers conclude that animal products, lacking cytosterols, might be a better dietary option for individuals with this genetic predisposition, and suggest a carnivore diet as an experiment to explore.
Supplement Considerations for a Rare Gene
01:10:26 - 01:12:49
This segment discusses the suitability of various supplements for an individual with a rare gene affecting cholesterol metabolism. The conversation begins by clarifying that purified supplements like resveratrol and vitamin C do not contain plant cholesterol. Tyrosine and other previously discussed supplements are deemed acceptable. However, mushrooms are identified as a potential concern due to their sterol content (specifically ergosterol in shiitake mushrooms). Further research is recommended to determine the impact of mushroom consumption on this specific genetic condition. The speaker notes that this gene is rare, and individuals with it often thrive on carnivore diets. The discussion concludes with a reflection on how dietary habits change over time, using bread and potato chips as examples of foods that were once staples but are now easily avoided due to changed preferences and dietary needs.
Carnivore Diet Discussion and COMT Gene
01:12:49 - 01:13:55
The conversation begins with a discussion on the benefits of adopting good habits, specifically mentioning the need to commit to a new habit for 90 days to determine its effectiveness, citing Sean Baker's advice. The discussion then shifts to the carnivore diet, noting its increasing popularity and the availability of resources like cookbooks by authors such as Maria Emmerich. The speakers share their experiences with the diet and its accessibility.
COMT Gene and Electrolyte Importance
01:13:55 - 01:14:26
The conversation transitions to the COMT gene and its impact on electrolyte balance. The speaker explains that individuals with a 2++ genotype for COMT may experience increased electrolyte excretion due to the gene's influence on catecholamine breakdown. This results in the kidneys receiving signals to excrete more water and electrolytes than necessary, highlighting the importance of electrolyte supplementation for those with this genotype.
Electrolyte Replacement During Fasting
01:14:27 - 01:15:48
This segment focuses on the importance of electrolyte replacement, particularly during intermittent fasting. The speakers discuss the necessity of replacing water and electrolytes lost during fasting to avoid headaches and other symptoms. The use of electrolyte pills is mentioned, with a specific concern raised about the typical high sodium and low potassium content in many commercially available options. One speaker emphasizes their efforts to find electrolyte pills without sugar and with a balanced potassium-sodium ratio. The conversation also touches upon a long list of supplements, including less common ones like phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, which are noted as being necessary for some individuals but not for most. The speaker clarifies that while a comprehensive list is available on their website, most people don't require these less common supplements.
Methionine, Amino Acids, and Ancestral Diet
01:15:48 - 01:16:23
The discussion begins with the MTRR gene's role in methionine production. A ++ genotype indicates reduced methionine production, necessitating dietary intake, particularly from sources like chicken and fish. This leads to a broader conversation about the body's need for various amino acids, electrolytes, and the implication of a high-meat ancestral diet. The speakers consider the potential benefits of incorporating more meat into their current diet.
Supplementing on a Carnivore Diet
01:16:23 - 01:17:28
The conversation shifts to the question of supplementation during a planned 90-day carnivore trial. The consensus is that supplementation remains an option, even with a carnivore diet, as none of the supplements pose a risk of exceeding safe levels. The discussion then focuses on specific vitamins. B12 supplementation is deemed unnecessary due to efficient gut absorption, further supporting the theory of a high-meat ancestral diet. However, due to the methylfolate gene (MTHFR), supplementation with 5-MTHF (methylfolate) is recommended.
Supplement Recommendations and Heavy Metal Testing
01:17:28 - 01:19:06
The conversation centers on supplement recommendations and the necessity of heavy metal testing. The speaker explains that methylfolate (5-MTHF) is a key supplement. The question of a heavy metals test arises, but the speaker advises against it due to the patient's genetic profile showing no significant concerns regarding heavy metal accumulation. The cost of the test ($150 without insurance) is mentioned. The speaker clarifies that the test might be considered if the patient experiences symptoms similar to those from 2010. Concerns about vitamin E are dismissed as the patient isn't using a multivitamin or a synthetic form of vitamin E. Finally, the discussion turns to fructose intolerance, indicated by a specific gene. The patient's preference for berries in their keto diet is noted, but the speaker advises caution with high-fructose fruits like melons.
Dietary Changes and Website Feedback
01:19:06 - 01:19:37
The conversation begins with a suggestion to try a new approach and reintroduce certain foods. A website link providing information on fructose levels in fruits is mentioned. The speaker reports positive changes in their diet, eliminating corn syrup and soda pop for years, opting for Zevia instead when consuming soda. The speaker confirms making dietary changes and the discussion moves to the next topic.
Joint Health Analysis: Inflammation, Insulin, Thyroid, and Blood Flow
01:19:38 - 01:21:00
The discussion shifts to the speaker's joint health, identifying four key factors: inflammation (interleukin genes like IL2RA and IL1B), high insulin levels triggering HLA genes, thyroid optimization (with iodine playing a crucial role), and the importance of blood flow through exercise to remove toxins. The speaker notes that high blood sugar and subsequently high insulin levels put joints at risk. The importance of maintaining good blood flow to the joints through exercise is emphasized. The discussion concludes with a mention of SLC-2A19 and its connection to sugar, indicating a continuation of the sugar discussion in the next section.
Gout and Fructose Intolerance
01:21:01 - 01:22:46
The discussion centers on the speaker's health concerns, particularly regarding gout and food sensitivities. High fructose consumption, from sources like fruits and soda, is linked to increased uric acid levels, leading to gout. The speaker mentions avoiding fructose and not experiencing gout. The conversation then shifts to other potential health issues, including a possible thyroid problem and hip/knee pain. The speaker reveals a past sensitivity to egg yolks, which caused knee inflammation when consuming multiple hard-boiled eggs daily. Muscle testing indicated this sensitivity, although it seems to have improved. The other speaker notes that egg white sensitivity is more common. The possibility of reintroducing egg yolks into a carnivore diet is considered, with the speaker indicating periodic consumption of egg yolks.
Dietary Changes and Health Issues
01:22:46 - 01:23:29
The speaker discusses a significant increase in hard-boiled egg consumption (2-6 per day) which coincided with the onset of health problems. They also mention a potential link to the ABCG5 gene and the possibility of additional dietary factors contributing to the issue. The conversation then shifts to bone health, with the speaker emphasizing the importance of bone broth and collagen, noting their own daily consumption of bone broth and suggesting that collagen intake might mitigate concerns.
Back Problems and Genetic Predisposition
01:23:31 - 01:24:28
The speaker shares a personal anecdote about back problems experienced in their early 30s, stemming from past sports injuries. A doctor diagnosed them with the L5 of an 80-year-old, attributing it to "bad genes." Despite this diagnosis, the speaker found relief through yoga and acupuncture, significantly improving their back condition. They conclude by wondering if this back issue might be related to the previously discussed health problems, questioning the role of genetics in both instances.
Genetic Predisposition and Pain Sensitivity
01:24:28 - 01:26:12
The discussion centers on the patient's genetic predisposition to low back issues, specifically related to the L5 vertebra. A positive finding is noted regarding good bone density, counteracting some risks. The patient also possesses a gene indicating low pain sensitivity, which is generally positive but carries the risk of undetected injuries. The patient confirms frequently experiencing this, often surprising doctors with their resilience to pain. The conversation shifts to the patient's nighttime bathroom trips, linked to their high water intake. It's suggested that adjusting the timing of water consumption, rather than the quantity, and incorporating more electrolytes might alleviate this. The presence of two CLMT genes, particularly relevant in men, is highlighted as a potential contributor to frequent nighttime urination.
Sleep Genes and Cognitive Performance
01:26:14 - 01:27:54
The discussion centers on the impact of a gene (WWC1) on sleep and memory recall. Poor sleep, potentially influenced by this gene, reduces memory recall by approximately 25%. While nicotine might offer some benefit, adequate sleep is emphasized as the key to optimal cognitive performance. The conversation then shifts to biohacking techniques involving methylene blue and nicotine, with mention of Ben Greenfield's work. However, the use of methylene blue is cautioned against due to its complex effects and potential risks if overdosed; low doses have opposite effects to high doses on mitochondria, involving redox reactions. The speakers advise against using methylene blue without expert guidance on dosage.
Blue Light Sensitivity and Eye Protection
01:27:55 - 01:28:58
Discussion on personal experiences with blue light sensitivity. Participants share their use of blue light blocking glasses, noting varying effectiveness depending on the brand and quality. Concerns are raised about the reliability of cheaper glasses, particularly those from online marketplaces like Amazon, highlighting the importance of verifying the actual blue light blocking capabilities.
Addressing Acid Reflux and Hiatal Hernia
01:28:58 - 01:29:38
A participant describes a past experience with painful symptoms initially attributed to acid reflux, later diagnosed as a hiatal hernia successfully treated by a chiropractor. The participant questions a potential link between histamine and the recurrence of these symptoms, noting ongoing efforts to track potential triggers and better understand the connection.
Throat Irritation and Supplement Discussion
01:29:39 - 01:31:17
A discussion ensues regarding throat irritation experienced after consuming a Spotted Cow beer. The speaker notes a raw and inflamed feeling in their upper throat, even after only drinking water. The possibility of this being linked to genes or histamine is explored, with a potential connection acknowledged but not definitively confirmed. The conversation then shifts to supplements for managing carb intake. Berberine is mentioned as a supplement to potentially help with blood sugar, but the speaker is advised that since they are highly responsive to metformin, prioritizing metformin is recommended due to its extensive research. Berberine is considered a viable option to explore alongside metformin, particularly if blood glucose levels exceed 90, but not a high priority given the effectiveness of metformin.
Discussion of Metformin and Alternative Approaches
01:31:18 - 01:32:41
Susan expresses concerns about the inconvenience of needing a prescription for metformin. The conversation then shifts to the Burberry diet, noted for not requiring a prescription. Susan thanks Dr. J for the provided PDF and notes she's made extensive notes. While intrigued by the carnivore diet, Susan expresses a need for further research before committing to such a significant lifestyle change. She emphasizes her desire for a healthy weight without excessive gym workouts, citing snoring as a weight-related concern. The high motivation for a 90-day trial is highlighted, and the possibility of working with Paul Saladino for consultation is mentioned.
Carnivore Diet Expert Recommendation and Return Shipping
01:32:45 - 01:33:19
Dr. J recommends consulting Paul Saladino, a carnivore diet expert in California, particularly for clients with the ABCD5 gene. Saladino has recently published a book on the subject and is a valuable resource for understanding the nuances of the carnivore diet. Many of Dr. J's clients, especially those with the ABCD5 gene, find his expertise beneficial.
Return Shipping Instructions
01:33:20 - 01:33:58
Following the discussion about Paul Saladino, the conversation shifts to the return shipping of a recorder. The original recorder was sent in a box, but a flat envelope was provided for return. Dr. J instructs to repackage the recorder securely in bubble wrap and tape it, then use the provided flat rate prepaid envelope for return shipping. The flat rate envelope ensures consistent pricing regardless of the package's size.
Meeting Conclusion and Closing Remarks
01:33:58 - 01:34:25
The meeting concluded with the speaker expressing hope that there would be no issues with the new system, acknowledging that it was still being refined. A participant expressed gratitude for the information shared, noting the amount of information presented, and requested access to the provided PDF for later review. The conversation ended with mutual thank yous and goodbyes.
DNA with Dr. Jay, Episode 07.
CARNIVORE MAN Justin (from Louisiana)
CARNIVORE MAN Justin (from Louisiana)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Podcast Details
00:00:00 - 00:01:11
The speaker introduces himself as a Mayo Clinic scientist with a DNA consulting company, AJ Consulting Company, and two YouTube channels: Anthony J. Cast (scientific information) and Anthony J. Family Cast (outdoor adventures). He mentions a recent podcast episode featuring Justin, a Louisiana farmer, discussing the carnivore diet. Audio processing was needed due to a fan in the background. The speaker promotes his DNA consulting services at ajconsultingcompany.com.
Technical Setup and Recording
00:01:16 - 00:02:27
The conversation begins with the host and Justin confirming the recording device's arrival and functionality. Justin mentions some initial difficulties with device initialization but ultimately confirms successful setup. They discuss the recording method (phone with recording device) and Justin encounters a minor issue with his earbuds and the connection type.
Initial Connection and Location Discussion
00:02:27 - 00:04:07
The call begins with technical adjustments regarding audio and video connection. The speakers confirm their connection and engage in brief pleasantries. One speaker mentions a previous conversation with the other's wife and recalls a recent trip to Mississippi and Covington, Louisiana. They discuss the proximity of their locations, with one speaker mentioning a visit to Top Velocity, a professional baseball training program in Covington, Louisiana, explaining their connection to the program through a friend who runs it and mentioning podcast recordings there.
Supplement Discussion
00:04:07 - 00:04:34
The conversation shifts to the listener's supplement regimen. The speaker inquires about the listener's intake of omega-3s (specifying whether they consume it as a pill or through food), grass-fed beef liver (pill or food), sulforaphane (broccoli or supplement), turmeric, and grape seed extract, noting that the listener uses supplements for both sulforaphane and turmeric.
Initial Genetic Overview and Discussion of Alzheimer's Risk
00:04:36 - 00:06:06
The discussion begins with a review of a supplement regimen including methylation, B-complex vitamins, Supergreen, psyllium husk fiber, vitamin C, and apple cider vinegar. The speaker then shifts to a review of the individual's genetic profile, noting exceptionally good brain gene results. The possibility of comparing the individual's genetic profile with their spouse's is mentioned, particularly regarding potential genetic risks for their children. The individual's low Alzheimer's risk is highlighted, with the exception of a common gene, CETP, which poses a risk only if triglycerides are very high. Given the individual's healthy lifestyle and weight (200 pounds), this risk is deemed low, but the speaker suggests checking triglyceride levels, aiming for a value below 125. The speaker offers to include specific numerical data in the report.
Cholesterol Management and Exercise
00:06:06 - 00:07:36
This segment discusses cholesterol levels and the impact of exercise and supplements. A speaker shares their experience of lowering their cholesterol from around 160 to 125 over two years. This was achieved primarily through regular omega-3 supplementation, following their doctor's advice to reduce sweets. The speaker's doctor considers 125 to be an optimized level, although most doctors are satisfied with levels below 150. The speaker also mentions doing CrossFit two or three times a week for about a year prior to their most recent blood test, suggesting that this exercise also contributed to the cholesterol reduction. The doctor's recommendation to increase cardio is noted, but the speaker's existing CrossFit routine is considered sufficient. The discussion concludes with the mention that doctors often prescribe omega-3 fatty acids for high triglycerides.
Triglyceride Levels and Cardiovascular Health
00:07:36 - 00:08:50
The discussion centers around triglyceride levels and their implications for health. The speakers discuss various levels, ranging from 150-160 to 500. A level of 500 is considered outrageous, while 300 is also noted as problematic, potentially linked to heart disease and genetic factors. The importance of cardio exercise to improve liver function and reduce triglycerides is highlighted. Optimal triglyceride levels are discussed, with a range of 50-80 mentioned as achievable for some individuals, while a level below 125 is deemed perfectly acceptable.
Genetic Predisposition and Health Outcomes
00:08:50 - 00:09:23
The conversation shifts to the impact of genetics on health. The speakers discuss the influence of family history on conditions like Alzheimer's disease, noting that a favorable genetic profile can mitigate risks. The individual's positive genetic makeup regarding caffeine metabolism is also mentioned, highlighting their ability to process caffeine efficiently. The discussion concludes by transitioning to the topic of diet, given the individual's positive brain gene.
Type 2 Diabetes Risk Assessment and Mitigation
00:09:24 - 00:10:56
The discussion centers on assessing and mitigating type 2 diabetes risk based on genetic predisposition and lifestyle. The speaker explains that nearly everyone carries type 2 diabetes risk genes, highlighting the HHEX gene as particularly relevant, with a "plus-plus" genotype indicating a threefold increased risk on a standard American diet. However, given the individual's ketogenic diet and exercise regimen, the risk is likely reduced. The importance of nitric oxide production in the pancreas, boosted by exercise, is emphasized. The speaker suggests checking fasted blood sugar levels; a target below 90 is mentioned. If levels are high, supplementing with L-citrulline and incorporating intermittent fasting protocols are proposed due to the presence of relevant genes. The conversation concludes by noting the existence of numerous genes associated with intermittent fasting.
Intermittent Fasting and Metformin Discussion
00:10:57 - 00:13:33
The conversation begins with a discussion of genes related to intermittent fasting, noting that many are common and beneficial. The metformin gene is highlighted; individuals with a positive response are better responders to metformin, a drug often associated with lifespan extension in animal studies, though human studies are lacking. While metformin offers potential lifespan and healthspan benefits by lowering blood sugar and boosting metabolism, it requires a prescription and convincing a doctor of its use for lifespan extension, even with good blood sugar levels. Ketogenic diets are presented as an alternative approach to achieve similar benefits. The discussion then shifts to potential side effects of metformin, with diarrhea mentioned as a common issue if too much is taken or if there's a poor genetic response. A personal anecdote is shared about a negative experience with metformin, resulting in severe illness. Finally, a case is mentioned where metformin was prescribed for a suspected diabetes issue, leading to debilitating side effects.
Negative Reaction to Medication and Gut Health
00:13:33 - 00:15:05
The conversation begins with a discussion of a negative reaction to medication. The patient reports passing glucose tests but experiencing adverse effects from medication due to thyroid and pituitary issues. The speaker suggests that gut bacteria issues could be a contributing factor, noting that the patient's gut was "pretty screwed up" at the time of the medication. The speaker reviews the patient's genetic report, revealing a lack of good response genes, further explaining the negative reaction. The possibility of restarting the medication at a lower dose (500 milligrams) is discussed, with the recommendation to take it before bed to minimize nausea. The speaker shares their personal experience of tolerating higher doses, emphasizing the importance of individual responses and the option to adjust dosage.
Intermittent Fasting Success
00:15:05 - 00:15:35
The conversation shifts to the patient's experience with intermittent fasting. The patient reports starting intermittent fasting five to six weeks prior and experiencing positive results, contrasting it with a history of regularly consuming meals. The patient expresses enthusiasm for the positive impact of intermittent fasting.
Intermittent Fasting and Coffee Consumption
00:15:35 - 00:17:07
The conversation centers on an individual's intermittent fasting practices and their impact on weight loss. The individual describes their routine of not eating after supper until lunch the next day, while consuming coffee with a small amount of cream (under 50 calories) in the morning. They've lost approximately 15 pounds. The other participant affirms this is positive and explains that even with coffee and cream, it's still considered intermittent fasting, albeit not the strictest form. Different levels of intermittent fasting are discussed, ranging from consuming carbs (least effective), protein, fats, coffee, and finally, only water (most effective). The individual's approach is deemed a "good level" of intermittent fasting. A suggestion is made to experiment with and without cream in coffee to observe any bodily response, though a significant difference is unlikely.
Coffee and MCT Oil Supplements
00:17:07 - 00:19:05
This segment discusses adding cinnamon and creamer to coffee to reduce bitterness. The conversation then shifts to MCT oil (medium-chain triglycerides) as a supplement. One speaker explains that MCTs have shorter fatty acid chains (8-12 carbons) compared to typical fats (16-18 carbons), making them easily burned for energy or eliminated through diarrhea. The discussion then turns to the appropriate dosage of C8 MCT chews (500mg). The speakers conclude that the optimal amount depends on individual factors like diet (ketogenic or otherwise). Taking MCT oil with every meal is suggested for those on a ketogenic diet, with the caveat that diarrhea indicates an excessive intake, allowing for dosage adjustment.
Keto Diet and Running Performance
00:19:05 - 00:21:13
This segment discusses the benefits of adding extra oils to a standard keto diet for runners, focusing on satiety and energy levels. One participant mentions struggling to get enough fats on a keto diet due to the difficulty of finding fatty foods without carbs, leading to the use of MCT oil. The conversation then shifts to the maximum daily carbohydrate intake for ketogenic runners, with a focus on avoiding energy crashes. The discussion highlights the need to adapt keto strategies based on individual goals and performance needs. The example of Zach Bitter, a 100-mile ultramarathon world record holder, is brought up. While he generally maintains a ketogenic diet, he strategically incorporates carbohydrates during long races to enhance performance, demonstrating that a strict keto approach may not be optimal for all endurance events.
Keto Diet Flexibility and Adaptation
00:21:13 - 00:22:08
The discussion begins with a question about the strictness of keto rules, particularly regarding eating a banana. It's clarified that while technically against strict keto guidelines, the rules are flexible and depend on individual goals, feelings, and hormonal responses. The speaker emphasizes that if someone feels good and achieves their goals, minor deviations aren't a major concern. However, it's acknowledged that adapting to keto can be a lengthy process, taking weeks or even a year for some, depending on prior experience with the diet. The body's ability to burn fat improves with repeated keto cycles.
Intermittent Fasting and Adiponectin
00:22:14 - 00:22:47
The conversation shifts to the relationship between heart disease, obesity, and adiponectin. Adiponectin is identified as a hormone crucial for fat burning, and its production is negatively impacted by certain genes. Intermittent fasting is presented as a simple and effective method to increase adiponectin levels, highlighting its role in mitigating the negative effects of these genes and promoting fat burning. The discussion concludes by summarizing the connection between intermittent fasting and several previously mentioned factors.
Heart Disease Risk Assessment and Family History
00:22:48 - 00:24:46
The discussion centers on the patient's genetic predisposition to heart disease. While the patient's genes related to heart disease show relatively low risk ("pretty darn good"), the presence of high triglycerides due to the LPL gene is noted. The conversation then shifts to the patient's family history, revealing that their grandfather died unexpectedly of a heart attack at 46, their father had a valve replacement due to calcification issues, and an uncle experienced a heart attack. Given this family history, the doctor recommends a calcium CT scan to assess coronary artery calcium. If the results are high, a follow-up consultation, potentially recorded as a free podcast, is offered. The doctor expresses surprise at the low genetic risk despite the family history, suggesting that the patient has "dodged some bullets."
Calcium CT Scans and Artery Plaque Formation
00:24:48 - 00:26:34
The discussion centers on the benefits of calcium CT scans, particularly as a baseline for individuals around age 40 to monitor artery health over time. The speakers explain that artery plaque formation begins with inflammation, damaging artery linings. The body repairs this damage with cholesterol and calcium, leading to plaque buildup. This process is described as a progression, starting with fatty streaks in arteries, which are now commonly found even in 12-year-old children due to poor diet. The speakers express concern about the early onset of artery damage in children, highlighting the long-term health implications.
Children's Nutrition and Healthy Eating Habits
00:26:35 - 00:27:46
The conversation centers on the challenges of children's nutrition, particularly the negative impact of processed foods and sugary drinks readily available in schools. Speakers discuss the difficulty of getting children to eat healthy food, with one speaker noting that many parents resort to giving their children processed junk food because it's the only thing they will eat. However, the speakers agree that if children are not given unhealthy options, they will eventually adapt and eat healthier foods. The importance of establishing healthy eating habits early in life is emphasized, as it becomes significantly more difficult to change these habits during the teenage years when children have more independence in their food choices.
Medical Consultation Offer
00:27:49 - 00:28:04
A speaker suggests checking a calcium CT scan and offers a free 15-20 minute consultation if needed. The speaker anticipates having helpful suggestions based on the scan results, but expresses low expectations of significant issues.
Leaky Gut and Heart Disease Gene Discussion
00:28:05 - 00:29:33
The discussion centers on the connection between specific genes (CDK gene, CDKAL1, and CDKN2A) and their impact on leaky gut and heart disease. The speaker explains that CDK relates to inflammation, increasing the risk of both gut and artery problems if not properly regulated. The genes mentioned help to regulate CDK, likened to controlling "hot water" levels in the body. A gene variation (plus/minus) indicates less efficient regulation of this inflammation. However, the speaker offers a solution: flavonoids found in colorful plants, such as those in grapeseed supplements, can help compensate for the gene's inefficiency by assisting in the regulation of CDK, effectively turning down the "hot water." The individual's history of not being a picky eater is noted as potentially beneficial in this context.
Gut Health and Supplement Discussion
00:29:33 - 00:31:10
The conversation centers on whether an individual ("you") needs supplements, given their generally healthy diet and few gut issues. The speaker notes that while the individual has a few genes associated with leaky gut, it's fewer than most people, indicating good gut health. Therefore, supplements are deemed unnecessary, unless there are specific issues. The speaker shares a personal anecdote about overdosing on a supplement, resulting in blood thinning and excessive bleeding from a minor injury, highlighting the importance of proper dosage and caution when using supplements.
Blood Thinning and Heart Disease
00:31:10 - 00:32:07
A speaker mentions their blood becoming too thin, a side effect they attribute to carelessness. The conversation then shifts to the role of flavonoids in heart disease, specifically mentioning a CDK (likely referring to cyclin-dependent kinase) connection. The speakers discuss the similarities between inflammation damaging gut lining and arteries. Ketogenic diet and intermittent fasting are mentioned as beneficial for gut health, with intermittent fasting potentially inducing ketosis even without a ketogenic diet.
Ketogenic Diet and Intermittent Fasting
00:32:07 - 00:32:54
The discussion continues on the benefits of ketogenic diet and intermittent fasting. One speaker explains their personal approach to keto, cycling on and off for six-week periods due to sleep disruption experienced with prolonged keto. Despite sleep issues, the speaker notes feeling amazing and experiencing enhanced brain function while on keto.
Keto Diet and Lifestyle Experiences
00:33:00 - 00:34:41
This segment focuses on personal experiences with the ketogenic diet. The speaker discusses their intermittent keto approach, typically doing six weeks of strict keto every six months or sometimes annually, depending on body weight and overall feeling. They mention the challenges of maintaining the diet long-term, specifically the difficulty of sustaining three hours of sleep nightly. The conversation then shifts to defining "excessive" keto, with the speaker noting that it's beneficial if sustainable, citing examples of people who have followed the diet for years, including keto podcasters and bodybuilders (both natural and those using steroids). The speaker specifically mentions Robert Sykes, a natural keto bodybuilder who owns Keto Savage and produces a product called the Keto Brick, which the speaker uses for lunch due to its convenient macro balance and ease of use in providing sufficient fat with minimal carbs.
Ketogenic Diets and Bodybuilding Success Stories
00:34:41 - 00:36:11
This segment discusses the success of two individuals, Robert Sykes and Danny Vega, in achieving significant muscle growth while maintaining a strict ketogenic diet. The speaker emphasizes that both men are natural bodybuilders, competing in competitions and consistently staying in ketosis without using steroids or other performance-enhancing substances. Their blood sugar levels are cited as examples: Robert Sykes's blood sugar was consistently around 50-55 mg/dL in the mornings, while the speaker's own was around 80-83 mg/dL. The speaker highlights the remarkable muscle growth achieved by both men despite their low blood sugar levels, suggesting that ketosis is a viable approach to bodybuilding. The speaker also mentions using Robert Sykes's DNA data on his podcast, confirming the absence of any performance-enhancing substances. The speaker concludes by noting the impressive results achieved by these individuals on a ketogenic diet.
Discussion of Intermittent Fasting and Leaky Gut
00:36:12 - 00:36:43
The discussion centers on the benefits of intermittent fasting, particularly its relevance to leaky gut. The speakers confirm the feasibility and long-term sustainability of intermittent fasting. A transition to the next section is proposed after confirming there are no further questions on this topic. The speakers also briefly comment on the good genes of one of the individuals involved.
Analysis of Vitamin, Hormone, and Detoxification Gene Reports
00:36:44 - 00:37:47
A question arises regarding discrepancies in DNA reports. A parent notes that their children's reports show plus-plus results for vitamin D, B12, vitamin E, heavy metals, pesticides, and estrogen, while these markers are absent from the parents' reports. The discussion clarifies that all reports were generated using selfDecode. The speakers then begin to explore the genetic inheritance patterns, specifically addressing the scenario where both parents have a plus-minus result for a particular gene.
Report Interpretation and Genetic Markers
00:37:47 - 00:39:36
This segment discusses the interpretation of genetic reports, specifically focusing on the significance of "plus-minus" markers. The speaker explains that not all plus-minus results are clinically significant; some are omitted from reports due to lack of substantial impact. However, certain plus-minus markers, like the FOXE1 gene (RS965513), indicate a higher risk of thyroid issues and are included. The speaker clarifies that while strong positive markers ("plus plus") in parents usually result in positive markers in children, plus-minus markers in parents may or may not manifest in children. The discussion also touches upon the variability in genetic results across different testing companies (23andMe, Ancestry, SelfDecode), highlighting the importance of considering this when interpreting results. Finally, the speaker acknowledges the commonality of questions regarding thyroid-related genetic markers and transitions to a more detailed discussion of this topic.
Thyroid Health and Gene Analysis
00:39:36 - 00:41:19
This segment focuses on analyzing a patient's genetic report, specifically looking for genes with substantial risks. The discussion highlights the potential impact of thyroid issues, even with minor genetic variations. The speaker suggests iodine supplementation as a preventative measure, especially for those who don't consume seafood regularly. The importance of monitoring thyroid hormones and considering thyroid replacement therapy if energy levels decline is emphasized. The conversation then shifts to the FOXV1 gene, discovered in Chernobyl accident victims, and its role in thyroid healing. The speaker explains that individuals with damaged thyroids who don't heal well typically possess a particular version of this gene, while those who heal successfully have a different version. The connection between this gene and autophagy is also mentioned.
Iodine Supplementation and Autophagy
00:41:21 - 00:42:59
The conversation centers around iodine supplementation and its role in autophagy ("cells taking out the trash, cells healing"). Intermittent fasting is mentioned as a method to increase autophagy. The speaker recommends iodine supplementation, suggesting seafood as a good source. They describe their personal method of taking iodine: a single drop from a dropper bottle in water, emphasizing that their brand is a microdose and that overdosing is unnecessary. The speaker notes that their iodine supplement contains 250 micrograms per drop (150% daily value) from kelp and that it doesn't need to be taken daily due to the body's storage capacity. This is contrasted with other supplements that also don't require daily intake. The possibility of side effects, such as heart palpitations, is briefly discussed, although it's noted as rare. The conversation concludes with a question about the type of iodine supplement used.
Iodine Supplement Dosage and Side Effects
00:43:01 - 00:44:23
A discussion ensues regarding iodine supplementation. One participant mentions obtaining a lower dose of iodine from a natural health practitioner, contrasting it with Lugol's solution, a high-dose iodine preparation used for radiation exposure. Concerns are raised about potential side effects, such as irregular heartbeat, due to the body's unfamiliarity with high iodine levels. The speaker suggests starting with a low dose, possibly diluting it in water, or trying a different form of iodine if side effects occur. The possibility of individual sensitivity to specific iodine forms is also mentioned. The conversation then transitions to the next topic, plant sterols.
Plant Sterols and Genetic Sensitivity
00:44:23 - 00:44:49
The discussion moves to plant sterols and a related gene, ABCG5. It's noted that less than 5% of individuals possess a gene variant that increases sensitivity to plant consumption. The implication is that while plant consumption is generally beneficial, those with this gene variant should moderate their intake to avoid potential negative effects.
Plant Cholesterol and Genetic Predisposition
00:44:49 - 00:46:06
This segment discusses the impact of a gene involved in breaking down plant cholesterol. The speaker explains that individuals with this gene may not process plant cholesterol efficiently, leading to a buildup in the body that mimics high human cholesterol. The speaker notes that doctors rarely test for cytosterol, the plant cholesterol, and that Mayo Clinic is one of the few places that offer this test. They advise against overconsumption of plants, especially for those with a positive genetic predisposition (plus-minus or plus-plus on the gene), suggesting a focus on animal products instead.
Dietary Recommendations and Diagnostic Testing
00:46:07 - 00:46:42
The speaker recommends a calcium CT scan to assess artery plaque as a way to monitor the effects of diet on cholesterol levels. The absence of artery plaque is considered a positive indicator. The discussion then shifts to the speaker's speculation about the family history of the listener, suggesting that their father or grandfather likely had a stronger genetic predisposition (plus-plus) to high plant cholesterol, explaining the listener's current genetic makeup.
High Cholesterol and Plant Sterols
00:46:42 - 00:48:31
This segment discusses the impact of high cholesterol, both human LDL cholesterol and plant sterols (cytosterols). The speaker explains that while high human LDL cholesterol can lead to serious health problems like arterial damage and inflammation due to oxidation, this is typically only a concern at extremely high levels. The speaker mentions familial hypercholesterolemia as an example of a genetic condition causing dangerously high cholesterol, where statins can be life-saving. However, the speaker criticizes the tendency to generalize this extreme case to advocate for widespread statin use, pointing out that plant sterol levels are rarely checked, and individuals with rare genetic predispositions might have dangerously high levels of plant cholesterol without knowing it. The speaker highlights the potential danger of high plant cholesterol levels in individuals with specific genetic vulnerabilities, emphasizing the need for more comprehensive testing beyond just human LDL cholesterol.
The Impact of Plant Cholesterol and a Rare Gene
00:48:31 - 00:50:09
This segment discusses the potential dangers of high plant cholesterol levels in individuals with a rare gene. The speaker explains that even if standard cholesterol tests show healthy LDL levels, consuming large quantities of plants can lead to dangerously high levels of plant cholesterol. This, in turn, can react with oxygen, damage arteries, and cause premature heart attacks. The speaker suggests a more cautious approach to plant consumption, recommending not to "pound" them, even suggesting complete elimination in extreme cases. The rarity of this gene makes it challenging to counter the common advice to eat plenty of vegetables. The conversation then shifts to another gene (MTRR, or methyltetrahydrofolate homocysteine methyltransferase reductase), which suggests ancestral meat-heavy diets. This gene is crucial in methionine production, an essential amino acid not readily produced by the body, highlighting the importance of consuming chicken or fish to obtain sufficient methionine. Supplementation is also mentioned as an alternative.
Supplement Optimization and Sleep Tracking
00:50:10 - 00:51:21
This segment focuses on optimizing B vitamin supplementation, specifically B9 (methylfolate) and B12. The discussion begins by noting that the individual's ancestors likely consumed a meat-heavy diet, influencing their current genetic predisposition. The conversation then shifts to B9, found in leafy greens, with the suggestion to take a methylfolate supplement instead of relying solely on dietary sources. The individual mentions already taking a methylation supplement containing B12, and questions whether to increase the dosage. The advice given is to not increase the dosage and potentially discontinue B12 supplementation due to their meat consumption and good B12 genes. The recommendation is to focus on 5-MTHF (5-methyltetrahydrofolate) due to its cost-effectiveness. Finally, tracking sleep quality using an oral ring is suggested as a way to assess the effectiveness of methylfolate supplementation, noting that improved sleep is a common benefit.
Supplement Recommendations and Experiences
00:51:21 - 00:52:52
The discussion centers on supplement recommendations, specifically 5MTHF and B12. The speakers discuss the importance of sleep tracking to notice the effects of these supplements, noting that some individuals experience immediate benefits while others don't, suggesting pre-existing deficiencies. The conversation then shifts to iodine, specifically Lugol's solution, which is described as a high dose often used in radiation poisoning. A participant shares a personal experience of significant hand and foot swelling after taking Lugol's solution, prompting a suggestion to switch to a lower-dose iodine supplement from the speaker's website due to the difficulty of accurately measuring and diluting the Lugol's solution.
Dosage and Body Reaction
00:52:53 - 00:54:07
The conversation discusses the individual's reaction to a high dose of a supplement, possibly around five or six pounds. The individual reports ingesting it by putting it in their mouth and drinking water. While this method is acceptable for many, the speaker suggests the body may not be tolerating the high dose. The suggestion is made to dilute the supplement significantly, even to a single drop in a large glass of water, or to simply switch to a different supplement due to its low cost. The discussion then shifts to the absence of multivitamin use, implying a reduced risk of issues related to tocopherol.
Vitamin E and Tocopherol
00:54:07 - 00:54:25
The conversation turns to vitamin E and its synthetic counterpart, tocopherol. The speakers acknowledge prior discussions on this topic, particularly its relevance to the individual's family history. A podcast by Ben Greenfield and Barry Tan on this subject is mentioned. Tocopherol is identified as potentially problematic, triggering interleukin-6 and causing inflammation. However, since the individual doesn't take a multivitamin, the risk is deemed low. The presence of tocopherol as a preservative in various foods and supplements is noted, with the question raised about whether trace amounts are a concern, particularly in DHA supplements. The conclusion is that unless chronic inflammation is experienced, it's likely not a significant worry.
Vitamin E and Genetic Considerations
00:54:26 - 00:56:06
This segment discusses the implications of a specific gene on vitamin E supplementation. The speakers advise against unnecessary supplementation, especially for individuals without significant symptoms like joint issues or brain fog. They highlight that vitamin E is often found in DHA and that supplementation is generally unnecessary unless specific health concerns exist. One speaker shares a personal experience with corneal erosion, an eye condition exacerbated by stress and poor diet. They mention that while vitamin E is often recommended for this condition, it can be problematic for individuals with the specific gene in question, potentially worsening symptoms unless a specific type of vitamin E, tocotrienols (from annanato, a fermented soy product), is used. The discussion concludes with a note about the phytoestrogen content in soybeans.
Fermentation and Estrogen in Soy Products
00:56:06 - 00:57:46
The discussion centers on the impact of fermentation on estrogen levels in soy products. Speakers note that true fermentation, using real microorganisms, significantly reduces estrogen content in soy, with a claim that 99% can be broken down. Examples of properly fermented soy products with low estrogen levels include natto, soy sauce, tempeh, and miso. A contrast is drawn between these and improperly fermented or unfermented soy products, which contain significantly higher levels of estrogen. One speaker mentions a Canadian study showing soy and flax had over 100,000 units of estrogen, while other plants were under 1,000. However, fermented soy products like soy sauce had only around 100 units, highlighting the importance of proper fermentation in reducing estrogen content. A speaker expresses previous concern about soy sauce consumption due to a book on estrogen, but now feels reassured by the discussion.
Keto Diet and Dietary Preferences
00:57:47 - 00:59:09
The conversation shifts to a discussion about ketogenic diets and dietary preferences, specifically concerning the inclusion of flaxseed or flour in keto bricks. One participant expresses a preference for minimal plant-based ingredients, while another notes the presence of cocoa butter as the main ingredient. The importance of considering the ABCG5 gene (carnivore gene) is highlighted, advising caution with plant consumption for individuals with this gene. The recommendation is to prioritize animal fats like egg yolks, lard, duck fat, and other animal fats, especially given the current abundance and low cost of pig lard from local farmers. The conversation concludes with a mention of raising grass-fed beef and pigs.
Discussion on Pig Diets and Health
00:59:09 - 01:00:31
The conversation begins with a discussion about a type of pig that can eat grass. One speaker expresses surprise at this fact, leading to a discussion about the challenges of finding clean, non-GMO feed for pigs. The speakers agree that even healthier feed is a significant improvement over conventional options. The conversation then shifts to a specific breed of pig, possibly called "Kune Kune," that is known for its grazing habits. One speaker offers to research this breed further.
Heavy Metal Gene and Nutritional Considerations
01:00:32 - 01:01:04
The discussion turns to the impact of heavy metals on a specific gene. The speakers mention that heavy metals can accumulate in mitochondria unless sufficient manganese is consumed. While manganese supplements are mentioned, the speakers suggest that obtaining manganese through foods like pecans might be a more practical approach. The conversation concludes with a note about the implications of this gene for overall health.
Plant Sterols and Dietary Choices
01:01:04 - 01:02:02
The discussion centers on the potential negative effects of plant sterols, particularly for individuals with arterial plaque. The speakers consider the possibility of manganese supplementation as a countermeasure, but emphasize the importance of first determining the presence of arterial plaque through a calcium CT scan. The conversation highlights a person's high plant consumption, including frequent consumption of sweet potatoes and green beans directly from the garden. The speakers acknowledge that a high plant intake might be beneficial for some, but recommend caution and further investigation due to potential issues with plant sterols. The potential negative effects of plant sterols in nuts are also briefly discussed.
The Carnivore Diet and its Effects
01:02:04 - 01:02:49
The conversation shifts to the carnivore diet, its varying effects on individuals, and the potential need for supplementation. The speakers note that while some individuals experience immediate and long-term health improvements and feel amazing while following the diet without supplementation, others find it unenjoyable and experience negative effects. The speakers suggest that even those who thrive on the carnivore diet might benefit from supplementation and genetic testing.
Genetic Predisposition and Dietary Response
01:02:49 - 01:04:32
This segment discusses the correlation between genetic predisposition and individual responses to the carnivore diet. The speakers note that individuals with specific genes respond strongly to the diet, with some exhibiting extreme positive effects. They criticize the current medical approach, highlighting how doctors often misinterpret symptoms and provide ineffective advice, such as recommending whole grains, which can be detrimental for those with specific genetic profiles. The importance of DNA testing as a standard of care is emphasized, although concerns about privacy and potential government misuse of genetic data are raised. One speaker describes using aliases and purchasing DNA kits for clients (special forces and pro athletes) to maintain anonymity and avoid detection. The discussion concludes with a reflection on the potential cost savings associated with preventative healthcare enabled by genetic testing, noting the significant decrease in the cost of DNA sequencing over time and the relevance of epigenetics.
Fructose and Fruit Consumption
01:04:32 - 01:06:00
The discussion centers on fructose consumption and its impact on the body. It's noted that the body stores fructose as fat more easily than burning it for fuel. The speakers advise avoiding high-fructose fruits, suggesting berries (blackberries, strawberries, raspberries) as lower-fructose alternatives. Bananas and pineapple are identified as high in fructose, while figs are cited as particularly problematic (17 grams per half cup versus pineapple's 2 grams). A website link offering further details on fruit fructose content is offered. The conversation touches upon the keto diet and its incompatibility with high fructose intake. A speaker mentions owning fig trees, prompting a humorous exchange about the potential conflict between enjoying figs and limiting fructose intake. The fructose content of watermelon is briefly questioned but the answer is cut off.
Discussion on Ancestral Diet and Genetics
01:06:03 - 01:06:21
The conversation begins with a comment about watermelons' high fructose content. The discussion then shifts to the speaker's ancestors' likely diet, speculating that their low fruit and vegetable consumption, focusing instead on meats and animal products, may explain the individual's current genetic predispositions.
Questions Regarding Metabolic Panels and Genetic Testing
01:06:23 - 01:07:12
A question is raised about the benefits of a comprehensive metabolic panel compared to a standard doctor's panel. The difficulty in finding labs that measure cytosterols is highlighted, with the speaker recommending seeking a functional doctor for more thorough metabolic panel testing. The conversation confirms that functional doctor panels are superior and provide more comprehensive information.
Analysis of Genetic Predisposition and Gym Recommendations
01:07:14 - 01:07:31
The conversation transitions to a discussion of the individual's genetics, specifically praising their "great genes." The discussion then briefly touches upon the SLC2A9 gene related to gout, before the chapter ends.
The Risks of Fructose and Gout
01:07:32 - 01:08:55
The discussion centers on the link between fructose consumption and gout. High fructose intake, particularly from sodas containing high fructose corn syrup, increases the risk of gout due to the fructose transporter's role in transporting uric acid into joints. Uric acid crystal formation in the joints causes the pain associated with gout. While a genetic predisposition exists, maintaining a generally healthy diet and avoiding excessive fructose intake can mitigate the risk, even with the presence of the risk gene. The irony is highlighted that doctors often advise gout sufferers to avoid meats, while the actual culprit is often excessive fructose consumption. A specific gene related to fructose metabolism is identified as a key factor, rather than genes previously associated with gout. The conversation briefly touches upon other HLA genes before the excerpt ends.
Genetic Predisposition to Rheumatoid Arthritis and the Role of Diet
01:09:00 - 01:11:10
The discussion centers on the patient's genetic predisposition to rheumatoid arthritis, specifically highlighting the high risk factors associated with HLA-DRB1 (four-fold increased risk) and HLA-DQA1 (five-fold increased risk) genes. The speaker connects these genetic markers to the patient's reported back pain. The patient's family history is briefly explored, revealing that their mother experiences joint issues, while their father remains unaffected despite shared lifestyle factors (living on a farm and engaging in physical labor). The conversation then shifts to the impact of diet, particularly the role of carbohydrates and insulin levels on the expression of these genes. High insulin levels, resulting from high blood sugar, are identified as significant risk factors for arthritis. The speaker suggests a ketogenic diet as a potential mitigating strategy for managing joint pain related to these genetic predispositions, emphasizing that its effectiveness in completely eliminating the risk is uncertain but likely significant. The patient inquires about the extent to which keto diets can mitigate the genetic risks, and the speaker confirms that while complete mitigation is not guaranteed, the impact is substantial.
The High Cost of High-Carb Diets and Knee Replacements
01:11:10 - 01:12:48
This segment discusses the link between high-carb diets and the increased risk of rheumatoid arthritis, leading to knee replacements. The speakers note that studies on arthritis risk are often based on average Americans with high-carb diets, resulting in skewed data. They argue that a ketogenic diet could significantly reduce the need for knee replacements, potentially saving healthcare systems substantial costs. However, they acknowledge that health insurance companies aren't incentivized to promote dietary changes due to the profitability of procedures like knee replacements. The difficulty of influencing individual dietary choices and the genetic variations affecting health outcomes are also mentioned. Finally, the speakers observe a correlation between unhealthy diets and a lack of personal motivation towards healthier lifestyles, using the example of observing people at events like 4th of July fireworks.
Arthritis Risk Gene Discussion
01:12:48 - 01:13:18
The discussion begins with a review of the PTPN22 gene, identified as an arthritis risk gene also linked to gut issues. The speaker notes that while a problematic gut can lead to joint inflammation, the individual's gut health is good, and this particular gene is not a major concern due to its plus-minus status. The speaker then asks if there are any questions about the genes discussed and confirms the overall assessment is positive.
Gut Health and Dietary Changes
01:13:19 - 01:14:28
The conversation shifts to the speaker's personal experience with gut health. Several years ago, they started a regimen of increased fiber intake following advice from a functional medicine doctor. However, with age, their regularity decreased despite the fiber supplements. Interestingly, since adopting a ketogenic diet and intermittent fasting, their regularity has improved, even without the fiber supplements. The speaker expresses surprise at this outcome and questions whether the type of fiber (plant-based) or the presence of plant sterols might be a factor in their improved gut health. The speaker doubts plant sterols are a significant issue due to the non-digestible nature of most fiber.
Dietary Fiber and its Effects on Bowel Health
01:14:29 - 01:16:37
The discussion centers on a 2012 study published in the World Journal of Gastroenterology regarding dietary fiber intake and its impact on bowel health. The speaker notes the common medical advice promoting fiber's benefits, but highlights a contradictory finding: the study showed a significant increase in symptoms like anal bleeding, constipation, bloating, straining during bowel movements, and abdominal pain among individuals with high fiber diets. Conversely, when fiber intake was reduced or eliminated, these symptoms disappeared entirely. The speaker emphasizes the counterintuitive nature of this finding, contrasting it with conventional medical wisdom. Specific numbers from the study are cited, illustrating the dramatic reduction in reported symptoms when participants eliminated fiber from their diets. The speaker expresses surprise at the study's results, highlighting its challenge to established medical advice.
Gut Bacteria and Dietary Balance
01:16:41 - 01:18:01
This segment discusses the impact of antibiotics and fiber on gut bacteria. The speakers note that antibiotics should not be used long-term, and fiber helps rebalance gut flora after antibiotic use. The discussion then shifts to the role of gut bacteria in breaking down fiber into short-chain fatty acids and medium-chain triglycerides (MCTs), similar to those found in MCT oil and produced by the body's processing of apple cider vinegar. One speaker mentions a personal experience of reduced bowel movements while on a ketogenic diet, describing it as a temporary adjustment. The conversation concludes by transitioning to the next topic: sleep.
Sleep Quality and Genetics Discussion
01:18:17 - 01:19:50
The discussion centers on Justin's sleep quality, influenced by physical work, outdoor lifestyle, and geographical location (south, avoiding harsh winters). The WWC1 gene is mentioned, highlighting its variable prevalence across different populations and its potential impact on sleep. The speaker notes that poor sleep significantly impacts cognitive function and speech clarity. While Justin's sleep genes are deemed excellent, the importance of sufficient sleep (7-8 hours) is emphasized. Supplements are discouraged if sleep is already good. The conversation concludes with a summary of Justin's sleep patterns and a general assessment of his sleep genetics as "great," comparable to professional athletes.
Overall Sleep Genetics Assessment
01:19:50 - 01:20:15
Justin expresses satisfaction with the discussion, and the speaker ranks his sleep genetics favorably, comparing them to those of a professional athlete discussed in a previous podcast.
Discussion of David Arzma and Genetic Comparisons
01:20:15 - 01:21:08
The conversation begins with a discussion of David Arzma, a professional pitcher who played for the Yankees and Red Sox, among other teams. The speaker notes Arzma's success despite potentially having less advantageous genes compared to the podcast guest. The speaker then jokingly suggests the guest should have been a pitcher. The speaker mentions that Arzma's podcast episode was fun and encourages listeners to check it out. The conversation shifts to a comparison with another individual, Justin Norton, whose DNA file the speaker received and plans to feature on a future podcast episode. The speaker acknowledges the audio quality difference between the two recordings.
Podcast Conclusion and Thanks
01:21:09 - 01:21:31
The speaker expresses gratitude to the guest for participating in the podcast, highlighting the enjoyment and potential benefits for listeners. The guest reciprocates the appreciation. The guest mentions that this is their first podcast appearance and expresses excitement about sharing it with friends and family. Finally, the speaker thanks Tessie for attending.
Meeting Closing
01:21:31 - 01:21:34
The meeting concluded with pleasantries exchanged between participants, including expressions of gratitude and farewells.
00:00:00 - 00:01:11
The speaker introduces himself as a Mayo Clinic scientist with a DNA consulting company, AJ Consulting Company, and two YouTube channels: Anthony J. Cast (scientific information) and Anthony J. Family Cast (outdoor adventures). He mentions a recent podcast episode featuring Justin, a Louisiana farmer, discussing the carnivore diet. Audio processing was needed due to a fan in the background. The speaker promotes his DNA consulting services at ajconsultingcompany.com.
Technical Setup and Recording
00:01:16 - 00:02:27
The conversation begins with the host and Justin confirming the recording device's arrival and functionality. Justin mentions some initial difficulties with device initialization but ultimately confirms successful setup. They discuss the recording method (phone with recording device) and Justin encounters a minor issue with his earbuds and the connection type.
Initial Connection and Location Discussion
00:02:27 - 00:04:07
The call begins with technical adjustments regarding audio and video connection. The speakers confirm their connection and engage in brief pleasantries. One speaker mentions a previous conversation with the other's wife and recalls a recent trip to Mississippi and Covington, Louisiana. They discuss the proximity of their locations, with one speaker mentioning a visit to Top Velocity, a professional baseball training program in Covington, Louisiana, explaining their connection to the program through a friend who runs it and mentioning podcast recordings there.
Supplement Discussion
00:04:07 - 00:04:34
The conversation shifts to the listener's supplement regimen. The speaker inquires about the listener's intake of omega-3s (specifying whether they consume it as a pill or through food), grass-fed beef liver (pill or food), sulforaphane (broccoli or supplement), turmeric, and grape seed extract, noting that the listener uses supplements for both sulforaphane and turmeric.
Initial Genetic Overview and Discussion of Alzheimer's Risk
00:04:36 - 00:06:06
The discussion begins with a review of a supplement regimen including methylation, B-complex vitamins, Supergreen, psyllium husk fiber, vitamin C, and apple cider vinegar. The speaker then shifts to a review of the individual's genetic profile, noting exceptionally good brain gene results. The possibility of comparing the individual's genetic profile with their spouse's is mentioned, particularly regarding potential genetic risks for their children. The individual's low Alzheimer's risk is highlighted, with the exception of a common gene, CETP, which poses a risk only if triglycerides are very high. Given the individual's healthy lifestyle and weight (200 pounds), this risk is deemed low, but the speaker suggests checking triglyceride levels, aiming for a value below 125. The speaker offers to include specific numerical data in the report.
Cholesterol Management and Exercise
00:06:06 - 00:07:36
This segment discusses cholesterol levels and the impact of exercise and supplements. A speaker shares their experience of lowering their cholesterol from around 160 to 125 over two years. This was achieved primarily through regular omega-3 supplementation, following their doctor's advice to reduce sweets. The speaker's doctor considers 125 to be an optimized level, although most doctors are satisfied with levels below 150. The speaker also mentions doing CrossFit two or three times a week for about a year prior to their most recent blood test, suggesting that this exercise also contributed to the cholesterol reduction. The doctor's recommendation to increase cardio is noted, but the speaker's existing CrossFit routine is considered sufficient. The discussion concludes with the mention that doctors often prescribe omega-3 fatty acids for high triglycerides.
Triglyceride Levels and Cardiovascular Health
00:07:36 - 00:08:50
The discussion centers around triglyceride levels and their implications for health. The speakers discuss various levels, ranging from 150-160 to 500. A level of 500 is considered outrageous, while 300 is also noted as problematic, potentially linked to heart disease and genetic factors. The importance of cardio exercise to improve liver function and reduce triglycerides is highlighted. Optimal triglyceride levels are discussed, with a range of 50-80 mentioned as achievable for some individuals, while a level below 125 is deemed perfectly acceptable.
Genetic Predisposition and Health Outcomes
00:08:50 - 00:09:23
The conversation shifts to the impact of genetics on health. The speakers discuss the influence of family history on conditions like Alzheimer's disease, noting that a favorable genetic profile can mitigate risks. The individual's positive genetic makeup regarding caffeine metabolism is also mentioned, highlighting their ability to process caffeine efficiently. The discussion concludes by transitioning to the topic of diet, given the individual's positive brain gene.
Type 2 Diabetes Risk Assessment and Mitigation
00:09:24 - 00:10:56
The discussion centers on assessing and mitigating type 2 diabetes risk based on genetic predisposition and lifestyle. The speaker explains that nearly everyone carries type 2 diabetes risk genes, highlighting the HHEX gene as particularly relevant, with a "plus-plus" genotype indicating a threefold increased risk on a standard American diet. However, given the individual's ketogenic diet and exercise regimen, the risk is likely reduced. The importance of nitric oxide production in the pancreas, boosted by exercise, is emphasized. The speaker suggests checking fasted blood sugar levels; a target below 90 is mentioned. If levels are high, supplementing with L-citrulline and incorporating intermittent fasting protocols are proposed due to the presence of relevant genes. The conversation concludes by noting the existence of numerous genes associated with intermittent fasting.
Intermittent Fasting and Metformin Discussion
00:10:57 - 00:13:33
The conversation begins with a discussion of genes related to intermittent fasting, noting that many are common and beneficial. The metformin gene is highlighted; individuals with a positive response are better responders to metformin, a drug often associated with lifespan extension in animal studies, though human studies are lacking. While metformin offers potential lifespan and healthspan benefits by lowering blood sugar and boosting metabolism, it requires a prescription and convincing a doctor of its use for lifespan extension, even with good blood sugar levels. Ketogenic diets are presented as an alternative approach to achieve similar benefits. The discussion then shifts to potential side effects of metformin, with diarrhea mentioned as a common issue if too much is taken or if there's a poor genetic response. A personal anecdote is shared about a negative experience with metformin, resulting in severe illness. Finally, a case is mentioned where metformin was prescribed for a suspected diabetes issue, leading to debilitating side effects.
Negative Reaction to Medication and Gut Health
00:13:33 - 00:15:05
The conversation begins with a discussion of a negative reaction to medication. The patient reports passing glucose tests but experiencing adverse effects from medication due to thyroid and pituitary issues. The speaker suggests that gut bacteria issues could be a contributing factor, noting that the patient's gut was "pretty screwed up" at the time of the medication. The speaker reviews the patient's genetic report, revealing a lack of good response genes, further explaining the negative reaction. The possibility of restarting the medication at a lower dose (500 milligrams) is discussed, with the recommendation to take it before bed to minimize nausea. The speaker shares their personal experience of tolerating higher doses, emphasizing the importance of individual responses and the option to adjust dosage.
Intermittent Fasting Success
00:15:05 - 00:15:35
The conversation shifts to the patient's experience with intermittent fasting. The patient reports starting intermittent fasting five to six weeks prior and experiencing positive results, contrasting it with a history of regularly consuming meals. The patient expresses enthusiasm for the positive impact of intermittent fasting.
Intermittent Fasting and Coffee Consumption
00:15:35 - 00:17:07
The conversation centers on an individual's intermittent fasting practices and their impact on weight loss. The individual describes their routine of not eating after supper until lunch the next day, while consuming coffee with a small amount of cream (under 50 calories) in the morning. They've lost approximately 15 pounds. The other participant affirms this is positive and explains that even with coffee and cream, it's still considered intermittent fasting, albeit not the strictest form. Different levels of intermittent fasting are discussed, ranging from consuming carbs (least effective), protein, fats, coffee, and finally, only water (most effective). The individual's approach is deemed a "good level" of intermittent fasting. A suggestion is made to experiment with and without cream in coffee to observe any bodily response, though a significant difference is unlikely.
Coffee and MCT Oil Supplements
00:17:07 - 00:19:05
This segment discusses adding cinnamon and creamer to coffee to reduce bitterness. The conversation then shifts to MCT oil (medium-chain triglycerides) as a supplement. One speaker explains that MCTs have shorter fatty acid chains (8-12 carbons) compared to typical fats (16-18 carbons), making them easily burned for energy or eliminated through diarrhea. The discussion then turns to the appropriate dosage of C8 MCT chews (500mg). The speakers conclude that the optimal amount depends on individual factors like diet (ketogenic or otherwise). Taking MCT oil with every meal is suggested for those on a ketogenic diet, with the caveat that diarrhea indicates an excessive intake, allowing for dosage adjustment.
Keto Diet and Running Performance
00:19:05 - 00:21:13
This segment discusses the benefits of adding extra oils to a standard keto diet for runners, focusing on satiety and energy levels. One participant mentions struggling to get enough fats on a keto diet due to the difficulty of finding fatty foods without carbs, leading to the use of MCT oil. The conversation then shifts to the maximum daily carbohydrate intake for ketogenic runners, with a focus on avoiding energy crashes. The discussion highlights the need to adapt keto strategies based on individual goals and performance needs. The example of Zach Bitter, a 100-mile ultramarathon world record holder, is brought up. While he generally maintains a ketogenic diet, he strategically incorporates carbohydrates during long races to enhance performance, demonstrating that a strict keto approach may not be optimal for all endurance events.
Keto Diet Flexibility and Adaptation
00:21:13 - 00:22:08
The discussion begins with a question about the strictness of keto rules, particularly regarding eating a banana. It's clarified that while technically against strict keto guidelines, the rules are flexible and depend on individual goals, feelings, and hormonal responses. The speaker emphasizes that if someone feels good and achieves their goals, minor deviations aren't a major concern. However, it's acknowledged that adapting to keto can be a lengthy process, taking weeks or even a year for some, depending on prior experience with the diet. The body's ability to burn fat improves with repeated keto cycles.
Intermittent Fasting and Adiponectin
00:22:14 - 00:22:47
The conversation shifts to the relationship between heart disease, obesity, and adiponectin. Adiponectin is identified as a hormone crucial for fat burning, and its production is negatively impacted by certain genes. Intermittent fasting is presented as a simple and effective method to increase adiponectin levels, highlighting its role in mitigating the negative effects of these genes and promoting fat burning. The discussion concludes by summarizing the connection between intermittent fasting and several previously mentioned factors.
Heart Disease Risk Assessment and Family History
00:22:48 - 00:24:46
The discussion centers on the patient's genetic predisposition to heart disease. While the patient's genes related to heart disease show relatively low risk ("pretty darn good"), the presence of high triglycerides due to the LPL gene is noted. The conversation then shifts to the patient's family history, revealing that their grandfather died unexpectedly of a heart attack at 46, their father had a valve replacement due to calcification issues, and an uncle experienced a heart attack. Given this family history, the doctor recommends a calcium CT scan to assess coronary artery calcium. If the results are high, a follow-up consultation, potentially recorded as a free podcast, is offered. The doctor expresses surprise at the low genetic risk despite the family history, suggesting that the patient has "dodged some bullets."
Calcium CT Scans and Artery Plaque Formation
00:24:48 - 00:26:34
The discussion centers on the benefits of calcium CT scans, particularly as a baseline for individuals around age 40 to monitor artery health over time. The speakers explain that artery plaque formation begins with inflammation, damaging artery linings. The body repairs this damage with cholesterol and calcium, leading to plaque buildup. This process is described as a progression, starting with fatty streaks in arteries, which are now commonly found even in 12-year-old children due to poor diet. The speakers express concern about the early onset of artery damage in children, highlighting the long-term health implications.
Children's Nutrition and Healthy Eating Habits
00:26:35 - 00:27:46
The conversation centers on the challenges of children's nutrition, particularly the negative impact of processed foods and sugary drinks readily available in schools. Speakers discuss the difficulty of getting children to eat healthy food, with one speaker noting that many parents resort to giving their children processed junk food because it's the only thing they will eat. However, the speakers agree that if children are not given unhealthy options, they will eventually adapt and eat healthier foods. The importance of establishing healthy eating habits early in life is emphasized, as it becomes significantly more difficult to change these habits during the teenage years when children have more independence in their food choices.
Medical Consultation Offer
00:27:49 - 00:28:04
A speaker suggests checking a calcium CT scan and offers a free 15-20 minute consultation if needed. The speaker anticipates having helpful suggestions based on the scan results, but expresses low expectations of significant issues.
Leaky Gut and Heart Disease Gene Discussion
00:28:05 - 00:29:33
The discussion centers on the connection between specific genes (CDK gene, CDKAL1, and CDKN2A) and their impact on leaky gut and heart disease. The speaker explains that CDK relates to inflammation, increasing the risk of both gut and artery problems if not properly regulated. The genes mentioned help to regulate CDK, likened to controlling "hot water" levels in the body. A gene variation (plus/minus) indicates less efficient regulation of this inflammation. However, the speaker offers a solution: flavonoids found in colorful plants, such as those in grapeseed supplements, can help compensate for the gene's inefficiency by assisting in the regulation of CDK, effectively turning down the "hot water." The individual's history of not being a picky eater is noted as potentially beneficial in this context.
Gut Health and Supplement Discussion
00:29:33 - 00:31:10
The conversation centers on whether an individual ("you") needs supplements, given their generally healthy diet and few gut issues. The speaker notes that while the individual has a few genes associated with leaky gut, it's fewer than most people, indicating good gut health. Therefore, supplements are deemed unnecessary, unless there are specific issues. The speaker shares a personal anecdote about overdosing on a supplement, resulting in blood thinning and excessive bleeding from a minor injury, highlighting the importance of proper dosage and caution when using supplements.
Blood Thinning and Heart Disease
00:31:10 - 00:32:07
A speaker mentions their blood becoming too thin, a side effect they attribute to carelessness. The conversation then shifts to the role of flavonoids in heart disease, specifically mentioning a CDK (likely referring to cyclin-dependent kinase) connection. The speakers discuss the similarities between inflammation damaging gut lining and arteries. Ketogenic diet and intermittent fasting are mentioned as beneficial for gut health, with intermittent fasting potentially inducing ketosis even without a ketogenic diet.
Ketogenic Diet and Intermittent Fasting
00:32:07 - 00:32:54
The discussion continues on the benefits of ketogenic diet and intermittent fasting. One speaker explains their personal approach to keto, cycling on and off for six-week periods due to sleep disruption experienced with prolonged keto. Despite sleep issues, the speaker notes feeling amazing and experiencing enhanced brain function while on keto.
Keto Diet and Lifestyle Experiences
00:33:00 - 00:34:41
This segment focuses on personal experiences with the ketogenic diet. The speaker discusses their intermittent keto approach, typically doing six weeks of strict keto every six months or sometimes annually, depending on body weight and overall feeling. They mention the challenges of maintaining the diet long-term, specifically the difficulty of sustaining three hours of sleep nightly. The conversation then shifts to defining "excessive" keto, with the speaker noting that it's beneficial if sustainable, citing examples of people who have followed the diet for years, including keto podcasters and bodybuilders (both natural and those using steroids). The speaker specifically mentions Robert Sykes, a natural keto bodybuilder who owns Keto Savage and produces a product called the Keto Brick, which the speaker uses for lunch due to its convenient macro balance and ease of use in providing sufficient fat with minimal carbs.
Ketogenic Diets and Bodybuilding Success Stories
00:34:41 - 00:36:11
This segment discusses the success of two individuals, Robert Sykes and Danny Vega, in achieving significant muscle growth while maintaining a strict ketogenic diet. The speaker emphasizes that both men are natural bodybuilders, competing in competitions and consistently staying in ketosis without using steroids or other performance-enhancing substances. Their blood sugar levels are cited as examples: Robert Sykes's blood sugar was consistently around 50-55 mg/dL in the mornings, while the speaker's own was around 80-83 mg/dL. The speaker highlights the remarkable muscle growth achieved by both men despite their low blood sugar levels, suggesting that ketosis is a viable approach to bodybuilding. The speaker also mentions using Robert Sykes's DNA data on his podcast, confirming the absence of any performance-enhancing substances. The speaker concludes by noting the impressive results achieved by these individuals on a ketogenic diet.
Discussion of Intermittent Fasting and Leaky Gut
00:36:12 - 00:36:43
The discussion centers on the benefits of intermittent fasting, particularly its relevance to leaky gut. The speakers confirm the feasibility and long-term sustainability of intermittent fasting. A transition to the next section is proposed after confirming there are no further questions on this topic. The speakers also briefly comment on the good genes of one of the individuals involved.
Analysis of Vitamin, Hormone, and Detoxification Gene Reports
00:36:44 - 00:37:47
A question arises regarding discrepancies in DNA reports. A parent notes that their children's reports show plus-plus results for vitamin D, B12, vitamin E, heavy metals, pesticides, and estrogen, while these markers are absent from the parents' reports. The discussion clarifies that all reports were generated using selfDecode. The speakers then begin to explore the genetic inheritance patterns, specifically addressing the scenario where both parents have a plus-minus result for a particular gene.
Report Interpretation and Genetic Markers
00:37:47 - 00:39:36
This segment discusses the interpretation of genetic reports, specifically focusing on the significance of "plus-minus" markers. The speaker explains that not all plus-minus results are clinically significant; some are omitted from reports due to lack of substantial impact. However, certain plus-minus markers, like the FOXE1 gene (RS965513), indicate a higher risk of thyroid issues and are included. The speaker clarifies that while strong positive markers ("plus plus") in parents usually result in positive markers in children, plus-minus markers in parents may or may not manifest in children. The discussion also touches upon the variability in genetic results across different testing companies (23andMe, Ancestry, SelfDecode), highlighting the importance of considering this when interpreting results. Finally, the speaker acknowledges the commonality of questions regarding thyroid-related genetic markers and transitions to a more detailed discussion of this topic.
Thyroid Health and Gene Analysis
00:39:36 - 00:41:19
This segment focuses on analyzing a patient's genetic report, specifically looking for genes with substantial risks. The discussion highlights the potential impact of thyroid issues, even with minor genetic variations. The speaker suggests iodine supplementation as a preventative measure, especially for those who don't consume seafood regularly. The importance of monitoring thyroid hormones and considering thyroid replacement therapy if energy levels decline is emphasized. The conversation then shifts to the FOXV1 gene, discovered in Chernobyl accident victims, and its role in thyroid healing. The speaker explains that individuals with damaged thyroids who don't heal well typically possess a particular version of this gene, while those who heal successfully have a different version. The connection between this gene and autophagy is also mentioned.
Iodine Supplementation and Autophagy
00:41:21 - 00:42:59
The conversation centers around iodine supplementation and its role in autophagy ("cells taking out the trash, cells healing"). Intermittent fasting is mentioned as a method to increase autophagy. The speaker recommends iodine supplementation, suggesting seafood as a good source. They describe their personal method of taking iodine: a single drop from a dropper bottle in water, emphasizing that their brand is a microdose and that overdosing is unnecessary. The speaker notes that their iodine supplement contains 250 micrograms per drop (150% daily value) from kelp and that it doesn't need to be taken daily due to the body's storage capacity. This is contrasted with other supplements that also don't require daily intake. The possibility of side effects, such as heart palpitations, is briefly discussed, although it's noted as rare. The conversation concludes with a question about the type of iodine supplement used.
Iodine Supplement Dosage and Side Effects
00:43:01 - 00:44:23
A discussion ensues regarding iodine supplementation. One participant mentions obtaining a lower dose of iodine from a natural health practitioner, contrasting it with Lugol's solution, a high-dose iodine preparation used for radiation exposure. Concerns are raised about potential side effects, such as irregular heartbeat, due to the body's unfamiliarity with high iodine levels. The speaker suggests starting with a low dose, possibly diluting it in water, or trying a different form of iodine if side effects occur. The possibility of individual sensitivity to specific iodine forms is also mentioned. The conversation then transitions to the next topic, plant sterols.
Plant Sterols and Genetic Sensitivity
00:44:23 - 00:44:49
The discussion moves to plant sterols and a related gene, ABCG5. It's noted that less than 5% of individuals possess a gene variant that increases sensitivity to plant consumption. The implication is that while plant consumption is generally beneficial, those with this gene variant should moderate their intake to avoid potential negative effects.
Plant Cholesterol and Genetic Predisposition
00:44:49 - 00:46:06
This segment discusses the impact of a gene involved in breaking down plant cholesterol. The speaker explains that individuals with this gene may not process plant cholesterol efficiently, leading to a buildup in the body that mimics high human cholesterol. The speaker notes that doctors rarely test for cytosterol, the plant cholesterol, and that Mayo Clinic is one of the few places that offer this test. They advise against overconsumption of plants, especially for those with a positive genetic predisposition (plus-minus or plus-plus on the gene), suggesting a focus on animal products instead.
Dietary Recommendations and Diagnostic Testing
00:46:07 - 00:46:42
The speaker recommends a calcium CT scan to assess artery plaque as a way to monitor the effects of diet on cholesterol levels. The absence of artery plaque is considered a positive indicator. The discussion then shifts to the speaker's speculation about the family history of the listener, suggesting that their father or grandfather likely had a stronger genetic predisposition (plus-plus) to high plant cholesterol, explaining the listener's current genetic makeup.
High Cholesterol and Plant Sterols
00:46:42 - 00:48:31
This segment discusses the impact of high cholesterol, both human LDL cholesterol and plant sterols (cytosterols). The speaker explains that while high human LDL cholesterol can lead to serious health problems like arterial damage and inflammation due to oxidation, this is typically only a concern at extremely high levels. The speaker mentions familial hypercholesterolemia as an example of a genetic condition causing dangerously high cholesterol, where statins can be life-saving. However, the speaker criticizes the tendency to generalize this extreme case to advocate for widespread statin use, pointing out that plant sterol levels are rarely checked, and individuals with rare genetic predispositions might have dangerously high levels of plant cholesterol without knowing it. The speaker highlights the potential danger of high plant cholesterol levels in individuals with specific genetic vulnerabilities, emphasizing the need for more comprehensive testing beyond just human LDL cholesterol.
The Impact of Plant Cholesterol and a Rare Gene
00:48:31 - 00:50:09
This segment discusses the potential dangers of high plant cholesterol levels in individuals with a rare gene. The speaker explains that even if standard cholesterol tests show healthy LDL levels, consuming large quantities of plants can lead to dangerously high levels of plant cholesterol. This, in turn, can react with oxygen, damage arteries, and cause premature heart attacks. The speaker suggests a more cautious approach to plant consumption, recommending not to "pound" them, even suggesting complete elimination in extreme cases. The rarity of this gene makes it challenging to counter the common advice to eat plenty of vegetables. The conversation then shifts to another gene (MTRR, or methyltetrahydrofolate homocysteine methyltransferase reductase), which suggests ancestral meat-heavy diets. This gene is crucial in methionine production, an essential amino acid not readily produced by the body, highlighting the importance of consuming chicken or fish to obtain sufficient methionine. Supplementation is also mentioned as an alternative.
Supplement Optimization and Sleep Tracking
00:50:10 - 00:51:21
This segment focuses on optimizing B vitamin supplementation, specifically B9 (methylfolate) and B12. The discussion begins by noting that the individual's ancestors likely consumed a meat-heavy diet, influencing their current genetic predisposition. The conversation then shifts to B9, found in leafy greens, with the suggestion to take a methylfolate supplement instead of relying solely on dietary sources. The individual mentions already taking a methylation supplement containing B12, and questions whether to increase the dosage. The advice given is to not increase the dosage and potentially discontinue B12 supplementation due to their meat consumption and good B12 genes. The recommendation is to focus on 5-MTHF (5-methyltetrahydrofolate) due to its cost-effectiveness. Finally, tracking sleep quality using an oral ring is suggested as a way to assess the effectiveness of methylfolate supplementation, noting that improved sleep is a common benefit.
Supplement Recommendations and Experiences
00:51:21 - 00:52:52
The discussion centers on supplement recommendations, specifically 5MTHF and B12. The speakers discuss the importance of sleep tracking to notice the effects of these supplements, noting that some individuals experience immediate benefits while others don't, suggesting pre-existing deficiencies. The conversation then shifts to iodine, specifically Lugol's solution, which is described as a high dose often used in radiation poisoning. A participant shares a personal experience of significant hand and foot swelling after taking Lugol's solution, prompting a suggestion to switch to a lower-dose iodine supplement from the speaker's website due to the difficulty of accurately measuring and diluting the Lugol's solution.
Dosage and Body Reaction
00:52:53 - 00:54:07
The conversation discusses the individual's reaction to a high dose of a supplement, possibly around five or six pounds. The individual reports ingesting it by putting it in their mouth and drinking water. While this method is acceptable for many, the speaker suggests the body may not be tolerating the high dose. The suggestion is made to dilute the supplement significantly, even to a single drop in a large glass of water, or to simply switch to a different supplement due to its low cost. The discussion then shifts to the absence of multivitamin use, implying a reduced risk of issues related to tocopherol.
Vitamin E and Tocopherol
00:54:07 - 00:54:25
The conversation turns to vitamin E and its synthetic counterpart, tocopherol. The speakers acknowledge prior discussions on this topic, particularly its relevance to the individual's family history. A podcast by Ben Greenfield and Barry Tan on this subject is mentioned. Tocopherol is identified as potentially problematic, triggering interleukin-6 and causing inflammation. However, since the individual doesn't take a multivitamin, the risk is deemed low. The presence of tocopherol as a preservative in various foods and supplements is noted, with the question raised about whether trace amounts are a concern, particularly in DHA supplements. The conclusion is that unless chronic inflammation is experienced, it's likely not a significant worry.
Vitamin E and Genetic Considerations
00:54:26 - 00:56:06
This segment discusses the implications of a specific gene on vitamin E supplementation. The speakers advise against unnecessary supplementation, especially for individuals without significant symptoms like joint issues or brain fog. They highlight that vitamin E is often found in DHA and that supplementation is generally unnecessary unless specific health concerns exist. One speaker shares a personal experience with corneal erosion, an eye condition exacerbated by stress and poor diet. They mention that while vitamin E is often recommended for this condition, it can be problematic for individuals with the specific gene in question, potentially worsening symptoms unless a specific type of vitamin E, tocotrienols (from annanato, a fermented soy product), is used. The discussion concludes with a note about the phytoestrogen content in soybeans.
Fermentation and Estrogen in Soy Products
00:56:06 - 00:57:46
The discussion centers on the impact of fermentation on estrogen levels in soy products. Speakers note that true fermentation, using real microorganisms, significantly reduces estrogen content in soy, with a claim that 99% can be broken down. Examples of properly fermented soy products with low estrogen levels include natto, soy sauce, tempeh, and miso. A contrast is drawn between these and improperly fermented or unfermented soy products, which contain significantly higher levels of estrogen. One speaker mentions a Canadian study showing soy and flax had over 100,000 units of estrogen, while other plants were under 1,000. However, fermented soy products like soy sauce had only around 100 units, highlighting the importance of proper fermentation in reducing estrogen content. A speaker expresses previous concern about soy sauce consumption due to a book on estrogen, but now feels reassured by the discussion.
Keto Diet and Dietary Preferences
00:57:47 - 00:59:09
The conversation shifts to a discussion about ketogenic diets and dietary preferences, specifically concerning the inclusion of flaxseed or flour in keto bricks. One participant expresses a preference for minimal plant-based ingredients, while another notes the presence of cocoa butter as the main ingredient. The importance of considering the ABCG5 gene (carnivore gene) is highlighted, advising caution with plant consumption for individuals with this gene. The recommendation is to prioritize animal fats like egg yolks, lard, duck fat, and other animal fats, especially given the current abundance and low cost of pig lard from local farmers. The conversation concludes with a mention of raising grass-fed beef and pigs.
Discussion on Pig Diets and Health
00:59:09 - 01:00:31
The conversation begins with a discussion about a type of pig that can eat grass. One speaker expresses surprise at this fact, leading to a discussion about the challenges of finding clean, non-GMO feed for pigs. The speakers agree that even healthier feed is a significant improvement over conventional options. The conversation then shifts to a specific breed of pig, possibly called "Kune Kune," that is known for its grazing habits. One speaker offers to research this breed further.
Heavy Metal Gene and Nutritional Considerations
01:00:32 - 01:01:04
The discussion turns to the impact of heavy metals on a specific gene. The speakers mention that heavy metals can accumulate in mitochondria unless sufficient manganese is consumed. While manganese supplements are mentioned, the speakers suggest that obtaining manganese through foods like pecans might be a more practical approach. The conversation concludes with a note about the implications of this gene for overall health.
Plant Sterols and Dietary Choices
01:01:04 - 01:02:02
The discussion centers on the potential negative effects of plant sterols, particularly for individuals with arterial plaque. The speakers consider the possibility of manganese supplementation as a countermeasure, but emphasize the importance of first determining the presence of arterial plaque through a calcium CT scan. The conversation highlights a person's high plant consumption, including frequent consumption of sweet potatoes and green beans directly from the garden. The speakers acknowledge that a high plant intake might be beneficial for some, but recommend caution and further investigation due to potential issues with plant sterols. The potential negative effects of plant sterols in nuts are also briefly discussed.
The Carnivore Diet and its Effects
01:02:04 - 01:02:49
The conversation shifts to the carnivore diet, its varying effects on individuals, and the potential need for supplementation. The speakers note that while some individuals experience immediate and long-term health improvements and feel amazing while following the diet without supplementation, others find it unenjoyable and experience negative effects. The speakers suggest that even those who thrive on the carnivore diet might benefit from supplementation and genetic testing.
Genetic Predisposition and Dietary Response
01:02:49 - 01:04:32
This segment discusses the correlation between genetic predisposition and individual responses to the carnivore diet. The speakers note that individuals with specific genes respond strongly to the diet, with some exhibiting extreme positive effects. They criticize the current medical approach, highlighting how doctors often misinterpret symptoms and provide ineffective advice, such as recommending whole grains, which can be detrimental for those with specific genetic profiles. The importance of DNA testing as a standard of care is emphasized, although concerns about privacy and potential government misuse of genetic data are raised. One speaker describes using aliases and purchasing DNA kits for clients (special forces and pro athletes) to maintain anonymity and avoid detection. The discussion concludes with a reflection on the potential cost savings associated with preventative healthcare enabled by genetic testing, noting the significant decrease in the cost of DNA sequencing over time and the relevance of epigenetics.
Fructose and Fruit Consumption
01:04:32 - 01:06:00
The discussion centers on fructose consumption and its impact on the body. It's noted that the body stores fructose as fat more easily than burning it for fuel. The speakers advise avoiding high-fructose fruits, suggesting berries (blackberries, strawberries, raspberries) as lower-fructose alternatives. Bananas and pineapple are identified as high in fructose, while figs are cited as particularly problematic (17 grams per half cup versus pineapple's 2 grams). A website link offering further details on fruit fructose content is offered. The conversation touches upon the keto diet and its incompatibility with high fructose intake. A speaker mentions owning fig trees, prompting a humorous exchange about the potential conflict between enjoying figs and limiting fructose intake. The fructose content of watermelon is briefly questioned but the answer is cut off.
Discussion on Ancestral Diet and Genetics
01:06:03 - 01:06:21
The conversation begins with a comment about watermelons' high fructose content. The discussion then shifts to the speaker's ancestors' likely diet, speculating that their low fruit and vegetable consumption, focusing instead on meats and animal products, may explain the individual's current genetic predispositions.
Questions Regarding Metabolic Panels and Genetic Testing
01:06:23 - 01:07:12
A question is raised about the benefits of a comprehensive metabolic panel compared to a standard doctor's panel. The difficulty in finding labs that measure cytosterols is highlighted, with the speaker recommending seeking a functional doctor for more thorough metabolic panel testing. The conversation confirms that functional doctor panels are superior and provide more comprehensive information.
Analysis of Genetic Predisposition and Gym Recommendations
01:07:14 - 01:07:31
The conversation transitions to a discussion of the individual's genetics, specifically praising their "great genes." The discussion then briefly touches upon the SLC2A9 gene related to gout, before the chapter ends.
The Risks of Fructose and Gout
01:07:32 - 01:08:55
The discussion centers on the link between fructose consumption and gout. High fructose intake, particularly from sodas containing high fructose corn syrup, increases the risk of gout due to the fructose transporter's role in transporting uric acid into joints. Uric acid crystal formation in the joints causes the pain associated with gout. While a genetic predisposition exists, maintaining a generally healthy diet and avoiding excessive fructose intake can mitigate the risk, even with the presence of the risk gene. The irony is highlighted that doctors often advise gout sufferers to avoid meats, while the actual culprit is often excessive fructose consumption. A specific gene related to fructose metabolism is identified as a key factor, rather than genes previously associated with gout. The conversation briefly touches upon other HLA genes before the excerpt ends.
Genetic Predisposition to Rheumatoid Arthritis and the Role of Diet
01:09:00 - 01:11:10
The discussion centers on the patient's genetic predisposition to rheumatoid arthritis, specifically highlighting the high risk factors associated with HLA-DRB1 (four-fold increased risk) and HLA-DQA1 (five-fold increased risk) genes. The speaker connects these genetic markers to the patient's reported back pain. The patient's family history is briefly explored, revealing that their mother experiences joint issues, while their father remains unaffected despite shared lifestyle factors (living on a farm and engaging in physical labor). The conversation then shifts to the impact of diet, particularly the role of carbohydrates and insulin levels on the expression of these genes. High insulin levels, resulting from high blood sugar, are identified as significant risk factors for arthritis. The speaker suggests a ketogenic diet as a potential mitigating strategy for managing joint pain related to these genetic predispositions, emphasizing that its effectiveness in completely eliminating the risk is uncertain but likely significant. The patient inquires about the extent to which keto diets can mitigate the genetic risks, and the speaker confirms that while complete mitigation is not guaranteed, the impact is substantial.
The High Cost of High-Carb Diets and Knee Replacements
01:11:10 - 01:12:48
This segment discusses the link between high-carb diets and the increased risk of rheumatoid arthritis, leading to knee replacements. The speakers note that studies on arthritis risk are often based on average Americans with high-carb diets, resulting in skewed data. They argue that a ketogenic diet could significantly reduce the need for knee replacements, potentially saving healthcare systems substantial costs. However, they acknowledge that health insurance companies aren't incentivized to promote dietary changes due to the profitability of procedures like knee replacements. The difficulty of influencing individual dietary choices and the genetic variations affecting health outcomes are also mentioned. Finally, the speakers observe a correlation between unhealthy diets and a lack of personal motivation towards healthier lifestyles, using the example of observing people at events like 4th of July fireworks.
Arthritis Risk Gene Discussion
01:12:48 - 01:13:18
The discussion begins with a review of the PTPN22 gene, identified as an arthritis risk gene also linked to gut issues. The speaker notes that while a problematic gut can lead to joint inflammation, the individual's gut health is good, and this particular gene is not a major concern due to its plus-minus status. The speaker then asks if there are any questions about the genes discussed and confirms the overall assessment is positive.
Gut Health and Dietary Changes
01:13:19 - 01:14:28
The conversation shifts to the speaker's personal experience with gut health. Several years ago, they started a regimen of increased fiber intake following advice from a functional medicine doctor. However, with age, their regularity decreased despite the fiber supplements. Interestingly, since adopting a ketogenic diet and intermittent fasting, their regularity has improved, even without the fiber supplements. The speaker expresses surprise at this outcome and questions whether the type of fiber (plant-based) or the presence of plant sterols might be a factor in their improved gut health. The speaker doubts plant sterols are a significant issue due to the non-digestible nature of most fiber.
Dietary Fiber and its Effects on Bowel Health
01:14:29 - 01:16:37
The discussion centers on a 2012 study published in the World Journal of Gastroenterology regarding dietary fiber intake and its impact on bowel health. The speaker notes the common medical advice promoting fiber's benefits, but highlights a contradictory finding: the study showed a significant increase in symptoms like anal bleeding, constipation, bloating, straining during bowel movements, and abdominal pain among individuals with high fiber diets. Conversely, when fiber intake was reduced or eliminated, these symptoms disappeared entirely. The speaker emphasizes the counterintuitive nature of this finding, contrasting it with conventional medical wisdom. Specific numbers from the study are cited, illustrating the dramatic reduction in reported symptoms when participants eliminated fiber from their diets. The speaker expresses surprise at the study's results, highlighting its challenge to established medical advice.
Gut Bacteria and Dietary Balance
01:16:41 - 01:18:01
This segment discusses the impact of antibiotics and fiber on gut bacteria. The speakers note that antibiotics should not be used long-term, and fiber helps rebalance gut flora after antibiotic use. The discussion then shifts to the role of gut bacteria in breaking down fiber into short-chain fatty acids and medium-chain triglycerides (MCTs), similar to those found in MCT oil and produced by the body's processing of apple cider vinegar. One speaker mentions a personal experience of reduced bowel movements while on a ketogenic diet, describing it as a temporary adjustment. The conversation concludes by transitioning to the next topic: sleep.
Sleep Quality and Genetics Discussion
01:18:17 - 01:19:50
The discussion centers on Justin's sleep quality, influenced by physical work, outdoor lifestyle, and geographical location (south, avoiding harsh winters). The WWC1 gene is mentioned, highlighting its variable prevalence across different populations and its potential impact on sleep. The speaker notes that poor sleep significantly impacts cognitive function and speech clarity. While Justin's sleep genes are deemed excellent, the importance of sufficient sleep (7-8 hours) is emphasized. Supplements are discouraged if sleep is already good. The conversation concludes with a summary of Justin's sleep patterns and a general assessment of his sleep genetics as "great," comparable to professional athletes.
Overall Sleep Genetics Assessment
01:19:50 - 01:20:15
Justin expresses satisfaction with the discussion, and the speaker ranks his sleep genetics favorably, comparing them to those of a professional athlete discussed in a previous podcast.
Discussion of David Arzma and Genetic Comparisons
01:20:15 - 01:21:08
The conversation begins with a discussion of David Arzma, a professional pitcher who played for the Yankees and Red Sox, among other teams. The speaker notes Arzma's success despite potentially having less advantageous genes compared to the podcast guest. The speaker then jokingly suggests the guest should have been a pitcher. The speaker mentions that Arzma's podcast episode was fun and encourages listeners to check it out. The conversation shifts to a comparison with another individual, Justin Norton, whose DNA file the speaker received and plans to feature on a future podcast episode. The speaker acknowledges the audio quality difference between the two recordings.
Podcast Conclusion and Thanks
01:21:09 - 01:21:31
The speaker expresses gratitude to the guest for participating in the podcast, highlighting the enjoyment and potential benefits for listeners. The guest reciprocates the appreciation. The guest mentions that this is their first podcast appearance and expresses excitement about sharing it with friends and family. Finally, the speaker thanks Tessie for attending.
Meeting Closing
01:21:31 - 01:21:34
The meeting concluded with pleasantries exchanged between participants, including expressions of gratitude and farewells.
DNA with Dr. Jay, Episode 08.
PEPTIDES Stacy (from South Dakota)
PEPTIDES Stacy (from South Dakota)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Technical Check
00:00:00 - 00:01:32
Dr. J introduces himself as a Mayo Clinic scientist, author of "Estrogeneration," and owner of AJ Consulting Company. He mentions a consultation with Stacy from South Dakota focusing on peptides, describing the topic as advanced. He promotes his DNA consulting services and podcast. The initial segment concludes with a brief technical check between Dr. J and Stacy to confirm recording devices and Bluetooth connectivity are functioning correctly.
Location and Background
00:01:33 - 00:01:56
Dr. J clarifies Stacy's location as South Dakota, despite her retaining an East Coast phone number. They briefly discuss maintaining old phone numbers after relocating, both having done so themselves. Dr. J asks about the specific location within South Dakota, prompting Stacy to mention Sioux Falls.
Dr. J's Family and the Fighting Sioux
00:01:54 - 00:02:54
Dr. J shares a personal anecdote about his father being the medical doctor for the Fighting Sioux hockey team, prompting Stacy to inquire about the team's name change to UND Hockey due to the term "Sioux." Dr. J mentions his sister living in a town called Britain in eastern South Dakota, a place he recently visited and describes as having good fishing. The conversation concludes with Stacy commenting on Dr. J's known enjoyment of fishing.
Discussion of Stacy's Supplements and Peptide Cycling
00:02:56 - 00:03:30
Dr. J and Stacy discuss Stacy's supplement regimen, specifically mentioning peptides. Stacy acknowledges that her extensive supplement use might seem excessive but explains the rationale behind including them. Dr. J inquires about Stacy's peptide cycling practices, and Stacy confirms she cycles them. The conversation briefly touches upon specific peptides like ipameraline and melanotan, with Stacy noting that melanotan cycling is less crucial when used at lower doses for its anti-inflammatory properties. She admits to inconsistent melanotan usage, resulting in an unintentional cycling effect.
Peptide Sourcing and Sleep Tracking
00:03:33 - 00:04:56
Stacy discusses her peptide sourcing from TaylorMade, noting upcoming changes and the availability of new oral medications. She mentions upcoming webinars by Ryan Smith regarding these new products, specifically a reformulated semerelin replacing epimerelin CJC. The conversation then shifts to sleep tracking using Aura devices, both Stacy and Dr. J using them for over a year and two years respectively. Dr. J inquires about Stacy's experience with melanotan's impact on sleep, with Stacy expressing difficulty isolating its effects among other lifestyle factors. Dr. J shares their own experience of unexpectedly improved sleep, particularly increased deep sleep, with melanotan, contrasting with Stacy's reported decrease in REM sleep. Dr. J then asks about the duration of Stacy's deep sleep, indicating a desire to compare experiences.
Sleep Aid Strategies and Experiences
00:04:56 - 00:06:22
Stacy discusses her consistent difficulty achieving sufficient deep sleep, reporting sleep durations always exceeding one hour. She details various strategies employed to improve sleep quality, including DSIP (deep sleep-inducing peptide), DHHB (dihydra, hinocchial, with an unspecified B portion), melatonin, blue light blockers, and using red/incandescent lighting in the evenings and bright blue light in the mornings. While initially finding DSIP effective, she notes that overdosing led to disrupted sleep. She describes DHHB as a pill purported to increase non-REM sleep and possess potent anti-inflammatory properties exceeding those of NSAIDs. Dr. J expresses interest, clarifying the name of DHHB and indicating an intention to research it further as a supplement.
Discussion of a Sunscreen Chemical Compound
00:06:25 - 00:07:37
Dr. J expresses surprise at an unfamiliar compound mentioned by 22, resembling a sunscreen chemical. Stacy mentions Tillermade and Dr. Seeds' involvement with DHHB. Dr. J suggests potentially reducing the number of compounds used, citing Lyra Glutide (a GLP-1 agonist) as an example. Stacy explains its use as a metformin alternative, but notes its phasing out due to expense. Dr. J explains that Lyra Glutide's effectiveness depends on genetic factors, deeming it unnecessary in Stacy's case. The conversation concludes with Dr. J acknowledging Stacy's biohacking approach.
FDA Regulation of Peptides and Biohacking
00:07:38 - 00:08:04
Dr. J expresses disappointment over the FDA's crackdown on peptides, advocating for individual choice in biohacking and utilizing readily available online information. The discussion concludes with Dr. J's opinion that the government's regulation of personal health choices is excessive.
Peptide Therapy Discussion
00:08:06 - 00:08:29
Dr. J discusses the accessibility of peptide therapy, noting the availability of safety and dosage information, although acknowledging the challenges of injections. Stacy agrees, emphasizing the benefits often outweighing the risks, explaining her interest in peptide therapy. Dr. J then transitions the conversation to the topic of DNA analysis.
DNA Analysis and Interpretation
00:08:30 - 00:09:44
Dr. J refers to a previously emailed PDF containing DNA analysis results, explaining the notation system used: "++" indicates inheriting a bad gene copy from both parents, while "+-" signifies one bad and one good copy. Dr. J explains the basics of DNA inheritance, mentioning that each cell (except egg and sperm cells) contains two copies of DNA, one from each parent. Due to time constraints, Dr. J states they will primarily focus on the "++" results (two bad gene copies), briefly mentioning "+-" results but deferring detailed discussion.
Gene Analysis and Interpretation
00:09:47 - 00:11:19
Dr. J explains that the impact of certain genetic factors is unpredictable, sometimes influencing health outcomes and sometimes not. This variability is attributed to epigenetics and environmental factors. Stacy confirms understanding and mentions having printed copies of the genetic reports for visual reference, although she also has a digital record. Dr. J clarifies that "plus plus" in genetic results doesn't automatically indicate negative health implications, providing examples of how it can relate to muscle types in athletes. Dr. J states that she includes such nuances in her reports. The discussion then focuses on specific genes. Dr. J indicates that the CETP gene is less concerning unless triglycerides are high. Stacy confirms having recent blood work with favorable cholesterol markers, including a higher HDL than LDL. Dr. J expresses low expectation of high triglycerides but suggests checking the results. The conversation moves to the CLU gene, identified as an intermittent fasting gene related to clusterin.
Intermittent Fasting and its Effects
00:11:24 - 00:12:35
Dr. J explains that intermittent fasting increases autophagy, the process of clearing cell debris, which is beneficial for brain health and reducing Alzheimer's risk. Stacy mentions her past experience with 16/8 intermittent fasting and longer fasts while doing keto. She currently focuses on gym workouts and is gradually reintroducing shorter eating windows. The conversation concludes with Dr. J suggesting that intermittent fasting would be beneficial for Stacy, especially considering her age and activity level. An additional point is made that at younger ages, it matters less.
Impact of FOXO3 Gene and High-Intensity Workouts
00:12:35 - 00:13:27
Dr. J introduces the FOXO3 gene, which affects how the brain processes carbohydrates and higher blood sugar levels. The discussion shifts to Stacy's intense workout routine, including CrossFit and Orange Theory Fitness. Dr. J explains that for individuals with this gene and high activity levels, the impact of carbohydrates is less significant because they are burned during exercise. However, for those with less intense activity, consuming a large amount of carbohydrates might lead to fatigue.
Blood Sugar and Brain Function
00:13:28 - 00:14:01
Dr. J explains that individual responses to carbohydrates vary, impacting both body and brain function. Higher blood sugar, as seen in diabetes, increases the risk of Alzheimer's due to the brain's sensitivity to glucose levels. The discussion then transitions to the connection between specific genes (TPH2 and HTR2A) and anxiety/melancholy. These genes relate to serotonin receptors and transporters, impacting serotonin uptake and binding in the brain.
Serotonin, Gut Health, and Anxiety
00:14:03 - 00:15:34
Dr. J continues by explaining the significant role of gut health in serotonin production (90% originates in the gut). Insufficient serotonin production due to poor gut health or inefficient transport and receptor binding can lead to anxiety. Dr. J inquires about Stacy's history with anxiety, noting that it seems less significant recently. Stacy confirms that anxiety was more prevalent in her younger years, but currently, it's more of a baseline personality trait than a major issue. Dr. J emphasizes the positive impact of healthy lifestyle choices (diet, exercise, sleep) on managing anxiety. The conversation concludes with a brief discussion of Stacy's caffeine metabolism, which Dr. J deems not a significant concern.
Sirtuin and Lifespan Enhancement
00:15:36 - 00:17:32
Dr. J discusses the gene sirtuin (SIRT1) and its impact on lifespan, explaining that increasing sirtuin levels in mice doubled their lifespan. While continuously increasing sirtuin doesn't indefinitely extend lifespan, it does offer some increase. Dr. J notes that a version of the gene produces less sirtuin, highlighting the importance of consistently increasing it. Resveratrol is mentioned as a known enhancer, but Dr. J cautions about its estrogen-like effects, suggesting grapeseed pro-anthocyanidans as an alternative that also increases sirtuin without the estrogenic effect. Stacy inquires about astaxanthin's role, but Dr. J clarifies it's a different compound. The discussion concludes with Dr. J confirming there are no further questions on the brain health section.
Diet and Genetic Predisposition to Type 2 Diabetes
00:17:35 - 00:19:16
Dr. J discusses the patient's genetic predisposition to type 2 diabetes, focusing on the HHEX gene, which indicates a three-fold increased risk. The doctor emphasizes that this increased risk doesn't guarantee the development of the disease. Exercise is highlighted as crucial due to the gene's relation to nitric oxide production in the pancreas; beet juice and citrulline are mentioned as supplementary aids. The discussion then shifts to the SLC30A8 gene, a zinc transporter, suggesting the importance of zinc intake. The patient, Stacy, confirms daily meat consumption, although acknowledging that lunch meats might not be the optimal source of zinc. An unknown participant suggests zinc supplementation if meat intake is low. Finally, Dr. J inquires about Stacy's fasted blood sugar levels, with Stacy reporting initial readings in the 60s and 70s during keto, progressing to the 80s and 90s. Dr. J considers these levels acceptable, and Stacy mentions reading about compensatory glucose production after glucose depletion.
Blood Sugar Regulation and Obesity Risk Genes
00:19:16 - 00:21:22
Dr. J discusses Stacy's genetic predisposition to reactive hyperglycemia and elevated blood sugar, noting the presence of genes that influence type 2 diabetes. While some individuals with similar genetic profiles disregard carb intake, Dr. J emphasizes the importance of managing blood sugar levels, especially when exceeding 90. Zinc and intermittent fasting are suggested as management tools. The conversation then shifts to obesity risk genes, which Stacy possesses despite maintaining a healthy weight. Dr. J mentions Stacy's use of melanotan, highlighting its potential to improve blood glucose through the stimulation of alpha-melanocyte stimulating hormone (alpha MSH) and its impact on the MC4R gene. The doctor suggests monitoring blood sugar levels with and without melanotan use as an experiment. Sunshine is also proposed as a natural way to stimulate alpha MSH and regulate metabolism through the same gene. Finally, Dr. J acknowledges the presence of obesity risk genes despite Stacy's healthy weight, finding it noteworthy.
Family History and Genetics of Obesity
00:21:26 - 00:23:18
Dr. J inquires about Stacy's family history of obesity, noting that a genetic predisposition can make weight loss more challenging. Stacy reports that while some relatives may be slightly overweight, there's no significant history of obesity in her family. Dr. J then discusses the FTO gene, referencing a BBC documentary, "Why Are We Getting So Fat?", which highlighted the gene's role in obesity risk but lacked practical solutions. Dr. J explains that the FTO gene is involved in the conversion of white fat to brown fat. Brown fat, unlike white fat, is rich in mitochondria and burns significant energy, aiding in weight loss. Dr. J mentions that Stacy's familiarity with MOTS peptides (possibly referring to MOTS-c) is relevant, as brown fat's function is crucial in energy expenditure and is particularly important in infants for thermoregulation. The discussion concludes with Dr. J emphasizing the FTO gene's role in the white-to-brown fat conversion process.
MOTC Peptide Injection Reactions
00:23:18 - 00:24:49
Stacy and Dr. J discuss their adverse reactions to MOTC peptide injections. Stacy describes significant rashes and welts after injections, despite attempts to mitigate inflammation with thymus and alpha peptides, Alka-Seltzer Gold, and topical cortisone. The reactions were so severe that Stacy considered stopping injections due to fear of a life-threatening reaction. Dr. J corroborates Stacy's experience, reporting a similar reaction after a single injection, leading them to discontinue use. Despite the theoretical benefits of the peptide in addressing a gene issue related to fat metabolism and mitochondrial function, both individuals found the adverse reactions outweigh the potential advantages. Stacy details attempts to reduce the dosage to 5 milligrams three times a week, eventually reducing to once a week, but still experienced a severe reaction upon resuming injections after a two-week break.
Cold Exposure and Weight Management Strategies
00:24:50 - 00:26:39
Stacy expresses concern about the excessiveness of a previous weight management strategy. Dr. J suggests intermittent fasting, cold showers, or cryotherapy as alternatives, noting Stacy's potential as a "super responder" to cold exposure. The discussion shifts to the practicality of cold showers, with Dr. J highlighting the need for extended durations (20 minutes) for optimal benefits, contrasting this with the efficiency of cryotherapy (3 minutes). The use of saunas before cold showers or cycling between saunas and cold showers is proposed as a more sustainable approach. The conversation then turns to genetic factors influencing weight management, specifically mentioning diponectin and ADI-POQ genes, and Stacy's high level of discipline in maintaining weight despite genetic predispositions. Finally, Stacy clarifies that her use of fat-loss targeting peptides began after a period of weight gain experienced while following a ketogenic diet.
Ketogenic Diet Experiences and Strategies
00:26:39 - 00:28:32
This segment details personal experiences and strategies related to the ketogenic diet. Dr. J discusses their weight loss success on a very high-fat (80% fat by calories) ketogenic diet, noting the high satiety but acknowledging its lack of sustainability. They describe their typical food choices, emphasizing whole foods like egg yolks, salads with olive oil, MCT oil, and butter, while occasionally using keto bricks for lunch. The conversation touches upon the availability of processed keto products and the potential pitfalls of relying on them, including artificial sweeteners. Stacy mentions a previous ketogenic diet experience where tracking wasn't strictly enforced, focusing instead on maintaining ketosis. The discussion highlights the challenges of balancing effective weight loss strategies with sustainable dietary practices.
Metformin and Rapamycin Discussion
00:28:33 - 00:30:09
Dr. J commends Stacy on her weight management success despite having obesity risk genes. The conversation turns to Metformin, which Stacy had tried for a couple of months after hearing Dr. J discuss it on a podcast. Stacy monitored her blood glucose levels during this time, using continuous glucose monitoring, and found the results to be good, although she acknowledges not knowing her insulin levels. Dr. J notes that Stacy is a poor responder to Metformin, a relatively rare occurrence, and advises against its continued use due to the limited benefits compared to potential side effects. The discussion then shifts to Rapamycin, with Dr. J expressing concern about its immunosuppressant effects and suggesting it's a risky option.
Rapamycin Discussion and Alternatives
00:30:11 - 00:31:37
Dr. J expresses reservations about rapamycin, citing its potential negative effects on the immune system. The discussion clarifies that while rapamycin affects mTOR (mammalian target of rapamycin), intermittent or extended fasting also impacts mTOR, potentially offering similar benefits without the risks associated with rapamycin. Stacy mentions that rapamycin is available through TaylorMade under the name Cheryl Lemith, in various forms including 3mg capsules and creams, and suggests it as a possible alternative to metformin. Dr. J acknowledges rapamycin's lifespan-extending effects in animals but points out that calorie and carbohydrate restriction achieve similar results with less risk. While Dr. J generally avoids rapamycin, they acknowledge potential benefits at specific doses. Stacy notes that rapamycin is often used in a cyclical manner, perhaps only once or twice a year. The conversation then transitions to the SOD2 gene (superoxide dismutase 2).
Gene Variant and Iron Levels Discussion
00:31:45 - 00:33:20
The conversation begins with a question about a specific gene variant observed in previous DNA reports. Stacy mentions learning about the related pathway during a peptides certification course (parts one and two completed, with three and four remaining). Dr. J explains that the gene variant, related to superoxide dismutase (which neutralizes superoxides), doesn't pose a significant heart disease risk unless iron levels are high, in which case the risk increases tenfold. Dr. J notes that high iron levels are a concern because of the prevalence of heart attacks. However, Dr. J suggests that Stacy likely doesn't have high iron levels, given that women typically have lower iron due to monthly blood loss. Nevertheless, Dr. J recommends monitoring iron levels, including ferritin and iron-binding capacity, due to the increased heart disease risk associated with this specific gene variant and high iron. Stacy agrees and asks about recommended iron studies.
Optimizing Iron Levels and Heart Disease Risk
00:33:20 - 00:34:47
Dr. J discusses a patient's blood test results, specifically focusing on iron levels and their connection to heart disease. The patient has a specific gene that increases concern about heart disease risk, prompting Dr. J to share a Mercola article on optimal iron levels. Dr. J emphasizes the importance of personalized optimization, noting that standard blood test ranges are too broad for this purpose. High iron levels are explained as potentially damaging arteries through a reaction with oxygen, similar to rust formation. The patient's specific gene is mentioned as usually suppressing this reactivity, but since it's not functioning optimally, careful monitoring of iron levels is advised.
Assessment of Other Heart Disease Risk Genes
00:34:50 - 00:35:00
Dr. J continues the discussion by assessing other heart disease risk genes. The next gene is deemed less concerning as it's triglyceride-related. The exact details of this assessment are cut off in the provided transcript.
Gut Gene Analysis and Gluten Sensitivity
00:35:02 - 00:36:34
Dr. J reviews the patient's genetic report, focusing on the "leaky gut" section. The NOD2 gene shows a twofold increased risk for gut issues, considered minor compared to other genes. Dr. J explains that NOD2 is often called inflammatory bowel disease protein number two, highlighting its link to inflammatory bowel disease, but emphasizes its common occurrence. The doctor notes that many gut gene issues are common, making a list appear more intimidating than it is. The patient's results show mostly plus-minus genes, indicating better-than-average genetic predisposition. Dr. J suggests a likely gluten sensitivity based on the results, particularly the ATG-1601 gene, which is commonly associated with such sensitivity. This is corroborated by the patient's previous food allergy/sensitivity test. Finally, the RTN4RL2 gene, linked to increased gut issue risk, is discussed; healthy eating is emphasized as a mitigating factor. This gene's connection to the vagus nerve is mentioned, with exercise suggested as a beneficial stimulator.
Vagus Nerve Stimulation and Dietary Considerations
00:36:38 - 00:37:07
Dr. J suggests exploring ways to stimulate the vagus nerve due to Stacy's gene, referencing a linked article with 32 methods. Following a review of the diet section, Stacy confirms she doesn't have specific questions about the genes but expresses difficulty balancing dietary needs due to genetic predispositions against both high fat and high carb diets. Dr. J acknowledges this common challenge.
Dietary Recommendations for FTO Genes
00:37:07 - 00:38:15
Stacy discusses the challenge of balancing a diet with conflicting genetic predispositions (e.g., FTO genes impacting fat storage). Dr. J suggests a higher protein diet as a potential solution, acknowledging the difficulty of balancing macronutrients when training hard. Dr. J commends Stacy's current efforts and overall health based on a previous questionnaire. The conversation transitions to the vitamin, hormone, and detox section.
Vitamin D Supplementation
00:38:15 - 00:38:34
Dr. J notes Stacy's plus-plus vitamin D gene, common but requiring supplementation, especially in South Dakota, to maintain optimal blood levels.
Vitamin D Levels and Seed Oil Consumption
00:38:34 - 00:40:15
This segment focuses on the discussion of optimal Vitamin D levels and the avoidance of seed oils. Stacy inquires about ideal Vitamin D levels, mentioning a past result of 50. Dr. J explains that levels above 50 are desirable, referencing studies on hunter-gatherer tribes with levels between 70 and 100, contrasting this with the average American level of 30. The conversation highlights the importance of maintaining Vitamin D levels above 50, especially in light of recent COVID-19 research linking Vitamin D to health outcomes. The discussion then shifts to seed oils, with Dr. J emphasizing their avoidance. An unknown participant clarifies that this includes canola and soybean oils. Stacy confirms her avoidance of seed oils, mentioning limited use of coconut oil for high-temperature cooking and preference for olive oil.
Healthy Oils and Pesticide Exposure
00:40:15 - 00:41:20
Dr. J discusses the health benefits of various oils, including olive, coconut, and avocado oil, noting that avocado seed oil is less beneficial than regular avocado oil. The conversation then shifts to the potential negative effects of organophosphate pesticides, commonly used in mosquito sprays, particularly in areas like Florida. Stacy mentions the frequent spraying in her area and the precautions she takes to minimize exposure by closing windows and turning down the air conditioner. Other participants share similar experiences and concerns about pesticide exposure.
FAM9B Gene and Testosterone Levels
00:41:21 - 00:41:40
Dr. J comments on a patient's genetic profile, highlighting a positive result for testosterone and an unknown association between the FAM9B gene and lower testosterone levels. Dr. J expresses frustration at the lack of understanding regarding the FAM9B gene and its impact on testosterone, emphasizing the desire to find solutions for related issues.
Blood Test Results and Diindolylmethane Discussion
00:41:40 - 00:43:20
Dr. J discusses the challenges of finding effective solutions for certain gene-related issues. They then comment on the inaccuracy and potentially misleading nature of blood tests, specifically mentioning a women's testosterone range listed as 0-70 or 0-80, highlighting the absurdity of considering zero testosterone as normal. Dr. J advises aiming for the higher end of the normal range for testosterone. The conversation shifts to Stacy's use of diindolylmethane (DIM), which Stacy explains she experimented with for acne. She completed a 90-day trial and plans to discontinue use to observe any changes. Dr. J expresses general disapproval of DIM, citing its tendency to increase estrogen levels, often counteracting its intended purpose. Dr. J acknowledges the challenges in dosing DIM effectively but remains open to trying it in certain situations.
Hormone and Thyroid Gene Analysis
00:43:20 - 00:45:09
Dr. J discusses Stacy's genetic predisposition to hormone levels, noting conflicting genes for estrogen (four genes with offsetting high and low indicators). While this makes prediction difficult, it's considered better than consistently high or low indicators. Dr. J expresses less concern despite some indicators lighting up. However, genes indicating low thyroid hormones are identified, prompting a recommendation to monitor thyroid hormone levels. Low thyroid hormones are linked to low energy and potential difficulties in fat burning, especially considering Stacy's fat genes (FTO genes). Dr. J advises Stacy not to fear thyroid optimization. Stacy mentions an upcoming annual exam and plans to request specific lab tests based on the genetic information, which Dr. J affirms as a benefit of the DNA analysis, specifically mentioning the FOXE1 gene.
Thyroid Gene and Iodine Supplementation
00:45:09 - 00:46:46
Dr. J discusses a gene related to thyroid function, noting a threefold higher risk of thyroid issues in individuals with a specific gene variant, discovered through Chernobyl radiation accident studies. This gene variant impacts autophagy in the thyroid, hindering its ability to remove waste. Dr. J suggests intermittent fasting as beneficial. An unknown participant emphasizes monitoring thyroid hormones, especially with age. Stacy asks about iodine supplementation, and Dr. J strongly recommends it as a crucial building block for thyroid hormones, particularly important with the discussed gene variant. A full thyroid panel is suggested, despite potential daily fluctuations in hormone levels, as significant deviations will still be apparent.
BC01 Gene and Carotene to Retinol Conversion
00:46:50 - 00:47:19
Dr. J addresses the BC01 gene (beta-carotene oxygenase), classifying the patient's variant as minor. This variant results in reduced conversion of carotene to retinol, but the impact is not significant compared to other, more substantial variants of the same gene. The discussion highlights the body's need for retinol.
Vitamin A and Dietary Considerations
00:47:20 - 00:49:06
Dr. J explains the difference between retinol and carotene, clarifying that while carrots are often touted as good for the eyes, the body needs to convert carotene to retinol, which is the form the eyes actually use. Better sources of retinol include butter, egg yolks, and liver, with liver being the most potent. Dr. J expresses a personal preference for liver pâté, but cautions against consuming excessive amounts of liver due to potential iron levels. Considering the patient's SOD2 gene, Dr. J recommends a vitamin A supplement containing retinol, such as cod liver oil, as a safer alternative to liver or liver pills. Stacy mentions using an ADK2 supplement. Dr. J notes that most vitamin A supplements use carotene due to its cost-effectiveness and availability, but that retinol is preferable and more difficult to obtain due to its sensitivity to oxidation. Stacy then asks if retinol supplements are on Dr. J's recommended list.
Supplement Recommendations and Genetic Considerations
00:49:06 - 00:50:41
Dr. J and Stacy discuss supplements listed on Dr. J's website. Stacy reviewed the list and notes that there are many supplements. Dr. J advises waiting for DNA results before starting any supplements due to potential gene interactions. He uses lutein as an example, explaining that while it can be beneficial, some individuals have a higher risk of prostate cancer related to lutein metabolism. Dr. J then discusses the C-O-M-T gene and its relation to cannabis use. A "plus plus" result indicates faster dopamine breakdown, potentially leading to demotivation and increased schizophrenia risk if cannabis is consumed. Therefore, individuals with this gene marker are advised against cannabis use. The existence of a specific gene increasing schizophrenia risk from cannabis use is debated, but this gene is considered a strong indicator.
MTHFR Gene and Supplement Discussion
00:50:41 - 00:52:23
Dr. J and Stacy discuss Stacy's genetic results, specifically focusing on the MTHFR C677T gene. Dr. J points out that this is a significant gene, impacting folic acid processing efficiency. Stacy confirms she's taking a supplement with methylfolate, rather than folic acid, from Douglas Labs' Ultra Preventative multivitamin. Dr. J emphasizes the importance of methylfolate over folic acid, given Stacy's genetic profile, highlighting that the C677T variant makes her 80-90% less efficient at processing folic acid. Stacy mentions using methylfolate prenatals during her pregnancies, expressing relief at having avoided potential complications related to the MTHFR gene. Dr. J concludes by stating that the MTHFR gene is a major risk factor for miscarriages.
Genetic Factors and Nutritional Recommendations
00:52:23 - 00:53:46
Dr. J explains the impact of genetic factors on miscarriage, specifically mentioning a gene issue related to consistent miscarriage problems. The doctor clarifies that a "plus-plus" gene, while often problematic, is easily manageable in this case by avoiding folic acid and opting for methylfolate instead. Failure to do so might lead to heavy metal buildup, although this is less common. The conversation then shifts to B12, where Dr. J highlights that the patient possesses a beneficial "plus-plus" gene resulting in better B12 absorption than most. This means supplementation is unnecessary, saving the patient money. The patient, Stacy, mentions supplementing B12 while on Metformin due to a previous recommendation from Dr. J, which the doctor confirms as standard practice.
Heavy Metal Testing and Glutathione Supplementation
00:53:49 - 00:55:21
Dr. J inquires about Stacy's heavy metal testing, noting elevated levels on her report related to her GSTP1 gene and glutathione. Stacy expresses curiosity about heavy metal testing, having heard about it from Dave Asprey. Dr. J recommends testing, especially given her GSTP1 gene results and their connection to glutathione. Stacy mentions her current glutathione injections, which Dr. J approves of as the best method of administration. The discussion then shifts to the lack of readily available dosing information for glutathione, attributed to the fact that it's injectable, inconvenient, and unpatentable since the body naturally produces it. Dr. J explains that pharmaceutical companies prioritize patentable products like vaccines over glutathione, despite its effectiveness for individuals with GSTP1 gene issues. Dr. J typically advises against heavy metal testing if patients already supplement with glutathione, as the results might be insignificant due to the chelation effect of glutathione. However, the usual recommendation is to test for heavy metals first and then start glutathione supplementation if levels are high. The conversation concludes with Stacy asking for dosing recommendations for glutathione.
Addressing a Specific Gene Issue and Supplement Protocols
00:55:21 - 00:57:13
Dr. J recommends consulting a functional doctor for advice on managing a specific gene issue related to a supplement. While acknowledging the benefits of high levels of the supplement, Dr. J admits unfamiliarity with specific protocols, noting their personal use of a liposomal version without experiencing the gene-related concerns. The conversation then shifts to the impact of fructose, particularly for individuals with PNPLA3 gene variants. Dr. J explains that fructose is more readily stored as fat in the liver for these individuals, increasing the risk of fatty liver disease. However, Dr. J clarifies that not all fruits are high in fructose, emphasizing the availability of low-fructose options and referencing a created article detailing these choices to avoid unnecessary dietary restrictions.
Histamine Intolerance Discussion
00:57:13 - 00:58:48
The conversation begins with a brief discussion about sugary drinks and their high glucose content, contrasting with lower fructose levels in some alternatives. Stacy then raises a question about her recent histamine intolerance, experiencing flushing, itching, and burning, particularly after exercise and hot baths. Dr. J explains this is likely related to the AOC1 gene (amine oxidase, copper-containing, number one), an oxidase that breaks down amines including histamines. A plus-minus result on this gene indicates an increased risk of histamine intolerance. Dr. J emphasizes the widespread presence of histamines in food, referencing scientific studies on histamine-free diets which are extremely restrictive, highlighting the challenge in managing this condition.
GHK-CU and Copper Supplementation for Improved Health
00:58:48 - 01:00:19
This segment focuses on the use of GHK-CU (copper peptide) supplementation, particularly its benefits and potential for higher dosing. Dr. J and Stacy discuss the advantages of increasing copper levels, especially for individuals with a specific gene. Stacy shares her experience with a 21-day GHK-CU treatment, noting noticeable skin improvements. She emphasizes the numerous bodily processes involving copper, making supplementation beneficial even without immediately noticeable effects. Stacy mentions listening to a podcast featuring Carl Lenore and Betsy discussing GHK-CU and higher dosing possibilities due to the rarity of copper toxicity. Dr. J confirms familiarity with Carl's work and highlights GHK-CU's role in wound healing and collagen production, further emphasizing its stimulation of stem cell numbers.
Copper Supplementation and Genetic Predisposition
01:00:23 - 01:01:09
Dr. J recommends copper supplementation due to its importance in amine oxidase copper-containing enzymes. The best source is liver. Further investigation into a specific gene is suggested, but copper supplementation is deemed the most effective immediate action, alongside general health practices like sufficient sleep. Stacy agrees with this assessment.
Genetic Analysis of Muscle Fiber Type and Endurance
01:01:09 - 01:02:01
Dr. J discusses Stacy's genetic profile related to muscle fiber type, noting a mixed profile of slow and fast twitch fibers. A rare endurance gene, BDKRB2 (present in 30% of people but common in elite endurance athletes), is identified, suggesting an advantage in endurance training with benefits like increased blood flow, reduced muscle spasms, and less pain. Additionally, the ACBR1B gene is noted, indicating higher muscle strength per muscle volume.
Athletic Genes and Joint Health
01:02:02 - 01:03:48
Dr. J reviews Stacy's phenomenal athletic genes, emphasizing the importance of continued training. The conversation then shifts to joint health, with Stacy mentioning occasional pain from running, attributing it to the need for stretching and the demands of caring for two children. Dr. J shares a personal anecdote about a meniscus injury, initially advised to have surgery but healing naturally after six months. He mentions other treatment options like injections and BPC. The discussion focuses on barefoot running as a solution for Dr. J's knee pain, referencing Chris McDougall's "Born to Run." Dr. J describes his experience transitioning to barefoot running, initially extreme, then adopting minimal shoes and a barefoot running cadence, ultimately resolving his knee issues.
Running Style and Minimally Invasive Shoes
01:03:51 - 01:04:38
Dr. J discusses running style, mentioning a preference for minimal shoes like Merrells, focusing on running closer to the toes. They acknowledge Stacy's knowledge of this topic. The conversation then shifts to genetic predispositions, specifically mentioning the IL-2RA gene, linked to poor diet and processed food consumption.
Genetic Predispositions and Age-Related Concerns
01:04:39 - 01:05:48
Dr. J expresses concern about the DIO2 gene, related to thyroid hormones, and its connection to osteoarthritis. The importance of maintaining healthy thyroid hormone levels and sufficient iodine intake is emphasized. The conversation also touches upon the HTR2A gene, a blood flow gene related to serotonin receptors, and its link to arthritis risk. The importance of maintaining good serotonin levels is highlighted.
Lifestyle, Diet, and Serotonin Levels
01:05:49 - 01:07:09
Dr. J explains that Stacy's past anxiety and depression might have been linked to low serotonin levels due to unhealthy eating habits during a stressful period, such as when she graduated with her LPN. The doctor connects this to potential joint issues. However, now that Stacy maintains a healthy diet and lifestyle, her serotonin levels are likely higher, positively impacting her joint health. Dr. J dismisses concerns about gout despite a positive genetic marker (SLC2A9 gene) because Stacy's healthy lifestyle mitigates the risk. The doctor highlights the common misconception that doctors advise against meat consumption for gout, while the actual culprit is often high fructose intake, which Stacy avoids.
Low Back Issues and IL-1A Gene
01:07:11 - 01:07:29
Dr. J discusses the IL-1A gene, noting that even with a plus-minus result, it indicates a doubled risk of low back problems. Stacy confirms a history of low back pain from a young age, corroborating the genetic predisposition discussed.
Back Pain and Treatment Options
01:07:29 - 01:09:04
Stacy mentions experiencing back pain, a common issue exacerbated by prolonged standing. Dr. J shares a similar experience, attributing his recurring back pain to a specific gene and past injuries. Dr. J explains that he's had back problems since age 12, often requiring several weeks to heal. He highlights testosterone as a significant factor in accelerating his recovery, noting that increased testosterone levels inhibit inflammation. He describes using testosterone cream, primarily when experiencing back pain, to expedite healing. Dr. J emphasizes the importance of checking testosterone levels, as low levels can contribute to inflammation. He also mentions curcumin and other supplements as effective inhibitors of interleukin, a type of inflammation linked to various health problems. Stacy mentions using red light therapy.
Back Injury and Testosterone Treatment
01:09:04 - 01:10:33
Stacy describes a back injury sustained a year prior during a CrossFit box step-up exercise. She clarifies it wasn't disc-related but rather a muscular pull, unfortunately occurring two days before her black belt Taekwondo test. Dr. J empathizes, noting that back injuries often occur unexpectedly during seemingly innocuous activities. Dr. J shares personal anecdotes of back pain arising from strenuous activities like lifting heavy posts, only to manifest later during simple actions like tying shoes. The conversation shifts to treatment, with Stacy inquiring about topical testosterone application. Dr. J explains he uses testosterone cream to increase his overall levels (to 1000), not directly on the injury site, suggesting that this approach, while effective for him, should be managed carefully with a doctor's guidance for women. Stacy mentions PQQ as a supplement she's seen recommended.
Interleukin Inhibition and Muscle Growth
01:10:40 - 01:12:37
Dr. J discusses various interleukin inhibitors, starting with PQQ (pyroluquinoline quinone) produced by gut bacteria. He mentions Stacy's use of ECGC (epicatechin gallate), highlighting its role in myostatin and follistatin regulation for muscle building and its interleukin-inhibiting properties. Dr. J suggests cycling these and other options for optimal results. He then introduces alpha-MSH (melanotan), another interleukin inhibitor, as a potential treatment for back pain. Stacy confirms the anti-inflammatory benefits, and Dr. J explains that this is due to interleukin inhibition. He clarifies that various forms of inflammation exist (TNF-alpha, interferon, etc.), with melanotan specifically targeting interleukin. Finally, Dr. J touches upon the IGF-1 receptor gene, noting that lower IGF-1 levels, while generally acceptable, can make muscle mass gain difficult, particularly for men.
Supplement and Training Discussion
01:12:39 - 01:14:21
Dr. J suggests increasing zinc intake through red meat consumption, mentioning IGF injections (tessamoralin) as an alternative, although Stacy experiences significant swelling from its use, limiting her to three-week cycles. Dr. J notes Stacy's genetic predisposition, resulting in low pain sensitivity (C1MT version), which, while not inherently negative, necessitates caution during intense training to avoid injuries. The discussion shifts to Stacy's training regimen, highlighting her genetic advantage of rare endurance genes, allowing for longer cardio sessions with less inflammation compared to others. Stacy expresses surprise at her endurance capabilities, contrasting her self-perception with her actual performance.
The Importance of Epigenetics and Early Childhood Training
01:14:21 - 01:15:06
Dr. J discusses the significant role of epigenetics in athletic training, emphasizing that early childhood activities, particularly during teenage years when hormones are high, create epigenetic marks on DNA that influence later performance. These marks, developed through activities like heavy lifting, are crucial for future success. Dr. J highlights that what one does as a child, especially as a teenager, significantly impacts their potential for later athletic achievements.
Stacy's Childhood and its Impact on Current Training
01:15:06 - 01:15:30
Stacy reflects on her own childhood, noting the limited opportunities for weightlifting and diverse sports in her small town and school. She explains that her sports options were limited to baseball, softball, soccer, and basketball, lacking activities like track and field, which she believes may have negatively impacted her current athletic capabilities.
Overcoming Past Limitations and Future Training Strategies
01:15:30 - 01:16:05
Dr. J acknowledges that while past limitations can be overcome through hard work, it requires more effort. Stacy expresses her intention to provide her children with more diverse and intensive training opportunities, starting at a younger age, based on her understanding of epigenetics and early childhood development's impact on athletic potential. Dr. J shares an anecdote about his four-year-old daughter running four miles with him, illustrating the surprising endurance capacity of young children.
Motivating Young Children for Physical Activity
01:16:05 - 01:17:06
Dr. J recounts a story about a four-year-old who unexpectedly ran four miles to a train station in Boston, motivated by the prospect of visiting the station. The discussion highlights the challenge of motivating young children for exercise without resorting to sugary rewards, which could create unhealthy associations. Dr. J emphasizes the importance of finding alternative incentives, such as enjoyable destinations, to encourage physical activity and avoid creating negative experiences that might deter future exercise. Stacy agrees, suggesting avoiding increasing the hedonic effect of food, particularly sugar, as a reward.
The Importance of Avoiding Negative Associations with Exercise
01:17:06 - 01:17:18
Dr. J continues by explaining the importance of avoiding pushing children too hard during physical activity, to prevent them from developing negative associations with exercise. The anecdote of the four-year-old running four miles is used to illustrate the point that children can surprise you with their capabilities if properly motivated. The discussion emphasizes the need for positive reinforcement and avoiding creating miserable experiences that could lead to lifelong aversion to exercise.
Genetics and Sleep Issues
01:17:18 - 01:17:40
Dr. J briefly shifts the topic to discuss genetics and their influence on sleep patterns. Mentioning the MTHFR gene, Dr. J notes that many individuals with this gene experience sleep problems. The connection between genetics and sleep is introduced, with a reference to further information available on Amazon.
Methylfolate and Sleep
01:17:40 - 01:19:17
Dr. J discusses the importance of the 5-MTHF supplement, citing numerous positive reviews regarding its impact on depression and sleep. Dr. J explains that the PER3 gene can sometimes lead to delayed phase sleep disorder, affecting sleep cycle onset. The conversation then shifts to Stacy's sleep patterns, with Stacy reporting inconsistent REM and deep sleep data from her Aura device. She notes variations in her sleep stages, with deep sleep ranging from 15 minutes to 1 hour and 35 minutes, and REM sleep fluctuating significantly. On average, her deep sleep is usually below 20% of her total sleep time, and rarely exceeds one hour. Dr. J inquires about the average duration of Stacy's deep sleep.
Melatonin and Sleep Optimization
01:19:20 - 01:21:04
Dr. J discusses melatonin use, noting its effectiveness for individuals with significant deep sleep but lacking REM sleep. He explains that melatonin typically reduces deep sleep and increases REM, making it less necessary for most. However, he acknowledges that some individuals may not respond well to sleep tracking devices, and melatonin could be an option in such rare cases. Dr. J emphasizes that the device used is generally excellent but individual responses vary. He suggests dietary adjustments for Stacy, who mentions trying a glymphatic system cleansing approach by avoiding food several hours before sleep. Stacy explains that she's inconsistent with this due to current life circumstances, but aims for at least a two-hour window between eating and bedtime. She also mentions peptide injections, requiring a 90-minute fasting period beforehand.
Magnesium Supplementation Discussion
01:21:05 - 01:22:43
Dr. J expresses surprise at the number of peptides Stacy is using, prompting a discussion about magnesium supplementation. Stacy mentions using magnesium glycinate, but finds the pill size inconvenient and inconsistent in her intake. Dr. J agrees that the pills are large and suggests magnesium citrate as a more convenient and tasteless alternative, readily available in bulk. Dr. J emphasizes the ease of use—simply adding a scoop to water before bed—and highlights magnesium's value for sleep improvement, especially considering Stacy's genetics. Stacy mentions prior experience with Mag Calm, which Dr. J also approves of. The conversation concludes with a recommendation for a simpler magnesium supplementation method to ensure consistent use.
Magnesium Supplement and Sleep Discussion
01:22:43 - 01:23:09
Stacy and Dr. J discuss a magnesium supplement, casually referred to as "Mag Calm," due to frequent forgetting of its precise name. Dr. J mentions using it for their children because of its palatable taste, noting the presence of stevia as a sweetener (avoiding the term "artificial sweetener" to prevent misunderstandings). They agree that it's a good product.
The WWC1 Gene and Sleep's Impact on Memory
01:23:11 - 01:23:54
Dr. J introduces the WWC1 gene, explaining that while it doesn't directly cause poor sleep, insufficient sleep significantly reduces memory recall (approximately 25%) in individuals with this gene. The importance of sleep for optimal brain function is emphasized. An unknown speaker adds a comment (partially audible). Dr. J then cautions against nicotine addiction but acknowledges that in rare instances of severe sleep deprivation, nicotine gum might offer a temporary boost to WWC1 gene production. However, prioritizing sleep is strongly recommended. Stacy shares her experience using nicotine gum during fasting.
Nootropics and Smoking Habits
01:24:00 - 01:25:52
Dr. J mentions that Ben Greenfield and he use nicotine for cognitive enhancement, with Dr. J preferring cigars or pipes about once a week for social and brain performance benefits. Stacy brings up a nicotine and CBD product containing methylene blue, recalling Ben Greenfield's research on it as a nootropic. Dr. J confirms methylene blue's presence and shares his experience using smoking (cigars, pipes) as a tool to overcome writer's block, emphasizing that he's never struggled with addiction. He details his past pipe smoking in college and current habit of growing his own tobacco to avoid chemicals sprayed on commercially grown products, questioning whether the cognitive benefits stem from nicotine or other substances in commercially produced tobacco.
Seasonal Affective Disorder Treatment Discussion
01:25:52 - 01:27:42
Dr. J discusses seasonal affective disorder (SAD), mentioning the PER3 gene's link to its higher incidence. The doctor suggests sunshine and a trip to Florida as the best solution, but also mentions the Sperti UV light device as an alternative, despite its high cost. Stacy clarifies if it's a high-lux light, but Dr. J specifies it's UVB, emphasizing the need for caution and eye protection due to potential sunburn. The doctor explains the importance of maintaining a safe distance and gradually increasing exposure time. They highlight the device's effectiveness for SAD, contrasting it favorably with blue light therapy. Stacy agrees, noting the preference for this method over tanning beds, even though she used them previously for vitamin D synthesis. Dr. J concludes by emphasizing the importance of short exposure times for safe vitamin D production.
Tanning Beds and Melanotan Injections
01:27:42 - 01:28:14
Dr. J discusses the use of tanning beds and melanotan injections. Dr. J expresses acceptance of tanning beds as long as users aren't aiming for extreme tans. Stacy suggests melanotan injections as an alternative. Dr. J acknowledges that most people dislike injections. The conversation then shifts to the risks associated with self-injecting, highlighting the danger of introducing bacteria and the potential harm to the heart valve if proper procedures aren't followed. However, Dr. J notes that the process isn't inherently difficult if done correctly.
Seasonal Affective Disorder and Sunlight Exposure
01:28:14 - 01:29:30
The discussion turns to seasonal affective disorder (SAD) and its relation to sunlight exposure. Stacy shares her experience of experiencing mood changes and a desire for relocation around February, attributing it to the lack of sunlight in New York compared to South Dakota. She notes the significantly longer periods of dimness and darkness in New York. Dr. J relates their experience growing up in Morris, Minnesota, where the open landscape allowed for unobstructed views of sunrises and sunsets, contrasting it with their experience in Boston, where abundant trees blocked sunlight for much of the day. Stacy agrees, mentioning the hilly terrain of upstate New York further limiting sunlight exposure.
Post-Consultation Review and Next Steps
01:29:30 - 01:31:23
Dr. J asks Stacy if anything from the consultation requires further discussion. Stacy confirms understanding of the explained information and expresses anticipation for lab results. Dr. J prioritizes checking iron levels, recommending annual or biannual checks depending on results, suggesting blood donation if levels are high. Thyroid hormones and triglycerides are also mentioned as areas for monitoring. Dr. J concludes that Stacy's genetics are generally positive. An unknown speaker expresses appreciation for Stacy's training and activities. Stacy discusses her food sensitivities, particularly sesame and yeast, suggesting a possible underlying inflammatory issue and the potential benefit of prebiotics and probiotics. Dr. J agrees and mentions using a foam roller to assess leaky gut.
Foam Rolling and Diet's Impact on Body Pain
01:31:23 - 01:32:21
Dr. J discusses how their sensitivity to gluten affects their experience using a foam roller. They explain that after consuming gluten, foam rolling reveals significant pain, unlike when eating healthily, where the experience is positive. Stacy expresses surprise at this connection. Dr. J comments on the unusual appearance of foam rolling, especially in a gym setting, but advocates for building tolerance to others' opinions by doing what's beneficial, as long as it doesn't cause injury. They cite examples of risky gym exercises, such as improper deadlifts, that should be avoided.
Conclusion of Conversation
01:32:22 - 01:32:35
Stacy agrees that self-care should prioritize injury prevention. The conversation concludes with pleasantries and mutual farewells between Dr. J and Stacy.
00:00:00 - 00:01:32
Dr. J introduces himself as a Mayo Clinic scientist, author of "Estrogeneration," and owner of AJ Consulting Company. He mentions a consultation with Stacy from South Dakota focusing on peptides, describing the topic as advanced. He promotes his DNA consulting services and podcast. The initial segment concludes with a brief technical check between Dr. J and Stacy to confirm recording devices and Bluetooth connectivity are functioning correctly.
Location and Background
00:01:33 - 00:01:56
Dr. J clarifies Stacy's location as South Dakota, despite her retaining an East Coast phone number. They briefly discuss maintaining old phone numbers after relocating, both having done so themselves. Dr. J asks about the specific location within South Dakota, prompting Stacy to mention Sioux Falls.
Dr. J's Family and the Fighting Sioux
00:01:54 - 00:02:54
Dr. J shares a personal anecdote about his father being the medical doctor for the Fighting Sioux hockey team, prompting Stacy to inquire about the team's name change to UND Hockey due to the term "Sioux." Dr. J mentions his sister living in a town called Britain in eastern South Dakota, a place he recently visited and describes as having good fishing. The conversation concludes with Stacy commenting on Dr. J's known enjoyment of fishing.
Discussion of Stacy's Supplements and Peptide Cycling
00:02:56 - 00:03:30
Dr. J and Stacy discuss Stacy's supplement regimen, specifically mentioning peptides. Stacy acknowledges that her extensive supplement use might seem excessive but explains the rationale behind including them. Dr. J inquires about Stacy's peptide cycling practices, and Stacy confirms she cycles them. The conversation briefly touches upon specific peptides like ipameraline and melanotan, with Stacy noting that melanotan cycling is less crucial when used at lower doses for its anti-inflammatory properties. She admits to inconsistent melanotan usage, resulting in an unintentional cycling effect.
Peptide Sourcing and Sleep Tracking
00:03:33 - 00:04:56
Stacy discusses her peptide sourcing from TaylorMade, noting upcoming changes and the availability of new oral medications. She mentions upcoming webinars by Ryan Smith regarding these new products, specifically a reformulated semerelin replacing epimerelin CJC. The conversation then shifts to sleep tracking using Aura devices, both Stacy and Dr. J using them for over a year and two years respectively. Dr. J inquires about Stacy's experience with melanotan's impact on sleep, with Stacy expressing difficulty isolating its effects among other lifestyle factors. Dr. J shares their own experience of unexpectedly improved sleep, particularly increased deep sleep, with melanotan, contrasting with Stacy's reported decrease in REM sleep. Dr. J then asks about the duration of Stacy's deep sleep, indicating a desire to compare experiences.
Sleep Aid Strategies and Experiences
00:04:56 - 00:06:22
Stacy discusses her consistent difficulty achieving sufficient deep sleep, reporting sleep durations always exceeding one hour. She details various strategies employed to improve sleep quality, including DSIP (deep sleep-inducing peptide), DHHB (dihydra, hinocchial, with an unspecified B portion), melatonin, blue light blockers, and using red/incandescent lighting in the evenings and bright blue light in the mornings. While initially finding DSIP effective, she notes that overdosing led to disrupted sleep. She describes DHHB as a pill purported to increase non-REM sleep and possess potent anti-inflammatory properties exceeding those of NSAIDs. Dr. J expresses interest, clarifying the name of DHHB and indicating an intention to research it further as a supplement.
Discussion of a Sunscreen Chemical Compound
00:06:25 - 00:07:37
Dr. J expresses surprise at an unfamiliar compound mentioned by 22, resembling a sunscreen chemical. Stacy mentions Tillermade and Dr. Seeds' involvement with DHHB. Dr. J suggests potentially reducing the number of compounds used, citing Lyra Glutide (a GLP-1 agonist) as an example. Stacy explains its use as a metformin alternative, but notes its phasing out due to expense. Dr. J explains that Lyra Glutide's effectiveness depends on genetic factors, deeming it unnecessary in Stacy's case. The conversation concludes with Dr. J acknowledging Stacy's biohacking approach.
FDA Regulation of Peptides and Biohacking
00:07:38 - 00:08:04
Dr. J expresses disappointment over the FDA's crackdown on peptides, advocating for individual choice in biohacking and utilizing readily available online information. The discussion concludes with Dr. J's opinion that the government's regulation of personal health choices is excessive.
Peptide Therapy Discussion
00:08:06 - 00:08:29
Dr. J discusses the accessibility of peptide therapy, noting the availability of safety and dosage information, although acknowledging the challenges of injections. Stacy agrees, emphasizing the benefits often outweighing the risks, explaining her interest in peptide therapy. Dr. J then transitions the conversation to the topic of DNA analysis.
DNA Analysis and Interpretation
00:08:30 - 00:09:44
Dr. J refers to a previously emailed PDF containing DNA analysis results, explaining the notation system used: "++" indicates inheriting a bad gene copy from both parents, while "+-" signifies one bad and one good copy. Dr. J explains the basics of DNA inheritance, mentioning that each cell (except egg and sperm cells) contains two copies of DNA, one from each parent. Due to time constraints, Dr. J states they will primarily focus on the "++" results (two bad gene copies), briefly mentioning "+-" results but deferring detailed discussion.
Gene Analysis and Interpretation
00:09:47 - 00:11:19
Dr. J explains that the impact of certain genetic factors is unpredictable, sometimes influencing health outcomes and sometimes not. This variability is attributed to epigenetics and environmental factors. Stacy confirms understanding and mentions having printed copies of the genetic reports for visual reference, although she also has a digital record. Dr. J clarifies that "plus plus" in genetic results doesn't automatically indicate negative health implications, providing examples of how it can relate to muscle types in athletes. Dr. J states that she includes such nuances in her reports. The discussion then focuses on specific genes. Dr. J indicates that the CETP gene is less concerning unless triglycerides are high. Stacy confirms having recent blood work with favorable cholesterol markers, including a higher HDL than LDL. Dr. J expresses low expectation of high triglycerides but suggests checking the results. The conversation moves to the CLU gene, identified as an intermittent fasting gene related to clusterin.
Intermittent Fasting and its Effects
00:11:24 - 00:12:35
Dr. J explains that intermittent fasting increases autophagy, the process of clearing cell debris, which is beneficial for brain health and reducing Alzheimer's risk. Stacy mentions her past experience with 16/8 intermittent fasting and longer fasts while doing keto. She currently focuses on gym workouts and is gradually reintroducing shorter eating windows. The conversation concludes with Dr. J suggesting that intermittent fasting would be beneficial for Stacy, especially considering her age and activity level. An additional point is made that at younger ages, it matters less.
Impact of FOXO3 Gene and High-Intensity Workouts
00:12:35 - 00:13:27
Dr. J introduces the FOXO3 gene, which affects how the brain processes carbohydrates and higher blood sugar levels. The discussion shifts to Stacy's intense workout routine, including CrossFit and Orange Theory Fitness. Dr. J explains that for individuals with this gene and high activity levels, the impact of carbohydrates is less significant because they are burned during exercise. However, for those with less intense activity, consuming a large amount of carbohydrates might lead to fatigue.
Blood Sugar and Brain Function
00:13:28 - 00:14:01
Dr. J explains that individual responses to carbohydrates vary, impacting both body and brain function. Higher blood sugar, as seen in diabetes, increases the risk of Alzheimer's due to the brain's sensitivity to glucose levels. The discussion then transitions to the connection between specific genes (TPH2 and HTR2A) and anxiety/melancholy. These genes relate to serotonin receptors and transporters, impacting serotonin uptake and binding in the brain.
Serotonin, Gut Health, and Anxiety
00:14:03 - 00:15:34
Dr. J continues by explaining the significant role of gut health in serotonin production (90% originates in the gut). Insufficient serotonin production due to poor gut health or inefficient transport and receptor binding can lead to anxiety. Dr. J inquires about Stacy's history with anxiety, noting that it seems less significant recently. Stacy confirms that anxiety was more prevalent in her younger years, but currently, it's more of a baseline personality trait than a major issue. Dr. J emphasizes the positive impact of healthy lifestyle choices (diet, exercise, sleep) on managing anxiety. The conversation concludes with a brief discussion of Stacy's caffeine metabolism, which Dr. J deems not a significant concern.
Sirtuin and Lifespan Enhancement
00:15:36 - 00:17:32
Dr. J discusses the gene sirtuin (SIRT1) and its impact on lifespan, explaining that increasing sirtuin levels in mice doubled their lifespan. While continuously increasing sirtuin doesn't indefinitely extend lifespan, it does offer some increase. Dr. J notes that a version of the gene produces less sirtuin, highlighting the importance of consistently increasing it. Resveratrol is mentioned as a known enhancer, but Dr. J cautions about its estrogen-like effects, suggesting grapeseed pro-anthocyanidans as an alternative that also increases sirtuin without the estrogenic effect. Stacy inquires about astaxanthin's role, but Dr. J clarifies it's a different compound. The discussion concludes with Dr. J confirming there are no further questions on the brain health section.
Diet and Genetic Predisposition to Type 2 Diabetes
00:17:35 - 00:19:16
Dr. J discusses the patient's genetic predisposition to type 2 diabetes, focusing on the HHEX gene, which indicates a three-fold increased risk. The doctor emphasizes that this increased risk doesn't guarantee the development of the disease. Exercise is highlighted as crucial due to the gene's relation to nitric oxide production in the pancreas; beet juice and citrulline are mentioned as supplementary aids. The discussion then shifts to the SLC30A8 gene, a zinc transporter, suggesting the importance of zinc intake. The patient, Stacy, confirms daily meat consumption, although acknowledging that lunch meats might not be the optimal source of zinc. An unknown participant suggests zinc supplementation if meat intake is low. Finally, Dr. J inquires about Stacy's fasted blood sugar levels, with Stacy reporting initial readings in the 60s and 70s during keto, progressing to the 80s and 90s. Dr. J considers these levels acceptable, and Stacy mentions reading about compensatory glucose production after glucose depletion.
Blood Sugar Regulation and Obesity Risk Genes
00:19:16 - 00:21:22
Dr. J discusses Stacy's genetic predisposition to reactive hyperglycemia and elevated blood sugar, noting the presence of genes that influence type 2 diabetes. While some individuals with similar genetic profiles disregard carb intake, Dr. J emphasizes the importance of managing blood sugar levels, especially when exceeding 90. Zinc and intermittent fasting are suggested as management tools. The conversation then shifts to obesity risk genes, which Stacy possesses despite maintaining a healthy weight. Dr. J mentions Stacy's use of melanotan, highlighting its potential to improve blood glucose through the stimulation of alpha-melanocyte stimulating hormone (alpha MSH) and its impact on the MC4R gene. The doctor suggests monitoring blood sugar levels with and without melanotan use as an experiment. Sunshine is also proposed as a natural way to stimulate alpha MSH and regulate metabolism through the same gene. Finally, Dr. J acknowledges the presence of obesity risk genes despite Stacy's healthy weight, finding it noteworthy.
Family History and Genetics of Obesity
00:21:26 - 00:23:18
Dr. J inquires about Stacy's family history of obesity, noting that a genetic predisposition can make weight loss more challenging. Stacy reports that while some relatives may be slightly overweight, there's no significant history of obesity in her family. Dr. J then discusses the FTO gene, referencing a BBC documentary, "Why Are We Getting So Fat?", which highlighted the gene's role in obesity risk but lacked practical solutions. Dr. J explains that the FTO gene is involved in the conversion of white fat to brown fat. Brown fat, unlike white fat, is rich in mitochondria and burns significant energy, aiding in weight loss. Dr. J mentions that Stacy's familiarity with MOTS peptides (possibly referring to MOTS-c) is relevant, as brown fat's function is crucial in energy expenditure and is particularly important in infants for thermoregulation. The discussion concludes with Dr. J emphasizing the FTO gene's role in the white-to-brown fat conversion process.
MOTC Peptide Injection Reactions
00:23:18 - 00:24:49
Stacy and Dr. J discuss their adverse reactions to MOTC peptide injections. Stacy describes significant rashes and welts after injections, despite attempts to mitigate inflammation with thymus and alpha peptides, Alka-Seltzer Gold, and topical cortisone. The reactions were so severe that Stacy considered stopping injections due to fear of a life-threatening reaction. Dr. J corroborates Stacy's experience, reporting a similar reaction after a single injection, leading them to discontinue use. Despite the theoretical benefits of the peptide in addressing a gene issue related to fat metabolism and mitochondrial function, both individuals found the adverse reactions outweigh the potential advantages. Stacy details attempts to reduce the dosage to 5 milligrams three times a week, eventually reducing to once a week, but still experienced a severe reaction upon resuming injections after a two-week break.
Cold Exposure and Weight Management Strategies
00:24:50 - 00:26:39
Stacy expresses concern about the excessiveness of a previous weight management strategy. Dr. J suggests intermittent fasting, cold showers, or cryotherapy as alternatives, noting Stacy's potential as a "super responder" to cold exposure. The discussion shifts to the practicality of cold showers, with Dr. J highlighting the need for extended durations (20 minutes) for optimal benefits, contrasting this with the efficiency of cryotherapy (3 minutes). The use of saunas before cold showers or cycling between saunas and cold showers is proposed as a more sustainable approach. The conversation then turns to genetic factors influencing weight management, specifically mentioning diponectin and ADI-POQ genes, and Stacy's high level of discipline in maintaining weight despite genetic predispositions. Finally, Stacy clarifies that her use of fat-loss targeting peptides began after a period of weight gain experienced while following a ketogenic diet.
Ketogenic Diet Experiences and Strategies
00:26:39 - 00:28:32
This segment details personal experiences and strategies related to the ketogenic diet. Dr. J discusses their weight loss success on a very high-fat (80% fat by calories) ketogenic diet, noting the high satiety but acknowledging its lack of sustainability. They describe their typical food choices, emphasizing whole foods like egg yolks, salads with olive oil, MCT oil, and butter, while occasionally using keto bricks for lunch. The conversation touches upon the availability of processed keto products and the potential pitfalls of relying on them, including artificial sweeteners. Stacy mentions a previous ketogenic diet experience where tracking wasn't strictly enforced, focusing instead on maintaining ketosis. The discussion highlights the challenges of balancing effective weight loss strategies with sustainable dietary practices.
Metformin and Rapamycin Discussion
00:28:33 - 00:30:09
Dr. J commends Stacy on her weight management success despite having obesity risk genes. The conversation turns to Metformin, which Stacy had tried for a couple of months after hearing Dr. J discuss it on a podcast. Stacy monitored her blood glucose levels during this time, using continuous glucose monitoring, and found the results to be good, although she acknowledges not knowing her insulin levels. Dr. J notes that Stacy is a poor responder to Metformin, a relatively rare occurrence, and advises against its continued use due to the limited benefits compared to potential side effects. The discussion then shifts to Rapamycin, with Dr. J expressing concern about its immunosuppressant effects and suggesting it's a risky option.
Rapamycin Discussion and Alternatives
00:30:11 - 00:31:37
Dr. J expresses reservations about rapamycin, citing its potential negative effects on the immune system. The discussion clarifies that while rapamycin affects mTOR (mammalian target of rapamycin), intermittent or extended fasting also impacts mTOR, potentially offering similar benefits without the risks associated with rapamycin. Stacy mentions that rapamycin is available through TaylorMade under the name Cheryl Lemith, in various forms including 3mg capsules and creams, and suggests it as a possible alternative to metformin. Dr. J acknowledges rapamycin's lifespan-extending effects in animals but points out that calorie and carbohydrate restriction achieve similar results with less risk. While Dr. J generally avoids rapamycin, they acknowledge potential benefits at specific doses. Stacy notes that rapamycin is often used in a cyclical manner, perhaps only once or twice a year. The conversation then transitions to the SOD2 gene (superoxide dismutase 2).
Gene Variant and Iron Levels Discussion
00:31:45 - 00:33:20
The conversation begins with a question about a specific gene variant observed in previous DNA reports. Stacy mentions learning about the related pathway during a peptides certification course (parts one and two completed, with three and four remaining). Dr. J explains that the gene variant, related to superoxide dismutase (which neutralizes superoxides), doesn't pose a significant heart disease risk unless iron levels are high, in which case the risk increases tenfold. Dr. J notes that high iron levels are a concern because of the prevalence of heart attacks. However, Dr. J suggests that Stacy likely doesn't have high iron levels, given that women typically have lower iron due to monthly blood loss. Nevertheless, Dr. J recommends monitoring iron levels, including ferritin and iron-binding capacity, due to the increased heart disease risk associated with this specific gene variant and high iron. Stacy agrees and asks about recommended iron studies.
Optimizing Iron Levels and Heart Disease Risk
00:33:20 - 00:34:47
Dr. J discusses a patient's blood test results, specifically focusing on iron levels and their connection to heart disease. The patient has a specific gene that increases concern about heart disease risk, prompting Dr. J to share a Mercola article on optimal iron levels. Dr. J emphasizes the importance of personalized optimization, noting that standard blood test ranges are too broad for this purpose. High iron levels are explained as potentially damaging arteries through a reaction with oxygen, similar to rust formation. The patient's specific gene is mentioned as usually suppressing this reactivity, but since it's not functioning optimally, careful monitoring of iron levels is advised.
Assessment of Other Heart Disease Risk Genes
00:34:50 - 00:35:00
Dr. J continues the discussion by assessing other heart disease risk genes. The next gene is deemed less concerning as it's triglyceride-related. The exact details of this assessment are cut off in the provided transcript.
Gut Gene Analysis and Gluten Sensitivity
00:35:02 - 00:36:34
Dr. J reviews the patient's genetic report, focusing on the "leaky gut" section. The NOD2 gene shows a twofold increased risk for gut issues, considered minor compared to other genes. Dr. J explains that NOD2 is often called inflammatory bowel disease protein number two, highlighting its link to inflammatory bowel disease, but emphasizes its common occurrence. The doctor notes that many gut gene issues are common, making a list appear more intimidating than it is. The patient's results show mostly plus-minus genes, indicating better-than-average genetic predisposition. Dr. J suggests a likely gluten sensitivity based on the results, particularly the ATG-1601 gene, which is commonly associated with such sensitivity. This is corroborated by the patient's previous food allergy/sensitivity test. Finally, the RTN4RL2 gene, linked to increased gut issue risk, is discussed; healthy eating is emphasized as a mitigating factor. This gene's connection to the vagus nerve is mentioned, with exercise suggested as a beneficial stimulator.
Vagus Nerve Stimulation and Dietary Considerations
00:36:38 - 00:37:07
Dr. J suggests exploring ways to stimulate the vagus nerve due to Stacy's gene, referencing a linked article with 32 methods. Following a review of the diet section, Stacy confirms she doesn't have specific questions about the genes but expresses difficulty balancing dietary needs due to genetic predispositions against both high fat and high carb diets. Dr. J acknowledges this common challenge.
Dietary Recommendations for FTO Genes
00:37:07 - 00:38:15
Stacy discusses the challenge of balancing a diet with conflicting genetic predispositions (e.g., FTO genes impacting fat storage). Dr. J suggests a higher protein diet as a potential solution, acknowledging the difficulty of balancing macronutrients when training hard. Dr. J commends Stacy's current efforts and overall health based on a previous questionnaire. The conversation transitions to the vitamin, hormone, and detox section.
Vitamin D Supplementation
00:38:15 - 00:38:34
Dr. J notes Stacy's plus-plus vitamin D gene, common but requiring supplementation, especially in South Dakota, to maintain optimal blood levels.
Vitamin D Levels and Seed Oil Consumption
00:38:34 - 00:40:15
This segment focuses on the discussion of optimal Vitamin D levels and the avoidance of seed oils. Stacy inquires about ideal Vitamin D levels, mentioning a past result of 50. Dr. J explains that levels above 50 are desirable, referencing studies on hunter-gatherer tribes with levels between 70 and 100, contrasting this with the average American level of 30. The conversation highlights the importance of maintaining Vitamin D levels above 50, especially in light of recent COVID-19 research linking Vitamin D to health outcomes. The discussion then shifts to seed oils, with Dr. J emphasizing their avoidance. An unknown participant clarifies that this includes canola and soybean oils. Stacy confirms her avoidance of seed oils, mentioning limited use of coconut oil for high-temperature cooking and preference for olive oil.
Healthy Oils and Pesticide Exposure
00:40:15 - 00:41:20
Dr. J discusses the health benefits of various oils, including olive, coconut, and avocado oil, noting that avocado seed oil is less beneficial than regular avocado oil. The conversation then shifts to the potential negative effects of organophosphate pesticides, commonly used in mosquito sprays, particularly in areas like Florida. Stacy mentions the frequent spraying in her area and the precautions she takes to minimize exposure by closing windows and turning down the air conditioner. Other participants share similar experiences and concerns about pesticide exposure.
FAM9B Gene and Testosterone Levels
00:41:21 - 00:41:40
Dr. J comments on a patient's genetic profile, highlighting a positive result for testosterone and an unknown association between the FAM9B gene and lower testosterone levels. Dr. J expresses frustration at the lack of understanding regarding the FAM9B gene and its impact on testosterone, emphasizing the desire to find solutions for related issues.
Blood Test Results and Diindolylmethane Discussion
00:41:40 - 00:43:20
Dr. J discusses the challenges of finding effective solutions for certain gene-related issues. They then comment on the inaccuracy and potentially misleading nature of blood tests, specifically mentioning a women's testosterone range listed as 0-70 or 0-80, highlighting the absurdity of considering zero testosterone as normal. Dr. J advises aiming for the higher end of the normal range for testosterone. The conversation shifts to Stacy's use of diindolylmethane (DIM), which Stacy explains she experimented with for acne. She completed a 90-day trial and plans to discontinue use to observe any changes. Dr. J expresses general disapproval of DIM, citing its tendency to increase estrogen levels, often counteracting its intended purpose. Dr. J acknowledges the challenges in dosing DIM effectively but remains open to trying it in certain situations.
Hormone and Thyroid Gene Analysis
00:43:20 - 00:45:09
Dr. J discusses Stacy's genetic predisposition to hormone levels, noting conflicting genes for estrogen (four genes with offsetting high and low indicators). While this makes prediction difficult, it's considered better than consistently high or low indicators. Dr. J expresses less concern despite some indicators lighting up. However, genes indicating low thyroid hormones are identified, prompting a recommendation to monitor thyroid hormone levels. Low thyroid hormones are linked to low energy and potential difficulties in fat burning, especially considering Stacy's fat genes (FTO genes). Dr. J advises Stacy not to fear thyroid optimization. Stacy mentions an upcoming annual exam and plans to request specific lab tests based on the genetic information, which Dr. J affirms as a benefit of the DNA analysis, specifically mentioning the FOXE1 gene.
Thyroid Gene and Iodine Supplementation
00:45:09 - 00:46:46
Dr. J discusses a gene related to thyroid function, noting a threefold higher risk of thyroid issues in individuals with a specific gene variant, discovered through Chernobyl radiation accident studies. This gene variant impacts autophagy in the thyroid, hindering its ability to remove waste. Dr. J suggests intermittent fasting as beneficial. An unknown participant emphasizes monitoring thyroid hormones, especially with age. Stacy asks about iodine supplementation, and Dr. J strongly recommends it as a crucial building block for thyroid hormones, particularly important with the discussed gene variant. A full thyroid panel is suggested, despite potential daily fluctuations in hormone levels, as significant deviations will still be apparent.
BC01 Gene and Carotene to Retinol Conversion
00:46:50 - 00:47:19
Dr. J addresses the BC01 gene (beta-carotene oxygenase), classifying the patient's variant as minor. This variant results in reduced conversion of carotene to retinol, but the impact is not significant compared to other, more substantial variants of the same gene. The discussion highlights the body's need for retinol.
Vitamin A and Dietary Considerations
00:47:20 - 00:49:06
Dr. J explains the difference between retinol and carotene, clarifying that while carrots are often touted as good for the eyes, the body needs to convert carotene to retinol, which is the form the eyes actually use. Better sources of retinol include butter, egg yolks, and liver, with liver being the most potent. Dr. J expresses a personal preference for liver pâté, but cautions against consuming excessive amounts of liver due to potential iron levels. Considering the patient's SOD2 gene, Dr. J recommends a vitamin A supplement containing retinol, such as cod liver oil, as a safer alternative to liver or liver pills. Stacy mentions using an ADK2 supplement. Dr. J notes that most vitamin A supplements use carotene due to its cost-effectiveness and availability, but that retinol is preferable and more difficult to obtain due to its sensitivity to oxidation. Stacy then asks if retinol supplements are on Dr. J's recommended list.
Supplement Recommendations and Genetic Considerations
00:49:06 - 00:50:41
Dr. J and Stacy discuss supplements listed on Dr. J's website. Stacy reviewed the list and notes that there are many supplements. Dr. J advises waiting for DNA results before starting any supplements due to potential gene interactions. He uses lutein as an example, explaining that while it can be beneficial, some individuals have a higher risk of prostate cancer related to lutein metabolism. Dr. J then discusses the C-O-M-T gene and its relation to cannabis use. A "plus plus" result indicates faster dopamine breakdown, potentially leading to demotivation and increased schizophrenia risk if cannabis is consumed. Therefore, individuals with this gene marker are advised against cannabis use. The existence of a specific gene increasing schizophrenia risk from cannabis use is debated, but this gene is considered a strong indicator.
MTHFR Gene and Supplement Discussion
00:50:41 - 00:52:23
Dr. J and Stacy discuss Stacy's genetic results, specifically focusing on the MTHFR C677T gene. Dr. J points out that this is a significant gene, impacting folic acid processing efficiency. Stacy confirms she's taking a supplement with methylfolate, rather than folic acid, from Douglas Labs' Ultra Preventative multivitamin. Dr. J emphasizes the importance of methylfolate over folic acid, given Stacy's genetic profile, highlighting that the C677T variant makes her 80-90% less efficient at processing folic acid. Stacy mentions using methylfolate prenatals during her pregnancies, expressing relief at having avoided potential complications related to the MTHFR gene. Dr. J concludes by stating that the MTHFR gene is a major risk factor for miscarriages.
Genetic Factors and Nutritional Recommendations
00:52:23 - 00:53:46
Dr. J explains the impact of genetic factors on miscarriage, specifically mentioning a gene issue related to consistent miscarriage problems. The doctor clarifies that a "plus-plus" gene, while often problematic, is easily manageable in this case by avoiding folic acid and opting for methylfolate instead. Failure to do so might lead to heavy metal buildup, although this is less common. The conversation then shifts to B12, where Dr. J highlights that the patient possesses a beneficial "plus-plus" gene resulting in better B12 absorption than most. This means supplementation is unnecessary, saving the patient money. The patient, Stacy, mentions supplementing B12 while on Metformin due to a previous recommendation from Dr. J, which the doctor confirms as standard practice.
Heavy Metal Testing and Glutathione Supplementation
00:53:49 - 00:55:21
Dr. J inquires about Stacy's heavy metal testing, noting elevated levels on her report related to her GSTP1 gene and glutathione. Stacy expresses curiosity about heavy metal testing, having heard about it from Dave Asprey. Dr. J recommends testing, especially given her GSTP1 gene results and their connection to glutathione. Stacy mentions her current glutathione injections, which Dr. J approves of as the best method of administration. The discussion then shifts to the lack of readily available dosing information for glutathione, attributed to the fact that it's injectable, inconvenient, and unpatentable since the body naturally produces it. Dr. J explains that pharmaceutical companies prioritize patentable products like vaccines over glutathione, despite its effectiveness for individuals with GSTP1 gene issues. Dr. J typically advises against heavy metal testing if patients already supplement with glutathione, as the results might be insignificant due to the chelation effect of glutathione. However, the usual recommendation is to test for heavy metals first and then start glutathione supplementation if levels are high. The conversation concludes with Stacy asking for dosing recommendations for glutathione.
Addressing a Specific Gene Issue and Supplement Protocols
00:55:21 - 00:57:13
Dr. J recommends consulting a functional doctor for advice on managing a specific gene issue related to a supplement. While acknowledging the benefits of high levels of the supplement, Dr. J admits unfamiliarity with specific protocols, noting their personal use of a liposomal version without experiencing the gene-related concerns. The conversation then shifts to the impact of fructose, particularly for individuals with PNPLA3 gene variants. Dr. J explains that fructose is more readily stored as fat in the liver for these individuals, increasing the risk of fatty liver disease. However, Dr. J clarifies that not all fruits are high in fructose, emphasizing the availability of low-fructose options and referencing a created article detailing these choices to avoid unnecessary dietary restrictions.
Histamine Intolerance Discussion
00:57:13 - 00:58:48
The conversation begins with a brief discussion about sugary drinks and their high glucose content, contrasting with lower fructose levels in some alternatives. Stacy then raises a question about her recent histamine intolerance, experiencing flushing, itching, and burning, particularly after exercise and hot baths. Dr. J explains this is likely related to the AOC1 gene (amine oxidase, copper-containing, number one), an oxidase that breaks down amines including histamines. A plus-minus result on this gene indicates an increased risk of histamine intolerance. Dr. J emphasizes the widespread presence of histamines in food, referencing scientific studies on histamine-free diets which are extremely restrictive, highlighting the challenge in managing this condition.
GHK-CU and Copper Supplementation for Improved Health
00:58:48 - 01:00:19
This segment focuses on the use of GHK-CU (copper peptide) supplementation, particularly its benefits and potential for higher dosing. Dr. J and Stacy discuss the advantages of increasing copper levels, especially for individuals with a specific gene. Stacy shares her experience with a 21-day GHK-CU treatment, noting noticeable skin improvements. She emphasizes the numerous bodily processes involving copper, making supplementation beneficial even without immediately noticeable effects. Stacy mentions listening to a podcast featuring Carl Lenore and Betsy discussing GHK-CU and higher dosing possibilities due to the rarity of copper toxicity. Dr. J confirms familiarity with Carl's work and highlights GHK-CU's role in wound healing and collagen production, further emphasizing its stimulation of stem cell numbers.
Copper Supplementation and Genetic Predisposition
01:00:23 - 01:01:09
Dr. J recommends copper supplementation due to its importance in amine oxidase copper-containing enzymes. The best source is liver. Further investigation into a specific gene is suggested, but copper supplementation is deemed the most effective immediate action, alongside general health practices like sufficient sleep. Stacy agrees with this assessment.
Genetic Analysis of Muscle Fiber Type and Endurance
01:01:09 - 01:02:01
Dr. J discusses Stacy's genetic profile related to muscle fiber type, noting a mixed profile of slow and fast twitch fibers. A rare endurance gene, BDKRB2 (present in 30% of people but common in elite endurance athletes), is identified, suggesting an advantage in endurance training with benefits like increased blood flow, reduced muscle spasms, and less pain. Additionally, the ACBR1B gene is noted, indicating higher muscle strength per muscle volume.
Athletic Genes and Joint Health
01:02:02 - 01:03:48
Dr. J reviews Stacy's phenomenal athletic genes, emphasizing the importance of continued training. The conversation then shifts to joint health, with Stacy mentioning occasional pain from running, attributing it to the need for stretching and the demands of caring for two children. Dr. J shares a personal anecdote about a meniscus injury, initially advised to have surgery but healing naturally after six months. He mentions other treatment options like injections and BPC. The discussion focuses on barefoot running as a solution for Dr. J's knee pain, referencing Chris McDougall's "Born to Run." Dr. J describes his experience transitioning to barefoot running, initially extreme, then adopting minimal shoes and a barefoot running cadence, ultimately resolving his knee issues.
Running Style and Minimally Invasive Shoes
01:03:51 - 01:04:38
Dr. J discusses running style, mentioning a preference for minimal shoes like Merrells, focusing on running closer to the toes. They acknowledge Stacy's knowledge of this topic. The conversation then shifts to genetic predispositions, specifically mentioning the IL-2RA gene, linked to poor diet and processed food consumption.
Genetic Predispositions and Age-Related Concerns
01:04:39 - 01:05:48
Dr. J expresses concern about the DIO2 gene, related to thyroid hormones, and its connection to osteoarthritis. The importance of maintaining healthy thyroid hormone levels and sufficient iodine intake is emphasized. The conversation also touches upon the HTR2A gene, a blood flow gene related to serotonin receptors, and its link to arthritis risk. The importance of maintaining good serotonin levels is highlighted.
Lifestyle, Diet, and Serotonin Levels
01:05:49 - 01:07:09
Dr. J explains that Stacy's past anxiety and depression might have been linked to low serotonin levels due to unhealthy eating habits during a stressful period, such as when she graduated with her LPN. The doctor connects this to potential joint issues. However, now that Stacy maintains a healthy diet and lifestyle, her serotonin levels are likely higher, positively impacting her joint health. Dr. J dismisses concerns about gout despite a positive genetic marker (SLC2A9 gene) because Stacy's healthy lifestyle mitigates the risk. The doctor highlights the common misconception that doctors advise against meat consumption for gout, while the actual culprit is often high fructose intake, which Stacy avoids.
Low Back Issues and IL-1A Gene
01:07:11 - 01:07:29
Dr. J discusses the IL-1A gene, noting that even with a plus-minus result, it indicates a doubled risk of low back problems. Stacy confirms a history of low back pain from a young age, corroborating the genetic predisposition discussed.
Back Pain and Treatment Options
01:07:29 - 01:09:04
Stacy mentions experiencing back pain, a common issue exacerbated by prolonged standing. Dr. J shares a similar experience, attributing his recurring back pain to a specific gene and past injuries. Dr. J explains that he's had back problems since age 12, often requiring several weeks to heal. He highlights testosterone as a significant factor in accelerating his recovery, noting that increased testosterone levels inhibit inflammation. He describes using testosterone cream, primarily when experiencing back pain, to expedite healing. Dr. J emphasizes the importance of checking testosterone levels, as low levels can contribute to inflammation. He also mentions curcumin and other supplements as effective inhibitors of interleukin, a type of inflammation linked to various health problems. Stacy mentions using red light therapy.
Back Injury and Testosterone Treatment
01:09:04 - 01:10:33
Stacy describes a back injury sustained a year prior during a CrossFit box step-up exercise. She clarifies it wasn't disc-related but rather a muscular pull, unfortunately occurring two days before her black belt Taekwondo test. Dr. J empathizes, noting that back injuries often occur unexpectedly during seemingly innocuous activities. Dr. J shares personal anecdotes of back pain arising from strenuous activities like lifting heavy posts, only to manifest later during simple actions like tying shoes. The conversation shifts to treatment, with Stacy inquiring about topical testosterone application. Dr. J explains he uses testosterone cream to increase his overall levels (to 1000), not directly on the injury site, suggesting that this approach, while effective for him, should be managed carefully with a doctor's guidance for women. Stacy mentions PQQ as a supplement she's seen recommended.
Interleukin Inhibition and Muscle Growth
01:10:40 - 01:12:37
Dr. J discusses various interleukin inhibitors, starting with PQQ (pyroluquinoline quinone) produced by gut bacteria. He mentions Stacy's use of ECGC (epicatechin gallate), highlighting its role in myostatin and follistatin regulation for muscle building and its interleukin-inhibiting properties. Dr. J suggests cycling these and other options for optimal results. He then introduces alpha-MSH (melanotan), another interleukin inhibitor, as a potential treatment for back pain. Stacy confirms the anti-inflammatory benefits, and Dr. J explains that this is due to interleukin inhibition. He clarifies that various forms of inflammation exist (TNF-alpha, interferon, etc.), with melanotan specifically targeting interleukin. Finally, Dr. J touches upon the IGF-1 receptor gene, noting that lower IGF-1 levels, while generally acceptable, can make muscle mass gain difficult, particularly for men.
Supplement and Training Discussion
01:12:39 - 01:14:21
Dr. J suggests increasing zinc intake through red meat consumption, mentioning IGF injections (tessamoralin) as an alternative, although Stacy experiences significant swelling from its use, limiting her to three-week cycles. Dr. J notes Stacy's genetic predisposition, resulting in low pain sensitivity (C1MT version), which, while not inherently negative, necessitates caution during intense training to avoid injuries. The discussion shifts to Stacy's training regimen, highlighting her genetic advantage of rare endurance genes, allowing for longer cardio sessions with less inflammation compared to others. Stacy expresses surprise at her endurance capabilities, contrasting her self-perception with her actual performance.
The Importance of Epigenetics and Early Childhood Training
01:14:21 - 01:15:06
Dr. J discusses the significant role of epigenetics in athletic training, emphasizing that early childhood activities, particularly during teenage years when hormones are high, create epigenetic marks on DNA that influence later performance. These marks, developed through activities like heavy lifting, are crucial for future success. Dr. J highlights that what one does as a child, especially as a teenager, significantly impacts their potential for later athletic achievements.
Stacy's Childhood and its Impact on Current Training
01:15:06 - 01:15:30
Stacy reflects on her own childhood, noting the limited opportunities for weightlifting and diverse sports in her small town and school. She explains that her sports options were limited to baseball, softball, soccer, and basketball, lacking activities like track and field, which she believes may have negatively impacted her current athletic capabilities.
Overcoming Past Limitations and Future Training Strategies
01:15:30 - 01:16:05
Dr. J acknowledges that while past limitations can be overcome through hard work, it requires more effort. Stacy expresses her intention to provide her children with more diverse and intensive training opportunities, starting at a younger age, based on her understanding of epigenetics and early childhood development's impact on athletic potential. Dr. J shares an anecdote about his four-year-old daughter running four miles with him, illustrating the surprising endurance capacity of young children.
Motivating Young Children for Physical Activity
01:16:05 - 01:17:06
Dr. J recounts a story about a four-year-old who unexpectedly ran four miles to a train station in Boston, motivated by the prospect of visiting the station. The discussion highlights the challenge of motivating young children for exercise without resorting to sugary rewards, which could create unhealthy associations. Dr. J emphasizes the importance of finding alternative incentives, such as enjoyable destinations, to encourage physical activity and avoid creating negative experiences that might deter future exercise. Stacy agrees, suggesting avoiding increasing the hedonic effect of food, particularly sugar, as a reward.
The Importance of Avoiding Negative Associations with Exercise
01:17:06 - 01:17:18
Dr. J continues by explaining the importance of avoiding pushing children too hard during physical activity, to prevent them from developing negative associations with exercise. The anecdote of the four-year-old running four miles is used to illustrate the point that children can surprise you with their capabilities if properly motivated. The discussion emphasizes the need for positive reinforcement and avoiding creating miserable experiences that could lead to lifelong aversion to exercise.
Genetics and Sleep Issues
01:17:18 - 01:17:40
Dr. J briefly shifts the topic to discuss genetics and their influence on sleep patterns. Mentioning the MTHFR gene, Dr. J notes that many individuals with this gene experience sleep problems. The connection between genetics and sleep is introduced, with a reference to further information available on Amazon.
Methylfolate and Sleep
01:17:40 - 01:19:17
Dr. J discusses the importance of the 5-MTHF supplement, citing numerous positive reviews regarding its impact on depression and sleep. Dr. J explains that the PER3 gene can sometimes lead to delayed phase sleep disorder, affecting sleep cycle onset. The conversation then shifts to Stacy's sleep patterns, with Stacy reporting inconsistent REM and deep sleep data from her Aura device. She notes variations in her sleep stages, with deep sleep ranging from 15 minutes to 1 hour and 35 minutes, and REM sleep fluctuating significantly. On average, her deep sleep is usually below 20% of her total sleep time, and rarely exceeds one hour. Dr. J inquires about the average duration of Stacy's deep sleep.
Melatonin and Sleep Optimization
01:19:20 - 01:21:04
Dr. J discusses melatonin use, noting its effectiveness for individuals with significant deep sleep but lacking REM sleep. He explains that melatonin typically reduces deep sleep and increases REM, making it less necessary for most. However, he acknowledges that some individuals may not respond well to sleep tracking devices, and melatonin could be an option in such rare cases. Dr. J emphasizes that the device used is generally excellent but individual responses vary. He suggests dietary adjustments for Stacy, who mentions trying a glymphatic system cleansing approach by avoiding food several hours before sleep. Stacy explains that she's inconsistent with this due to current life circumstances, but aims for at least a two-hour window between eating and bedtime. She also mentions peptide injections, requiring a 90-minute fasting period beforehand.
Magnesium Supplementation Discussion
01:21:05 - 01:22:43
Dr. J expresses surprise at the number of peptides Stacy is using, prompting a discussion about magnesium supplementation. Stacy mentions using magnesium glycinate, but finds the pill size inconvenient and inconsistent in her intake. Dr. J agrees that the pills are large and suggests magnesium citrate as a more convenient and tasteless alternative, readily available in bulk. Dr. J emphasizes the ease of use—simply adding a scoop to water before bed—and highlights magnesium's value for sleep improvement, especially considering Stacy's genetics. Stacy mentions prior experience with Mag Calm, which Dr. J also approves of. The conversation concludes with a recommendation for a simpler magnesium supplementation method to ensure consistent use.
Magnesium Supplement and Sleep Discussion
01:22:43 - 01:23:09
Stacy and Dr. J discuss a magnesium supplement, casually referred to as "Mag Calm," due to frequent forgetting of its precise name. Dr. J mentions using it for their children because of its palatable taste, noting the presence of stevia as a sweetener (avoiding the term "artificial sweetener" to prevent misunderstandings). They agree that it's a good product.
The WWC1 Gene and Sleep's Impact on Memory
01:23:11 - 01:23:54
Dr. J introduces the WWC1 gene, explaining that while it doesn't directly cause poor sleep, insufficient sleep significantly reduces memory recall (approximately 25%) in individuals with this gene. The importance of sleep for optimal brain function is emphasized. An unknown speaker adds a comment (partially audible). Dr. J then cautions against nicotine addiction but acknowledges that in rare instances of severe sleep deprivation, nicotine gum might offer a temporary boost to WWC1 gene production. However, prioritizing sleep is strongly recommended. Stacy shares her experience using nicotine gum during fasting.
Nootropics and Smoking Habits
01:24:00 - 01:25:52
Dr. J mentions that Ben Greenfield and he use nicotine for cognitive enhancement, with Dr. J preferring cigars or pipes about once a week for social and brain performance benefits. Stacy brings up a nicotine and CBD product containing methylene blue, recalling Ben Greenfield's research on it as a nootropic. Dr. J confirms methylene blue's presence and shares his experience using smoking (cigars, pipes) as a tool to overcome writer's block, emphasizing that he's never struggled with addiction. He details his past pipe smoking in college and current habit of growing his own tobacco to avoid chemicals sprayed on commercially grown products, questioning whether the cognitive benefits stem from nicotine or other substances in commercially produced tobacco.
Seasonal Affective Disorder Treatment Discussion
01:25:52 - 01:27:42
Dr. J discusses seasonal affective disorder (SAD), mentioning the PER3 gene's link to its higher incidence. The doctor suggests sunshine and a trip to Florida as the best solution, but also mentions the Sperti UV light device as an alternative, despite its high cost. Stacy clarifies if it's a high-lux light, but Dr. J specifies it's UVB, emphasizing the need for caution and eye protection due to potential sunburn. The doctor explains the importance of maintaining a safe distance and gradually increasing exposure time. They highlight the device's effectiveness for SAD, contrasting it favorably with blue light therapy. Stacy agrees, noting the preference for this method over tanning beds, even though she used them previously for vitamin D synthesis. Dr. J concludes by emphasizing the importance of short exposure times for safe vitamin D production.
Tanning Beds and Melanotan Injections
01:27:42 - 01:28:14
Dr. J discusses the use of tanning beds and melanotan injections. Dr. J expresses acceptance of tanning beds as long as users aren't aiming for extreme tans. Stacy suggests melanotan injections as an alternative. Dr. J acknowledges that most people dislike injections. The conversation then shifts to the risks associated with self-injecting, highlighting the danger of introducing bacteria and the potential harm to the heart valve if proper procedures aren't followed. However, Dr. J notes that the process isn't inherently difficult if done correctly.
Seasonal Affective Disorder and Sunlight Exposure
01:28:14 - 01:29:30
The discussion turns to seasonal affective disorder (SAD) and its relation to sunlight exposure. Stacy shares her experience of experiencing mood changes and a desire for relocation around February, attributing it to the lack of sunlight in New York compared to South Dakota. She notes the significantly longer periods of dimness and darkness in New York. Dr. J relates their experience growing up in Morris, Minnesota, where the open landscape allowed for unobstructed views of sunrises and sunsets, contrasting it with their experience in Boston, where abundant trees blocked sunlight for much of the day. Stacy agrees, mentioning the hilly terrain of upstate New York further limiting sunlight exposure.
Post-Consultation Review and Next Steps
01:29:30 - 01:31:23
Dr. J asks Stacy if anything from the consultation requires further discussion. Stacy confirms understanding of the explained information and expresses anticipation for lab results. Dr. J prioritizes checking iron levels, recommending annual or biannual checks depending on results, suggesting blood donation if levels are high. Thyroid hormones and triglycerides are also mentioned as areas for monitoring. Dr. J concludes that Stacy's genetics are generally positive. An unknown speaker expresses appreciation for Stacy's training and activities. Stacy discusses her food sensitivities, particularly sesame and yeast, suggesting a possible underlying inflammatory issue and the potential benefit of prebiotics and probiotics. Dr. J agrees and mentions using a foam roller to assess leaky gut.
Foam Rolling and Diet's Impact on Body Pain
01:31:23 - 01:32:21
Dr. J discusses how their sensitivity to gluten affects their experience using a foam roller. They explain that after consuming gluten, foam rolling reveals significant pain, unlike when eating healthily, where the experience is positive. Stacy expresses surprise at this connection. Dr. J comments on the unusual appearance of foam rolling, especially in a gym setting, but advocates for building tolerance to others' opinions by doing what's beneficial, as long as it doesn't cause injury. They cite examples of risky gym exercises, such as improper deadlifts, that should be avoided.
Conclusion of Conversation
01:32:22 - 01:32:35
Stacy agrees that self-care should prioritize injury prevention. The conversation concludes with pleasantries and mutual farewells between Dr. J and Stacy.
DNA with Dr. Jay, Episode 09.
KETO Meagan (from Minnesota)
KETO Meagan (from Minnesota)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Podcast Details
00:00:00 - 00:00:56
The speaker introduces himself as a Mayo Clinic scientist, DNA consultant, and author with YouTube channels "Anthony J. Cast" and "Anthony J. Family Cast." He mentions his current coffee roasting activity and his practice of sending roasted coffee beans and t-shirts to podcast guests. He introduces the episode's guest, Megan from Minnesota, and the episode's focus on keto. He promotes his DNA analysis services through ajconsultingcompany.com, offering both podcast episode and confidential options.
Technical Setup and Recording
00:01:00 - 00:01:43
The hosts exchange greetings and briefly discuss the recording setup. A slight delay is acknowledged. They discuss the challenges of using Skype for recording due to choppy audio quality, particularly during the COVID-19 situation. The hosts adjust their audio equipment, switching to headphones and confirming clear communication.
Initial Greetings and Catch-Up
00:01:43 - 00:02:17
The conversation begins with confirmations of document availability and pleasantries. Participants check in with each other, noting previous contact approximately two weeks prior. Their geographic locations are discussed; both Derek and another participant are from Wisconsin, currently residing in Minnesota. One participant mentions recent travel to South Dakota.
Discussion of Vitamin Use and Vinnie Tordridge
00:02:18 - 00:02:58
The conversation shifts to the participants' use of Pure Vitamin Club vitamins, prompted by the observation of their use. One participant expresses their fandom of Vinnie Tordridge, and another reveals an upcoming podcast appearance with him. The spontaneous nature of the podcast invitation is highlighted.
DNA Profile Review and Initial Assessment
00:02:58 - 00:04:01
The discussion begins with a review of the individual's DNA profile. The speaker notes the excellent genetics, focusing primarily on the "plus-plus" genes while acknowledging some "plus-minus" genes, particularly a significant one at the beginning of the profile. Despite this, the overall assessment is positive. Pre-existing conditions are noted, including polycystic ovarian syndrome (PCOS), low iron, and vitamin D deficiency. The speaker mentions that PCOS will be addressed later in the hormone section, while low iron and vitamin D are easily correctable.
Keto Diet Progress and Discussion
00:04:01 - 00:04:24
The conversation shifts to the individual's ketogenic diet. The individual reports that it's going better than expected, although initial attempts involved some cheating. The speaker emphasizes that keto requires full commitment, as cheating significantly hinders its effectiveness. A previous experience of a prolonged "keto flu" is mentioned as an example of the consequences of inconsistent adherence.
Keto Diet and Initial Reactions
00:04:24 - 00:04:48
The conversation begins with discussions about the ketogenic diet. Participants share experiences, with one describing the "keto flu" as brutal. Another participant mentions having a mostly chicken-based keto meal, including chicken skins, due to feeling they had consumed too many carbs. They also mention taking electrolytes to mitigate the effects, acknowledging that it wasn't a strict keto day.
Keto Diet Benefits and Upcoming Talk
00:04:50 - 00:05:07
One participant expresses enthusiasm for the keto diet, mentioning they are giving a talk at a keto conference. The talk is being pre-recorded and will be released online in early June. The conversation then transitions to the topic of brain optimization, indicating the start of a new section.
DNA Basics and Parental Gene Contribution
00:05:08 - 00:05:42
The discussion shifts to foundational genetics. Megan emphasizes that every cell in the body (except egg and sperm cells) contains two copies of DNA, one from each parent. A common question about determining which parent contributed a particular gene variant is addressed; the answer is that it's not possible to definitively determine the parental origin of a specific gene variant based on the presence of a "good" or "bad" version.
Genetic Predisposition to Alzheimer's
00:05:48 - 00:07:21
This section focuses on the individual's genetic risk for Alzheimer's disease. The discussion clarifies the meaning of "plus plus" (inheriting a bad gene version from both parents) and "plus minus" (inheriting one bad and one good gene version). The individual's family history of memory issues (the dad's mother) is noted. The individual possesses a "plus minus" APOE3-4 gene, which carries a near 50% risk of developing Alzheimer's if following a Standard American Diet. While other risk genes are present, they are all "plus minus," making APOE3-4 the most significant risk factor. The speaker emphasizes the importance of addressing this risk, suggesting DHA supplementation as a relatively easy solution.
DHA Supplementation and Alzheimer's Risk
00:07:22 - 00:08:01
The speaker emphasizes the importance of taking high-quality fish oil, specifically noting that phospholipid DHA or triglyceride DHA is the best form for brain uptake. They recommend two grams daily and suggest that with regular exercise and a decent diet, along with this supplementation, one should be fine. The speaker highlights the preventative nature of this approach, stating that addressing the issue before problems arise is key, as studies show that simply adding DHA later doesn't solve existing problems.
APOC1 and Triglyceride Levels
00:08:03 - 00:09:05
The conversation shifts to APOC1, a triglyceride transporter. High triglycerides are linked to a two-fold increased risk of Alzheimer's, particularly in individuals following a standard American diet. The speaker notes that the studies are based on average Americans' eating habits. The speaker asks the listener about their triglyceride levels, but the listener is unable to immediately locate their lab results, explaining that they are part of their yearly work health exams and not readily accessible.
Checking Triglyceride Levels and Cardio
00:09:06 - 00:09:58
The conversation begins with a discussion about checking triglyceride levels, with one participant suggesting it's standard practice. Another participant confirms that their levels have generally been good but agrees to check them. The importance of tracking these levels for future reference is highlighted. Methods for lowering high triglyceride levels are discussed, with cardio being identified as the most effective way. The beneficial effect of DHA fish oil supplements in reducing triglycerides is also mentioned. One participant shares that they've started incorporating more cardio into their routine due to training for an Ironman competition in Florida in November. The potential for hot weather during the competition is briefly discussed, along with a question about whether the event coincides with the rainy season.
Florida Weather and Sauna Training
00:09:58 - 00:11:28
The conversation begins with a discussion about the weather in Naples, Florida, specifically its rainy season, which is described as having daily rain, especially in September. The conversation then shifts to the location of an upcoming trip, Panama City, Florida. The possibility of sauna training is raised, with one participant expressing interest and another mentioning seeing notes about it. The conversation concludes with an anecdote about an extreme athlete in Hawaii who trains in a 225-degree sauna, highlighting the diverse approaches to heat acclimatization.
BDNF and Cardio Exercise
00:11:33 - 00:13:07
The discussion centers on the BDNF gene and its relationship to exercise. Cardiovascular exercise is highlighted as key for increasing BDNF levels, unlike heavy lifting which shows less impact. The speaker emphasizes the importance of BDNF for brain growth and performance, particularly as one ages. Endurance exercises like running, rowing, or even slow bench pressing are suggested, advocating for an hour-long session maintaining a sustainable heart rate. Nose breathing is recommended as a pacing technique to ensure the heart rate remains in the optimal zone.
FOXO3 Gene and Carbohydrate Metabolism
00:13:07 - 00:13:22
The conversation moves to the FOXO3 gene, which suggests suboptimal brain handling of carbohydrates and higher blood sugar. Individuals with this gene may experience fatigue after consuming carbs. The speaker notes the age of the individual being discussed is 29.
Brain Fog and Carb Sensitivity
00:13:22 - 00:14:21
The discussion centers on the impact of carbohydrates on brain fog. Participants share personal experiences, noting that brain fog is more prevalent with age and that younger individuals may tolerate higher carb intake better due to faster metabolisms. The consensus is that carb sensitivity is partly genetic and that managing carb intake, potentially through cyclical approaches or reductions, can be beneficial. The conversation concludes by transitioning to the next topic.
Anxiety and the TPH2 Gene
00:14:22 - 00:14:55
The conversation shifts to anxiety, with participants acknowledging past struggles and the contributing role of societal stress. The TPH2 gene, responsible for converting tryptophan (an amino acid) into serotonin, is introduced as a potential factor influencing anxiety levels. The discussion briefly explains the role of tryptophan and serotonin in the body.
Anxiety and Serotonin Levels
00:14:55 - 00:16:39
The discussion centers on the patient's anxiety and its connection to serotonin levels. 90% of serotonin is produced in the gut and transported to the brain. A specific gene variation ("plus-plus") hinders this transport, increasing anxiety risk. The recommended approach involves improving gut health through diet, exercise, and sleep. If these measures are insufficient, additional options are available. The early detection of the gene variation is positive, and lifestyle changes are expected to manage anxiety effectively. Caffeine's effect is discussed, with the patient reporting sensitivity only to coffee. The patient's genes are described as "phenomenal," even with some Alzheimer's risk genes showing a "plus minus" variation, offering some relief. The conversation then transitions to dietary considerations.
Dietary Considerations and Gene Analysis
00:16:39 - 00:16:48
The discussion moves to a gene analysis, focusing on a "plus minus" variation in a gene that wouldn't typically warrant discussion. The conversation is cut off before further details are provided.
Genetic Predisposition and Dietary Choices
00:16:48 - 00:17:38
A discussion regarding genetic predisposition to colon cancer and dietary choices ensues. The speaker mentions a gene, GATA3, linked to a 20% increased risk of colon cancer when consuming processed meats. The conversation then shifts to personal preferences and habits, with one participant mentioning their aversion to summer sausage and their preference for homemade alternatives. Another participant mentions discussing similar genetic factors with Derek and their shared interest in processing their own meats, such as brats and summer sausage, to maintain control over ingredients and preparation methods.
Childhood Exposure to Animal Processing
00:17:39 - 00:18:28
The conversation transitions to a personal anecdote about the speaker's children's early exposure to handling animals and fish. The speaker describes their two-year-old daughter's nonchalant approach to handling a live, flopping fish, contrasting it with the reaction of another two-year-old who was frightened by the same experience. The discussion highlights the contrasting reactions of the children and their parents, suggesting that parental response significantly influences a child's comfort level with such situations. The speaker concludes by emphasizing the benefits of early exposure and the importance of parental reactions in shaping a child's response to handling animals.
Childhood Exposure to Hunting
00:18:31 - 00:18:43
The speaker recounts their children's nonchalant reaction to witnessing deer butchering, highlighting their desensitization to the process and lack of exposure to Disney's portrayal of animals. The children's acceptance of the activity is emphasized as a positive aspect.
Diabetes Risk Genes and GLP-1 Hormone
00:18:44 - 00:19:45
Discussion focuses on the speaker's genetic predisposition to diabetes, specifically mentioning the TCF7L2 gene and its impact on GLP-1 (glucagon-like peptide 1) hormone levels. Lower GLP-1 levels result in less efficient sugar uptake, potentially leading to higher blood sugar. The speaker advises against consuming pure carbohydrates and recommends combining carbs with protein and fat to increase GLP-1 production and manage blood sugar. The speaker's blood sugar levels are mentioned as being generally good, in the 80-90 range, even while following a ketogenic diet.
Genetic Factors and Weight Management
00:19:46 - 00:21:13
The discussion centers on the impact of genetics, specifically the MC4R gene, on body weight. The speaker explains that this gene, present in approximately 90% of the population, acts as a body weight thermostat, regulating hormones to maintain a set weight. Weight gain can cause the body to adjust its set point, making weight loss difficult even with calorie restriction. The speaker highlights that sunshine and intermittent fasting help regulate the MC4R gene, positively impacting metabolism. The benefits of intermittent fasting, potentially in conjunction with a ketogenic diet, are also mentioned.
Ketogenic Diet and Intermittent Fasting
00:21:13 - 00:22:27
The discussion centers on the ketogenic diet and intermittent fasting. The speaker advises against starting keto immediately but suggests skipping breakfast and eating only after noon once adapted to the diet. If this proves difficult, incorporating fats like MCT oil, protein powder, collagen powder, or bone broth is suggested as a temporary measure. Intermittent fasting is highlighted as a powerful method for hormone regulation. The speaker mentions adiponectin, a hormone involved in fat metabolism, noting that its levels decrease in many individuals. Intermittent fasting is presented as a way to increase adiponectin levels, making it a recommended approach for most people.
Metformin Usage
00:22:29 - 00:22:41
The conversation shifts to metformin. The speaker confirms the individual's past use of metformin at a high dosage (two grams daily) and notes the recent discontinuation of the medication.
Metformin and Ketogenic Diet Experience
00:22:41 - 00:24:43
This segment discusses the speaker's experience with Metformin, a medication used to treat PCOS, in conjunction with a ketogenic diet. The speaker initially used Metformin for PCOS and found it helpful. However, after starting a ketogenic diet, they experienced side effects from Metformin and stopped taking it to see if the keto diet alone would provide similar benefits. This proved unsuccessful, leading to the decision to resume Metformin. The conversation then shifts to dosage, with the speaker mentioning their personal experimentation with different dosages (500mg to 2g), noting that 500mg is generally effective for them. They clarify that many in their community use Metformin for lifespan extension rather than specifically for conditions like diabetes or PCOS. The speaker's experience is described as that of a "plus minus higher responder," not a "super high responder," which is suggested as a reason for the side effects. The speaker's ability to manage carbohydrates well on keto is also discussed, with the expectation that brain performance will improve with continued keto and intermittent fasting. The conversation concludes with the speaker considering reducing their Metformin dosage upon restarting the medication.
Genetic Predisposition to Heart Disease and Gut Issues
00:24:43 - 00:26:16
The discussion centers on the patient's genetic predisposition to heart disease and gut issues. The doctor notes that while the patient's LPL gene shows a common plus-plus genotype found in about 50% of the population, the risk is mitigated by the patient's generally healthy lifestyle. High triglycerides are highlighted as a potential concern, especially for sedentary individuals. The doctor then shifts focus to the patient's gut health, noting a significant number of genes related to gut issues, though most are plus-minus, indicating a less severe impact. The patient confirms experiencing gut issues, particularly with dairy. The doctor explains that while genetics are predictive of dairy intolerance (bad genes almost always lead to inflammation), even with good genes, dairy issues can still occur, but are often reversible.
Dietary Changes and Impact on Health Issues
00:26:17 - 00:27:04
Discussion centers on the positive effects of a low-sugar, low-carb diet, specifically keto, on resolving health issues. One participant notes that switching to keto eliminated their problems. The connection between lactose intolerance and sugar in dairy is highlighted, with the suggestion to avoid dairy products containing carbohydrates. The discussion expands to include the inflammatory nature of casein, although another participant mentions consuming whey protein without issues. The impact of dietary changes on those with dairy sensitivities is also addressed.
The Role of Genes and Keto Diet in Inflammation
00:27:04 - 00:28:04
The conversation shifts to the influence of genes, specifically NOD2 and ATG16L1, on health. The NOD2 gene's role in inflammasome creation is explained, along with the interaction between NOD2 and the NLRC4 protein. The discussion emphasizes that ketones inhibit inflammasomes, reducing inflammation. The work of scientist Dom DeAgostino on this topic is mentioned.
Ketogenic Diet and Gut Health
00:28:11 - 00:29:15
The discussion centers on the benefits of ketosis for gut health, with one participant noting improvements in stomach issues since adopting a ketogenic diet. The ATG6101 gene is mentioned as a potential risk factor for leaky gut, particularly in conjunction with gluten consumption. While not a direct gluten sensitivity gene, it increases the likelihood of gluten sensitivity. Another participant shares their experience trying to determine the cause of stomach aches, suspecting dairy initially but experiencing issues even without dairy, suggesting other factors might be at play. The complexities of gluten sensitivity are discussed, highlighting the role of pesticides, mold in grains, and the impact of high-carb intake on gut lining.
Gluten Sensitivity and the Role of Other Factors
00:29:15 - 00:29:48
The conversation continues on the challenges of identifying the root cause of gluten-related issues. It's noted that various factors beyond gluten itself, such as pesticides, mold in grains, and the sheer volume of carbohydrates, can contribute to digestive problems. The rough nature of fiber in some grains is also mentioned as a potential irritant to the gut lining. Cutting gluten is suggested as a beneficial step, especially for those experiencing digestive issues.
The CNR1 Gene and CBD Oil
00:29:19 - 00:29:51
The CNR1 gene (cannabinoid receptor) is introduced, explaining its role in binding CBD oil. It's suggested that CBD oil can be helpful in mitigating the negative effects of consuming foods that trigger digestive distress. However, it's clarified that CBD oil is not a complete solution and won't allow for unrestricted consumption of problematic foods, but rather offers relief from symptoms.
Podcast Discussion and Future Topics
00:29:51 - 00:30:07
A recent podcast focusing solely on "plus-plus" genes is mentioned, contrasting with the current discussion that includes "plus-minus" genes. The conversation concludes by expressing a desire to revisit a previously discussed "plus-plus" gene.
Understanding CDK Inflammation and Dietary Solutions
00:30:08 - 00:31:19
This section discusses CDK, a type of inflammation. A specific gene helps lower CDK levels, likened to turning down a hot water tap. However, a genetic plus-plus variant reduces the gene's effectiveness. Flavonoids, found in colorful plants like blueberries and red bell peppers, also inhibit CDK, acting as a further "hot water shut-off." Grapeseed pro-ampicyanidins are highlighted as a potent CDK inhibitor, though the name is noted as being difficult. The discussion concludes with a confirmation that the topic is covered and a transition to the next section.
Vitamin, Hormone, and Detoxification: Addressing Polycystic Issues
00:31:20 - 00:31:43
This section focuses on the vitamin, hormone, and detoxification aspects, specifically related to polycystic conditions. The speaker identifies a gene related to ceramide production, suggesting it's not a primary concern unless skin issues arise. Phytoceramides are mentioned as a potential solution if such issues develop in the future. The section ends before a full discussion of this gene's role.
Skin Health and Vitamin D Levels
00:31:44 - 00:33:15
The discussion begins with the importance of ceramides for skin and cell membranes. Low vitamin D levels are noted, attributed to a lack of supplementation in the past, especially considering the speaker's residence in Minnesota. The speaker's past experience of winter gloominess led to a vitamin D check, revealing significantly low levels. The conversation then shifts to the discovery of a risk gene (PDR3 gene, plus plus) for seasonal affective disorder, explaining the winter depression even with optimized vitamin D levels. The speaker's current use of Vinny's vitamin supplement, including olive oil, is mentioned positively. The speaker also mentions having heard Vinny's podcast, where he discusses his olive oil consumption.
Genetic Predisposition and Lifestyle Recommendations
00:33:15 - 00:34:56
This segment focuses on the discussion of genetic predispositions and their implications for lifestyle choices. The speaker mentions a gene related to vitamin D levels, suggesting supplementation and sun exposure as countermeasures. Another gene, PON1++, affecting the breakdown of oxidized oils, is discussed, with a recommendation to avoid seed oils (canola, grapeseed) while consuming olive oil, coconut oil, and avocado oil as alternatives. The conversation then shifts to genes related to polycystic conditions, specifically a testosterone++ gene and several estrogen-related genes. The speaker strongly recommends sauna use, referencing a previous conversation about a CYP gene and its presence in another individual's genetic profile. The discussion concludes with a mention of the CYP1B1 gene and its less common plus-plus version, noting its presence in many men the speaker has consulted.
Liver Enzyme and Artificial Estrogens
00:34:56 - 00:36:44
This segment discusses the impact of a gene related to gynecomastia and its connection to the body's ability to clear artificial estrogens. The speaker explains that individuals with a certain gene variant don't clear artificial estrogens as efficiently, leading to a buildup from sources like BPA in plastics, phthalates, atrazine (a herbicide), and mold estrogens. Birth control, being an estrogen, also contributes to this buildup. The speaker mentions a scientist, Michael Skinner, and his research on epigenetics and the effects of estrogen chemicals, particularly atrazine and BPA, on polycystic ovary syndrome in mice. The speaker highlights the significance of this gene and mentions studies showing that saunas help eliminate estrogens through sweat.
Sauna Use for Detoxification
00:36:52 - 00:37:51
Skin patch studies show that sauna use significantly accelerates the clearance of BPAs, phthalates, and other chemicals from the body. Individuals using saunas showed higher levels of these chemicals on their skin patches after sauna use, but lower levels in their urine, suggesting that saunas help the liver eliminate these toxins more effectively. The speaker recommends sauna use every other day for 10-20 minutes at 180 degrees Fahrenheit, suggesting that even 10 minutes is sufficient if the individual is already warmed up and sweating profusely from prior exercise.
Testosterone Gene and Levels
00:37:51 - 00:38:31
The speaker discusses a testosterone gene, noting a "plus-plus" result indicating lower testosterone levels. Despite this genetic predisposition, the speaker's testosterone levels were high (85 compared to a maximum standard range of 55). The speaker observes that this gene is more predictive of lower testosterone in men than in women, making it harder to interpret in women. The speaker expresses satisfaction with the individual's high testosterone levels despite the genetic marker.
Birth Control and its Effects
00:38:31 - 00:40:46
The conversation begins with a discussion about the speaker's low levels of a certain substance, which were later found to have returned to normal. It's revealed that the initial low levels were attributed to birth control use. The impact of birth control, particularly its risks given a CYP gene issue, is highlighted. The speaker mentions experiencing anxiety and depression, potentially linked to prolonged birth control use. A study on suicide rates in relation to birth control use in the UK is referenced. The discussion then shifts to thyroid issues, emphasizing their unpredictable nature due to genetic variations. The speaker's energy levels are assessed as "pretty decent." Proactive thyroid checks are mentioned due to family history. The importance of iodine intake and the use of a specific multivitamin (from Pure Vitamin Club) containing iodine and the beneficial form of folic acid (5-MTHF) are stressed. Finally, the conversation touches upon histamine and beta-carotene genes, deemed less concerning. The speaker's past limited cannabis use is noted, along with a discussion of a gene that might increase the risk of paranoia when using cannabis.
Blood Test Results Review and Fertility Discussion
00:40:46 - 00:42:04
The discussion begins with a review of blood test results. Low dopamine levels are deemed not a major concern unless the individual is a frequent cannabis user. Bilirubin levels are slightly elevated, prompting a recommendation for a check-up, although it's noted that chronically high levels are a concern, potentially leading to gallstones. The conversation then shifts to B9 levels (methyl folate) and the individual's need for supplementation. It's determined that high levels of methyl folate aren't necessary for this individual. The context changes to the individual's attempts to conceive, explaining the doctor's prescription of folic acid. The speaker explains that folic acid is a generic approach, and that a gram of a recommended alternative supplement is not as crucial in this specific case.
Fertility Recommendations and Lifestyle Changes
00:42:05 - 00:42:19
The reason for the generic folic acid prescription is explained: many people have MTHFR genes, necessitating this approach. However, for this individual, the focus shifts to lifestyle changes as key to improving fertility. Specifically, the use of a sauna and a ketogenic diet are recommended, with a projected timeframe of six months for noticeable results.
Keto Diet and Fertility
00:42:21 - 00:43:51
The conversation centers around the impact of diet on fertility, specifically highlighting a coach's experience. Karen, a DNA consultant, struggled with infertility for 15 years before switching to a paleo/keto diet. Following this change, she conceived at age 40 and now has a healthy child. Her husband, Joe, actively promotes the keto diet due to their positive experience. The speaker emphasizes the benefits of the keto diet, along with sauna use, for hormonal balance. The discussion also touches upon B12 supplementation (unnecessary with a meat-rich keto diet) and the importance of manganese for the SOD2 gene, while expressing less concern about heavy metals due to good genetics.
Manganese, Magnesium, and Nuts
00:43:51 - 00:45:05
The conversation begins with a discussion about manganese's role in mitochondrial health, emphasizing its importance for energy production. The speaker recommends consuming pecans as a natural source of manganese rather than supplements, citing the low manganese content and high cornstarch filler in many supplements. The conversation then shifts to magnesium, with the participants sharing their experiences of incorporating hazelnuts and macadamia nuts into their diet to increase magnesium intake due to previously low levels.
Fructose and High Fructose Corn Syrup
00:45:05 - 00:45:53
The discussion turns to fructose, with the speaker expressing less concern about it compared to other factors. The speaker mentions Derek's genetic predisposition (a "plus plus" on a certain gene) which might influence fructose metabolism. The conversation then delves into the use of high fructose corn syrup in the past, recalling the making of cookies and popsicles with it, highlighting its taste and the advantage of preventing "sugar cutting your lips" when frozen. The discussion concludes with acknowledging the widespread use of high fructose corn syrup in some processed foods despite its health implications, highlighting the conflict between taste and health concerns.
Food Engineering and Addiction
00:45:53 - 00:47:22
This section discusses how food is engineered to be addictive, referencing the abundance of readily available fruit in contrast to the limited access our ancestors had. The conversation then shifts to a question about iron deficiency, a personal struggle for one participant. The response suggests that genetic predisposition usually leads to high iron levels, and low iron is more common in women due to menstruation. As a solution, eating liver is recommended, specifically suggesting a liver pâté recipe with bacon and rosemary to improve palatability. The ease of making and the delicious taste of the pâté are emphasized.
Family Experiences with Liver and Spleen
00:47:22 - 00:48:47
This segment discusses family members' experiences with eating liver and spleen. One speaker shares that their children enjoy liver, while another speaker's child prefers the flavor but dislikes the texture. The possibility of pâté improving the texture is mentioned. The use of an ancestral spleen supplement is discussed, along with the purchase of grass-fed beef spleen, which was rejected by the family member. The conversation then shifts to the general preference for food, suggesting that hunger might increase the palatability of less commonly consumed organ meats like spleen. The speakers agree that liver is a superior source of iron compared to other options, highlighting its nutritional benefits and the importance of proper preparation.
Keto Diet Discussion
00:48:47 - 00:48:52
A keto diet recipe is mentioned, praised for its taste and keto macro-friendliness. The speakers briefly confirm there are no further points in this section.
Gym Section and Muscle Fiber Type Discussion
00:48:53 - 00:50:09
The conversation shifts to the gym section. One speaker expresses a preference for shorter workouts due to good genetics, identifying as a fast-twitch, power-lifting type rather than endurance-focused. This surprises another speaker, who believed the first speaker was more endurance-oriented. The discussion touches on the speaker's family history and genetics, suggesting a predisposition towards fast-twitch muscles. The advice given is to develop fast-twitch muscles through exercises like deadlifts, emphasizing the positive hormonal effects of heavy lifting.
Hormonal Benefits of Heavy Lifting
00:50:10 - 00:50:59
An anecdote is shared about a young woman with significant hormone imbalances despite being very thin and lacking muscle mass. The speakers highlight the crucial role of muscle mass in hormone regulation and balance. Deadlifts are again recommended as a primary exercise, emphasizing their importance for overall health and hormonal well-being.
Workout Routine and Joint Health Discussion
00:50:59 - 00:52:33
This segment focuses on a discussion about workout routines, specifically the 5x5 method, and its impact on joint health. The speakers discuss the effectiveness of 5x5 for exercises like deadlifts and pull-ups, concluding that for some exercises, like deadlifts and pull-ups, a 1x5 approach is preferable to reduce stress on the nervous system and allow for continued weight progression. The conversation then shifts to the importance of gradual weight increases (10-pound increments) to protect joints. The speakers touch upon the influence of genetics (HLA genes) on joint health, noting a potential increased risk of arthritis linked to high insulin levels. However, given the individual's age (29) and seemingly good genetic predisposition, along with healthy blood sugar levels, the risk is deemed low.
Blood Flow and Joint Health
00:52:33 - 00:54:04
The discussion focuses on maintaining good blood flow to mitigate joint issues. The speaker emphasizes the importance of regular movement and exercise to prevent sedentary behavior, suggesting getting up and moving every hour to improve circulation. The benefits of saunas and infrared light, particularly for those with limited mobility due to surgery or illness, are mentioned. Gout risk is addressed, highlighting the increased risk associated with the individual's genetic profile (ABCG2 and SLC2A9 genes). The SLC2A9 gene, a fructose transporter, is identified as a significant factor, indicating a four-fold higher risk of gout with a plus-plus genotype. The speaker notes that while doctors often advise patients with gout to reduce meat consumption, the key factor is fructose intake.
Fructose, Uric Acid, and Dietary Recommendations
00:54:05 - 00:55:04
The discussion centers on the impact of fructose consumption, particularly from soda and high fructose corn syrup, on health. A podcast by Dr. Peter Atiyah interviewing Rick Johnson is recommended for further information on the relationship between fructose and uric acid. While most people possess a gene related to fructose metabolism, reducing consumption of fruits, high fructose corn syrup, and soda is advised. The conversation also touches upon the reduced risk of high blood pressure from salt intake in individuals with a specific gene variant.
Blood Pressure and Lifestyle Factors
00:55:05 - 00:55:45
The conversation shifts to the angiotensinogen gene (AGT), a common gene often associated with higher blood pressure. However, maintaining a healthy body weight, regular exercise, and managing chronic inflammation are highlighted as crucial factors in mitigating the risk of high blood pressure, even with the presence of AGT. The importance of lifestyle choices over solely focusing on salt intake in blood pressure management is emphasized, cautioning against potential misinformation from doctors regarding salt's role.
Genetic Predispositions and Their Implications
00:55:45 - 00:57:11
This segment focuses on the analysis of the individual's genetic profile, specifically highlighting genes related to bone strength and blood pressure. The discussion reveals a "yin-yang" effect where genes with opposing effects on bone density (Wnt16 leading to weaker bones and FAM3C increasing bone density) offset each other. Similarly, genes related to blood pressure show a balance of protective and risk-increasing factors. The conversation then shifts to the IGF1 receptor gene, which impacts muscle mass gain, but is deemed less relevant to the individual's goals. Finally, the individual's COMT gene is identified as contributing to lower pain sensitivity, although not to an extreme degree. The overall assessment emphasizes the balancing effects of various genes and focuses on identifying and addressing potentially problematic genes rather than solely focusing on beneficial ones.
Managing Pain and Injury Risk
00:57:12 - 00:57:32
The discussion emphasizes the importance of being cautious about pain, especially for individuals who may not experience pain in the same way as others. This reduced pain sensation increases the risk of injury, such as a knee injury occurring without prior warning. The advice given is to pay attention to pain and not push through it, contradicting the "no pain, no gain" mentality. Careful attention to pain signals is crucial for injury prevention.
Gym Section Review and Transition to Sleep
00:57:33 - 00:57:45
The speaker asks if there are any questions regarding the gym section of the document, noting it as a particularly good section. No questions are raised, and the conversation transitions to the final section on sleep.
Sleep Section: Sunshine and Light Therapy
00:57:46 - 00:58:32
The sleep section focuses on the benefits of the "freezing effective gene" previously mentioned, but emphasizes that nothing surpasses the effects of natural sunshine. While blue light devices can help regulate light exposure, they are not as effective as sunlight. The use of UV lamps is mentioned as an alternative, but their high cost ($500) and potential eye damage necessitate caution and proper usage (goggles, limited exposure). The conversation concludes with a suggestion to spend winters in sunny locations like Florida to maximize sunlight exposure.
Sleep Patterns and Genetics
00:58:32 - 00:59:57
This segment discusses the role of genetics in sleep patterns. The conversation begins by mentioning the clock gene ABCC9 and its potential connection to sleep issues, particularly late sleep cycles. The speaker inquires about the individual's sleep habits, noting that while they identify as a night owl, this wasn't initially mentioned in their email. The discussion then explores the influence of environmental factors versus genetics on sleep patterns, with the individual mentioning a history of sleeping late as a child. The speaker explains that environmentally influenced sleep habits are easier to change than genetically determined ones, emphasizing the importance of adjusting sleep schedules to align with genetic predispositions for better overall health and metabolism. The speaker highlights that those genetically predisposed to later sleep cycles should strive to maintain this pattern, while those with early-bird genes should aim for early sleep and wake times.
Genetic Predisposition and Health Discussion
00:59:57 - 01:01:20
The discussion centers on the patient's genetic predispositions and their implications for health. The practitioner explains that the patient's blood sugar levels are generally lower due to genetic factors. The patient's magnesium intake is highlighted as important given their genetic profile. The practitioner notes a slight sensitivity to blue light, but emphasizes that it's not a significant concern. Overall, the patient's genetics are described as "phenomenal." The patient then inquires about a tendency to bruise easily, which the practitioner suggests may be related to estrogen levels or aspirin use, a medication the patient takes for PCOS and fertility purposes. The practitioner notes that women generally bruise more easily than men and that aspirin can also contribute to easier bruising.
Aspirin and Bruising
01:01:20 - 01:02:11
The discussion centers on excessive bruising and its potential link to aspirin consumption. The speaker explains that aspirin inhibits platelets, impacting blood clotting and potentially leading to prolonged bruising. The half-life of aspirin is noted as approximately 90 days, meaning the effects can persist for a considerable time after cessation. The speaker also mentions that certain flavonoids, sometimes found in vitamin C supplements, can further thin the blood, exacerbating the bruising. The recommended course of action is to reduce or eliminate aspirin intake. In addition to reducing aspirin, the speaker suggests lifting heavy weights and using a sauna to help balance hormones, which may offer additional benefits regardless of the bruising issue.
Bruising, Genetics, and Aspirin
01:02:11 - 01:02:44
The conversation shifts to the individual's increased bruising and the exploration of potential causes. While the speaker initially suggests aspirin as the likely culprit, the possibility of genetic predisposition to aspirin sensitivity is also raised. However, the speaker clarifies that they don't routinely test for genes related to aspirin sensitivity. The exception is metformin, which is considered a plant-based supplement derived from the French lilac plant.
Prescription Drug Discussion
01:02:44 - 01:03:38
The conversation begins with a discussion about the prescription status of a drug, with one participant expressing a preference for it to be over-the-counter. The challenges of managing numerous prescription drugs are highlighted, leading to a discussion about genetic testing to assess individual responses to medications. While genetic screening for drug compatibility is mentioned as a possibility, it's noted that this service isn't routinely offered due to time constraints, although it might be provided for a fee. The conversation then shifts to a more casual tone, with updates on personal well-being and the use of previously discussed supplements.
Personal Updates and Supplement Use
01:03:38 - 01:03:54
The final segment of the conversation involves personal updates. One participant shares that they have obtained and started taking the supplements previously discussed. Another participant mentions a "seasonal effective gene," suggesting a shared genetic trait related to seasonal changes. The conversation ends with brief pleasantries.
Winter Vacation Plans and Health Updates
01:03:54 - 01:05:10
The conversation begins with a discussion of winter vacation plans. Speakers initially mention their usual Caribbean trip in October, but then discuss potentially shifting it to February to escape the winter weather. The conversation then transitions to health updates, specifically regarding heavy metal tests. One speaker mentions having a hair metal test and waiting to take it after starting new supplements. Another speaker notes that they have already taken the test and had significantly higher levels of heavy metals than another individual (Megan), who is presented as having exceptionally low levels. The speakers compare their test results, noting discrepancies even when similar metals were tested. The conversation concludes with one speaker advising another to be grateful for their relatively lower heavy metal levels.
Closing Remarks and Gift Exchange
01:05:10 - 01:06:17
The meeting concluded with final questions and comments from participants. The speaker expressed gratitude for the participants' involvement, particularly their contribution to the podcast version of the meeting. A promise was made to send gift packages containing home-roasted coffee and T-shirts featuring a DNA motif with "Dr. J" and the number 23 (representing the 23 chromosome pairs, referencing the company 23andMe). Concerns were voiced about the coffee's potential breakage during shipping. The meeting ended with mutual farewells and thanks.
00:00:00 - 00:00:56
The speaker introduces himself as a Mayo Clinic scientist, DNA consultant, and author with YouTube channels "Anthony J. Cast" and "Anthony J. Family Cast." He mentions his current coffee roasting activity and his practice of sending roasted coffee beans and t-shirts to podcast guests. He introduces the episode's guest, Megan from Minnesota, and the episode's focus on keto. He promotes his DNA analysis services through ajconsultingcompany.com, offering both podcast episode and confidential options.
Technical Setup and Recording
00:01:00 - 00:01:43
The hosts exchange greetings and briefly discuss the recording setup. A slight delay is acknowledged. They discuss the challenges of using Skype for recording due to choppy audio quality, particularly during the COVID-19 situation. The hosts adjust their audio equipment, switching to headphones and confirming clear communication.
Initial Greetings and Catch-Up
00:01:43 - 00:02:17
The conversation begins with confirmations of document availability and pleasantries. Participants check in with each other, noting previous contact approximately two weeks prior. Their geographic locations are discussed; both Derek and another participant are from Wisconsin, currently residing in Minnesota. One participant mentions recent travel to South Dakota.
Discussion of Vitamin Use and Vinnie Tordridge
00:02:18 - 00:02:58
The conversation shifts to the participants' use of Pure Vitamin Club vitamins, prompted by the observation of their use. One participant expresses their fandom of Vinnie Tordridge, and another reveals an upcoming podcast appearance with him. The spontaneous nature of the podcast invitation is highlighted.
DNA Profile Review and Initial Assessment
00:02:58 - 00:04:01
The discussion begins with a review of the individual's DNA profile. The speaker notes the excellent genetics, focusing primarily on the "plus-plus" genes while acknowledging some "plus-minus" genes, particularly a significant one at the beginning of the profile. Despite this, the overall assessment is positive. Pre-existing conditions are noted, including polycystic ovarian syndrome (PCOS), low iron, and vitamin D deficiency. The speaker mentions that PCOS will be addressed later in the hormone section, while low iron and vitamin D are easily correctable.
Keto Diet Progress and Discussion
00:04:01 - 00:04:24
The conversation shifts to the individual's ketogenic diet. The individual reports that it's going better than expected, although initial attempts involved some cheating. The speaker emphasizes that keto requires full commitment, as cheating significantly hinders its effectiveness. A previous experience of a prolonged "keto flu" is mentioned as an example of the consequences of inconsistent adherence.
Keto Diet and Initial Reactions
00:04:24 - 00:04:48
The conversation begins with discussions about the ketogenic diet. Participants share experiences, with one describing the "keto flu" as brutal. Another participant mentions having a mostly chicken-based keto meal, including chicken skins, due to feeling they had consumed too many carbs. They also mention taking electrolytes to mitigate the effects, acknowledging that it wasn't a strict keto day.
Keto Diet Benefits and Upcoming Talk
00:04:50 - 00:05:07
One participant expresses enthusiasm for the keto diet, mentioning they are giving a talk at a keto conference. The talk is being pre-recorded and will be released online in early June. The conversation then transitions to the topic of brain optimization, indicating the start of a new section.
DNA Basics and Parental Gene Contribution
00:05:08 - 00:05:42
The discussion shifts to foundational genetics. Megan emphasizes that every cell in the body (except egg and sperm cells) contains two copies of DNA, one from each parent. A common question about determining which parent contributed a particular gene variant is addressed; the answer is that it's not possible to definitively determine the parental origin of a specific gene variant based on the presence of a "good" or "bad" version.
Genetic Predisposition to Alzheimer's
00:05:48 - 00:07:21
This section focuses on the individual's genetic risk for Alzheimer's disease. The discussion clarifies the meaning of "plus plus" (inheriting a bad gene version from both parents) and "plus minus" (inheriting one bad and one good gene version). The individual's family history of memory issues (the dad's mother) is noted. The individual possesses a "plus minus" APOE3-4 gene, which carries a near 50% risk of developing Alzheimer's if following a Standard American Diet. While other risk genes are present, they are all "plus minus," making APOE3-4 the most significant risk factor. The speaker emphasizes the importance of addressing this risk, suggesting DHA supplementation as a relatively easy solution.
DHA Supplementation and Alzheimer's Risk
00:07:22 - 00:08:01
The speaker emphasizes the importance of taking high-quality fish oil, specifically noting that phospholipid DHA or triglyceride DHA is the best form for brain uptake. They recommend two grams daily and suggest that with regular exercise and a decent diet, along with this supplementation, one should be fine. The speaker highlights the preventative nature of this approach, stating that addressing the issue before problems arise is key, as studies show that simply adding DHA later doesn't solve existing problems.
APOC1 and Triglyceride Levels
00:08:03 - 00:09:05
The conversation shifts to APOC1, a triglyceride transporter. High triglycerides are linked to a two-fold increased risk of Alzheimer's, particularly in individuals following a standard American diet. The speaker notes that the studies are based on average Americans' eating habits. The speaker asks the listener about their triglyceride levels, but the listener is unable to immediately locate their lab results, explaining that they are part of their yearly work health exams and not readily accessible.
Checking Triglyceride Levels and Cardio
00:09:06 - 00:09:58
The conversation begins with a discussion about checking triglyceride levels, with one participant suggesting it's standard practice. Another participant confirms that their levels have generally been good but agrees to check them. The importance of tracking these levels for future reference is highlighted. Methods for lowering high triglyceride levels are discussed, with cardio being identified as the most effective way. The beneficial effect of DHA fish oil supplements in reducing triglycerides is also mentioned. One participant shares that they've started incorporating more cardio into their routine due to training for an Ironman competition in Florida in November. The potential for hot weather during the competition is briefly discussed, along with a question about whether the event coincides with the rainy season.
Florida Weather and Sauna Training
00:09:58 - 00:11:28
The conversation begins with a discussion about the weather in Naples, Florida, specifically its rainy season, which is described as having daily rain, especially in September. The conversation then shifts to the location of an upcoming trip, Panama City, Florida. The possibility of sauna training is raised, with one participant expressing interest and another mentioning seeing notes about it. The conversation concludes with an anecdote about an extreme athlete in Hawaii who trains in a 225-degree sauna, highlighting the diverse approaches to heat acclimatization.
BDNF and Cardio Exercise
00:11:33 - 00:13:07
The discussion centers on the BDNF gene and its relationship to exercise. Cardiovascular exercise is highlighted as key for increasing BDNF levels, unlike heavy lifting which shows less impact. The speaker emphasizes the importance of BDNF for brain growth and performance, particularly as one ages. Endurance exercises like running, rowing, or even slow bench pressing are suggested, advocating for an hour-long session maintaining a sustainable heart rate. Nose breathing is recommended as a pacing technique to ensure the heart rate remains in the optimal zone.
FOXO3 Gene and Carbohydrate Metabolism
00:13:07 - 00:13:22
The conversation moves to the FOXO3 gene, which suggests suboptimal brain handling of carbohydrates and higher blood sugar. Individuals with this gene may experience fatigue after consuming carbs. The speaker notes the age of the individual being discussed is 29.
Brain Fog and Carb Sensitivity
00:13:22 - 00:14:21
The discussion centers on the impact of carbohydrates on brain fog. Participants share personal experiences, noting that brain fog is more prevalent with age and that younger individuals may tolerate higher carb intake better due to faster metabolisms. The consensus is that carb sensitivity is partly genetic and that managing carb intake, potentially through cyclical approaches or reductions, can be beneficial. The conversation concludes by transitioning to the next topic.
Anxiety and the TPH2 Gene
00:14:22 - 00:14:55
The conversation shifts to anxiety, with participants acknowledging past struggles and the contributing role of societal stress. The TPH2 gene, responsible for converting tryptophan (an amino acid) into serotonin, is introduced as a potential factor influencing anxiety levels. The discussion briefly explains the role of tryptophan and serotonin in the body.
Anxiety and Serotonin Levels
00:14:55 - 00:16:39
The discussion centers on the patient's anxiety and its connection to serotonin levels. 90% of serotonin is produced in the gut and transported to the brain. A specific gene variation ("plus-plus") hinders this transport, increasing anxiety risk. The recommended approach involves improving gut health through diet, exercise, and sleep. If these measures are insufficient, additional options are available. The early detection of the gene variation is positive, and lifestyle changes are expected to manage anxiety effectively. Caffeine's effect is discussed, with the patient reporting sensitivity only to coffee. The patient's genes are described as "phenomenal," even with some Alzheimer's risk genes showing a "plus minus" variation, offering some relief. The conversation then transitions to dietary considerations.
Dietary Considerations and Gene Analysis
00:16:39 - 00:16:48
The discussion moves to a gene analysis, focusing on a "plus minus" variation in a gene that wouldn't typically warrant discussion. The conversation is cut off before further details are provided.
Genetic Predisposition and Dietary Choices
00:16:48 - 00:17:38
A discussion regarding genetic predisposition to colon cancer and dietary choices ensues. The speaker mentions a gene, GATA3, linked to a 20% increased risk of colon cancer when consuming processed meats. The conversation then shifts to personal preferences and habits, with one participant mentioning their aversion to summer sausage and their preference for homemade alternatives. Another participant mentions discussing similar genetic factors with Derek and their shared interest in processing their own meats, such as brats and summer sausage, to maintain control over ingredients and preparation methods.
Childhood Exposure to Animal Processing
00:17:39 - 00:18:28
The conversation transitions to a personal anecdote about the speaker's children's early exposure to handling animals and fish. The speaker describes their two-year-old daughter's nonchalant approach to handling a live, flopping fish, contrasting it with the reaction of another two-year-old who was frightened by the same experience. The discussion highlights the contrasting reactions of the children and their parents, suggesting that parental response significantly influences a child's comfort level with such situations. The speaker concludes by emphasizing the benefits of early exposure and the importance of parental reactions in shaping a child's response to handling animals.
Childhood Exposure to Hunting
00:18:31 - 00:18:43
The speaker recounts their children's nonchalant reaction to witnessing deer butchering, highlighting their desensitization to the process and lack of exposure to Disney's portrayal of animals. The children's acceptance of the activity is emphasized as a positive aspect.
Diabetes Risk Genes and GLP-1 Hormone
00:18:44 - 00:19:45
Discussion focuses on the speaker's genetic predisposition to diabetes, specifically mentioning the TCF7L2 gene and its impact on GLP-1 (glucagon-like peptide 1) hormone levels. Lower GLP-1 levels result in less efficient sugar uptake, potentially leading to higher blood sugar. The speaker advises against consuming pure carbohydrates and recommends combining carbs with protein and fat to increase GLP-1 production and manage blood sugar. The speaker's blood sugar levels are mentioned as being generally good, in the 80-90 range, even while following a ketogenic diet.
Genetic Factors and Weight Management
00:19:46 - 00:21:13
The discussion centers on the impact of genetics, specifically the MC4R gene, on body weight. The speaker explains that this gene, present in approximately 90% of the population, acts as a body weight thermostat, regulating hormones to maintain a set weight. Weight gain can cause the body to adjust its set point, making weight loss difficult even with calorie restriction. The speaker highlights that sunshine and intermittent fasting help regulate the MC4R gene, positively impacting metabolism. The benefits of intermittent fasting, potentially in conjunction with a ketogenic diet, are also mentioned.
Ketogenic Diet and Intermittent Fasting
00:21:13 - 00:22:27
The discussion centers on the ketogenic diet and intermittent fasting. The speaker advises against starting keto immediately but suggests skipping breakfast and eating only after noon once adapted to the diet. If this proves difficult, incorporating fats like MCT oil, protein powder, collagen powder, or bone broth is suggested as a temporary measure. Intermittent fasting is highlighted as a powerful method for hormone regulation. The speaker mentions adiponectin, a hormone involved in fat metabolism, noting that its levels decrease in many individuals. Intermittent fasting is presented as a way to increase adiponectin levels, making it a recommended approach for most people.
Metformin Usage
00:22:29 - 00:22:41
The conversation shifts to metformin. The speaker confirms the individual's past use of metformin at a high dosage (two grams daily) and notes the recent discontinuation of the medication.
Metformin and Ketogenic Diet Experience
00:22:41 - 00:24:43
This segment discusses the speaker's experience with Metformin, a medication used to treat PCOS, in conjunction with a ketogenic diet. The speaker initially used Metformin for PCOS and found it helpful. However, after starting a ketogenic diet, they experienced side effects from Metformin and stopped taking it to see if the keto diet alone would provide similar benefits. This proved unsuccessful, leading to the decision to resume Metformin. The conversation then shifts to dosage, with the speaker mentioning their personal experimentation with different dosages (500mg to 2g), noting that 500mg is generally effective for them. They clarify that many in their community use Metformin for lifespan extension rather than specifically for conditions like diabetes or PCOS. The speaker's experience is described as that of a "plus minus higher responder," not a "super high responder," which is suggested as a reason for the side effects. The speaker's ability to manage carbohydrates well on keto is also discussed, with the expectation that brain performance will improve with continued keto and intermittent fasting. The conversation concludes with the speaker considering reducing their Metformin dosage upon restarting the medication.
Genetic Predisposition to Heart Disease and Gut Issues
00:24:43 - 00:26:16
The discussion centers on the patient's genetic predisposition to heart disease and gut issues. The doctor notes that while the patient's LPL gene shows a common plus-plus genotype found in about 50% of the population, the risk is mitigated by the patient's generally healthy lifestyle. High triglycerides are highlighted as a potential concern, especially for sedentary individuals. The doctor then shifts focus to the patient's gut health, noting a significant number of genes related to gut issues, though most are plus-minus, indicating a less severe impact. The patient confirms experiencing gut issues, particularly with dairy. The doctor explains that while genetics are predictive of dairy intolerance (bad genes almost always lead to inflammation), even with good genes, dairy issues can still occur, but are often reversible.
Dietary Changes and Impact on Health Issues
00:26:17 - 00:27:04
Discussion centers on the positive effects of a low-sugar, low-carb diet, specifically keto, on resolving health issues. One participant notes that switching to keto eliminated their problems. The connection between lactose intolerance and sugar in dairy is highlighted, with the suggestion to avoid dairy products containing carbohydrates. The discussion expands to include the inflammatory nature of casein, although another participant mentions consuming whey protein without issues. The impact of dietary changes on those with dairy sensitivities is also addressed.
The Role of Genes and Keto Diet in Inflammation
00:27:04 - 00:28:04
The conversation shifts to the influence of genes, specifically NOD2 and ATG16L1, on health. The NOD2 gene's role in inflammasome creation is explained, along with the interaction between NOD2 and the NLRC4 protein. The discussion emphasizes that ketones inhibit inflammasomes, reducing inflammation. The work of scientist Dom DeAgostino on this topic is mentioned.
Ketogenic Diet and Gut Health
00:28:11 - 00:29:15
The discussion centers on the benefits of ketosis for gut health, with one participant noting improvements in stomach issues since adopting a ketogenic diet. The ATG6101 gene is mentioned as a potential risk factor for leaky gut, particularly in conjunction with gluten consumption. While not a direct gluten sensitivity gene, it increases the likelihood of gluten sensitivity. Another participant shares their experience trying to determine the cause of stomach aches, suspecting dairy initially but experiencing issues even without dairy, suggesting other factors might be at play. The complexities of gluten sensitivity are discussed, highlighting the role of pesticides, mold in grains, and the impact of high-carb intake on gut lining.
Gluten Sensitivity and the Role of Other Factors
00:29:15 - 00:29:48
The conversation continues on the challenges of identifying the root cause of gluten-related issues. It's noted that various factors beyond gluten itself, such as pesticides, mold in grains, and the sheer volume of carbohydrates, can contribute to digestive problems. The rough nature of fiber in some grains is also mentioned as a potential irritant to the gut lining. Cutting gluten is suggested as a beneficial step, especially for those experiencing digestive issues.
The CNR1 Gene and CBD Oil
00:29:19 - 00:29:51
The CNR1 gene (cannabinoid receptor) is introduced, explaining its role in binding CBD oil. It's suggested that CBD oil can be helpful in mitigating the negative effects of consuming foods that trigger digestive distress. However, it's clarified that CBD oil is not a complete solution and won't allow for unrestricted consumption of problematic foods, but rather offers relief from symptoms.
Podcast Discussion and Future Topics
00:29:51 - 00:30:07
A recent podcast focusing solely on "plus-plus" genes is mentioned, contrasting with the current discussion that includes "plus-minus" genes. The conversation concludes by expressing a desire to revisit a previously discussed "plus-plus" gene.
Understanding CDK Inflammation and Dietary Solutions
00:30:08 - 00:31:19
This section discusses CDK, a type of inflammation. A specific gene helps lower CDK levels, likened to turning down a hot water tap. However, a genetic plus-plus variant reduces the gene's effectiveness. Flavonoids, found in colorful plants like blueberries and red bell peppers, also inhibit CDK, acting as a further "hot water shut-off." Grapeseed pro-ampicyanidins are highlighted as a potent CDK inhibitor, though the name is noted as being difficult. The discussion concludes with a confirmation that the topic is covered and a transition to the next section.
Vitamin, Hormone, and Detoxification: Addressing Polycystic Issues
00:31:20 - 00:31:43
This section focuses on the vitamin, hormone, and detoxification aspects, specifically related to polycystic conditions. The speaker identifies a gene related to ceramide production, suggesting it's not a primary concern unless skin issues arise. Phytoceramides are mentioned as a potential solution if such issues develop in the future. The section ends before a full discussion of this gene's role.
Skin Health and Vitamin D Levels
00:31:44 - 00:33:15
The discussion begins with the importance of ceramides for skin and cell membranes. Low vitamin D levels are noted, attributed to a lack of supplementation in the past, especially considering the speaker's residence in Minnesota. The speaker's past experience of winter gloominess led to a vitamin D check, revealing significantly low levels. The conversation then shifts to the discovery of a risk gene (PDR3 gene, plus plus) for seasonal affective disorder, explaining the winter depression even with optimized vitamin D levels. The speaker's current use of Vinny's vitamin supplement, including olive oil, is mentioned positively. The speaker also mentions having heard Vinny's podcast, where he discusses his olive oil consumption.
Genetic Predisposition and Lifestyle Recommendations
00:33:15 - 00:34:56
This segment focuses on the discussion of genetic predispositions and their implications for lifestyle choices. The speaker mentions a gene related to vitamin D levels, suggesting supplementation and sun exposure as countermeasures. Another gene, PON1++, affecting the breakdown of oxidized oils, is discussed, with a recommendation to avoid seed oils (canola, grapeseed) while consuming olive oil, coconut oil, and avocado oil as alternatives. The conversation then shifts to genes related to polycystic conditions, specifically a testosterone++ gene and several estrogen-related genes. The speaker strongly recommends sauna use, referencing a previous conversation about a CYP gene and its presence in another individual's genetic profile. The discussion concludes with a mention of the CYP1B1 gene and its less common plus-plus version, noting its presence in many men the speaker has consulted.
Liver Enzyme and Artificial Estrogens
00:34:56 - 00:36:44
This segment discusses the impact of a gene related to gynecomastia and its connection to the body's ability to clear artificial estrogens. The speaker explains that individuals with a certain gene variant don't clear artificial estrogens as efficiently, leading to a buildup from sources like BPA in plastics, phthalates, atrazine (a herbicide), and mold estrogens. Birth control, being an estrogen, also contributes to this buildup. The speaker mentions a scientist, Michael Skinner, and his research on epigenetics and the effects of estrogen chemicals, particularly atrazine and BPA, on polycystic ovary syndrome in mice. The speaker highlights the significance of this gene and mentions studies showing that saunas help eliminate estrogens through sweat.
Sauna Use for Detoxification
00:36:52 - 00:37:51
Skin patch studies show that sauna use significantly accelerates the clearance of BPAs, phthalates, and other chemicals from the body. Individuals using saunas showed higher levels of these chemicals on their skin patches after sauna use, but lower levels in their urine, suggesting that saunas help the liver eliminate these toxins more effectively. The speaker recommends sauna use every other day for 10-20 minutes at 180 degrees Fahrenheit, suggesting that even 10 minutes is sufficient if the individual is already warmed up and sweating profusely from prior exercise.
Testosterone Gene and Levels
00:37:51 - 00:38:31
The speaker discusses a testosterone gene, noting a "plus-plus" result indicating lower testosterone levels. Despite this genetic predisposition, the speaker's testosterone levels were high (85 compared to a maximum standard range of 55). The speaker observes that this gene is more predictive of lower testosterone in men than in women, making it harder to interpret in women. The speaker expresses satisfaction with the individual's high testosterone levels despite the genetic marker.
Birth Control and its Effects
00:38:31 - 00:40:46
The conversation begins with a discussion about the speaker's low levels of a certain substance, which were later found to have returned to normal. It's revealed that the initial low levels were attributed to birth control use. The impact of birth control, particularly its risks given a CYP gene issue, is highlighted. The speaker mentions experiencing anxiety and depression, potentially linked to prolonged birth control use. A study on suicide rates in relation to birth control use in the UK is referenced. The discussion then shifts to thyroid issues, emphasizing their unpredictable nature due to genetic variations. The speaker's energy levels are assessed as "pretty decent." Proactive thyroid checks are mentioned due to family history. The importance of iodine intake and the use of a specific multivitamin (from Pure Vitamin Club) containing iodine and the beneficial form of folic acid (5-MTHF) are stressed. Finally, the conversation touches upon histamine and beta-carotene genes, deemed less concerning. The speaker's past limited cannabis use is noted, along with a discussion of a gene that might increase the risk of paranoia when using cannabis.
Blood Test Results Review and Fertility Discussion
00:40:46 - 00:42:04
The discussion begins with a review of blood test results. Low dopamine levels are deemed not a major concern unless the individual is a frequent cannabis user. Bilirubin levels are slightly elevated, prompting a recommendation for a check-up, although it's noted that chronically high levels are a concern, potentially leading to gallstones. The conversation then shifts to B9 levels (methyl folate) and the individual's need for supplementation. It's determined that high levels of methyl folate aren't necessary for this individual. The context changes to the individual's attempts to conceive, explaining the doctor's prescription of folic acid. The speaker explains that folic acid is a generic approach, and that a gram of a recommended alternative supplement is not as crucial in this specific case.
Fertility Recommendations and Lifestyle Changes
00:42:05 - 00:42:19
The reason for the generic folic acid prescription is explained: many people have MTHFR genes, necessitating this approach. However, for this individual, the focus shifts to lifestyle changes as key to improving fertility. Specifically, the use of a sauna and a ketogenic diet are recommended, with a projected timeframe of six months for noticeable results.
Keto Diet and Fertility
00:42:21 - 00:43:51
The conversation centers around the impact of diet on fertility, specifically highlighting a coach's experience. Karen, a DNA consultant, struggled with infertility for 15 years before switching to a paleo/keto diet. Following this change, she conceived at age 40 and now has a healthy child. Her husband, Joe, actively promotes the keto diet due to their positive experience. The speaker emphasizes the benefits of the keto diet, along with sauna use, for hormonal balance. The discussion also touches upon B12 supplementation (unnecessary with a meat-rich keto diet) and the importance of manganese for the SOD2 gene, while expressing less concern about heavy metals due to good genetics.
Manganese, Magnesium, and Nuts
00:43:51 - 00:45:05
The conversation begins with a discussion about manganese's role in mitochondrial health, emphasizing its importance for energy production. The speaker recommends consuming pecans as a natural source of manganese rather than supplements, citing the low manganese content and high cornstarch filler in many supplements. The conversation then shifts to magnesium, with the participants sharing their experiences of incorporating hazelnuts and macadamia nuts into their diet to increase magnesium intake due to previously low levels.
Fructose and High Fructose Corn Syrup
00:45:05 - 00:45:53
The discussion turns to fructose, with the speaker expressing less concern about it compared to other factors. The speaker mentions Derek's genetic predisposition (a "plus plus" on a certain gene) which might influence fructose metabolism. The conversation then delves into the use of high fructose corn syrup in the past, recalling the making of cookies and popsicles with it, highlighting its taste and the advantage of preventing "sugar cutting your lips" when frozen. The discussion concludes with acknowledging the widespread use of high fructose corn syrup in some processed foods despite its health implications, highlighting the conflict between taste and health concerns.
Food Engineering and Addiction
00:45:53 - 00:47:22
This section discusses how food is engineered to be addictive, referencing the abundance of readily available fruit in contrast to the limited access our ancestors had. The conversation then shifts to a question about iron deficiency, a personal struggle for one participant. The response suggests that genetic predisposition usually leads to high iron levels, and low iron is more common in women due to menstruation. As a solution, eating liver is recommended, specifically suggesting a liver pâté recipe with bacon and rosemary to improve palatability. The ease of making and the delicious taste of the pâté are emphasized.
Family Experiences with Liver and Spleen
00:47:22 - 00:48:47
This segment discusses family members' experiences with eating liver and spleen. One speaker shares that their children enjoy liver, while another speaker's child prefers the flavor but dislikes the texture. The possibility of pâté improving the texture is mentioned. The use of an ancestral spleen supplement is discussed, along with the purchase of grass-fed beef spleen, which was rejected by the family member. The conversation then shifts to the general preference for food, suggesting that hunger might increase the palatability of less commonly consumed organ meats like spleen. The speakers agree that liver is a superior source of iron compared to other options, highlighting its nutritional benefits and the importance of proper preparation.
Keto Diet Discussion
00:48:47 - 00:48:52
A keto diet recipe is mentioned, praised for its taste and keto macro-friendliness. The speakers briefly confirm there are no further points in this section.
Gym Section and Muscle Fiber Type Discussion
00:48:53 - 00:50:09
The conversation shifts to the gym section. One speaker expresses a preference for shorter workouts due to good genetics, identifying as a fast-twitch, power-lifting type rather than endurance-focused. This surprises another speaker, who believed the first speaker was more endurance-oriented. The discussion touches on the speaker's family history and genetics, suggesting a predisposition towards fast-twitch muscles. The advice given is to develop fast-twitch muscles through exercises like deadlifts, emphasizing the positive hormonal effects of heavy lifting.
Hormonal Benefits of Heavy Lifting
00:50:10 - 00:50:59
An anecdote is shared about a young woman with significant hormone imbalances despite being very thin and lacking muscle mass. The speakers highlight the crucial role of muscle mass in hormone regulation and balance. Deadlifts are again recommended as a primary exercise, emphasizing their importance for overall health and hormonal well-being.
Workout Routine and Joint Health Discussion
00:50:59 - 00:52:33
This segment focuses on a discussion about workout routines, specifically the 5x5 method, and its impact on joint health. The speakers discuss the effectiveness of 5x5 for exercises like deadlifts and pull-ups, concluding that for some exercises, like deadlifts and pull-ups, a 1x5 approach is preferable to reduce stress on the nervous system and allow for continued weight progression. The conversation then shifts to the importance of gradual weight increases (10-pound increments) to protect joints. The speakers touch upon the influence of genetics (HLA genes) on joint health, noting a potential increased risk of arthritis linked to high insulin levels. However, given the individual's age (29) and seemingly good genetic predisposition, along with healthy blood sugar levels, the risk is deemed low.
Blood Flow and Joint Health
00:52:33 - 00:54:04
The discussion focuses on maintaining good blood flow to mitigate joint issues. The speaker emphasizes the importance of regular movement and exercise to prevent sedentary behavior, suggesting getting up and moving every hour to improve circulation. The benefits of saunas and infrared light, particularly for those with limited mobility due to surgery or illness, are mentioned. Gout risk is addressed, highlighting the increased risk associated with the individual's genetic profile (ABCG2 and SLC2A9 genes). The SLC2A9 gene, a fructose transporter, is identified as a significant factor, indicating a four-fold higher risk of gout with a plus-plus genotype. The speaker notes that while doctors often advise patients with gout to reduce meat consumption, the key factor is fructose intake.
Fructose, Uric Acid, and Dietary Recommendations
00:54:05 - 00:55:04
The discussion centers on the impact of fructose consumption, particularly from soda and high fructose corn syrup, on health. A podcast by Dr. Peter Atiyah interviewing Rick Johnson is recommended for further information on the relationship between fructose and uric acid. While most people possess a gene related to fructose metabolism, reducing consumption of fruits, high fructose corn syrup, and soda is advised. The conversation also touches upon the reduced risk of high blood pressure from salt intake in individuals with a specific gene variant.
Blood Pressure and Lifestyle Factors
00:55:05 - 00:55:45
The conversation shifts to the angiotensinogen gene (AGT), a common gene often associated with higher blood pressure. However, maintaining a healthy body weight, regular exercise, and managing chronic inflammation are highlighted as crucial factors in mitigating the risk of high blood pressure, even with the presence of AGT. The importance of lifestyle choices over solely focusing on salt intake in blood pressure management is emphasized, cautioning against potential misinformation from doctors regarding salt's role.
Genetic Predispositions and Their Implications
00:55:45 - 00:57:11
This segment focuses on the analysis of the individual's genetic profile, specifically highlighting genes related to bone strength and blood pressure. The discussion reveals a "yin-yang" effect where genes with opposing effects on bone density (Wnt16 leading to weaker bones and FAM3C increasing bone density) offset each other. Similarly, genes related to blood pressure show a balance of protective and risk-increasing factors. The conversation then shifts to the IGF1 receptor gene, which impacts muscle mass gain, but is deemed less relevant to the individual's goals. Finally, the individual's COMT gene is identified as contributing to lower pain sensitivity, although not to an extreme degree. The overall assessment emphasizes the balancing effects of various genes and focuses on identifying and addressing potentially problematic genes rather than solely focusing on beneficial ones.
Managing Pain and Injury Risk
00:57:12 - 00:57:32
The discussion emphasizes the importance of being cautious about pain, especially for individuals who may not experience pain in the same way as others. This reduced pain sensation increases the risk of injury, such as a knee injury occurring without prior warning. The advice given is to pay attention to pain and not push through it, contradicting the "no pain, no gain" mentality. Careful attention to pain signals is crucial for injury prevention.
Gym Section Review and Transition to Sleep
00:57:33 - 00:57:45
The speaker asks if there are any questions regarding the gym section of the document, noting it as a particularly good section. No questions are raised, and the conversation transitions to the final section on sleep.
Sleep Section: Sunshine and Light Therapy
00:57:46 - 00:58:32
The sleep section focuses on the benefits of the "freezing effective gene" previously mentioned, but emphasizes that nothing surpasses the effects of natural sunshine. While blue light devices can help regulate light exposure, they are not as effective as sunlight. The use of UV lamps is mentioned as an alternative, but their high cost ($500) and potential eye damage necessitate caution and proper usage (goggles, limited exposure). The conversation concludes with a suggestion to spend winters in sunny locations like Florida to maximize sunlight exposure.
Sleep Patterns and Genetics
00:58:32 - 00:59:57
This segment discusses the role of genetics in sleep patterns. The conversation begins by mentioning the clock gene ABCC9 and its potential connection to sleep issues, particularly late sleep cycles. The speaker inquires about the individual's sleep habits, noting that while they identify as a night owl, this wasn't initially mentioned in their email. The discussion then explores the influence of environmental factors versus genetics on sleep patterns, with the individual mentioning a history of sleeping late as a child. The speaker explains that environmentally influenced sleep habits are easier to change than genetically determined ones, emphasizing the importance of adjusting sleep schedules to align with genetic predispositions for better overall health and metabolism. The speaker highlights that those genetically predisposed to later sleep cycles should strive to maintain this pattern, while those with early-bird genes should aim for early sleep and wake times.
Genetic Predisposition and Health Discussion
00:59:57 - 01:01:20
The discussion centers on the patient's genetic predispositions and their implications for health. The practitioner explains that the patient's blood sugar levels are generally lower due to genetic factors. The patient's magnesium intake is highlighted as important given their genetic profile. The practitioner notes a slight sensitivity to blue light, but emphasizes that it's not a significant concern. Overall, the patient's genetics are described as "phenomenal." The patient then inquires about a tendency to bruise easily, which the practitioner suggests may be related to estrogen levels or aspirin use, a medication the patient takes for PCOS and fertility purposes. The practitioner notes that women generally bruise more easily than men and that aspirin can also contribute to easier bruising.
Aspirin and Bruising
01:01:20 - 01:02:11
The discussion centers on excessive bruising and its potential link to aspirin consumption. The speaker explains that aspirin inhibits platelets, impacting blood clotting and potentially leading to prolonged bruising. The half-life of aspirin is noted as approximately 90 days, meaning the effects can persist for a considerable time after cessation. The speaker also mentions that certain flavonoids, sometimes found in vitamin C supplements, can further thin the blood, exacerbating the bruising. The recommended course of action is to reduce or eliminate aspirin intake. In addition to reducing aspirin, the speaker suggests lifting heavy weights and using a sauna to help balance hormones, which may offer additional benefits regardless of the bruising issue.
Bruising, Genetics, and Aspirin
01:02:11 - 01:02:44
The conversation shifts to the individual's increased bruising and the exploration of potential causes. While the speaker initially suggests aspirin as the likely culprit, the possibility of genetic predisposition to aspirin sensitivity is also raised. However, the speaker clarifies that they don't routinely test for genes related to aspirin sensitivity. The exception is metformin, which is considered a plant-based supplement derived from the French lilac plant.
Prescription Drug Discussion
01:02:44 - 01:03:38
The conversation begins with a discussion about the prescription status of a drug, with one participant expressing a preference for it to be over-the-counter. The challenges of managing numerous prescription drugs are highlighted, leading to a discussion about genetic testing to assess individual responses to medications. While genetic screening for drug compatibility is mentioned as a possibility, it's noted that this service isn't routinely offered due to time constraints, although it might be provided for a fee. The conversation then shifts to a more casual tone, with updates on personal well-being and the use of previously discussed supplements.
Personal Updates and Supplement Use
01:03:38 - 01:03:54
The final segment of the conversation involves personal updates. One participant shares that they have obtained and started taking the supplements previously discussed. Another participant mentions a "seasonal effective gene," suggesting a shared genetic trait related to seasonal changes. The conversation ends with brief pleasantries.
Winter Vacation Plans and Health Updates
01:03:54 - 01:05:10
The conversation begins with a discussion of winter vacation plans. Speakers initially mention their usual Caribbean trip in October, but then discuss potentially shifting it to February to escape the winter weather. The conversation then transitions to health updates, specifically regarding heavy metal tests. One speaker mentions having a hair metal test and waiting to take it after starting new supplements. Another speaker notes that they have already taken the test and had significantly higher levels of heavy metals than another individual (Megan), who is presented as having exceptionally low levels. The speakers compare their test results, noting discrepancies even when similar metals were tested. The conversation concludes with one speaker advising another to be grateful for their relatively lower heavy metal levels.
Closing Remarks and Gift Exchange
01:05:10 - 01:06:17
The meeting concluded with final questions and comments from participants. The speaker expressed gratitude for the participants' involvement, particularly their contribution to the podcast version of the meeting. A promise was made to send gift packages containing home-roasted coffee and T-shirts featuring a DNA motif with "Dr. J" and the number 23 (representing the 23 chromosome pairs, referencing the company 23andMe). Concerns were voiced about the coffee's potential breakage during shipping. The meeting ended with mutual farewells and thanks.
DNA with Dr. Jay, Episode 10.
KETO MAN Dan from (Minnesota)
KETO MAN Dan from (Minnesota)
Detailed A.I. Summary
**CLICK HERE TO READ
Introduction and Personal Background
00:00:00 - 00:00:44
Anthony J. Cast introduces himself as a Mayo Clinic scientist, DNA consultant (AJ Consulting Company), author, and YouTuber, mentioning his YouTube channels focused on scientific content and family adventures. He promotes his DNA consulting services and mentions Dan's upcoming podcast episode focusing on the keto diet.
Technical Check and Pre-Interview Discussion
00:00:49 - 00:02:26
Anthony and Dan conduct a brief technical check, confirming the recording device is functioning correctly. They confirm Dan's location in Minnesota and discuss Dan's attendance at Anthony's previous talk in the Twin Cities. Dan mentions purchasing Anthony's book and expresses his enthusiasm for the keto diet, which he started 15 months prior as a New Year's resolution. Dan apologizes for the delayed submission of his blood panel results.
The Long-Term Benefits of a Healthy Diet
00:02:27 - 00:04:50
Dan describes his experience transitioning to a primarily carnivore diet 15 months prior, noting a significant positive impact on his health. Anthony agrees, stating that many people initially resist changing their diets due to enjoyment of less healthy foods. Dan elaborates on the previously unacknowledged inflammation he experienced, such as shoulder and knee pain, which resolved after dietary changes. He emphasizes that the improved health outweighs the perceived loss of enjoying less healthy foods like IPAs, croissants, and donuts. Anthony adds that the palate adjusts, making processed foods taste like chemicals after a period of healthy eating. Dan concludes by explaining his shift in perspective on food, viewing it as fuel first and enjoyment second, appreciating high-quality ingredients and novel culinary experiences in gourmet restaurants.
Gene Analysis and Lifestyle Modification
00:04:50 - 00:07:11
Anthony J. Cast reviews a DNA report, focusing on "plus plus" genes indicating negative gene versions inherited from both parents. He clarifies that not all "plus plus" genes are negative; some, like those related to muscle fiber types for sprinting or endurance, are beneficial. The primary goal is identifying negative genes and mitigating their effects through lifestyle changes. Dan clarifies that "fixing" genes refers to counteracting their negative potential through lifestyle choices. Anthony J. Cast uses the BDNF gene as an example, explaining that increased endurance exercise can boost BDNF production, effectively mitigating the gene's negative impact. He notes Dan's rigorous exercise routine (100 pull-ups and 200 push-ups multiple times weekly) and inquires about the routine's structure. Dan begins to explain his workout schedule, but the chapter ends before he finishes.
Dan's Fitness Routine and Results
00:07:14 - 00:08:53
Dan describes his previous intense 15-20 minute workout routine involving multiple weight machines, aiming for maximum exertion. He contrasts this with his current approach, which involves daily walking and a less frequent, but more focused, calisthenics routine (pull-ups and push-ups). He tracks his body fat percentage daily using Withings and through DEXA scans, noting a decrease from 13-12% to 8-10%. He feels better, less sore, and stronger (more pull-ups and push-ups) with this new routine. His current routine consists of sets of pull-ups (varying grips) and push-ups, aiming for 100 pull-ups and several hundred push-ups per session, performed one to two times a week. He believes he is maintaining or even gaining muscle mass.
Anthony's Suggestion for Balanced Workout
00:08:55 - 00:09:31
Anthony expresses concern about the long-term effects of Dan's routine, specifically the potential for shoulder tightness from the emphasis on push-ups. He suggests incorporating rowing exercises to balance the routine and counteract the potential for muscle imbalances. He explains that while pull-ups provide vertical push-pull, rowing would add a horizontal push-pull component, creating a more balanced workout. He uses the example of bench press and row as a horizontal push-pull pairing.
Bodyweight Exercises and Muscle Fiber Type
00:09:31 - 00:10:53
Anthony J. Cast discusses bodyweight exercises, suggesting using a squat rack (or similar object like a bed post) to perform a rowing-like exercise by pulling oneself up to a low bar. He emphasizes the importance of slow, controlled movements (eccentric and concentric) to balance shoulder work. He notes that the individual's genetic predisposition leans towards endurance, leading to a discussion of the individual's genetic profile found on page 13, specifically mentioning the "gym genes" section and the presence of a rare gene, BDK RB2 (Bradykinin), common in endurance athletes. This gene is linked to improved blood flow, pain tolerance, and exercise performance.
Genetic Predisposition and Marathon Running
00:10:56 - 00:11:51
Following the discussion of the BDK RB2 gene, Dan shares a personal anecdote about his past attempts at marathon running and his wife's concerns about the potential for joint damage. He mentions a knee operation at age 39 and his renewed interest in attempting a marathon despite previous reservations.
Grandma's Marathon and Running Training
00:11:51 - 00:13:58
Dan describes his experience running Grandma's Marathon in Duluth, Minnesota, despite initially disliking running. He adopted a strategy of never running more than five miles during training, pacing himself to complete the marathon in 4:29. Anthony J. Cast comments on the marathon's reputation and then shares his perspective on running training, emphasizing the importance of slow and gradual progression to avoid injury. He advocates for a training pace that allows for consistent nose breathing, suggesting that if mouth breathing becomes necessary, the pace should be reduced. He explains that this method allows for sustainable running over long distances, even ultramarathons, without causing cardiac damage, contrasting it with the potential harm of intense, high-impact training common among some marathon runners.
Genetic Predisposition to Endurance and Exercise
00:13:58 - 00:16:07
Anthony discusses the impact of training on heart health, noting that overexertion can lead to scar tissue. He mentions genetic predisposition plays a role in individual responses to intense exercise. The conversation shifts to BDNF (Brain-Derived Neurotrophic Factor), described as a "miracle growth" for the brain, significantly boosted by endurance exercise. Anthony uses the analogy of a plant's growth with and without fertilizer to illustrate BDNF's effect on brain cell growth. He then explains the CETP gene, focusing on the "plus plus" genotype, which relates to cholesterol and triglyceride levels. Dan interjects, mentioning his blood panel results showing elevated triglycerides despite a strict ketogenic diet for 16 months, expressing confusion about this discrepancy.
Blood Lipid and Genetic Marker Analysis
00:16:08 - 00:18:20
Dan discusses his blood lipid levels, noting they are within a healthy range except for slightly higher triglycerides. Anthony suggests increasing exercise intensity to improve blood flow. They discuss the impact of high triglyceride levels, with Anthony emphasizing that levels significantly above 125 are concerning and linked to conditions like Alzheimer's. Dan mentions his low insulin, CRP, and CPAP levels due to his ketogenic diet. Anthony highlights Dan's favorable F-O-X-O-3 gene, a gene associated with lifespan extension, suggesting it allows for greater carbohydrate tolerance. However, Anthony cautions that this doesn't negate the risks associated with high carbohydrate intake, especially given Dan's heart disease risk genes, which will be discussed later. Finally, they briefly touch upon Dan's "melancholy gene" and its potential implications.
Ketogenic Diet and Blood Markers
00:18:20 - 00:20:49
Dan discusses the potential negative perceptions of ketogenic and low-carb diets, despite knowing they are logically sound. Anthony J. Cast points out the importance of gut health for serotonin production, suggesting a healthy gut is crucial for overall well-being. Dan shares his experience of increased mood stability since adopting a ketogenic diet, noting that his feelings are more stable. They discuss the effects of caffeine, with Dan mentioning experiments eliminating coffee to lower triglycerides, but finding no significant impact. Anthony J. Cast suggests DHA (fish oil) as a better supplement for triglycerides. Dan reveals his high Omega-3 levels (though within a healthy range), low Omega-6 levels, and high consumption of fish oil and cod liver oil. Anthony J. Cast reassures Dan that his current approach is appropriate, explaining that slightly higher triglycerides are common on a ketogenic diet due to the nature of triglycerides as three linked fatty acids.
Triglycerides and Fat Transport
00:20:49 - 00:21:22
Anthony J. Cast explains that triglycerides are the body's way of transporting fat, consisting of a glycerol backbone and three fatty acids (e.g., palmitic, arachadonic, DHA). High triglyceride levels are a natural consequence of consuming a lot of fat, but generally not a cause for concern unless they exceed 150.
Low-Fat Diet and Health
00:21:23 - 00:21:47
Dan shares his experience with a low-fat diet, noting that while his LDL and triglycerides were low, his HDL and overall health suffered, resulting in poor sleep and overall feeling unwell.
The MYNN Gene and Zinc
00:21:49 - 00:22:26
Anthony J. Cast discusses the MYNN gene, emphasizing the importance of sufficient zinc intake for telomere length and lifespan. Shorter telomeres are associated with a shorter lifespan.
Telomere Testing
00:22:28 - 00:23:07
Anthony J. Cast expresses his positive view on telomere testing, acknowledging minor fluctuations in results depending on the timing of the test but emphasizing that the changes are not substantial. He uses Dan's example (chronological age 57) to illustrate that biological age estimations from telomere tests won't drastically change from one test to another.
Telomere Length Fluctuations and Patient Concerns
00:23:07 - 00:23:49
Anthony J. Cast explains that minor fluctuations in telomere length test results (e.g., 57, 58, 56) are normal and acceptable due to the nature of lab tests. However, he acknowledges that patients often express concern over these variations. He emphasizes that a significant difference (e.g., chronological age 57, telomere age 37) would be exceptional and noteworthy. While telomere testing is valuable for tracking benefits over time, it's not a top priority. Dan then asks about telomere enhancement and protection.
Diet's Impact on Telomere Length and Genetic Predisposition
00:23:49 - 00:25:31
Dan inquires about the relative importance of diet versus other factors in telomere protection. Anthony J. Cast responds that while it depends on individual genes, diet is generally more crucial. He notes that Dan's genetic profile shows a strong dependence on nutrients found in red meat, specifically highlighting B12 and the SLC38A8 gene related to zinc and blood sugar regulation. Dan's genetic markers for B12 and zinc transport are less efficient, indicating the importance of dietary adjustments to compensate.
Zinc Supplementation and its Benefits
00:25:31 - 00:26:43
Cast mentions zinc's role in blood sugar management and its abundance in red meat. Dan inquires about potential downsides to zinc supplementation for someone who already consumes a lot of meat. Cast assures him there are no downsides, highlighting the positive effects many people experience with increased zinc intake. Dan asks about specific zinc compounds and brands, leading Cast to recommend zinc carnosine from his website due to its reduced acid reflux side effects, a common issue with zinc supplementation. The conversation then transitions to intermittent fasting.
Intermittent Fasting and its Impact
00:26:39 - 00:28:10
Cast asks Dan about his experience with intermittent fasting. Dan describes his positive experience with restricted eating windows, emphasizing the significant improvement in his overall well-being, particularly the elimination of stomach aches, bloating, and gas, issues he had experienced throughout his life. He highlights the transformative effect on his quality of life, contrasting his current state with his previous assumption that digestive discomfort was normal. The discussion concludes with Dan mentioning occasional migraines or TIA experiences in the past.
Dan's Health Concerns and Genetic Predisposition
00:28:10 - 00:30:28
Dan describes a recent health incident that felt like a stroke but was diagnosed as a traumatic attack. Dr. Cast notes the importance of creatine, particularly given a gene regulating creatine kinase, and mentions his own heart research involving creatine and taurine. Dan mentions taking five grams of creatine daily. Dr. Cast affirms the benefits of creatine supplementation, especially considering Dan's diet. The conversation then shifts to heart disease risk, given Dan's family history of heart attacks and strokes. Dan mentions a low calcium score (1.2), but acknowledges a family history and past unhealthy lifestyle. Dr. Cast connects this to Dan's genes. The discussion then turns to the SOD2 gene (super-oxidous meat taste), noting that good iron levels mitigate heart disease risk associated with this gene. Dr. Cast emphasizes the importance of maintaining healthy iron levels (not too high, not too low) to avoid increased heart disease risk.
Blood Lipid and Genetic Marker Discussion
00:30:32 - 00:32:49
Anthony J. Cast reviews Dan's blood test results, focusing on lipid levels and genetic markers. He notes Dan's ferritin level is slightly elevated at 125, but acceptable given his ketogenic diet, suggesting a target range of 150. He emphasizes the importance of avoiding levels above 150. Dan shares his past triglyceride levels, noting significant reductions with vegan and ketogenic diets, highlighting the effectiveness of veganism in rapidly lowering triglycerides but also LDL. Dr. Cast acknowledges the rapid impact of veganism but cautions against its long-term sustainability. Finally, Dr. Cast discusses the CTH gene, which can lead to high homocysteine levels, recommending monitoring homocysteine levels in future blood tests and supplementing with B vitamins if necessary.
Heart Disease Gene Analysis and Risk Factors
00:32:49 - 00:34:55
This segment focuses on the discussion of specific genes related to heart disease. Anthony J. Cast explains the role of homocysteine and its relation to searing, an amino acid that helps clear homocysteine. He then introduces the APC gene, highlighting its rarity and strong predictive power for heart disease, particularly in individuals consuming high-carb diets. Dan speculates about the potential influence of these genes on his deceased grandfather and father, considering their heart attacks and likely high-carb and alcohol consumption. Cast confirms that alcohol increases blood iron levels, and emphasizes the significant impact of high-carb diets on the APC gene's risk assessment, due to the high-carb intake of participants in related studies. He explains that the APC gene affects cell adhesion, linking it to high hemoglobin A1c levels, a measure of blood cell stickiness and long-term blood sugar control.
Blood Sugar, Inflammation, and Supplementation
00:34:55 - 00:37:13
Anthony J. Cast explains how high-carb diets can cause blood cells to become stickier, leading to problems like clots. He suggests curcumin can help thin the blood, but avoiding high-carb diets is crucial. Dan mentions supplementing with curcumin and grapeseed extract. Anthony J. Cast points out Dan's positive genetic markers related to flavonoids and their impact on heart disease, highlighting multiple "plus" indicators linked to the CDK gene. He uses the analogy of a hot water tap to explain how this gene regulates inflammation, and Dan's results show less effective inflammation regulation. Grapeseed extract is identified as an important supplement because it inhibits CDK information, effectively "shutting off" inflammation. Dan shares his experience with grapeseed extract, noting a reduction in seasonal allergies after five or six years of use, initially taken as a general antioxidant. Anthony J. Cast agrees that decreasing arterial inflammation is beneficial and recommends continuing grapeseed extract supplementation, considering it more important than other supplements that can be obtained through diet.
Resveratrol and Supplement Effectiveness
00:37:14 - 00:39:33
This segment discusses the effectiveness of Resveratrol supplements. Anthony J. Cast mentions Resveratrol as a component of Grape Seed Extract. Dan shares his experience with Resveratrol supplements over the years, noting that Grape Seed Extract with Pine Bark Extract has been a consistent part of his routine for 30 years. Anthony J. Cast clarifies that obtaining sufficient Resveratrol through diet alone is difficult, requiring an unrealistic amount of red wine consumption (approximately 100 glasses). He explains that a supplement provides a significantly higher concentration (100-500 mg) compared to the average red wine glass (0.2-2 mg). Dan confirms his previous assumption that Resveratrol from red wine alone was ineffective. The conversation concludes with Anthony J. Cast emphasizing the importance of continuing Resveratrol supplementation and Dan sharing his recent HSCRP (high-sensitivity C-reactive protein) blood test results, which showed a value below 1.0, despite a previous elevated result (1.0) following a wrist fracture.
Leaky Gut and Genetic Predisposition
00:39:33 - 00:41:48
This segment focuses on Dan's genetic predisposition to leaky gut, indicated by a high CRP level and ten genes associated with leaky gut. Anthony explains that while some individuals experience noticeable symptoms like stomach aches when consuming certain foods, others, like himself, might only feel exhaustion or pain when physically manipulating their abdominal area. Dan shares his experience of chronic gut aches, believing it to be normal until realizing the correlation with specific foods. Anthony highlights Dan's sensitivity to certain foods and mentions that one of his genes is highly responsive to a ketogenic diet, which can be beneficial due to its ability to inhibit inflammasomes.
Ketones, Gut Health, and Dietary Recommendations
00:41:49 - 00:43:21
Anthony and Dan discuss the benefits of ketones, specifically mentioning deuteridacin found in butter. Anthony highlights Dom De Agostino's research on ketones inhibiting inflammation. They then analyze IBD5, a gene related to gut health, and the positive impact of mushrooms on gut health due to their erythinine content. Dan shares his daily mushroom consumption habits, incorporating mushroom powder into coffee and green tea. Anthony confirms that various mushroom types, including white, portabella, and shiitake, are beneficial sources of erythinine.
Cannabinoid Receptors and Sleep Optimization
00:43:21 - 00:44:15
Anthony mentions the positive influence of the cannabinoid receptor on gut health, prompting Dan to share his experience with CBD. Dan describes his dedication to optimizing sleep hygiene, using various sleep tracking devices like an aura ring, withings pad, EMC pad, and chile pad. He details his sleep routine, aiming for a 10 PM bedtime in a dark room, and waking up around 5 AM to follow his nutrition routine.
Dan's Sleep Issues and CBD Trials
00:44:15 - 00:46:32
Dan discusses his sleep patterns, noting he sleeps well in 6.5-7 hours but struggles to sleep longer. He's tried various CBD brands and dosages without significant improvement, likening the effect to weak caffeine. He contrasts this with past experiences with other substances, highlighting the stark difference in impact. Anthony J. Cast mentions Dan's sleep genes indicate a predisposition to being a night owl. They discuss the possibility of shifting Dan's sleep schedule, but Dan explains that he consistently wakes up early regardless of bedtime. Anthony suggests that carb consumption before bed might help, leaving the discussion unfinished.
Continuous Glucose Monitoring (CGM) and its Use
00:46:33 - 00:48:57
This segment focuses on Dan's experience with a continuous glucose monitor (CGM), specifically the Abbott Libre. Anthony inquires about amulopectin, a type of carbohydrate, but the conversation quickly shifts to Dan's use of the CGM. Dan explains that he purchases the sensors for around $30 at Walgreens, finding them affordable and easy to use. He initially wore it on his tricep but now prefers placing it above his hip for comfort and to avoid accidental bumps. The application process is described as quick and simple, involving attaching the sensor to a launcher device. The sensor remains in place for two weeks and is water-resistant, even suitable for hot tubs. Dan highlights the benefits of constantly monitoring his glucose levels, noting that it helps him understand the impact of different foods and drinks, including alcohol, on his blood sugar. He challenges the common misconception that only dark liquors raise blood sugar levels.
Alcohol Consumption and Blood Sugar Levels
00:48:57 - 00:51:26
Dan discusses the effects of alcohol consumption on his blood sugar levels, monitored using a CGM. He notes that alcohol initially lowers blood sugar, sometimes dropping to the 60s, but a few hours after a meal, his blood sugar may spike to 100-110 the following morning. He observes that his blood sugar remains generally within the normal range throughout the day, even after meals, suggesting his liver's glucose production adjusts to food intake. He contrasts this with instances of heavier alcohol consumption, where he experiences a significant blood sugar spike the following day, accompanied by a hangover. Anthony J. Cast relates this to observations about alcohol consumption on a ketogenic diet, where a threshold effect is noted, with a small increase in alcohol intake leading to a sharp negative consequence. Dan confirms this, describing experiences with excessive alcohol consumption resulting in sluggishness the following day.
Keto Diet and Sleep Optimization
00:51:27 - 00:53:31
This segment focuses on optimizing sleep while on a ketogenic diet. J. Cast and Anthony J. Cast discuss the potential benefits of branch chain glucose (annual pectin) to improve sleep, suggesting a trial with varying dosages, starting small and potentially increasing to a full scoop. They also consider the addition of blueberries or honey, acknowledging honey's high fructose content. The timing of carbohydrate consumption is discussed, with a recommendation to consume them 1-2 hours before bed. However, Anthony J. Cast emphasizes that adjusting sleep schedules (staying up and waking up later) is a more significant factor in improving sleep quality. The conversation touches upon the importance of deep sleep for regeneration and the potential benefits of infrared light therapy, citing cadaver studies showing its penetration through the skull and positive anecdotal results.
Nighttime Juve Light Therapy for Sleep Improvement
00:53:31 - 00:55:05
Cast suggests using Juve lights right before bed for improved sleep. He describes placing the light directly on the head, close to the scalp, for approximately 10 minutes. Dan mentions owning two Juve lights and a UVB light, but hasn't used them at night. Cast shares a story about Ben Picolsky, an Olympic contender and builder, whose clients using Juve lights reported significant sleep improvements. The discussion clarifies the application method: the light should be positioned directly on the crown of the head, not stared at like during morning use. Cast emphasizes the proximity of the light to the scalp, suggesting it can almost touch the skull. He expresses excitement about trying this method himself, highlighting the effectiveness of Juve lights in improving sleep for many people.
DEFB1 (Beta Defensin 1) and Gut Health
00:55:05 - 00:55:34
The conversation shifts to DEFB1 (Beta Defensin 1), a peptide that combats harmful bacteria in the gut. Cast explains that lower levels of this peptide are undesirable, likening its function to a "weed killer" that eliminates bad bacteria. He clarifies that it's not a chemical but a natural peptide. The discussion ends mid-sentence.
Gut Gene Analysis and Dietary Implications
00:55:34 - 00:57:50
Cast explains that reducing weed killer use allows good plants to thrive, minimizing weed growth. He emphasizes the importance of diet, particularly avoiding sugars, in managing gut health. Dan finds this information helpful, particularly regarding his concerns about gut issues. Cast notes that some individuals have zero gut genes, while others have two to six, with ten being rare. Dan mentions his children's varying susceptibility to gut problems, noting that two of his four sons experience gut issues, unlike his wife and two other sons who have "iron stomachs." Cast shares that he's discussed DNA results publicly, citing Mike Matthews' example of having excellent gut and carb genes, which allows him to tolerate carbs well. Cast concludes that most people without gut issue genes believe gluten sensitivity is overblown, and that moderation is key, a sentiment echoed by Dan's wife. Cast cautions against judgment, given the genetic variations in gut health.
Vitamin D and Seed Oil Sensitivity
00:57:56 - 01:00:17
Anthony J. Cast discusses Dan's vitamin D levels and genes, noting that Dan's genes are good despite living in Minnesota. Dan mentions his vitamin D levels were low (in the 20s) but improved to the 40s after starting daily outdoor walks. Cast explains the importance of fats for vitamin D absorption and points out that government recommendations for vitamin D intake (400 IU) are often insufficient; many people need 4000 IU. Cast then highlights Dan's G-O-N-1 gene, indicating a seed oil sensitivity. This means Dan doesn't break down seed oils (like canola oil) efficiently. Dan reveals he consumed flaxseed oil for several years, which Cast identifies as problematic due to its effect on estrogen levels. Cast recommends avoiding seed oils and suggests olive oil, avocado oil, and coconut oil as healthier alternatives.
Estrogen and Testosterone Gene Analysis
01:00:20 - 01:02:07
Anthony J. Cast reviews Dan's estrogen and testosterone genes. Dan's estrogen genes show a mix of higher and lower estrogen levels, making the overall effect uncertain but potentially beneficial. Dan mentions his current testosterone replacement therapy due to low levels (around 350) before supplementation, feeling better with the current higher levels. He started a ketogenic diet concurrently. Anthony suggests that a sauna could be beneficial due to a connection between one of Dan's estrogen genes (CYP1B1) and detoxification of artificial estrogen. He also notes that a healthy gut, ketones, fats, and cholesterol can help boost testosterone. Anthony believes Dan might be fine without the T supplement, but if levels remain low after a future check, he wouldn't hesitate to continue the therapy. Overall, Anthony considers Dan's genes to be very good.
Thyroid and Iodine Discussion
01:02:07 - 01:02:44
Dan mentions his thyroid levels are within a normal range, but he still takes iodine, albeit inconsistently. Anthony agrees that consistent iodine supplementation isn't necessary and suggests taking it every few days instead of daily.
Homocysteine and B Vitamin Levels
01:02:44 - 01:05:09
This segment focuses on Dan's homocysteine levels and B vitamin intake. Cast explains that even with low inflammation markers, homocysteine is a separate pathway to consider, especially given Dan's MTRR and CBS genes. The discussion highlights the importance of monitoring homocysteine levels, noting its repeated appearance in relation to B9 (folate). Dan mentions his B12 levels are consistently high (703 in the last test) and that his vitamin mix likely contains folate, though he's unsure. He confirms taking niacin (B3) at 500mg, experiencing the characteristic flush. Cast notes that while niacin is a B vitamin, homocysteine remains a key factor to monitor.
Vitamin and Nutrient Levels and Dietary Recommendations
01:05:09 - 01:07:28
Anthony J. Cast discusses Dan's vitamin B12 and folate levels, noting that while Dan consumes a lot of meat, his genes indicate minimal B12 uptake. He suggests B12 supplementation if needed. Heavy metal levels are also discussed, with Dan showing slightly higher than average arsenic levels. Anthony advises caution with arsenic-containing foods like brussels sprouts, suggesting moderation rather than complete avoidance. Dan expresses his love for brussels sprouts, particularly caramelized ones, and mentions potential gut reactions. Anthony recommends spacing out consumption of these foods to allow the body time to clear arsenic and other substances. The conversation also touches upon arsenic levels in various fish, including salmon and sardines, with Anthony suggesting testing for arsenic levels as a precautionary measure.
Dietary Changes and Heavy Metal Testing
01:07:28 - 01:09:38
Anthony and Dan discuss the potential long-term effects of dietary choices, specifically concerning arsenic levels in seafood. Dan mentions switching from sardines to macro, prompting Anthony to explain that arsenic levels depend on the ocean source, stating he's not an arsenic expert but relies on online scientific information. They then discuss the frequency of heavy metal testing via hair analysis. Anthony advises against frequent testing if diet remains consistent, suggesting retesting only after significant dietary changes. Dan agrees that if initial results are high, subsequent testing would track improvement. Anthony recommends testing, especially given Dan's unusual diet, highlighting the benefit of proactive health monitoring. Finally, they discuss the PNPLA3 gene, linked to a higher risk of fatty liver disease, particularly with high fructose consumption. Anthony emphasizes the negative impact of soda and provides a resource for identifying high-fructose fruits, using figs as an example.
Diet and Exercise Discussion
01:09:38 - 01:11:52
Anthony and Dan discuss Dan's diet and exercise routine. Dan mentions his current diet consists primarily of blueberries, blackberries, and strawberries. They review the detox section, which Dan appreciates as a topic he's considered but never acted upon. The conversation then shifts to Dan's gym routine, which he describes as super compressed due to time constraints. Anthony explains that individuals with a specific dopamine receptor (DR4) often prefer novelty in their workouts, suggesting variety to avoid plateaus. Dan explains his current focus is on maintenance rather than muscle building, aiming to retain his current muscle mass with minimal effort as he ages. He finds Keto, walking, pull-ups, push-ups, and bodyweight exercises helpful in this regard. Anthony affirms that Dan's goal of maintenance is perfectly reasonable. The discussion concludes with Anthony mentioning the role of testosterone.
Testosterone Replacement Therapy and Keto Diet Discussion
01:11:52 - 01:14:07
Dan discusses the challenges of maintaining a high testosterone level (around 900) due to testosterone replacement therapy (TRT), which he administers via weekly injections. He started TRT concurrently with a ketogenic diet, making it difficult to isolate the effects of each. Anthony J. Cast clarifies a misunderstanding about Dan's use of supplements, confirming that Dan uses injections, not creams, for TRT. Anthony J. Cast expresses preference for cream-based TRT due to its consistent levels compared to the fluctuating levels caused by weekly injections. Dan explains that despite the fluctuating levels, he doesn't experience significant mood swings or other side effects, comparing the experience to caffeine consumption. He attributes his overall positive feeling to a combination of TRT and the keto diet.
Keto, Testosterone, and Joint Health
01:14:07 - 01:16:29
Dan discusses the positive effects of keto and testosterone on his health, noting improved energy levels and reduced joint pain. Anthony J. Cast then focuses on the genetic aspects of joint health, specifically mentioning interleukin 2 (IL-2) and interleukin 1 beta, both influenced by testosterone levels. He explains that testosterone can decrease interleukins, thereby reducing inflammation. The discussion then shifts to the difference between rheumatoid arthritis (immune system attacking joints) and osteoarthritis (gradual erosion of soft tissue). Anthony J. Cast highlights that a gene related to osteoarthritis risk, diadenase, is dependent on thyroid hormone levels. He concludes by reviewing Dan's genetic profile, noting a lack of significant risk factors for thyroid issues or osteoarthritis, but emphasizes the importance of maintaining optimized thyroid hormone levels.
Thyroid Health and Seafood Consumption
01:16:30 - 01:18:40
Anthony suggests checking thyroid levels every five years, or even annually if desired, especially focusing on heavy metals. He notes that thyroid hormone declines with age. Dan mentions his regular thyroid checks as part of his keto panel, showing good T3, T4, and PSA levels. Anthony attributes Dan's good results to his genetics and seafood consumption, highlighting the importance of seafood as a natural supplement. Dan expresses slight concern about potentially consuming too much cod liver oil, wondering if it could affect blood clotting. He clarifies that he checks his blood daily for ketones and glucose, noting that his blood flows easily when pricked, unlike his sons'. Anthony confirms that easy bleeding is an indicator of potential issues, while Dan reassures that he doesn't experience excessive bleeding from minor cuts. The conversation concludes with Dan emphasizing the ease with which he obtains blood samples for testing.
Review of Dan's Health Markers and Genetic Predispositions
01:18:41 - 01:20:48
Anthony J. Cast reviews Dan's health markers and genetic predispositions, starting with positive comments on Dan's iodine levels and blood flow, emphasizing the importance of exercise. He then discusses Dan's gout risk, linking it to fructose transport via SLC-2A9 and assuring Dan that his diet mitigates this risk. Low back issues are addressed, connecting them to IL-1A gene presence, although acknowledging the gene's plus-minus nature. Dan mentions occasional back tweaks, prompting Anthony to comment on how seemingly minor movements can cause such issues. The conversation then shifts to testosterone's positive impact on back health. Anthony reassures Dan about his blood pressure, noting a common gene variant but emphasizing that Dan's healthy weight and good blood pressure currently negate any concerns. He mentions angiotensin type drugs as a potential future option if needed but stresses the importance of maintaining a healthy lifestyle. Finally, the discussion concludes with a mention of the insulin IGF-1 gene in relation to gym performance.
Muscle Mass and Body Composition Analysis
01:20:48 - 01:21:27
Anthony discusses Dan's genetic predisposition to lower muscle mass due to a gene associated with lower IGF-1 levels. However, Anthony notes that Dan's high zinc intake naturally increases IGF-1, potentially mitigating this genetic factor. Dan provides his body composition data (height, weight, body fat percentage from DEXA and another method), indicating relatively low body fat and good muscle mass despite limited weight training.
Sleep Genes and Their Impact
01:21:30 - 01:23:02
The conversation shifts to Dan's sleep genes. Anthony explains the EER-3 gene, associated with being a late riser, but emphasizes its variability and potential for manipulation. He suggests using blue blockers to trick the body into thinking it's later than it is, potentially improving sleep. Dan jokes about the impact on his family if he stays up later. Finally, Anthony discusses the WWC1 gene, highlighting its impact on memory recall when sleep is poor, emphasizing the importance of good sleep for cognitive function.
Sleep and Keto Diet Discussion
01:23:02 - 01:24:46
Anthony and Dan discuss the impact of ketogenic diets on sleep. Anthony explains that he cycles keto to avoid sleep disruption, noting that continuous keto affects his sleep cycles negatively. Dan shares his experience of being a light sleeper due to years of running his own business and working long hours with limited sleep. They both acknowledge the challenges of maintaining sufficient sleep, especially with demanding schedules. Anthony emphasizes the importance of tracking sleep patterns for improvement and mentions the influence of blue light, although he considers Dan's genetics to be a significant factor in his sleep quality. Dan expresses gratitude for the insights and mentions his luck in inadvertently adopting beneficial habits.
DNA Report Review and Conclusion
01:24:50 - 01:25:34
Dan expresses his appreciation for the DNA report and the subsequent analysis. He mentions starting intermittent fasting later in life but feels fortunate to have incorporated it. The conversation concludes with Dan stating he has no further overarching questions at this time, satisfied with the 90-minute discussion and the provided analysis. Anthony suggests Dan try a few things and some tests.
Dan's Testing Plan and Genetic Understanding
01:25:34 - 01:27:09
Dan outlines his plan to conduct genetic testing in stages, starting with a few tests and gradually adding heavy metal and lab tests. He expresses excitement about learning from the process and emphasizes the importance of understanding the genetic information. He acknowledges the vastness of genetic information and trusts Anthony's expertise in selecting impactful data for improving his healthspan. He expresses a desire for doctors to embrace this genetic innovation and encourages self-advocacy for patients to bring this information to their physicians.
Doctors' Approach to Genetic Information and Future Collaboration
01:27:09 - 01:28:08
Dan discusses the challenges of doctors fully integrating genetic information into their practice, noting that even highly intelligent doctors may struggle with the sheer volume of information. Anthony acknowledges this, mentioning that some doctors are already incorporating genetic consulting into their practice, while others are less receptive. The conversation concludes with Dan expressing gratitude for the consultation and his eagerness to participate in future discussions and presentations.
Meeting Adjournment
01:28:08 - 01:28:13
Anthony J. Cast bids farewell to Dan and concludes the meeting with pleasantries.
00:00:00 - 00:00:44
Anthony J. Cast introduces himself as a Mayo Clinic scientist, DNA consultant (AJ Consulting Company), author, and YouTuber, mentioning his YouTube channels focused on scientific content and family adventures. He promotes his DNA consulting services and mentions Dan's upcoming podcast episode focusing on the keto diet.
Technical Check and Pre-Interview Discussion
00:00:49 - 00:02:26
Anthony and Dan conduct a brief technical check, confirming the recording device is functioning correctly. They confirm Dan's location in Minnesota and discuss Dan's attendance at Anthony's previous talk in the Twin Cities. Dan mentions purchasing Anthony's book and expresses his enthusiasm for the keto diet, which he started 15 months prior as a New Year's resolution. Dan apologizes for the delayed submission of his blood panel results.
The Long-Term Benefits of a Healthy Diet
00:02:27 - 00:04:50
Dan describes his experience transitioning to a primarily carnivore diet 15 months prior, noting a significant positive impact on his health. Anthony agrees, stating that many people initially resist changing their diets due to enjoyment of less healthy foods. Dan elaborates on the previously unacknowledged inflammation he experienced, such as shoulder and knee pain, which resolved after dietary changes. He emphasizes that the improved health outweighs the perceived loss of enjoying less healthy foods like IPAs, croissants, and donuts. Anthony adds that the palate adjusts, making processed foods taste like chemicals after a period of healthy eating. Dan concludes by explaining his shift in perspective on food, viewing it as fuel first and enjoyment second, appreciating high-quality ingredients and novel culinary experiences in gourmet restaurants.
Gene Analysis and Lifestyle Modification
00:04:50 - 00:07:11
Anthony J. Cast reviews a DNA report, focusing on "plus plus" genes indicating negative gene versions inherited from both parents. He clarifies that not all "plus plus" genes are negative; some, like those related to muscle fiber types for sprinting or endurance, are beneficial. The primary goal is identifying negative genes and mitigating their effects through lifestyle changes. Dan clarifies that "fixing" genes refers to counteracting their negative potential through lifestyle choices. Anthony J. Cast uses the BDNF gene as an example, explaining that increased endurance exercise can boost BDNF production, effectively mitigating the gene's negative impact. He notes Dan's rigorous exercise routine (100 pull-ups and 200 push-ups multiple times weekly) and inquires about the routine's structure. Dan begins to explain his workout schedule, but the chapter ends before he finishes.
Dan's Fitness Routine and Results
00:07:14 - 00:08:53
Dan describes his previous intense 15-20 minute workout routine involving multiple weight machines, aiming for maximum exertion. He contrasts this with his current approach, which involves daily walking and a less frequent, but more focused, calisthenics routine (pull-ups and push-ups). He tracks his body fat percentage daily using Withings and through DEXA scans, noting a decrease from 13-12% to 8-10%. He feels better, less sore, and stronger (more pull-ups and push-ups) with this new routine. His current routine consists of sets of pull-ups (varying grips) and push-ups, aiming for 100 pull-ups and several hundred push-ups per session, performed one to two times a week. He believes he is maintaining or even gaining muscle mass.
Anthony's Suggestion for Balanced Workout
00:08:55 - 00:09:31
Anthony expresses concern about the long-term effects of Dan's routine, specifically the potential for shoulder tightness from the emphasis on push-ups. He suggests incorporating rowing exercises to balance the routine and counteract the potential for muscle imbalances. He explains that while pull-ups provide vertical push-pull, rowing would add a horizontal push-pull component, creating a more balanced workout. He uses the example of bench press and row as a horizontal push-pull pairing.
Bodyweight Exercises and Muscle Fiber Type
00:09:31 - 00:10:53
Anthony J. Cast discusses bodyweight exercises, suggesting using a squat rack (or similar object like a bed post) to perform a rowing-like exercise by pulling oneself up to a low bar. He emphasizes the importance of slow, controlled movements (eccentric and concentric) to balance shoulder work. He notes that the individual's genetic predisposition leans towards endurance, leading to a discussion of the individual's genetic profile found on page 13, specifically mentioning the "gym genes" section and the presence of a rare gene, BDK RB2 (Bradykinin), common in endurance athletes. This gene is linked to improved blood flow, pain tolerance, and exercise performance.
Genetic Predisposition and Marathon Running
00:10:56 - 00:11:51
Following the discussion of the BDK RB2 gene, Dan shares a personal anecdote about his past attempts at marathon running and his wife's concerns about the potential for joint damage. He mentions a knee operation at age 39 and his renewed interest in attempting a marathon despite previous reservations.
Grandma's Marathon and Running Training
00:11:51 - 00:13:58
Dan describes his experience running Grandma's Marathon in Duluth, Minnesota, despite initially disliking running. He adopted a strategy of never running more than five miles during training, pacing himself to complete the marathon in 4:29. Anthony J. Cast comments on the marathon's reputation and then shares his perspective on running training, emphasizing the importance of slow and gradual progression to avoid injury. He advocates for a training pace that allows for consistent nose breathing, suggesting that if mouth breathing becomes necessary, the pace should be reduced. He explains that this method allows for sustainable running over long distances, even ultramarathons, without causing cardiac damage, contrasting it with the potential harm of intense, high-impact training common among some marathon runners.
Genetic Predisposition to Endurance and Exercise
00:13:58 - 00:16:07
Anthony discusses the impact of training on heart health, noting that overexertion can lead to scar tissue. He mentions genetic predisposition plays a role in individual responses to intense exercise. The conversation shifts to BDNF (Brain-Derived Neurotrophic Factor), described as a "miracle growth" for the brain, significantly boosted by endurance exercise. Anthony uses the analogy of a plant's growth with and without fertilizer to illustrate BDNF's effect on brain cell growth. He then explains the CETP gene, focusing on the "plus plus" genotype, which relates to cholesterol and triglyceride levels. Dan interjects, mentioning his blood panel results showing elevated triglycerides despite a strict ketogenic diet for 16 months, expressing confusion about this discrepancy.
Blood Lipid and Genetic Marker Analysis
00:16:08 - 00:18:20
Dan discusses his blood lipid levels, noting they are within a healthy range except for slightly higher triglycerides. Anthony suggests increasing exercise intensity to improve blood flow. They discuss the impact of high triglyceride levels, with Anthony emphasizing that levels significantly above 125 are concerning and linked to conditions like Alzheimer's. Dan mentions his low insulin, CRP, and CPAP levels due to his ketogenic diet. Anthony highlights Dan's favorable F-O-X-O-3 gene, a gene associated with lifespan extension, suggesting it allows for greater carbohydrate tolerance. However, Anthony cautions that this doesn't negate the risks associated with high carbohydrate intake, especially given Dan's heart disease risk genes, which will be discussed later. Finally, they briefly touch upon Dan's "melancholy gene" and its potential implications.
Ketogenic Diet and Blood Markers
00:18:20 - 00:20:49
Dan discusses the potential negative perceptions of ketogenic and low-carb diets, despite knowing they are logically sound. Anthony J. Cast points out the importance of gut health for serotonin production, suggesting a healthy gut is crucial for overall well-being. Dan shares his experience of increased mood stability since adopting a ketogenic diet, noting that his feelings are more stable. They discuss the effects of caffeine, with Dan mentioning experiments eliminating coffee to lower triglycerides, but finding no significant impact. Anthony J. Cast suggests DHA (fish oil) as a better supplement for triglycerides. Dan reveals his high Omega-3 levels (though within a healthy range), low Omega-6 levels, and high consumption of fish oil and cod liver oil. Anthony J. Cast reassures Dan that his current approach is appropriate, explaining that slightly higher triglycerides are common on a ketogenic diet due to the nature of triglycerides as three linked fatty acids.
Triglycerides and Fat Transport
00:20:49 - 00:21:22
Anthony J. Cast explains that triglycerides are the body's way of transporting fat, consisting of a glycerol backbone and three fatty acids (e.g., palmitic, arachadonic, DHA). High triglyceride levels are a natural consequence of consuming a lot of fat, but generally not a cause for concern unless they exceed 150.
Low-Fat Diet and Health
00:21:23 - 00:21:47
Dan shares his experience with a low-fat diet, noting that while his LDL and triglycerides were low, his HDL and overall health suffered, resulting in poor sleep and overall feeling unwell.
The MYNN Gene and Zinc
00:21:49 - 00:22:26
Anthony J. Cast discusses the MYNN gene, emphasizing the importance of sufficient zinc intake for telomere length and lifespan. Shorter telomeres are associated with a shorter lifespan.
Telomere Testing
00:22:28 - 00:23:07
Anthony J. Cast expresses his positive view on telomere testing, acknowledging minor fluctuations in results depending on the timing of the test but emphasizing that the changes are not substantial. He uses Dan's example (chronological age 57) to illustrate that biological age estimations from telomere tests won't drastically change from one test to another.
Telomere Length Fluctuations and Patient Concerns
00:23:07 - 00:23:49
Anthony J. Cast explains that minor fluctuations in telomere length test results (e.g., 57, 58, 56) are normal and acceptable due to the nature of lab tests. However, he acknowledges that patients often express concern over these variations. He emphasizes that a significant difference (e.g., chronological age 57, telomere age 37) would be exceptional and noteworthy. While telomere testing is valuable for tracking benefits over time, it's not a top priority. Dan then asks about telomere enhancement and protection.
Diet's Impact on Telomere Length and Genetic Predisposition
00:23:49 - 00:25:31
Dan inquires about the relative importance of diet versus other factors in telomere protection. Anthony J. Cast responds that while it depends on individual genes, diet is generally more crucial. He notes that Dan's genetic profile shows a strong dependence on nutrients found in red meat, specifically highlighting B12 and the SLC38A8 gene related to zinc and blood sugar regulation. Dan's genetic markers for B12 and zinc transport are less efficient, indicating the importance of dietary adjustments to compensate.
Zinc Supplementation and its Benefits
00:25:31 - 00:26:43
Cast mentions zinc's role in blood sugar management and its abundance in red meat. Dan inquires about potential downsides to zinc supplementation for someone who already consumes a lot of meat. Cast assures him there are no downsides, highlighting the positive effects many people experience with increased zinc intake. Dan asks about specific zinc compounds and brands, leading Cast to recommend zinc carnosine from his website due to its reduced acid reflux side effects, a common issue with zinc supplementation. The conversation then transitions to intermittent fasting.
Intermittent Fasting and its Impact
00:26:39 - 00:28:10
Cast asks Dan about his experience with intermittent fasting. Dan describes his positive experience with restricted eating windows, emphasizing the significant improvement in his overall well-being, particularly the elimination of stomach aches, bloating, and gas, issues he had experienced throughout his life. He highlights the transformative effect on his quality of life, contrasting his current state with his previous assumption that digestive discomfort was normal. The discussion concludes with Dan mentioning occasional migraines or TIA experiences in the past.
Dan's Health Concerns and Genetic Predisposition
00:28:10 - 00:30:28
Dan describes a recent health incident that felt like a stroke but was diagnosed as a traumatic attack. Dr. Cast notes the importance of creatine, particularly given a gene regulating creatine kinase, and mentions his own heart research involving creatine and taurine. Dan mentions taking five grams of creatine daily. Dr. Cast affirms the benefits of creatine supplementation, especially considering Dan's diet. The conversation then shifts to heart disease risk, given Dan's family history of heart attacks and strokes. Dan mentions a low calcium score (1.2), but acknowledges a family history and past unhealthy lifestyle. Dr. Cast connects this to Dan's genes. The discussion then turns to the SOD2 gene (super-oxidous meat taste), noting that good iron levels mitigate heart disease risk associated with this gene. Dr. Cast emphasizes the importance of maintaining healthy iron levels (not too high, not too low) to avoid increased heart disease risk.
Blood Lipid and Genetic Marker Discussion
00:30:32 - 00:32:49
Anthony J. Cast reviews Dan's blood test results, focusing on lipid levels and genetic markers. He notes Dan's ferritin level is slightly elevated at 125, but acceptable given his ketogenic diet, suggesting a target range of 150. He emphasizes the importance of avoiding levels above 150. Dan shares his past triglyceride levels, noting significant reductions with vegan and ketogenic diets, highlighting the effectiveness of veganism in rapidly lowering triglycerides but also LDL. Dr. Cast acknowledges the rapid impact of veganism but cautions against its long-term sustainability. Finally, Dr. Cast discusses the CTH gene, which can lead to high homocysteine levels, recommending monitoring homocysteine levels in future blood tests and supplementing with B vitamins if necessary.
Heart Disease Gene Analysis and Risk Factors
00:32:49 - 00:34:55
This segment focuses on the discussion of specific genes related to heart disease. Anthony J. Cast explains the role of homocysteine and its relation to searing, an amino acid that helps clear homocysteine. He then introduces the APC gene, highlighting its rarity and strong predictive power for heart disease, particularly in individuals consuming high-carb diets. Dan speculates about the potential influence of these genes on his deceased grandfather and father, considering their heart attacks and likely high-carb and alcohol consumption. Cast confirms that alcohol increases blood iron levels, and emphasizes the significant impact of high-carb diets on the APC gene's risk assessment, due to the high-carb intake of participants in related studies. He explains that the APC gene affects cell adhesion, linking it to high hemoglobin A1c levels, a measure of blood cell stickiness and long-term blood sugar control.
Blood Sugar, Inflammation, and Supplementation
00:34:55 - 00:37:13
Anthony J. Cast explains how high-carb diets can cause blood cells to become stickier, leading to problems like clots. He suggests curcumin can help thin the blood, but avoiding high-carb diets is crucial. Dan mentions supplementing with curcumin and grapeseed extract. Anthony J. Cast points out Dan's positive genetic markers related to flavonoids and their impact on heart disease, highlighting multiple "plus" indicators linked to the CDK gene. He uses the analogy of a hot water tap to explain how this gene regulates inflammation, and Dan's results show less effective inflammation regulation. Grapeseed extract is identified as an important supplement because it inhibits CDK information, effectively "shutting off" inflammation. Dan shares his experience with grapeseed extract, noting a reduction in seasonal allergies after five or six years of use, initially taken as a general antioxidant. Anthony J. Cast agrees that decreasing arterial inflammation is beneficial and recommends continuing grapeseed extract supplementation, considering it more important than other supplements that can be obtained through diet.
Resveratrol and Supplement Effectiveness
00:37:14 - 00:39:33
This segment discusses the effectiveness of Resveratrol supplements. Anthony J. Cast mentions Resveratrol as a component of Grape Seed Extract. Dan shares his experience with Resveratrol supplements over the years, noting that Grape Seed Extract with Pine Bark Extract has been a consistent part of his routine for 30 years. Anthony J. Cast clarifies that obtaining sufficient Resveratrol through diet alone is difficult, requiring an unrealistic amount of red wine consumption (approximately 100 glasses). He explains that a supplement provides a significantly higher concentration (100-500 mg) compared to the average red wine glass (0.2-2 mg). Dan confirms his previous assumption that Resveratrol from red wine alone was ineffective. The conversation concludes with Anthony J. Cast emphasizing the importance of continuing Resveratrol supplementation and Dan sharing his recent HSCRP (high-sensitivity C-reactive protein) blood test results, which showed a value below 1.0, despite a previous elevated result (1.0) following a wrist fracture.
Leaky Gut and Genetic Predisposition
00:39:33 - 00:41:48
This segment focuses on Dan's genetic predisposition to leaky gut, indicated by a high CRP level and ten genes associated with leaky gut. Anthony explains that while some individuals experience noticeable symptoms like stomach aches when consuming certain foods, others, like himself, might only feel exhaustion or pain when physically manipulating their abdominal area. Dan shares his experience of chronic gut aches, believing it to be normal until realizing the correlation with specific foods. Anthony highlights Dan's sensitivity to certain foods and mentions that one of his genes is highly responsive to a ketogenic diet, which can be beneficial due to its ability to inhibit inflammasomes.
Ketones, Gut Health, and Dietary Recommendations
00:41:49 - 00:43:21
Anthony and Dan discuss the benefits of ketones, specifically mentioning deuteridacin found in butter. Anthony highlights Dom De Agostino's research on ketones inhibiting inflammation. They then analyze IBD5, a gene related to gut health, and the positive impact of mushrooms on gut health due to their erythinine content. Dan shares his daily mushroom consumption habits, incorporating mushroom powder into coffee and green tea. Anthony confirms that various mushroom types, including white, portabella, and shiitake, are beneficial sources of erythinine.
Cannabinoid Receptors and Sleep Optimization
00:43:21 - 00:44:15
Anthony mentions the positive influence of the cannabinoid receptor on gut health, prompting Dan to share his experience with CBD. Dan describes his dedication to optimizing sleep hygiene, using various sleep tracking devices like an aura ring, withings pad, EMC pad, and chile pad. He details his sleep routine, aiming for a 10 PM bedtime in a dark room, and waking up around 5 AM to follow his nutrition routine.
Dan's Sleep Issues and CBD Trials
00:44:15 - 00:46:32
Dan discusses his sleep patterns, noting he sleeps well in 6.5-7 hours but struggles to sleep longer. He's tried various CBD brands and dosages without significant improvement, likening the effect to weak caffeine. He contrasts this with past experiences with other substances, highlighting the stark difference in impact. Anthony J. Cast mentions Dan's sleep genes indicate a predisposition to being a night owl. They discuss the possibility of shifting Dan's sleep schedule, but Dan explains that he consistently wakes up early regardless of bedtime. Anthony suggests that carb consumption before bed might help, leaving the discussion unfinished.
Continuous Glucose Monitoring (CGM) and its Use
00:46:33 - 00:48:57
This segment focuses on Dan's experience with a continuous glucose monitor (CGM), specifically the Abbott Libre. Anthony inquires about amulopectin, a type of carbohydrate, but the conversation quickly shifts to Dan's use of the CGM. Dan explains that he purchases the sensors for around $30 at Walgreens, finding them affordable and easy to use. He initially wore it on his tricep but now prefers placing it above his hip for comfort and to avoid accidental bumps. The application process is described as quick and simple, involving attaching the sensor to a launcher device. The sensor remains in place for two weeks and is water-resistant, even suitable for hot tubs. Dan highlights the benefits of constantly monitoring his glucose levels, noting that it helps him understand the impact of different foods and drinks, including alcohol, on his blood sugar. He challenges the common misconception that only dark liquors raise blood sugar levels.
Alcohol Consumption and Blood Sugar Levels
00:48:57 - 00:51:26
Dan discusses the effects of alcohol consumption on his blood sugar levels, monitored using a CGM. He notes that alcohol initially lowers blood sugar, sometimes dropping to the 60s, but a few hours after a meal, his blood sugar may spike to 100-110 the following morning. He observes that his blood sugar remains generally within the normal range throughout the day, even after meals, suggesting his liver's glucose production adjusts to food intake. He contrasts this with instances of heavier alcohol consumption, where he experiences a significant blood sugar spike the following day, accompanied by a hangover. Anthony J. Cast relates this to observations about alcohol consumption on a ketogenic diet, where a threshold effect is noted, with a small increase in alcohol intake leading to a sharp negative consequence. Dan confirms this, describing experiences with excessive alcohol consumption resulting in sluggishness the following day.
Keto Diet and Sleep Optimization
00:51:27 - 00:53:31
This segment focuses on optimizing sleep while on a ketogenic diet. J. Cast and Anthony J. Cast discuss the potential benefits of branch chain glucose (annual pectin) to improve sleep, suggesting a trial with varying dosages, starting small and potentially increasing to a full scoop. They also consider the addition of blueberries or honey, acknowledging honey's high fructose content. The timing of carbohydrate consumption is discussed, with a recommendation to consume them 1-2 hours before bed. However, Anthony J. Cast emphasizes that adjusting sleep schedules (staying up and waking up later) is a more significant factor in improving sleep quality. The conversation touches upon the importance of deep sleep for regeneration and the potential benefits of infrared light therapy, citing cadaver studies showing its penetration through the skull and positive anecdotal results.
Nighttime Juve Light Therapy for Sleep Improvement
00:53:31 - 00:55:05
Cast suggests using Juve lights right before bed for improved sleep. He describes placing the light directly on the head, close to the scalp, for approximately 10 minutes. Dan mentions owning two Juve lights and a UVB light, but hasn't used them at night. Cast shares a story about Ben Picolsky, an Olympic contender and builder, whose clients using Juve lights reported significant sleep improvements. The discussion clarifies the application method: the light should be positioned directly on the crown of the head, not stared at like during morning use. Cast emphasizes the proximity of the light to the scalp, suggesting it can almost touch the skull. He expresses excitement about trying this method himself, highlighting the effectiveness of Juve lights in improving sleep for many people.
DEFB1 (Beta Defensin 1) and Gut Health
00:55:05 - 00:55:34
The conversation shifts to DEFB1 (Beta Defensin 1), a peptide that combats harmful bacteria in the gut. Cast explains that lower levels of this peptide are undesirable, likening its function to a "weed killer" that eliminates bad bacteria. He clarifies that it's not a chemical but a natural peptide. The discussion ends mid-sentence.
Gut Gene Analysis and Dietary Implications
00:55:34 - 00:57:50
Cast explains that reducing weed killer use allows good plants to thrive, minimizing weed growth. He emphasizes the importance of diet, particularly avoiding sugars, in managing gut health. Dan finds this information helpful, particularly regarding his concerns about gut issues. Cast notes that some individuals have zero gut genes, while others have two to six, with ten being rare. Dan mentions his children's varying susceptibility to gut problems, noting that two of his four sons experience gut issues, unlike his wife and two other sons who have "iron stomachs." Cast shares that he's discussed DNA results publicly, citing Mike Matthews' example of having excellent gut and carb genes, which allows him to tolerate carbs well. Cast concludes that most people without gut issue genes believe gluten sensitivity is overblown, and that moderation is key, a sentiment echoed by Dan's wife. Cast cautions against judgment, given the genetic variations in gut health.
Vitamin D and Seed Oil Sensitivity
00:57:56 - 01:00:17
Anthony J. Cast discusses Dan's vitamin D levels and genes, noting that Dan's genes are good despite living in Minnesota. Dan mentions his vitamin D levels were low (in the 20s) but improved to the 40s after starting daily outdoor walks. Cast explains the importance of fats for vitamin D absorption and points out that government recommendations for vitamin D intake (400 IU) are often insufficient; many people need 4000 IU. Cast then highlights Dan's G-O-N-1 gene, indicating a seed oil sensitivity. This means Dan doesn't break down seed oils (like canola oil) efficiently. Dan reveals he consumed flaxseed oil for several years, which Cast identifies as problematic due to its effect on estrogen levels. Cast recommends avoiding seed oils and suggests olive oil, avocado oil, and coconut oil as healthier alternatives.
Estrogen and Testosterone Gene Analysis
01:00:20 - 01:02:07
Anthony J. Cast reviews Dan's estrogen and testosterone genes. Dan's estrogen genes show a mix of higher and lower estrogen levels, making the overall effect uncertain but potentially beneficial. Dan mentions his current testosterone replacement therapy due to low levels (around 350) before supplementation, feeling better with the current higher levels. He started a ketogenic diet concurrently. Anthony suggests that a sauna could be beneficial due to a connection between one of Dan's estrogen genes (CYP1B1) and detoxification of artificial estrogen. He also notes that a healthy gut, ketones, fats, and cholesterol can help boost testosterone. Anthony believes Dan might be fine without the T supplement, but if levels remain low after a future check, he wouldn't hesitate to continue the therapy. Overall, Anthony considers Dan's genes to be very good.
Thyroid and Iodine Discussion
01:02:07 - 01:02:44
Dan mentions his thyroid levels are within a normal range, but he still takes iodine, albeit inconsistently. Anthony agrees that consistent iodine supplementation isn't necessary and suggests taking it every few days instead of daily.
Homocysteine and B Vitamin Levels
01:02:44 - 01:05:09
This segment focuses on Dan's homocysteine levels and B vitamin intake. Cast explains that even with low inflammation markers, homocysteine is a separate pathway to consider, especially given Dan's MTRR and CBS genes. The discussion highlights the importance of monitoring homocysteine levels, noting its repeated appearance in relation to B9 (folate). Dan mentions his B12 levels are consistently high (703 in the last test) and that his vitamin mix likely contains folate, though he's unsure. He confirms taking niacin (B3) at 500mg, experiencing the characteristic flush. Cast notes that while niacin is a B vitamin, homocysteine remains a key factor to monitor.
Vitamin and Nutrient Levels and Dietary Recommendations
01:05:09 - 01:07:28
Anthony J. Cast discusses Dan's vitamin B12 and folate levels, noting that while Dan consumes a lot of meat, his genes indicate minimal B12 uptake. He suggests B12 supplementation if needed. Heavy metal levels are also discussed, with Dan showing slightly higher than average arsenic levels. Anthony advises caution with arsenic-containing foods like brussels sprouts, suggesting moderation rather than complete avoidance. Dan expresses his love for brussels sprouts, particularly caramelized ones, and mentions potential gut reactions. Anthony recommends spacing out consumption of these foods to allow the body time to clear arsenic and other substances. The conversation also touches upon arsenic levels in various fish, including salmon and sardines, with Anthony suggesting testing for arsenic levels as a precautionary measure.
Dietary Changes and Heavy Metal Testing
01:07:28 - 01:09:38
Anthony and Dan discuss the potential long-term effects of dietary choices, specifically concerning arsenic levels in seafood. Dan mentions switching from sardines to macro, prompting Anthony to explain that arsenic levels depend on the ocean source, stating he's not an arsenic expert but relies on online scientific information. They then discuss the frequency of heavy metal testing via hair analysis. Anthony advises against frequent testing if diet remains consistent, suggesting retesting only after significant dietary changes. Dan agrees that if initial results are high, subsequent testing would track improvement. Anthony recommends testing, especially given Dan's unusual diet, highlighting the benefit of proactive health monitoring. Finally, they discuss the PNPLA3 gene, linked to a higher risk of fatty liver disease, particularly with high fructose consumption. Anthony emphasizes the negative impact of soda and provides a resource for identifying high-fructose fruits, using figs as an example.
Diet and Exercise Discussion
01:09:38 - 01:11:52
Anthony and Dan discuss Dan's diet and exercise routine. Dan mentions his current diet consists primarily of blueberries, blackberries, and strawberries. They review the detox section, which Dan appreciates as a topic he's considered but never acted upon. The conversation then shifts to Dan's gym routine, which he describes as super compressed due to time constraints. Anthony explains that individuals with a specific dopamine receptor (DR4) often prefer novelty in their workouts, suggesting variety to avoid plateaus. Dan explains his current focus is on maintenance rather than muscle building, aiming to retain his current muscle mass with minimal effort as he ages. He finds Keto, walking, pull-ups, push-ups, and bodyweight exercises helpful in this regard. Anthony affirms that Dan's goal of maintenance is perfectly reasonable. The discussion concludes with Anthony mentioning the role of testosterone.
Testosterone Replacement Therapy and Keto Diet Discussion
01:11:52 - 01:14:07
Dan discusses the challenges of maintaining a high testosterone level (around 900) due to testosterone replacement therapy (TRT), which he administers via weekly injections. He started TRT concurrently with a ketogenic diet, making it difficult to isolate the effects of each. Anthony J. Cast clarifies a misunderstanding about Dan's use of supplements, confirming that Dan uses injections, not creams, for TRT. Anthony J. Cast expresses preference for cream-based TRT due to its consistent levels compared to the fluctuating levels caused by weekly injections. Dan explains that despite the fluctuating levels, he doesn't experience significant mood swings or other side effects, comparing the experience to caffeine consumption. He attributes his overall positive feeling to a combination of TRT and the keto diet.
Keto, Testosterone, and Joint Health
01:14:07 - 01:16:29
Dan discusses the positive effects of keto and testosterone on his health, noting improved energy levels and reduced joint pain. Anthony J. Cast then focuses on the genetic aspects of joint health, specifically mentioning interleukin 2 (IL-2) and interleukin 1 beta, both influenced by testosterone levels. He explains that testosterone can decrease interleukins, thereby reducing inflammation. The discussion then shifts to the difference between rheumatoid arthritis (immune system attacking joints) and osteoarthritis (gradual erosion of soft tissue). Anthony J. Cast highlights that a gene related to osteoarthritis risk, diadenase, is dependent on thyroid hormone levels. He concludes by reviewing Dan's genetic profile, noting a lack of significant risk factors for thyroid issues or osteoarthritis, but emphasizes the importance of maintaining optimized thyroid hormone levels.
Thyroid Health and Seafood Consumption
01:16:30 - 01:18:40
Anthony suggests checking thyroid levels every five years, or even annually if desired, especially focusing on heavy metals. He notes that thyroid hormone declines with age. Dan mentions his regular thyroid checks as part of his keto panel, showing good T3, T4, and PSA levels. Anthony attributes Dan's good results to his genetics and seafood consumption, highlighting the importance of seafood as a natural supplement. Dan expresses slight concern about potentially consuming too much cod liver oil, wondering if it could affect blood clotting. He clarifies that he checks his blood daily for ketones and glucose, noting that his blood flows easily when pricked, unlike his sons'. Anthony confirms that easy bleeding is an indicator of potential issues, while Dan reassures that he doesn't experience excessive bleeding from minor cuts. The conversation concludes with Dan emphasizing the ease with which he obtains blood samples for testing.
Review of Dan's Health Markers and Genetic Predispositions
01:18:41 - 01:20:48
Anthony J. Cast reviews Dan's health markers and genetic predispositions, starting with positive comments on Dan's iodine levels and blood flow, emphasizing the importance of exercise. He then discusses Dan's gout risk, linking it to fructose transport via SLC-2A9 and assuring Dan that his diet mitigates this risk. Low back issues are addressed, connecting them to IL-1A gene presence, although acknowledging the gene's plus-minus nature. Dan mentions occasional back tweaks, prompting Anthony to comment on how seemingly minor movements can cause such issues. The conversation then shifts to testosterone's positive impact on back health. Anthony reassures Dan about his blood pressure, noting a common gene variant but emphasizing that Dan's healthy weight and good blood pressure currently negate any concerns. He mentions angiotensin type drugs as a potential future option if needed but stresses the importance of maintaining a healthy lifestyle. Finally, the discussion concludes with a mention of the insulin IGF-1 gene in relation to gym performance.
Muscle Mass and Body Composition Analysis
01:20:48 - 01:21:27
Anthony discusses Dan's genetic predisposition to lower muscle mass due to a gene associated with lower IGF-1 levels. However, Anthony notes that Dan's high zinc intake naturally increases IGF-1, potentially mitigating this genetic factor. Dan provides his body composition data (height, weight, body fat percentage from DEXA and another method), indicating relatively low body fat and good muscle mass despite limited weight training.
Sleep Genes and Their Impact
01:21:30 - 01:23:02
The conversation shifts to Dan's sleep genes. Anthony explains the EER-3 gene, associated with being a late riser, but emphasizes its variability and potential for manipulation. He suggests using blue blockers to trick the body into thinking it's later than it is, potentially improving sleep. Dan jokes about the impact on his family if he stays up later. Finally, Anthony discusses the WWC1 gene, highlighting its impact on memory recall when sleep is poor, emphasizing the importance of good sleep for cognitive function.
Sleep and Keto Diet Discussion
01:23:02 - 01:24:46
Anthony and Dan discuss the impact of ketogenic diets on sleep. Anthony explains that he cycles keto to avoid sleep disruption, noting that continuous keto affects his sleep cycles negatively. Dan shares his experience of being a light sleeper due to years of running his own business and working long hours with limited sleep. They both acknowledge the challenges of maintaining sufficient sleep, especially with demanding schedules. Anthony emphasizes the importance of tracking sleep patterns for improvement and mentions the influence of blue light, although he considers Dan's genetics to be a significant factor in his sleep quality. Dan expresses gratitude for the insights and mentions his luck in inadvertently adopting beneficial habits.
DNA Report Review and Conclusion
01:24:50 - 01:25:34
Dan expresses his appreciation for the DNA report and the subsequent analysis. He mentions starting intermittent fasting later in life but feels fortunate to have incorporated it. The conversation concludes with Dan stating he has no further overarching questions at this time, satisfied with the 90-minute discussion and the provided analysis. Anthony suggests Dan try a few things and some tests.
Dan's Testing Plan and Genetic Understanding
01:25:34 - 01:27:09
Dan outlines his plan to conduct genetic testing in stages, starting with a few tests and gradually adding heavy metal and lab tests. He expresses excitement about learning from the process and emphasizes the importance of understanding the genetic information. He acknowledges the vastness of genetic information and trusts Anthony's expertise in selecting impactful data for improving his healthspan. He expresses a desire for doctors to embrace this genetic innovation and encourages self-advocacy for patients to bring this information to their physicians.
Doctors' Approach to Genetic Information and Future Collaboration
01:27:09 - 01:28:08
Dan discusses the challenges of doctors fully integrating genetic information into their practice, noting that even highly intelligent doctors may struggle with the sheer volume of information. Anthony acknowledges this, mentioning that some doctors are already incorporating genetic consulting into their practice, while others are less receptive. The conversation concludes with Dan expressing gratitude for the consultation and his eagerness to participate in future discussions and presentations.
Meeting Adjournment
01:28:08 - 01:28:13
Anthony J. Cast bids farewell to Dan and concludes the meeting with pleasantries.
DNA with Dr. Jay, Episode 11.
BIOHACKER David Vader (from Melbourne)
BIOHACKER David Vader (from Melbourne)
Detailed A.I. Summary
**CLICK HERE TO READ
Podcast Introduction and Guest Introduction
00:00:00 - 00:01:15
The podcast begins with an introduction by the host, mentioning the podcast's website (AJConsultingCompany.com) for accessing episodes and confidential DNA analysis using 23andMe data. The host introduces himself as a Mayo Clinic scientist, business owner (AJ Consulting Company), author, and YouTuber with two channels: Anthony J. Cast (scientific content) and Anthony J. Family Cast (outdoor adventures). The guest is introduced as David Vander, a biohacking hobbyist from Australia. The conversation will cover nicotinamide riboside (NR), genetics, and other topics.
Initial Conversation and Time Zones
00:01:20 - 00:02:02
The host and David Vander begin their conversation. They discuss the time difference, with David in Australia (10:30 PM) and the host in a location with 7:30 AM. They briefly discuss their preferences for waking up, with David indicating he's not a morning person, generally waking up around 6:30 or 7 AM, and the host mentioning occasional 5:30 AM wake-up times. The host asks David which part of Australia he's from.
Australian Geography and Gold Rush
00:02:06 - 00:03:11
The conversation begins with a discussion about the speaker's location in Melbourne, Australia. The conversation then shifts to a television show called "Gold Rush" which features gold mining in Australia, specifically mentioning Queensland and the Northern Territories. The speakers discuss the presence of gold in Victoria and the challenges of gold mining in Australia's hot and dry climate. The possibility of increased filming in Australia due to the COVID-19 pandemic is briefly touched upon, with the speakers concluding that the "Gold Rush" show has been airing for some time. The conversation concludes with a transition to the main topic of DNA.
Preparing for DNA Discussion
00:03:11 - 00:03:33
The speakers transition to the main topic of the meeting: DNA. One speaker expresses excitement and willingness to follow the other's lead in structuring the discussion. Confirmation is given that a PDF document has been received and reviewed, with one speaker expressing surprise at some of its contents, prompting the other to inquire about the specific details.
Personal Experiences with Caffeine and Anxiety
00:03:33 - 00:05:35
This segment focuses on a discussion about personal experiences with caffeine and its effects, particularly anxiety. One individual shares their observation that their body retains caffeine longer, causing sleep disturbances if coffee is consumed after 2 p.m. The conversation touches upon the genetic predisposition to anxiety triggered by caffeine, noting that some individuals have multiple genes that amplify this response, leading to a prolonged fight-or-flight reaction. The discussion also explores the idea that while caffeine-induced anxiety can be a negative experience, it can also be channeled productively, for example, by using the heightened energy to tackle unpleasant tasks. The speakers agree that the key is managing the intensity of the anxiety response and preventing it from becoming problematic. The overall tone is one of shared understanding and relatable experience, with one speaker even likening the insights gained from this discussion to a "horoscope" or "crystal ball" due to its personal relevance and revealing nature.
Gene Analysis and Interpretation
00:05:35 - 00:06:45
This segment focuses on interpreting genetic results, specifically differentiating between "plus-plus" genes (both copies are bad), "plus-minus" genes (one bad, one good copy), and their implications. The speaker explains that they primarily focus on problematic "plus-plus" genes, acknowledging that not all genes listed are necessarily bad. The challenge of determining parental origin for "plus-plus" genes is discussed, with the speaker noting that sometimes it's evident. "Plus-minus" genes are considered less problematic, although exceptions exist. The speaker advises reviewing the report's paragraphs to assess individual gene relevance and potential impact, considering that a good gene copy can sometimes override a bad one, and vice versa.
Metformin Response and Personal Experience
00:06:46 - 00:07:11
The discussion shifts to Metformin, a medication identified in the report. The speaker notes being classified as a "high responder" despite having a "plus-minus" genetic marker, suggesting personal experience contradicts the report's classification. The speaker mentions writing a blog article about their experience using Metformin for anti-aging purposes.
Metformin Side Effects and Personal Experience
00:07:11 - 00:08:50
A discussion unfolds regarding a personal experience with Metformin. The speaker details taking Metformin as a supplement from an off-label supplier, initially noticing improvements in blood sugar and metabolism. However, a week later, they experienced intense panic and anxiety attacks, along with feelings of paranoia. These symptoms were unusual for the speaker. A visit to the doctor, prompted by these unexpected symptoms, led to the realization that the Metformin might be the cause. The speaker stopped taking Metformin, and within three days, the symptoms completely disappeared. The conversation then shifts to inquire about the speaker's diet at the time of Metformin use, specifically whether they were following a ketogenic or low-carb diet, referencing a "Tim Ferriss diet" mentioned in a previous email.
Diet and Anxiety
00:08:50 - 00:10:03
The conversation begins with a discussion of the slow-carb diet, characterized by the exclusion of white refined carbs, sugars, starches, and potatoes. One participant mentions following a low-carb diet and notes a reduction in anxiety after meals. The discussion then shifts to a medication requiring a prescription, with a brief exchange about the regulations surrounding its acquisition, including the possibility of personal import from the internet. The conversation concludes with a query about the medication's availability in other countries.
Discussion on Over-the-Counter Availability and Purity of a Drug
00:10:04 - 00:11:38
The conversation begins with a discussion about the difficulty of obtaining a specific drug over the counter, highlighting concerns about purity when sourcing it through less regulated channels. The discussion then shifts to another drug, Epithelon (or Epitalon), which is described as a peptide that affects telomeres. The speaker explains that the Terc gene influences telomere length, and shorter telomeres are associated with shorter lifespans. Epithelon is presented as a means to extend telomeres, likened to lengthening the "plastic caps" on shoelaces that protect DNA. The speaker emphasizes that this peptide is banned by the World Anti-Doping Agency (WADA) due to its potency in making cells younger and improving endurance. The conversation concludes with a humorous remark about the drug's effectiveness, implying that its ban is a testament to its efficacy.
Peptide Administration and Telomere Length
00:11:40 - 00:13:23
The discussion centers on a powerful solution for a particular gene, requiring injection due to its sensitivity and potential misuse in sports. The speakers detail the complexities of peptide administration, noting that peptides are often sold as lyophilized powder requiring reconstitution with bacteriostatic water. The process necessitates slow dripping to avoid air bubbles, which can destroy the peptides. Shaking is also discouraged. The speakers highlight the need for specialized knowledge beyond simply obtaining the peptide, emphasizing the importance of proper reconstitution techniques. Finally, the conversation touches upon the observed effects of these peptides on telomere length, suggesting a potential impact on lifespan as measured by telomere tests.
Biological Age and Epithelon
00:13:23 - 00:14:30
The discussion centers on the difference between chronological and biological age, using the example of a 32-year-old whose biological age might be 40. Epithelon is mentioned as a treatment that could potentially reduce biological age. The speakers discuss the potential benefits of Epithelon, noting that its effectiveness is dependent on a specific gene and that it might be more beneficial for older individuals (60 or 70) rather than someone already in their 30s who is healthy and biohacking. The injectable nature of the peptide is highlighted as a reason for its lack of mainstream adoption. Epithelon is described as a favorite among the speakers due to its amazing effects.
TP53 Gene and Cell Division
00:14:31 - 00:15:10
The conversation shifts to the TP53 gene, which plays a role in cell cycle and cell division, particularly concerning stem cells. The speakers explain that cells have a limited number of divisions before they die, and stem cells die off faster than they should. The discussion ends mid-sentence, leaving the topic incomplete.
Stem Cell Support Through Diet
00:15:10 - 00:16:27
The conversation centers on boosting stem cell levels, particularly as one ages. Retinol, found in liver, is highlighted as a beneficial supplement. The difficulty in obtaining effective retinol from typical vitamin A pills, which often contain carotene instead, is discussed. The speakers explore different ways to consume liver, including desiccated liver pills and eating liver directly. One speaker shares a positive experience with liver pâté made with bacon, describing its palatable taste and creamy texture, and how their children enjoy it spread on rice crackers. The recipe involves cooking bacon first, then processing it with the liver in a food processor for a smooth consistency with visible bacon pieces.
Liver Recipe and Retinol Discussion
00:16:33 - 00:16:50
The conversation begins with a question about the type of liver used in a recipe—cooked and blended. The speakers discuss the recipe's simplicity and the abundance of similar online recipes. One speaker mentions using the recipe as a way to obtain retinol. The discussion then shifts to biohacking and boosting stem cells.
Stem Cell Boosting Methods
00:16:50 - 00:18:14
The conversation focuses on methods to boost stem cells, with hyperbaric oxygen being highlighted as a particularly effective method. A speaker mentions a presentation given at KetoCon about stem cells and presents data on stem cell decline with age. The data shows a significant decrease in stem cell count from one in 10,000 cells in newborns to one in 2 million cells by age 80, and a decrease to one in 250,000 by age 30. Other methods mentioned to increase stem cells include sunshine, retinol, and oxytocin. Hyperbaric oxygen is again emphasized for its effectiveness.
Hyperbaric Chamber and Stem Cell Increase
00:18:14 - 00:19:33
This chapter discusses a human study showing that two hours in a hyperbaric chamber doubles stem cell count. A 20-treatment session (over about a year) resulted in an eightfold increase in stem cells. The speaker notes the study's popularity and credibility, emphasizing it's a human study, not animal research. The long-term effects of the stem cell increase are unknown, but the increase is not temporary. The speaker mentions the possibility of finding and using hyperbaric chambers, but cautions about the safety concerns related to oxygen tanks.
Hyperbaric Chambers and Their Uses
00:19:33 - 00:20:09
The conversation begins with a discussion about hyperbaric chambers, their accessibility, and the potential dangers of misuse. One speaker mentions Dr. Joseph Mercola's podcast as a valuable resource for detailed information on hyperbaric chambers, including specifications and pressure levels. The speaker notes that while owning a hyperbaric chamber is possible, it's not something readily encouraged due to safety concerns.
NAD, NMN, and NR for Stem Cell Boosting
00:20:09 - 00:21:18
The discussion shifts to NAD (nicotinamide adenine dinucleotide), NMN (nicotinamide mononucleotide), and NR (nicotinamide riboside) and their potential to boost stem cells. The speakers discuss the effectiveness of oral supplements versus injections, with one speaker noting that stomach acid often degrades oral supplements. Personal experiences with NR supplements are shared, with one speaker reporting noticeable non-stimulatory energy after several weeks of use, while another reports no initial effects.
Personal Experience and Effects of the Product
00:21:19 - 00:22:50
The speaker describes their experience with the product, noting a significant increase in mental energy and the ability to "power through" low-energy periods. They feel it's a "secret weapon" giving them an advantage over others. The effects weren't immediate; it took about a month to notice a difference. The speaker conducted a self-experiment, going off the product for six weeks and then resuming use, documenting various health metrics including blood pressure, aortic pulse, testosterone levels, and sleep quality. They reported beneficial boosts of around 10-15% in many of these areas.
Supplement Effectiveness and Dosage
00:22:50 - 00:23:48
The discussion centers on the effectiveness of a supplement, specifically comparing pills versus infusions. The speaker notes the immediate effect of infusions. They then describe a personal experiment involving a 500mg daily dose of NR (likely referring to Nicotinamide Riboside) for six weeks, measuring baseline and then the increase after reintroducing the supplement. The method of ingestion (pill vs. sublingual) is clarified, with the speaker mentioning trying both and planning further testing with the sublingual form, but ultimately deciding to stick with what works.
Diet and Lifestyle Factors
00:23:50 - 00:24:27
The conversation shifts to dietary factors, beginning with dairy. The speaker expresses a sensitivity to dairy, noting it causes lethargy. The discussion implies a correlation between diet and overall health, suggesting further exploration of dietary sensitivities is warranted.
Dairy and Inflammation
00:24:34 - 00:25:27
The discussion centers on the inflammatory effects of dairy products, particularly casein and lactose, in individuals with certain genetic predispositions. The speaker explains that while butter and 100% whipping cream (due to low protein and carb content) might be tolerated, other dairy products should be avoided, especially with age, as sensitivity increases. The speaker notes that developing dairy intolerances with age is common due to metabolic slowdown and increased sensitivity to genetic factors.
Genetic Predisposition to Type 1 Diabetes
00:25:27 - 00:26:12
The conversation shifts to a genetic link between a specific gene (with a "two plus pluses" marker) and a higher risk of type 1 diabetes. The speaker clarifies that having this gene doesn't guarantee developing the disease, nor does it indicate that family members will also have it, as it's relatively rare. However, individuals with type 1 diabetes often possess this gene. The possibility of misdiagnosing type 1 diabetes as type 2 is raised. The speaker inquires about the listener's blood sugar levels, using millimolar as a unit of measurement, and clarifies the different units used for blood sugar measurement (millimolar vs. milligrams per deciliter).
Genetic Predisposition and Melanotan
00:26:13 - 00:27:49
The conversation shifts to the speaker's genetic predisposition to high fasting blood sugar, even with a low-carb diet. The speaker mentions having both type 1 and type 2 diabetes genes, highlighting the MC4R gene as particularly significant (three plus pluses). The discussion then turns to melanotan, an injectable peptide that stimulates the MC4R gene. The speaker explains that melanotan is naturally produced by the body in response to sunlight, stimulating melanin production for tanning. Injectable melanotan can achieve the same tanning effect without sun exposure. A fragment of melanotan, PT-141, is also discussed, known as "female Viagra" due to its effects on libido. The speaker points out the often-overlooked connection between sunlight, vitamin D, and hormonal influences on sex drive, body weight, and body weight set point.
Gene Function and Lifestyle Factors
00:27:49 - 00:28:40
This segment discusses the influence of lifestyle factors on a specific gene involved in metabolism. Sunshine, intermittent fasting, and even melanotan injections are mentioned as potential ways to positively affect this gene's function. The speaker notes that while melanotan injection is an extreme measure, it's interesting to consider within the context of peptide use. The discussion also touches upon Milano Tan 2 as a potentially beneficial product related to MC4R. A personal anecdote follows, where the speaker observes that their family members have intuitively gravitated towards lower-carb diets or restricted eating windows, suggesting a possible genetic predisposition.
Personal Anecdotes and Low-Carb Diets
00:28:40 - 00:28:55
The conversation shifts to personal experiences with low-carb diets and intermittent fasting. The speakers express surprise at the rarity of discussions about low-carb diets in America, contrasting it with their own family's intuitive preference for such approaches. One speaker shares their personal habit of skipping breakfast for improved well-being.
Dietary Habits and Strategies for Increasing Adiponectin
00:28:55 - 00:31:11
The conversation begins with a discussion of individual dietary preferences, specifically the speaker's lack of morning hunger and preference for black coffee until lunch. The discussion then shifts to the MC4R gene and its impact on feeding times, suggesting that this can be mitigated by melanotan or, naturally, through increased sun exposure. The benefits of increasing adiponectin levels are highlighted, with intermittent fasting identified as a key strategy. Cold showers are introduced as a method to boost stem cells and increase adiponectin, with a detailed discussion of the adaptation process and the initial discomfort followed by a sense of peacefulness. The experience of cold showers is compared to swimming in cold water, and the speaker describes the fluctuating sensations experienced during a cold shower.
Personal Experience with Intense Physical Activity and Dietary Choices
00:31:11 - 00:32:05
A discussion unfolds regarding the speaker's experience with a strenuous activity characterized by alternating periods of intense discomfort and peace. The conversation then shifts to the topic of heart palpitations and irregular heartbeats, prompting a discussion about potential causes, including caffeine consumption. The speaker shares their six-month experience with a vegan diet, noting feelings of weakness and ultimately concluding that the diet wasn't suitable.
Nutritional Considerations for Vegans and Supplement Recommendations
00:32:07 - 00:32:46
The conversation focuses on the nutritional implications of a vegan diet, particularly concerning creatine levels. The speaker highlights the importance of creatine, especially for vegans, suggesting creatine supplementation for long-term veganism. The speaker also mentions that creatine is readily available in red meat. Finally, the speaker recommends taurine supplementation as a potential remedy for heart palpitations.
Creatine Supplementation and Heart Health
00:32:47 - 00:34:23
The conversation shifts to creatine supplementation and its potential impact on heart health, particularly in the context of a vegan diet. One participant mentions supplementing with creatine in protein shakes. Another participant notes that many individuals they've spoken to have experienced heart palpitations, potentially linked to a specific gene. The age of the individual is highlighted as a factor, with older individuals potentially being more sensitive to these effects. While these palpitations aren't life-threatening, they are unpleasant. The discussion then touches upon the LPL gene's role in keeping triglycerides low, emphasizing the importance of monitoring triglyceride levels (potentially requiring unit conversions). The CDKN2B gene is introduced, indicating a twofold increased risk of heart disease due to a form of inflammation. The speaker explains that cholesterol is often blamed for heart disease, but the underlying inflammation is usually the primary cause, necessitating artery repair with cholesterol.
Understanding CDKN2B Gene and Inflammation
00:34:24 - 00:36:15
This segment discusses the CDKN2B gene and its connection to inflammation and cholesterol. The speaker explains that inflammation can cause artery damage, leading to cholesterol buildup as a repair mechanism. The CDKN2B gene helps regulate inflammation, but a "plus-plus" variation means it's less effective. Grapeseed extract, specifically proanthocyanidins, is suggested as it inhibits CDK and reduces inflammation. The speaker advises against excessive resveratrol intake due to its estrogenic effects, recommending proanthocyanidins instead. The conversation also touches upon the speaker's website and the importance of cycling resveratrol usage due to a large existing supply. The speaker notes the relevance of this discussion to the listener's leaky gut gene.
Understanding and Managing Inflammation Markers
00:36:15 - 00:37:43
The discussion centers on inflammation markers, specifically CRP (C-reactive protein) and interleukin-6. Grape seed extract is highlighted as beneficial for gut health and arteries. Interleukin-6 is explained as a cytokine, a type of inflammatory molecule, and its elevated levels are linked to a "cytokine storm," a condition associated with severe COVID-19. While interleukin-6 is sometimes measured, CRP is more commonly used as an indicator of inflammation. A high CRP level (above 1 mg/L) signifies excessive inflammation. The speakers discuss that maintaining a healthy diet and exercise usually keeps CRP levels within a healthy range, even with a genetic predisposition (indicated by "plus-plus gene") towards higher inflammation. Suggestions for lowering high CRP include DHA supplementation.
Genetic Predisposition and Gut Health
00:37:44 - 00:39:01
This segment discusses the impact of genetics on health, specifically focusing on gut health. The speakers note that while healthy lifestyle choices like diet and exercise are beneficial, genetic predispositions can still influence health outcomes, making weight management more challenging for some individuals. A specific gene, CNR1 (cannabinoid receptor), is highlighted as a factor influencing gut issues. The speakers suggest that individuals with this gene variant may experience gut problems and that CBD (cannabidiol) can be a potential solution, recommending its use as needed rather than daily. The conversation then touches upon the varying degrees of genetic predisposition, with some individuals exhibiting significantly more genetic markers associated with gut issues than others. Finally, the discussion defines leaky gut as a condition where the gut lining, described as a mesh, becomes compromised.
Leaky Gut and Immune Response
00:39:01 - 00:40:39
This segment discusses the consequences of leaky gut syndrome. Undigested food particles, such as proteins (like Ovalbumin from eggs) and large carbohydrates and triglycerides, enter the bloodstream instead of being broken down into smaller components (amino acids, sugars, fatty acids). The immune system identifies these undigested particles as foreign invaders, triggering an immune response and chronic inflammation. This chronic inflammation is detrimental to arteries and overall health. While not constantly present, individuals often experience gut issues. A self-assessment method involves using a foam roller on the abdominal area; tenderness indicates the presence of leaky gut.
Post-Workout Pain and CBD Discussion
00:40:41 - 00:42:10
The conversation begins with a discussion of post-workout muscle pain, specifically mentioning the feeling of "rock-hard abs" and deep pain. The possibility of dairy consumption exacerbating this pain is raised. The discussion then shifts to the use of CBD oil for pain relief, with one speaker noting that they need a high dosage (20-30 milligrams) for effective pain management. The challenges of finding high-quality, third-party tested CBD oils are highlighted, along with concerns about the legality and limited brand availability in certain regions. One speaker mentions their website offers a reliable CBD product. The conversation concludes with a discussion of the absurdity of the military's ban on CBD, despite its non-psychoactive nature, speculating that the ban is likely due to the difficulty of distinguishing CBD from THC and the potential for high CBD doses to trigger THC effects.
Workplace Drug Testing Concerns
00:42:10 - 00:42:45
This section discusses the anxieties surrounding workplace drug testing, particularly concerning cannabis use. One participant shares a personal experience of a positive THC test result due to weed smoking, highlighting the fear of losing employment due to such results. The conversation emphasizes the reality of frequent urine testing in certain professions and the resulting need for abstinence to maintain employment. The discussion then transitions to the next topic.
Vitamin D Supplementation and Testosterone Levels
00:42:45 - 00:43:39
The conversation shifts to the participant's vitamin D supplementation and its potential impact on testosterone levels. The participant mentions having a genetic predisposition for higher vitamin D needs and has been taking 3000-4000 IU of supplemental vitamin D for a prolonged period, believing it optimizes testosterone. Their past blood test results (66 nanomoles per liter, a year prior) are reviewed, confirming healthy testosterone levels (above 50 nanomoles per liter is considered sufficient). The units of measurement (nanomoles per liter) are clarified.
Vitamin D Conversion and Levels
00:43:39 - 00:45:43
This segment focuses on converting vitamin D levels from nanomoles per liter to nanograms per milliliter. A patient's vitamin D level was initially 54 nanomoles per liter (equivalent to 24 nanograms per milliliter) in 2017 and increased to 66 nanomoles per liter (approximately 26 nanograms per milliliter) after two years of supplementation. The discussion highlights the confusion caused by different units of measurement, with the patient's level considered low (below 50 ng/ml) despite the higher nanomoles per liter reading. A recommendation is made to increase supplementation to 10,000 IU to achieve a level above 50 ng/ml. The speakers discuss the lack of a central resource for unit conversion, suggesting using online searches for specific conversions. The conversation concludes with the patient's intention to retest their vitamin D levels and a comparison to average American levels and those found in hunter-gatherer tribes, noting that a 30 ng/ml level is often considered acceptable in the US.
Vitamin D Levels and Societal Norms
00:45:43 - 00:47:28
This segment discusses the optimal levels of Vitamin D and how societal norms influence the definition of "normal" ranges in blood tests. The speakers note that average Vitamin D levels in a specific tribe ranged from 70-100 ng/ml, contrasting with potentially lower "normal" ranges in modern society. One speaker references their book, "Estrogeneration," to illustrate how societal changes can lower average hormone levels, leading to a shift in what's considered normal. The conversation highlights the concern that current "normal" ranges for Vitamin D might be too low, with potential health risks associated with levels below 50 ng/ml. While acknowledging that correlations don't equal causation, the speakers advocate for maintaining Vitamin D levels above 50 ng/ml to minimize health risks. A recent study questioning the effectiveness of Vitamin D supplementation is mentioned, but countered with the assertion that supplementation does increase serum levels, although individual responses may vary.
Vitamin D Dosage and Conversion
00:47:31 - 00:49:05
The discussion centers on the risks of exceeding 100 in unspecified units of vitamin D intake, citing potential calcium buildup and arterial stiffening. High daily doses (e.g., 50,000 units) can rapidly elevate levels above this threshold. The speakers then delve into the difference between vitamin D3 (cholecalciferol) and calcitriol, explaining that the body needs to convert D3 to the active form, calcitriol, via the CYP2R1 gene. The conversation highlights that while D3 is often considered the active form, it requires conversion, and individuals with less efficient conversion may need higher D3 intake to achieve optimal calcitriol levels. The inability to directly supplement with calcitriol is noted as a limitation.
Compound Supply and Conversion Efficiency
00:49:06 - 00:49:44
The discussion centers on the cost and supply of a compound. One speaker notes the high cost, making it accessible primarily in research settings like the Mayo Clinic. The speakers agree on the need for an oversupply of the first compound to ensure sufficient conversion, even if efficiency is reduced. A target of 60-70% is suggested, compared to the current 26%, with the expectation that this percentage will increase. Consistent supplementation is mentioned as a potential factor influencing the current level. Maintaining close monitoring of the compound levels is recommended.
Estrogen Receptor Analysis
00:49:45 - 00:50:22
The conversation shifts to estrogen levels and the analysis of the ESR1 gene (estrogen receptor alpha). The speaker highlights the relatively low number of positive genes related to estrogen, contrasting it with the potentially high number found in other areas like the gut. Only one "plus plus" gene is noted, specifically the estrogen receptor alpha. The existence of two estrogen receptors (alpha and beta) is explained, with the beta receptor identified as protective against prostate cancer in men and breast cancer in women.
Resveratrol and Alpha Receptor Discussion
00:50:22 - 00:51:14
The discussion centers on the impact of resveratrol on alpha receptors and its potential link to increased breast cancer risk. A gene variant resulting in increased alpha receptor production is identified as undesirable due to potential estrogen-related issues. While acknowledging the potential negative effects, the speaker suggests that cycling resveratrol intake might be acceptable, given the overall genetic context. The speaker also expresses approval for the recommendations in the report, specifically mentioning sauna use. Broccoli and cauliflower consumption are mentioned as part of a healthy diet.
Thyroid Hormone Conversion Analysis
00:51:14 - 00:52:11
The conversation shifts to a discussion of thyroid hormones and their conversion. The speaker explains the confusing labeling of thyroid hormones (T1, T2, T3, T4), noting that T4 converts to T3, contrary to typical expectations. The individual's genetic profile shows reduced T4 to T3 conversion. Based on this, the speaker advises against using T4-only thyroid medication (like Synthroid) in the future, as it would likely be poorly converted to the active T3 form, potentially leading to system overload.
Thyroid Hormone and Iodine Supplementation
00:52:12 - 00:53:26
The discussion cautions against using Synthroid for thyroid hormone replacement, suggesting it may not be suitable for everyone and carries risks, especially for individuals with heart palpitation risk. The speaker emphasizes the importance of iodine supplementation as a safer alternative, particularly given the potential for heart palpitations and even permanent AFib from thyroid hormone overdoses. The speaker notes that while many doctors prescribe Synthroid, it's crucial to be cautious, especially with a pre-existing heart condition. Iodine, a building block for thyroid hormones, is recommended as a safer approach, suggesting consuming iodine-rich foods like seafood or taking iodine supplements.
Retinol, Cannabis, and COMT Gene Considerations
00:53:26 - 00:53:49
The conversation briefly touches upon retinol, noting its appearance in subsequent discussions with both positive and negative aspects. The interaction between cannabis use and the COMT gene is also mentioned. While not necessarily a significant health concern, it's noted that cannabis use might lead to lower-than-normal dopamine levels in individuals with this specific gene. The discussion ends abruptly at this point.
MTHFR Gene and Health Implications
00:53:49 - 00:55:33
This segment discusses the MTHFR gene and its impact on health. The speakers initially talk about avoiding smoking due to negative health effects. The conversation then shifts to the MTHFR gene, specifically the C677T variant. It's noted that even a plus-minus variation of this gene can cause health problems, reducing folic acid processing efficiency by approximately 35%. The speakers emphasize avoiding folic acid supplements and instead recommending methylfolate, either through consuming leafy green vegetables or taking a supplement. Methylfolate is highlighted as a DNA building block that improves sleep and overall health. The importance of consistent leafy green consumption or methylfolate supplementation is stressed, particularly for individuals with the MTHFR gene variant.
Supplement Recommendations and Dietary Habits
00:55:39 - 00:57:36
The discussion centers on supplement recommendations, specifically focusing on 5-MTHF, B12, and creatine. The speaker highlights the benefits of 5-MTHF for sleep improvement, citing positive Amazon reviews. The importance of B12 is emphasized, particularly for vegans due to potential low gut uptake. Creatine is suggested as a potential supplement for vegans. The conversation then shifts to the speaker's past vegan diet, acknowledging that nutritional awareness was lacking. The speaker points out a common misconception where people prioritize veganism over nutritional value, similar to the gluten-free trend. The discussion concludes with the speaker's confirmation of a meat-heavy diet, leading to the suggestion that additional supplementation might be unnecessary due to sufficient nutrient intake from food. The potential for high blood test results from over-supplementation while consuming a meat-rich diet is mentioned, suggesting discontinuation of supplements in this case.
Fructose, Soda, and Dietary Choices
00:57:36 - 00:59:13
This segment focuses on the gene PNPLA3, its relation to fructose metabolism, and the impact of dietary choices, particularly soda consumption. The speakers discuss how the liver stores fructose as fat rather than burning it as energy, highlighting the negative effects of high fructose intake. The discussion emphasizes the high fructose content in soda, specifically mentioning high fructose corn syrup as a major concern. One speaker provides a link to a website listing fruits high and low in fructose, using figs and blueberries as examples. Differences in fructose consumption are noted between the US, with its high consumption of high fructose corn syrup, and Australia, where sucrose (table sugar) is more common in soft drinks. The conversation concludes with a personal anecdote about the occasional indulgence in soda, even while following a ketogenic diet, and a description of using a CO2 infuser to create carbonated water as a healthier alternative.
Dr. J's Recipes and Website Traffic
00:59:14 - 01:00:26
A discussion unfolds about a unique cold beverage recipe involving tangerine essential oil, stevia, and vanilla extract, described as similar to an Orange Julius. The suggestion is made to include this and other recipes on Dr. J's website under a "Recipes by Dr. J" section. The high traffic (3,000 unique visitors weekly) to Dr. J's existing "What I Use" page is highlighted, emphasizing its unexpected popularity and the actionable nature of its content for viewers seeking to identify products with undesirable chemicals. The page's success is attributed to its initial conception as an afterthought, yet its growth is driven by high user engagement and interest.
Transitioning to Fragrance-Free Products
01:00:27 - 01:00:37
The conversation shifts to the documentary "Stink" and its impact on Dr. J's decision to transition to fragrance-free products. The documentary is praised, and Dr. J confirms their current efforts in this transition.
Fragrance and Personal Care Products
01:00:38 - 01:01:22
The discussion begins with a conversation about fragrance-free products and personal care. One participant expresses a desire to use aftershave but is unsure about the potential impact on health. Another suggests focusing on applying products to clothing rather than skin to minimize exposure. The conversation touches upon the idea of balancing healthy habits, suggesting that if most choices are healthy, occasional indulgences might be acceptable. The discussion then transitions to the topic of fitness and exercise.
Genetics and Exercise Recommendations
01:01:22 - 01:02:14
The conversation shifts to the participant's genetic predisposition towards endurance activities. It's noted that the participant possesses slow-twitch muscle fibers and the ADRB3 gene, both associated with elite endurance athletes. Based on this genetic profile, the recommendation is to incorporate more endurance training into their fitness routine. The participant mentions their current workout regimen, which involves high-intensity interval training (HIIT) like P90X, and the impact of COVID-19 on their fitness habits.
High-Rep Training and Muscle Growth
01:02:19 - 01:03:09
The discussion centers on a training method involving high repetitions (15-20 reps) of exercises like pull-ups and push-ups, contrasting with traditional weightlifting approaches (e.g., 3 sets of 50 reps). The speaker highlights the significant muscle growth observed with this high-rep method, particularly for individuals possessing a specific gene variant. Anecdotal evidence is provided, mentioning conversations with Mr. Olympia competitors who, upon learning about this gene and training method, expressed regret at not knowing it sooner. The speaker emphasizes the gene's role in facilitating fat-to-energy conversion.
Genetic Predisposition to Diet and Exercise
01:03:09 - 01:04:00
The conversation shifts to the connection between genetics and dietary preferences. The speaker notes the gene variant's alignment with low-carb recommendations and the prevalence of genes favoring meat consumption, reflecting ancestral diets. However, the speaker acknowledges exceptions, mentioning encounters with individuals whose genes are compatible with vegan diets. The discussion also touches upon the variability in individual responses to carbohydrates, with some individuals exhibiting a high tolerance, although this is considered less common than the genetic predisposition towards meat consumption.
Dietary Approaches and Genetic Predisposition
01:04:06 - 01:04:58
The discussion begins with a reflection on the challenges of recommending diets, highlighting the importance of individual genetic predispositions. The speakers discuss how people often dogmatically adhere to specific diets without considering their unique genetic makeup. The conversation shifts to the oversimplification of information in the digital age, where nuanced discussions are replaced by simplistic solutions. The focus then turns to the individual's genetic profile, specifically mentioning a high number of genes related to joint health.
Genetic Risk Factors for Rheumatoid Arthritis
01:04:59 - 01:06:24
The speakers analyze the individual's genetic markers, specifically HLA genes (HLA, DRB1, DRB9, DQA1), noting a four-fold increased risk for rheumatoid arthritis due to the DRB9 gene and approximately two-fold increased risk from others. The discussion emphasizes that high insulin levels trigger the DRB9 gene's effect, suggesting that maintaining good blood sugar control mitigates this risk. Other genes, such as interleukin genes (IL2 and IL1), are identified as inflammation markers, highlighting the impact of diet on joint health. The conversation also touches upon the TRAF1 gene, another risk factor for rheumatoid arthritis related to TNF cytokine, reiterating the importance of a healthy diet and lifestyle. Finally, the speakers acknowledge that even with optimal lifestyle choices, joint pain might still occur later in life.
TNF-alpha and Rheumatoid Arthritis Treatment
01:06:25 - 01:07:30
This segment focuses on the TNF-alpha gene and its role in rheumatoid arthritis treatment. A speaker suggests investigating this gene due to its extensive research and the availability of effective solutions. They mention conversations with researchers in Boston who have seen remarkable results using an antibody against TNF-alpha, injected directly into the joints of patients with severe rheumatoid arthritis. This treatment reportedly provides dramatic pain relief, described as a "miracle," reducing pain from a 10/10 to nothing. However, the high cost due to patents on these antibody injections is noted, with the expectation that prices will decrease once patents expire in approximately 20 years.
Post-Patent Medication and Gout Risk Assessment
01:07:31 - 01:08:17
The discussion centers on the speaker's assessment of the patient's health risks, specifically concerning post-patent medications and gout. The speaker acknowledges that once medications go off-patent, generic versions will become available, potentially impacting the patient's access and cost. However, the speaker expresses minimal concern due to the patient's healthy lifestyle choices, including avoiding high-carb and processed foods, and sufficient sleep. The speaker also addresses the patient's genetic predisposition to gout, noting two risk genes. However, the speaker believes the risk is low due to the patient's lifestyle and suggests simple preventative measures like staying hydrated and limiting fructose consumption.
Nashville Trip and Music Industry Connections
01:08:17 - 01:08:51
The conversation shifts to a personal anecdote. The speaker mentions a recent conversation with someone from Nashville, Tennessee, who possesses a specific gene (SLC289) associated with gout and has experienced gout episodes. This individual, approximately 60 years old, has invited the speaker to Nashville. The speaker expresses excitement about the invitation, mentioning connections to various professional musicians, including Chris Jansen and Luke Combs, highlighting the contrast in their fame between the US and Australia. The speaker also expresses their fondness for the Nashville music genre.
YouTube Success and Gout Discussion
01:08:54 - 01:09:41
The speaker mentions plans to visit Ken Berry, a YouTuber with over a million subscribers, in Nashville. The speaker recounts a humorous interaction where Berry, despite his large following, sought advice on growing a YouTube channel from the speaker, who has a significantly smaller subscriber base (5,000 vs. 2 million). The difference is attributed to Berry's full-time dedication to YouTube, unlike the speaker who works at the Mayo Clinic. The conversation then transitions to a discussion about gout.
Gout and Diet
01:09:41 - 01:10:11
The conversation shifts to a discussion about gout and its connection to diet. A recent conversation with an individual suffering from gout is recounted. This person consumed a standard American diet high in soda, processed foods, and high fructose corn syrup, even in salad dressings. The speaker highlights the irony of doctors advising this individual to stop eating meat while ignoring the significant role of high fructose corn syrup and processed foods in his gout.
Spinal Disc Health and Exercise
01:10:12 - 01:10:52
The discussion centers on the risk of low back issues, linked to a specific gene related to spinal discs. A two-fold higher risk is noted. The speaker advises caution with deadlifts, recommending against excessive exertion. The role of curcumin in inhibiting interleukin, another cytokine gene, is mentioned, further emphasizing the need for careful exercise management.
Blood Pressure Management and Genetic Predisposition
01:10:52 - 01:11:55
The conversation shifts to blood pressure, specifically mentioning high blood pressure and the AGT gene (angiotensinogen). The speaker explains that this gene significantly impacts blood pressure and that if blood pressure medication becomes necessary, targeting angiotensin is crucial due to the genetic predisposition. The speaker highlights the often trial-and-error approach doctors take with blood pressure medication, emphasizing the advantage of using genetic information to guide treatment. The benefits of beet juice in increasing nitric oxide, relevant to blood pressure management, are also discussed.
Citrulline and Blood Vessel Health
01:11:55 - 01:12:33
The conversation begins with a discussion of citrulline's benefits for blood vessels. Citrulline is presented as a lower-carb alternative to another supplement with similar effects. One speaker mentions using citrulline specifically for workouts, suggesting pre-workout use. The discussion then shifts to the topic of blood pressure, with one speaker mentioning aspirin, which is quickly clarified as not being part of the discussed supplement. A speaker corrects their initial thought, clarifying they were considering heart health rather than blood pressure.
Aspirin and Blood Health
01:12:34 - 01:12:59
The conversation turns to the rare recommendation of aspirin, specifically a baby aspirin, for individuals with a specific gene, F5 (factor V), which can lead to thicker blood. Aspirin's role in inhibiting this effect is explained. The rarity of this recommendation is emphasized, and the speakers express surprise at the possibility of aspirin being mentioned in a related document, suggesting it would be a typo.
Bone Strength and DEXA Scans
01:13:03 - 01:13:21
The discussion concludes with a focus on bone strength. The speakers note the significant bone strength benefits of a particular supplement, mentioning two "pluses" indicating strong bone health. Despite this, a bone break is mentioned, which is not considered surprising given the context. The conversation ends with a suggestion to get a DEXA scan and share the results via email, anticipating positive feedback on bone density.
Genetic Factors Influencing Physical Capabilities
01:13:21 - 01:15:13
This segment focuses on the discussion of specific genes and their impact on physical attributes. The speakers analyze genes related to bone density, noting that while some individuals possess genes leading to exceptionally high bone density ("iron" bone density), others have a mix of good and bad genes resulting in an average bone strength. The conversation then shifts to a gene affecting pain sensitivity, specifically in the context of Charcot-Marie-Tooth disease (CMT). It's clarified that the impact of this gene on pain sensitivity isn't extreme, and that other genes play a more significant role. The speaker explains that the reduced pain sensitivity is categorized differently, possibly as mechanical versus proprioceptive pain, highlighting the importance of paying attention to pain signals despite the reduced sensitivity to prevent injuries like elbow or bicep damage during exercise. The discussion concludes with a question about any further inquiries regarding the genetic analysis of physical capabilities.
Sleep Gene Analysis and Lifestyle Discussion
01:15:13 - 01:17:08
The discussion shifts to the listener's sleep genes. The speaker explains that while several genes related to sleep patterns are present, two genes related to Seasonal Affective Disorder are less concerning due to the listener's location in Australia. The speaker notes the listener's conscious efforts to incorporate morning light exposure for melatonin regulation. The listener confirms not experiencing winter sadness. The speaker contrasts this with the potential for issues in a colder climate like Minnesota. The listener's genes suggest a predisposition towards being a night person, a preference the speaker advises not fighting unless career demands necessitate it. The speaker suggests manipulating the brain's perception of time to improve sleep, even if bedtime is early. The PER3 gene is highlighted as the primary indicator of morning versus night preference, with the listener's result being inconclusive but leaning towards a night owl preference.
Sleep Optimization Techniques
01:17:08 - 01:18:37
The conversation begins with a speaker discussing their interest in sleep hacking and a piece they're writing titled "How to Sleep Like a Caveman," focusing on applying paleo diet principles to sleep, including low light and temperature control. Another speaker shares an anecdote about staying in a San Francisco apartment with inadequate light blocking, highlighting the negative impact of streetlights on sleep. This leads to a discussion about the importance of creating a completely dark sleep environment. One speaker describes their own "slaughter room" bedroom, completely blacked out with aluminum foil on the windows to ensure no light penetration. The conversation concludes with a speaker mentioning their method of testing blackout curtains by purchasing them for their and their children's bedrooms.
Blackout Curtains and Travel Sleep Solutions
01:18:41 - 01:19:50
The conversation begins with a discussion about the effectiveness of blackout curtains. The speaker notes that many curtains advertised as "blackout" still allow light to penetrate, requiring a thorough check in-store by holding them up to a light source. The inadequacy of standard blackout curtains for complete light blockage is highlighted. An alternative solution is introduced: "Grow Blinds," a type of blackout blind with suction cups, allowing for easy travel and use in various locations, including hotel rooms. The speaker recommends these blinds for their effectiveness and portability, contrasting them with the difficulties of achieving darkness in hotel rooms using existing bedding. A link to the product is offered, and the recipient confirms they have already found it online.
Sleep Hacking and Genetic Factors
01:19:50 - 01:20:07
The discussion shifts to "sleep hacking" and the role of genetics. Two genes, CLOCK and ABCC9, are identified as particularly relevant. The CLOCK gene is highlighted as especially important, and clinical studies using lithium to influence this gene and improve deep sleep are mentioned.
Magnesium Supplementation and Sleep
01:20:09 - 01:21:18
The conversation centers on optimizing magnesium intake for improved sleep. One participant mentions using magnesium threonate for sleep but not regularly. Another suggests consistently taking magnesium, especially given a gene's higher responsiveness to it for sleep. The discussion then shifts to different magnesium types (e.g., glycinate, oxide) and their absorption. A participant notes that the type of magnesium matters most if one is deficient; otherwise, the body maintains magnesium levels regardless of the form taken. The importance of adequate magnesium levels and the impact of digestive system efficiency on absorption are also highlighted.
Glycine, Magnesium, and Sleep Supplements
01:21:18 - 01:23:19
The discussion centers on the use of glycine and magnesium supplements, particularly magnesium glycinate, to improve sleep. Concerns are raised about potential side effects like diarrhea from overdosing. While the speaker acknowledges that the effectiveness of glycine supplementation varies depending on individual sleep genes, they generally recommend it. Magnesium glycinate is highlighted as a way to increase glycine intake, leading to anecdotal improvements in sleep for some individuals. However, the speaker cautions against dogmatic adherence to this supplement, emphasizing that its impact is gene-dependent. The speaker prefers taking glycine and magnesium separately, citing the unpleasant taste of glycine powder and the convenience and tastelessness of magnesium citrate powder. The importance of sleep tracking to assess the effectiveness of any supplement is stressed. Finally, potassium supplements are suggested as another potential sleep aid, along with low-dose lithium (5mg/day).
Sleep Tracking and Improvement Strategies
01:23:20 - 01:24:34
This segment focuses on the importance of sleep tracking and the impact of various factors on sleep quality. One individual mentions using a sleep tracker and observing the effects of different interventions. They discuss the significance of REM sleep for emotional well-being and the less noticeable but crucial role of deep sleep in overall health. The individual highlights a 10% increase in deep sleep after darkening their room and a similar positive effect after starting Nicotinamide Riboside (NR) supplementation. Another individual expresses interest in trying NR and mentions having a large supply of supplements. The discussion concludes with a brief mention of ordering supplements through a clinic.
Post-Interview Reflections and Logistics
01:24:37 - 01:25:16
The speakers discuss the experimental nature of the interview's content, with one expressing surprise at the breadth of topics covered. One speaker mentions taking extensive notes, highlighting the interview's richness. The conversation then shifts to logistics, with a request to share the recorded file via Dropbox. A confirmation of this action is given.
Podcast Perks and International Shipping Challenges
01:25:16 - 01:26:15
One speaker explains their usual practice of sending T-shirts and roasted coffee to podcast guests, but notes that this won't be feasible for guests in Australia due to high shipping costs. An anecdote is shared about a famous Australian requesting several copies of the speaker's book, where the shipping cost significantly exceeded the book's value. The high cost of international shipping to Australia is reiterated, and a future visit to Australia is mentioned as a potential solution for delivering the gifts.
Hunting and Australian Wildlife
01:26:15 - 01:27:07
The conversation shifts to hunting, with one speaker mentioning deer hunting and the other sharing that kangaroo hunting is permitted in Australia, contrasting the perception of kangaroos in America versus Australia. The Australian speaker notes that kangaroo meat is readily available in supermarkets, and the other speaker expresses amusement and interest. Future plans to meet for coffee and engage in spearfishing and scuba diving in Australia are discussed.
Coffee Maker and AeroPress Discussion
01:27:07 - 01:27:34
One speaker mentions a copper AeroPress-style coffee maker they had custom-made, highlighting the difference between the plastic AeroPress and their copper version. The superior heat retention properties of the copper maker are discussed, emphasizing the importance of pouring hot water over coffee oils for optimal brewing.
Podcast Discussion and File Transfer
01:27:34 - 01:28:11
The conversation begins with a discussion about a copper mold, described as "amazing," contrasting it with a potentially problematic "soft plastic" alternative. One speaker mentions a recent message and tag in a post, expressing appreciation for the other's participation in a podcast. Gratitude is expressed for the podcast version and the enjoyable conversation. Finally, one speaker offers to send a file, suggesting they will either receive a message when it's ready or proactively check for it. The conversation concludes with pleasantries and farewells.
00:00:00 - 00:01:15
The podcast begins with an introduction by the host, mentioning the podcast's website (AJConsultingCompany.com) for accessing episodes and confidential DNA analysis using 23andMe data. The host introduces himself as a Mayo Clinic scientist, business owner (AJ Consulting Company), author, and YouTuber with two channels: Anthony J. Cast (scientific content) and Anthony J. Family Cast (outdoor adventures). The guest is introduced as David Vander, a biohacking hobbyist from Australia. The conversation will cover nicotinamide riboside (NR), genetics, and other topics.
Initial Conversation and Time Zones
00:01:20 - 00:02:02
The host and David Vander begin their conversation. They discuss the time difference, with David in Australia (10:30 PM) and the host in a location with 7:30 AM. They briefly discuss their preferences for waking up, with David indicating he's not a morning person, generally waking up around 6:30 or 7 AM, and the host mentioning occasional 5:30 AM wake-up times. The host asks David which part of Australia he's from.
Australian Geography and Gold Rush
00:02:06 - 00:03:11
The conversation begins with a discussion about the speaker's location in Melbourne, Australia. The conversation then shifts to a television show called "Gold Rush" which features gold mining in Australia, specifically mentioning Queensland and the Northern Territories. The speakers discuss the presence of gold in Victoria and the challenges of gold mining in Australia's hot and dry climate. The possibility of increased filming in Australia due to the COVID-19 pandemic is briefly touched upon, with the speakers concluding that the "Gold Rush" show has been airing for some time. The conversation concludes with a transition to the main topic of DNA.
Preparing for DNA Discussion
00:03:11 - 00:03:33
The speakers transition to the main topic of the meeting: DNA. One speaker expresses excitement and willingness to follow the other's lead in structuring the discussion. Confirmation is given that a PDF document has been received and reviewed, with one speaker expressing surprise at some of its contents, prompting the other to inquire about the specific details.
Personal Experiences with Caffeine and Anxiety
00:03:33 - 00:05:35
This segment focuses on a discussion about personal experiences with caffeine and its effects, particularly anxiety. One individual shares their observation that their body retains caffeine longer, causing sleep disturbances if coffee is consumed after 2 p.m. The conversation touches upon the genetic predisposition to anxiety triggered by caffeine, noting that some individuals have multiple genes that amplify this response, leading to a prolonged fight-or-flight reaction. The discussion also explores the idea that while caffeine-induced anxiety can be a negative experience, it can also be channeled productively, for example, by using the heightened energy to tackle unpleasant tasks. The speakers agree that the key is managing the intensity of the anxiety response and preventing it from becoming problematic. The overall tone is one of shared understanding and relatable experience, with one speaker even likening the insights gained from this discussion to a "horoscope" or "crystal ball" due to its personal relevance and revealing nature.
Gene Analysis and Interpretation
00:05:35 - 00:06:45
This segment focuses on interpreting genetic results, specifically differentiating between "plus-plus" genes (both copies are bad), "plus-minus" genes (one bad, one good copy), and their implications. The speaker explains that they primarily focus on problematic "plus-plus" genes, acknowledging that not all genes listed are necessarily bad. The challenge of determining parental origin for "plus-plus" genes is discussed, with the speaker noting that sometimes it's evident. "Plus-minus" genes are considered less problematic, although exceptions exist. The speaker advises reviewing the report's paragraphs to assess individual gene relevance and potential impact, considering that a good gene copy can sometimes override a bad one, and vice versa.
Metformin Response and Personal Experience
00:06:46 - 00:07:11
The discussion shifts to Metformin, a medication identified in the report. The speaker notes being classified as a "high responder" despite having a "plus-minus" genetic marker, suggesting personal experience contradicts the report's classification. The speaker mentions writing a blog article about their experience using Metformin for anti-aging purposes.
Metformin Side Effects and Personal Experience
00:07:11 - 00:08:50
A discussion unfolds regarding a personal experience with Metformin. The speaker details taking Metformin as a supplement from an off-label supplier, initially noticing improvements in blood sugar and metabolism. However, a week later, they experienced intense panic and anxiety attacks, along with feelings of paranoia. These symptoms were unusual for the speaker. A visit to the doctor, prompted by these unexpected symptoms, led to the realization that the Metformin might be the cause. The speaker stopped taking Metformin, and within three days, the symptoms completely disappeared. The conversation then shifts to inquire about the speaker's diet at the time of Metformin use, specifically whether they were following a ketogenic or low-carb diet, referencing a "Tim Ferriss diet" mentioned in a previous email.
Diet and Anxiety
00:08:50 - 00:10:03
The conversation begins with a discussion of the slow-carb diet, characterized by the exclusion of white refined carbs, sugars, starches, and potatoes. One participant mentions following a low-carb diet and notes a reduction in anxiety after meals. The discussion then shifts to a medication requiring a prescription, with a brief exchange about the regulations surrounding its acquisition, including the possibility of personal import from the internet. The conversation concludes with a query about the medication's availability in other countries.
Discussion on Over-the-Counter Availability and Purity of a Drug
00:10:04 - 00:11:38
The conversation begins with a discussion about the difficulty of obtaining a specific drug over the counter, highlighting concerns about purity when sourcing it through less regulated channels. The discussion then shifts to another drug, Epithelon (or Epitalon), which is described as a peptide that affects telomeres. The speaker explains that the Terc gene influences telomere length, and shorter telomeres are associated with shorter lifespans. Epithelon is presented as a means to extend telomeres, likened to lengthening the "plastic caps" on shoelaces that protect DNA. The speaker emphasizes that this peptide is banned by the World Anti-Doping Agency (WADA) due to its potency in making cells younger and improving endurance. The conversation concludes with a humorous remark about the drug's effectiveness, implying that its ban is a testament to its efficacy.
Peptide Administration and Telomere Length
00:11:40 - 00:13:23
The discussion centers on a powerful solution for a particular gene, requiring injection due to its sensitivity and potential misuse in sports. The speakers detail the complexities of peptide administration, noting that peptides are often sold as lyophilized powder requiring reconstitution with bacteriostatic water. The process necessitates slow dripping to avoid air bubbles, which can destroy the peptides. Shaking is also discouraged. The speakers highlight the need for specialized knowledge beyond simply obtaining the peptide, emphasizing the importance of proper reconstitution techniques. Finally, the conversation touches upon the observed effects of these peptides on telomere length, suggesting a potential impact on lifespan as measured by telomere tests.
Biological Age and Epithelon
00:13:23 - 00:14:30
The discussion centers on the difference between chronological and biological age, using the example of a 32-year-old whose biological age might be 40. Epithelon is mentioned as a treatment that could potentially reduce biological age. The speakers discuss the potential benefits of Epithelon, noting that its effectiveness is dependent on a specific gene and that it might be more beneficial for older individuals (60 or 70) rather than someone already in their 30s who is healthy and biohacking. The injectable nature of the peptide is highlighted as a reason for its lack of mainstream adoption. Epithelon is described as a favorite among the speakers due to its amazing effects.
TP53 Gene and Cell Division
00:14:31 - 00:15:10
The conversation shifts to the TP53 gene, which plays a role in cell cycle and cell division, particularly concerning stem cells. The speakers explain that cells have a limited number of divisions before they die, and stem cells die off faster than they should. The discussion ends mid-sentence, leaving the topic incomplete.
Stem Cell Support Through Diet
00:15:10 - 00:16:27
The conversation centers on boosting stem cell levels, particularly as one ages. Retinol, found in liver, is highlighted as a beneficial supplement. The difficulty in obtaining effective retinol from typical vitamin A pills, which often contain carotene instead, is discussed. The speakers explore different ways to consume liver, including desiccated liver pills and eating liver directly. One speaker shares a positive experience with liver pâté made with bacon, describing its palatable taste and creamy texture, and how their children enjoy it spread on rice crackers. The recipe involves cooking bacon first, then processing it with the liver in a food processor for a smooth consistency with visible bacon pieces.
Liver Recipe and Retinol Discussion
00:16:33 - 00:16:50
The conversation begins with a question about the type of liver used in a recipe—cooked and blended. The speakers discuss the recipe's simplicity and the abundance of similar online recipes. One speaker mentions using the recipe as a way to obtain retinol. The discussion then shifts to biohacking and boosting stem cells.
Stem Cell Boosting Methods
00:16:50 - 00:18:14
The conversation focuses on methods to boost stem cells, with hyperbaric oxygen being highlighted as a particularly effective method. A speaker mentions a presentation given at KetoCon about stem cells and presents data on stem cell decline with age. The data shows a significant decrease in stem cell count from one in 10,000 cells in newborns to one in 2 million cells by age 80, and a decrease to one in 250,000 by age 30. Other methods mentioned to increase stem cells include sunshine, retinol, and oxytocin. Hyperbaric oxygen is again emphasized for its effectiveness.
Hyperbaric Chamber and Stem Cell Increase
00:18:14 - 00:19:33
This chapter discusses a human study showing that two hours in a hyperbaric chamber doubles stem cell count. A 20-treatment session (over about a year) resulted in an eightfold increase in stem cells. The speaker notes the study's popularity and credibility, emphasizing it's a human study, not animal research. The long-term effects of the stem cell increase are unknown, but the increase is not temporary. The speaker mentions the possibility of finding and using hyperbaric chambers, but cautions about the safety concerns related to oxygen tanks.
Hyperbaric Chambers and Their Uses
00:19:33 - 00:20:09
The conversation begins with a discussion about hyperbaric chambers, their accessibility, and the potential dangers of misuse. One speaker mentions Dr. Joseph Mercola's podcast as a valuable resource for detailed information on hyperbaric chambers, including specifications and pressure levels. The speaker notes that while owning a hyperbaric chamber is possible, it's not something readily encouraged due to safety concerns.
NAD, NMN, and NR for Stem Cell Boosting
00:20:09 - 00:21:18
The discussion shifts to NAD (nicotinamide adenine dinucleotide), NMN (nicotinamide mononucleotide), and NR (nicotinamide riboside) and their potential to boost stem cells. The speakers discuss the effectiveness of oral supplements versus injections, with one speaker noting that stomach acid often degrades oral supplements. Personal experiences with NR supplements are shared, with one speaker reporting noticeable non-stimulatory energy after several weeks of use, while another reports no initial effects.
Personal Experience and Effects of the Product
00:21:19 - 00:22:50
The speaker describes their experience with the product, noting a significant increase in mental energy and the ability to "power through" low-energy periods. They feel it's a "secret weapon" giving them an advantage over others. The effects weren't immediate; it took about a month to notice a difference. The speaker conducted a self-experiment, going off the product for six weeks and then resuming use, documenting various health metrics including blood pressure, aortic pulse, testosterone levels, and sleep quality. They reported beneficial boosts of around 10-15% in many of these areas.
Supplement Effectiveness and Dosage
00:22:50 - 00:23:48
The discussion centers on the effectiveness of a supplement, specifically comparing pills versus infusions. The speaker notes the immediate effect of infusions. They then describe a personal experiment involving a 500mg daily dose of NR (likely referring to Nicotinamide Riboside) for six weeks, measuring baseline and then the increase after reintroducing the supplement. The method of ingestion (pill vs. sublingual) is clarified, with the speaker mentioning trying both and planning further testing with the sublingual form, but ultimately deciding to stick with what works.
Diet and Lifestyle Factors
00:23:50 - 00:24:27
The conversation shifts to dietary factors, beginning with dairy. The speaker expresses a sensitivity to dairy, noting it causes lethargy. The discussion implies a correlation between diet and overall health, suggesting further exploration of dietary sensitivities is warranted.
Dairy and Inflammation
00:24:34 - 00:25:27
The discussion centers on the inflammatory effects of dairy products, particularly casein and lactose, in individuals with certain genetic predispositions. The speaker explains that while butter and 100% whipping cream (due to low protein and carb content) might be tolerated, other dairy products should be avoided, especially with age, as sensitivity increases. The speaker notes that developing dairy intolerances with age is common due to metabolic slowdown and increased sensitivity to genetic factors.
Genetic Predisposition to Type 1 Diabetes
00:25:27 - 00:26:12
The conversation shifts to a genetic link between a specific gene (with a "two plus pluses" marker) and a higher risk of type 1 diabetes. The speaker clarifies that having this gene doesn't guarantee developing the disease, nor does it indicate that family members will also have it, as it's relatively rare. However, individuals with type 1 diabetes often possess this gene. The possibility of misdiagnosing type 1 diabetes as type 2 is raised. The speaker inquires about the listener's blood sugar levels, using millimolar as a unit of measurement, and clarifies the different units used for blood sugar measurement (millimolar vs. milligrams per deciliter).
Genetic Predisposition and Melanotan
00:26:13 - 00:27:49
The conversation shifts to the speaker's genetic predisposition to high fasting blood sugar, even with a low-carb diet. The speaker mentions having both type 1 and type 2 diabetes genes, highlighting the MC4R gene as particularly significant (three plus pluses). The discussion then turns to melanotan, an injectable peptide that stimulates the MC4R gene. The speaker explains that melanotan is naturally produced by the body in response to sunlight, stimulating melanin production for tanning. Injectable melanotan can achieve the same tanning effect without sun exposure. A fragment of melanotan, PT-141, is also discussed, known as "female Viagra" due to its effects on libido. The speaker points out the often-overlooked connection between sunlight, vitamin D, and hormonal influences on sex drive, body weight, and body weight set point.
Gene Function and Lifestyle Factors
00:27:49 - 00:28:40
This segment discusses the influence of lifestyle factors on a specific gene involved in metabolism. Sunshine, intermittent fasting, and even melanotan injections are mentioned as potential ways to positively affect this gene's function. The speaker notes that while melanotan injection is an extreme measure, it's interesting to consider within the context of peptide use. The discussion also touches upon Milano Tan 2 as a potentially beneficial product related to MC4R. A personal anecdote follows, where the speaker observes that their family members have intuitively gravitated towards lower-carb diets or restricted eating windows, suggesting a possible genetic predisposition.
Personal Anecdotes and Low-Carb Diets
00:28:40 - 00:28:55
The conversation shifts to personal experiences with low-carb diets and intermittent fasting. The speakers express surprise at the rarity of discussions about low-carb diets in America, contrasting it with their own family's intuitive preference for such approaches. One speaker shares their personal habit of skipping breakfast for improved well-being.
Dietary Habits and Strategies for Increasing Adiponectin
00:28:55 - 00:31:11
The conversation begins with a discussion of individual dietary preferences, specifically the speaker's lack of morning hunger and preference for black coffee until lunch. The discussion then shifts to the MC4R gene and its impact on feeding times, suggesting that this can be mitigated by melanotan or, naturally, through increased sun exposure. The benefits of increasing adiponectin levels are highlighted, with intermittent fasting identified as a key strategy. Cold showers are introduced as a method to boost stem cells and increase adiponectin, with a detailed discussion of the adaptation process and the initial discomfort followed by a sense of peacefulness. The experience of cold showers is compared to swimming in cold water, and the speaker describes the fluctuating sensations experienced during a cold shower.
Personal Experience with Intense Physical Activity and Dietary Choices
00:31:11 - 00:32:05
A discussion unfolds regarding the speaker's experience with a strenuous activity characterized by alternating periods of intense discomfort and peace. The conversation then shifts to the topic of heart palpitations and irregular heartbeats, prompting a discussion about potential causes, including caffeine consumption. The speaker shares their six-month experience with a vegan diet, noting feelings of weakness and ultimately concluding that the diet wasn't suitable.
Nutritional Considerations for Vegans and Supplement Recommendations
00:32:07 - 00:32:46
The conversation focuses on the nutritional implications of a vegan diet, particularly concerning creatine levels. The speaker highlights the importance of creatine, especially for vegans, suggesting creatine supplementation for long-term veganism. The speaker also mentions that creatine is readily available in red meat. Finally, the speaker recommends taurine supplementation as a potential remedy for heart palpitations.
Creatine Supplementation and Heart Health
00:32:47 - 00:34:23
The conversation shifts to creatine supplementation and its potential impact on heart health, particularly in the context of a vegan diet. One participant mentions supplementing with creatine in protein shakes. Another participant notes that many individuals they've spoken to have experienced heart palpitations, potentially linked to a specific gene. The age of the individual is highlighted as a factor, with older individuals potentially being more sensitive to these effects. While these palpitations aren't life-threatening, they are unpleasant. The discussion then touches upon the LPL gene's role in keeping triglycerides low, emphasizing the importance of monitoring triglyceride levels (potentially requiring unit conversions). The CDKN2B gene is introduced, indicating a twofold increased risk of heart disease due to a form of inflammation. The speaker explains that cholesterol is often blamed for heart disease, but the underlying inflammation is usually the primary cause, necessitating artery repair with cholesterol.
Understanding CDKN2B Gene and Inflammation
00:34:24 - 00:36:15
This segment discusses the CDKN2B gene and its connection to inflammation and cholesterol. The speaker explains that inflammation can cause artery damage, leading to cholesterol buildup as a repair mechanism. The CDKN2B gene helps regulate inflammation, but a "plus-plus" variation means it's less effective. Grapeseed extract, specifically proanthocyanidins, is suggested as it inhibits CDK and reduces inflammation. The speaker advises against excessive resveratrol intake due to its estrogenic effects, recommending proanthocyanidins instead. The conversation also touches upon the speaker's website and the importance of cycling resveratrol usage due to a large existing supply. The speaker notes the relevance of this discussion to the listener's leaky gut gene.
Understanding and Managing Inflammation Markers
00:36:15 - 00:37:43
The discussion centers on inflammation markers, specifically CRP (C-reactive protein) and interleukin-6. Grape seed extract is highlighted as beneficial for gut health and arteries. Interleukin-6 is explained as a cytokine, a type of inflammatory molecule, and its elevated levels are linked to a "cytokine storm," a condition associated with severe COVID-19. While interleukin-6 is sometimes measured, CRP is more commonly used as an indicator of inflammation. A high CRP level (above 1 mg/L) signifies excessive inflammation. The speakers discuss that maintaining a healthy diet and exercise usually keeps CRP levels within a healthy range, even with a genetic predisposition (indicated by "plus-plus gene") towards higher inflammation. Suggestions for lowering high CRP include DHA supplementation.
Genetic Predisposition and Gut Health
00:37:44 - 00:39:01
This segment discusses the impact of genetics on health, specifically focusing on gut health. The speakers note that while healthy lifestyle choices like diet and exercise are beneficial, genetic predispositions can still influence health outcomes, making weight management more challenging for some individuals. A specific gene, CNR1 (cannabinoid receptor), is highlighted as a factor influencing gut issues. The speakers suggest that individuals with this gene variant may experience gut problems and that CBD (cannabidiol) can be a potential solution, recommending its use as needed rather than daily. The conversation then touches upon the varying degrees of genetic predisposition, with some individuals exhibiting significantly more genetic markers associated with gut issues than others. Finally, the discussion defines leaky gut as a condition where the gut lining, described as a mesh, becomes compromised.
Leaky Gut and Immune Response
00:39:01 - 00:40:39
This segment discusses the consequences of leaky gut syndrome. Undigested food particles, such as proteins (like Ovalbumin from eggs) and large carbohydrates and triglycerides, enter the bloodstream instead of being broken down into smaller components (amino acids, sugars, fatty acids). The immune system identifies these undigested particles as foreign invaders, triggering an immune response and chronic inflammation. This chronic inflammation is detrimental to arteries and overall health. While not constantly present, individuals often experience gut issues. A self-assessment method involves using a foam roller on the abdominal area; tenderness indicates the presence of leaky gut.
Post-Workout Pain and CBD Discussion
00:40:41 - 00:42:10
The conversation begins with a discussion of post-workout muscle pain, specifically mentioning the feeling of "rock-hard abs" and deep pain. The possibility of dairy consumption exacerbating this pain is raised. The discussion then shifts to the use of CBD oil for pain relief, with one speaker noting that they need a high dosage (20-30 milligrams) for effective pain management. The challenges of finding high-quality, third-party tested CBD oils are highlighted, along with concerns about the legality and limited brand availability in certain regions. One speaker mentions their website offers a reliable CBD product. The conversation concludes with a discussion of the absurdity of the military's ban on CBD, despite its non-psychoactive nature, speculating that the ban is likely due to the difficulty of distinguishing CBD from THC and the potential for high CBD doses to trigger THC effects.
Workplace Drug Testing Concerns
00:42:10 - 00:42:45
This section discusses the anxieties surrounding workplace drug testing, particularly concerning cannabis use. One participant shares a personal experience of a positive THC test result due to weed smoking, highlighting the fear of losing employment due to such results. The conversation emphasizes the reality of frequent urine testing in certain professions and the resulting need for abstinence to maintain employment. The discussion then transitions to the next topic.
Vitamin D Supplementation and Testosterone Levels
00:42:45 - 00:43:39
The conversation shifts to the participant's vitamin D supplementation and its potential impact on testosterone levels. The participant mentions having a genetic predisposition for higher vitamin D needs and has been taking 3000-4000 IU of supplemental vitamin D for a prolonged period, believing it optimizes testosterone. Their past blood test results (66 nanomoles per liter, a year prior) are reviewed, confirming healthy testosterone levels (above 50 nanomoles per liter is considered sufficient). The units of measurement (nanomoles per liter) are clarified.
Vitamin D Conversion and Levels
00:43:39 - 00:45:43
This segment focuses on converting vitamin D levels from nanomoles per liter to nanograms per milliliter. A patient's vitamin D level was initially 54 nanomoles per liter (equivalent to 24 nanograms per milliliter) in 2017 and increased to 66 nanomoles per liter (approximately 26 nanograms per milliliter) after two years of supplementation. The discussion highlights the confusion caused by different units of measurement, with the patient's level considered low (below 50 ng/ml) despite the higher nanomoles per liter reading. A recommendation is made to increase supplementation to 10,000 IU to achieve a level above 50 ng/ml. The speakers discuss the lack of a central resource for unit conversion, suggesting using online searches for specific conversions. The conversation concludes with the patient's intention to retest their vitamin D levels and a comparison to average American levels and those found in hunter-gatherer tribes, noting that a 30 ng/ml level is often considered acceptable in the US.
Vitamin D Levels and Societal Norms
00:45:43 - 00:47:28
This segment discusses the optimal levels of Vitamin D and how societal norms influence the definition of "normal" ranges in blood tests. The speakers note that average Vitamin D levels in a specific tribe ranged from 70-100 ng/ml, contrasting with potentially lower "normal" ranges in modern society. One speaker references their book, "Estrogeneration," to illustrate how societal changes can lower average hormone levels, leading to a shift in what's considered normal. The conversation highlights the concern that current "normal" ranges for Vitamin D might be too low, with potential health risks associated with levels below 50 ng/ml. While acknowledging that correlations don't equal causation, the speakers advocate for maintaining Vitamin D levels above 50 ng/ml to minimize health risks. A recent study questioning the effectiveness of Vitamin D supplementation is mentioned, but countered with the assertion that supplementation does increase serum levels, although individual responses may vary.
Vitamin D Dosage and Conversion
00:47:31 - 00:49:05
The discussion centers on the risks of exceeding 100 in unspecified units of vitamin D intake, citing potential calcium buildup and arterial stiffening. High daily doses (e.g., 50,000 units) can rapidly elevate levels above this threshold. The speakers then delve into the difference between vitamin D3 (cholecalciferol) and calcitriol, explaining that the body needs to convert D3 to the active form, calcitriol, via the CYP2R1 gene. The conversation highlights that while D3 is often considered the active form, it requires conversion, and individuals with less efficient conversion may need higher D3 intake to achieve optimal calcitriol levels. The inability to directly supplement with calcitriol is noted as a limitation.
Compound Supply and Conversion Efficiency
00:49:06 - 00:49:44
The discussion centers on the cost and supply of a compound. One speaker notes the high cost, making it accessible primarily in research settings like the Mayo Clinic. The speakers agree on the need for an oversupply of the first compound to ensure sufficient conversion, even if efficiency is reduced. A target of 60-70% is suggested, compared to the current 26%, with the expectation that this percentage will increase. Consistent supplementation is mentioned as a potential factor influencing the current level. Maintaining close monitoring of the compound levels is recommended.
Estrogen Receptor Analysis
00:49:45 - 00:50:22
The conversation shifts to estrogen levels and the analysis of the ESR1 gene (estrogen receptor alpha). The speaker highlights the relatively low number of positive genes related to estrogen, contrasting it with the potentially high number found in other areas like the gut. Only one "plus plus" gene is noted, specifically the estrogen receptor alpha. The existence of two estrogen receptors (alpha and beta) is explained, with the beta receptor identified as protective against prostate cancer in men and breast cancer in women.
Resveratrol and Alpha Receptor Discussion
00:50:22 - 00:51:14
The discussion centers on the impact of resveratrol on alpha receptors and its potential link to increased breast cancer risk. A gene variant resulting in increased alpha receptor production is identified as undesirable due to potential estrogen-related issues. While acknowledging the potential negative effects, the speaker suggests that cycling resveratrol intake might be acceptable, given the overall genetic context. The speaker also expresses approval for the recommendations in the report, specifically mentioning sauna use. Broccoli and cauliflower consumption are mentioned as part of a healthy diet.
Thyroid Hormone Conversion Analysis
00:51:14 - 00:52:11
The conversation shifts to a discussion of thyroid hormones and their conversion. The speaker explains the confusing labeling of thyroid hormones (T1, T2, T3, T4), noting that T4 converts to T3, contrary to typical expectations. The individual's genetic profile shows reduced T4 to T3 conversion. Based on this, the speaker advises against using T4-only thyroid medication (like Synthroid) in the future, as it would likely be poorly converted to the active T3 form, potentially leading to system overload.
Thyroid Hormone and Iodine Supplementation
00:52:12 - 00:53:26
The discussion cautions against using Synthroid for thyroid hormone replacement, suggesting it may not be suitable for everyone and carries risks, especially for individuals with heart palpitation risk. The speaker emphasizes the importance of iodine supplementation as a safer alternative, particularly given the potential for heart palpitations and even permanent AFib from thyroid hormone overdoses. The speaker notes that while many doctors prescribe Synthroid, it's crucial to be cautious, especially with a pre-existing heart condition. Iodine, a building block for thyroid hormones, is recommended as a safer approach, suggesting consuming iodine-rich foods like seafood or taking iodine supplements.
Retinol, Cannabis, and COMT Gene Considerations
00:53:26 - 00:53:49
The conversation briefly touches upon retinol, noting its appearance in subsequent discussions with both positive and negative aspects. The interaction between cannabis use and the COMT gene is also mentioned. While not necessarily a significant health concern, it's noted that cannabis use might lead to lower-than-normal dopamine levels in individuals with this specific gene. The discussion ends abruptly at this point.
MTHFR Gene and Health Implications
00:53:49 - 00:55:33
This segment discusses the MTHFR gene and its impact on health. The speakers initially talk about avoiding smoking due to negative health effects. The conversation then shifts to the MTHFR gene, specifically the C677T variant. It's noted that even a plus-minus variation of this gene can cause health problems, reducing folic acid processing efficiency by approximately 35%. The speakers emphasize avoiding folic acid supplements and instead recommending methylfolate, either through consuming leafy green vegetables or taking a supplement. Methylfolate is highlighted as a DNA building block that improves sleep and overall health. The importance of consistent leafy green consumption or methylfolate supplementation is stressed, particularly for individuals with the MTHFR gene variant.
Supplement Recommendations and Dietary Habits
00:55:39 - 00:57:36
The discussion centers on supplement recommendations, specifically focusing on 5-MTHF, B12, and creatine. The speaker highlights the benefits of 5-MTHF for sleep improvement, citing positive Amazon reviews. The importance of B12 is emphasized, particularly for vegans due to potential low gut uptake. Creatine is suggested as a potential supplement for vegans. The conversation then shifts to the speaker's past vegan diet, acknowledging that nutritional awareness was lacking. The speaker points out a common misconception where people prioritize veganism over nutritional value, similar to the gluten-free trend. The discussion concludes with the speaker's confirmation of a meat-heavy diet, leading to the suggestion that additional supplementation might be unnecessary due to sufficient nutrient intake from food. The potential for high blood test results from over-supplementation while consuming a meat-rich diet is mentioned, suggesting discontinuation of supplements in this case.
Fructose, Soda, and Dietary Choices
00:57:36 - 00:59:13
This segment focuses on the gene PNPLA3, its relation to fructose metabolism, and the impact of dietary choices, particularly soda consumption. The speakers discuss how the liver stores fructose as fat rather than burning it as energy, highlighting the negative effects of high fructose intake. The discussion emphasizes the high fructose content in soda, specifically mentioning high fructose corn syrup as a major concern. One speaker provides a link to a website listing fruits high and low in fructose, using figs and blueberries as examples. Differences in fructose consumption are noted between the US, with its high consumption of high fructose corn syrup, and Australia, where sucrose (table sugar) is more common in soft drinks. The conversation concludes with a personal anecdote about the occasional indulgence in soda, even while following a ketogenic diet, and a description of using a CO2 infuser to create carbonated water as a healthier alternative.
Dr. J's Recipes and Website Traffic
00:59:14 - 01:00:26
A discussion unfolds about a unique cold beverage recipe involving tangerine essential oil, stevia, and vanilla extract, described as similar to an Orange Julius. The suggestion is made to include this and other recipes on Dr. J's website under a "Recipes by Dr. J" section. The high traffic (3,000 unique visitors weekly) to Dr. J's existing "What I Use" page is highlighted, emphasizing its unexpected popularity and the actionable nature of its content for viewers seeking to identify products with undesirable chemicals. The page's success is attributed to its initial conception as an afterthought, yet its growth is driven by high user engagement and interest.
Transitioning to Fragrance-Free Products
01:00:27 - 01:00:37
The conversation shifts to the documentary "Stink" and its impact on Dr. J's decision to transition to fragrance-free products. The documentary is praised, and Dr. J confirms their current efforts in this transition.
Fragrance and Personal Care Products
01:00:38 - 01:01:22
The discussion begins with a conversation about fragrance-free products and personal care. One participant expresses a desire to use aftershave but is unsure about the potential impact on health. Another suggests focusing on applying products to clothing rather than skin to minimize exposure. The conversation touches upon the idea of balancing healthy habits, suggesting that if most choices are healthy, occasional indulgences might be acceptable. The discussion then transitions to the topic of fitness and exercise.
Genetics and Exercise Recommendations
01:01:22 - 01:02:14
The conversation shifts to the participant's genetic predisposition towards endurance activities. It's noted that the participant possesses slow-twitch muscle fibers and the ADRB3 gene, both associated with elite endurance athletes. Based on this genetic profile, the recommendation is to incorporate more endurance training into their fitness routine. The participant mentions their current workout regimen, which involves high-intensity interval training (HIIT) like P90X, and the impact of COVID-19 on their fitness habits.
High-Rep Training and Muscle Growth
01:02:19 - 01:03:09
The discussion centers on a training method involving high repetitions (15-20 reps) of exercises like pull-ups and push-ups, contrasting with traditional weightlifting approaches (e.g., 3 sets of 50 reps). The speaker highlights the significant muscle growth observed with this high-rep method, particularly for individuals possessing a specific gene variant. Anecdotal evidence is provided, mentioning conversations with Mr. Olympia competitors who, upon learning about this gene and training method, expressed regret at not knowing it sooner. The speaker emphasizes the gene's role in facilitating fat-to-energy conversion.
Genetic Predisposition to Diet and Exercise
01:03:09 - 01:04:00
The conversation shifts to the connection between genetics and dietary preferences. The speaker notes the gene variant's alignment with low-carb recommendations and the prevalence of genes favoring meat consumption, reflecting ancestral diets. However, the speaker acknowledges exceptions, mentioning encounters with individuals whose genes are compatible with vegan diets. The discussion also touches upon the variability in individual responses to carbohydrates, with some individuals exhibiting a high tolerance, although this is considered less common than the genetic predisposition towards meat consumption.
Dietary Approaches and Genetic Predisposition
01:04:06 - 01:04:58
The discussion begins with a reflection on the challenges of recommending diets, highlighting the importance of individual genetic predispositions. The speakers discuss how people often dogmatically adhere to specific diets without considering their unique genetic makeup. The conversation shifts to the oversimplification of information in the digital age, where nuanced discussions are replaced by simplistic solutions. The focus then turns to the individual's genetic profile, specifically mentioning a high number of genes related to joint health.
Genetic Risk Factors for Rheumatoid Arthritis
01:04:59 - 01:06:24
The speakers analyze the individual's genetic markers, specifically HLA genes (HLA, DRB1, DRB9, DQA1), noting a four-fold increased risk for rheumatoid arthritis due to the DRB9 gene and approximately two-fold increased risk from others. The discussion emphasizes that high insulin levels trigger the DRB9 gene's effect, suggesting that maintaining good blood sugar control mitigates this risk. Other genes, such as interleukin genes (IL2 and IL1), are identified as inflammation markers, highlighting the impact of diet on joint health. The conversation also touches upon the TRAF1 gene, another risk factor for rheumatoid arthritis related to TNF cytokine, reiterating the importance of a healthy diet and lifestyle. Finally, the speakers acknowledge that even with optimal lifestyle choices, joint pain might still occur later in life.
TNF-alpha and Rheumatoid Arthritis Treatment
01:06:25 - 01:07:30
This segment focuses on the TNF-alpha gene and its role in rheumatoid arthritis treatment. A speaker suggests investigating this gene due to its extensive research and the availability of effective solutions. They mention conversations with researchers in Boston who have seen remarkable results using an antibody against TNF-alpha, injected directly into the joints of patients with severe rheumatoid arthritis. This treatment reportedly provides dramatic pain relief, described as a "miracle," reducing pain from a 10/10 to nothing. However, the high cost due to patents on these antibody injections is noted, with the expectation that prices will decrease once patents expire in approximately 20 years.
Post-Patent Medication and Gout Risk Assessment
01:07:31 - 01:08:17
The discussion centers on the speaker's assessment of the patient's health risks, specifically concerning post-patent medications and gout. The speaker acknowledges that once medications go off-patent, generic versions will become available, potentially impacting the patient's access and cost. However, the speaker expresses minimal concern due to the patient's healthy lifestyle choices, including avoiding high-carb and processed foods, and sufficient sleep. The speaker also addresses the patient's genetic predisposition to gout, noting two risk genes. However, the speaker believes the risk is low due to the patient's lifestyle and suggests simple preventative measures like staying hydrated and limiting fructose consumption.
Nashville Trip and Music Industry Connections
01:08:17 - 01:08:51
The conversation shifts to a personal anecdote. The speaker mentions a recent conversation with someone from Nashville, Tennessee, who possesses a specific gene (SLC289) associated with gout and has experienced gout episodes. This individual, approximately 60 years old, has invited the speaker to Nashville. The speaker expresses excitement about the invitation, mentioning connections to various professional musicians, including Chris Jansen and Luke Combs, highlighting the contrast in their fame between the US and Australia. The speaker also expresses their fondness for the Nashville music genre.
YouTube Success and Gout Discussion
01:08:54 - 01:09:41
The speaker mentions plans to visit Ken Berry, a YouTuber with over a million subscribers, in Nashville. The speaker recounts a humorous interaction where Berry, despite his large following, sought advice on growing a YouTube channel from the speaker, who has a significantly smaller subscriber base (5,000 vs. 2 million). The difference is attributed to Berry's full-time dedication to YouTube, unlike the speaker who works at the Mayo Clinic. The conversation then transitions to a discussion about gout.
Gout and Diet
01:09:41 - 01:10:11
The conversation shifts to a discussion about gout and its connection to diet. A recent conversation with an individual suffering from gout is recounted. This person consumed a standard American diet high in soda, processed foods, and high fructose corn syrup, even in salad dressings. The speaker highlights the irony of doctors advising this individual to stop eating meat while ignoring the significant role of high fructose corn syrup and processed foods in his gout.
Spinal Disc Health and Exercise
01:10:12 - 01:10:52
The discussion centers on the risk of low back issues, linked to a specific gene related to spinal discs. A two-fold higher risk is noted. The speaker advises caution with deadlifts, recommending against excessive exertion. The role of curcumin in inhibiting interleukin, another cytokine gene, is mentioned, further emphasizing the need for careful exercise management.
Blood Pressure Management and Genetic Predisposition
01:10:52 - 01:11:55
The conversation shifts to blood pressure, specifically mentioning high blood pressure and the AGT gene (angiotensinogen). The speaker explains that this gene significantly impacts blood pressure and that if blood pressure medication becomes necessary, targeting angiotensin is crucial due to the genetic predisposition. The speaker highlights the often trial-and-error approach doctors take with blood pressure medication, emphasizing the advantage of using genetic information to guide treatment. The benefits of beet juice in increasing nitric oxide, relevant to blood pressure management, are also discussed.
Citrulline and Blood Vessel Health
01:11:55 - 01:12:33
The conversation begins with a discussion of citrulline's benefits for blood vessels. Citrulline is presented as a lower-carb alternative to another supplement with similar effects. One speaker mentions using citrulline specifically for workouts, suggesting pre-workout use. The discussion then shifts to the topic of blood pressure, with one speaker mentioning aspirin, which is quickly clarified as not being part of the discussed supplement. A speaker corrects their initial thought, clarifying they were considering heart health rather than blood pressure.
Aspirin and Blood Health
01:12:34 - 01:12:59
The conversation turns to the rare recommendation of aspirin, specifically a baby aspirin, for individuals with a specific gene, F5 (factor V), which can lead to thicker blood. Aspirin's role in inhibiting this effect is explained. The rarity of this recommendation is emphasized, and the speakers express surprise at the possibility of aspirin being mentioned in a related document, suggesting it would be a typo.
Bone Strength and DEXA Scans
01:13:03 - 01:13:21
The discussion concludes with a focus on bone strength. The speakers note the significant bone strength benefits of a particular supplement, mentioning two "pluses" indicating strong bone health. Despite this, a bone break is mentioned, which is not considered surprising given the context. The conversation ends with a suggestion to get a DEXA scan and share the results via email, anticipating positive feedback on bone density.
Genetic Factors Influencing Physical Capabilities
01:13:21 - 01:15:13
This segment focuses on the discussion of specific genes and their impact on physical attributes. The speakers analyze genes related to bone density, noting that while some individuals possess genes leading to exceptionally high bone density ("iron" bone density), others have a mix of good and bad genes resulting in an average bone strength. The conversation then shifts to a gene affecting pain sensitivity, specifically in the context of Charcot-Marie-Tooth disease (CMT). It's clarified that the impact of this gene on pain sensitivity isn't extreme, and that other genes play a more significant role. The speaker explains that the reduced pain sensitivity is categorized differently, possibly as mechanical versus proprioceptive pain, highlighting the importance of paying attention to pain signals despite the reduced sensitivity to prevent injuries like elbow or bicep damage during exercise. The discussion concludes with a question about any further inquiries regarding the genetic analysis of physical capabilities.
Sleep Gene Analysis and Lifestyle Discussion
01:15:13 - 01:17:08
The discussion shifts to the listener's sleep genes. The speaker explains that while several genes related to sleep patterns are present, two genes related to Seasonal Affective Disorder are less concerning due to the listener's location in Australia. The speaker notes the listener's conscious efforts to incorporate morning light exposure for melatonin regulation. The listener confirms not experiencing winter sadness. The speaker contrasts this with the potential for issues in a colder climate like Minnesota. The listener's genes suggest a predisposition towards being a night person, a preference the speaker advises not fighting unless career demands necessitate it. The speaker suggests manipulating the brain's perception of time to improve sleep, even if bedtime is early. The PER3 gene is highlighted as the primary indicator of morning versus night preference, with the listener's result being inconclusive but leaning towards a night owl preference.
Sleep Optimization Techniques
01:17:08 - 01:18:37
The conversation begins with a speaker discussing their interest in sleep hacking and a piece they're writing titled "How to Sleep Like a Caveman," focusing on applying paleo diet principles to sleep, including low light and temperature control. Another speaker shares an anecdote about staying in a San Francisco apartment with inadequate light blocking, highlighting the negative impact of streetlights on sleep. This leads to a discussion about the importance of creating a completely dark sleep environment. One speaker describes their own "slaughter room" bedroom, completely blacked out with aluminum foil on the windows to ensure no light penetration. The conversation concludes with a speaker mentioning their method of testing blackout curtains by purchasing them for their and their children's bedrooms.
Blackout Curtains and Travel Sleep Solutions
01:18:41 - 01:19:50
The conversation begins with a discussion about the effectiveness of blackout curtains. The speaker notes that many curtains advertised as "blackout" still allow light to penetrate, requiring a thorough check in-store by holding them up to a light source. The inadequacy of standard blackout curtains for complete light blockage is highlighted. An alternative solution is introduced: "Grow Blinds," a type of blackout blind with suction cups, allowing for easy travel and use in various locations, including hotel rooms. The speaker recommends these blinds for their effectiveness and portability, contrasting them with the difficulties of achieving darkness in hotel rooms using existing bedding. A link to the product is offered, and the recipient confirms they have already found it online.
Sleep Hacking and Genetic Factors
01:19:50 - 01:20:07
The discussion shifts to "sleep hacking" and the role of genetics. Two genes, CLOCK and ABCC9, are identified as particularly relevant. The CLOCK gene is highlighted as especially important, and clinical studies using lithium to influence this gene and improve deep sleep are mentioned.
Magnesium Supplementation and Sleep
01:20:09 - 01:21:18
The conversation centers on optimizing magnesium intake for improved sleep. One participant mentions using magnesium threonate for sleep but not regularly. Another suggests consistently taking magnesium, especially given a gene's higher responsiveness to it for sleep. The discussion then shifts to different magnesium types (e.g., glycinate, oxide) and their absorption. A participant notes that the type of magnesium matters most if one is deficient; otherwise, the body maintains magnesium levels regardless of the form taken. The importance of adequate magnesium levels and the impact of digestive system efficiency on absorption are also highlighted.
Glycine, Magnesium, and Sleep Supplements
01:21:18 - 01:23:19
The discussion centers on the use of glycine and magnesium supplements, particularly magnesium glycinate, to improve sleep. Concerns are raised about potential side effects like diarrhea from overdosing. While the speaker acknowledges that the effectiveness of glycine supplementation varies depending on individual sleep genes, they generally recommend it. Magnesium glycinate is highlighted as a way to increase glycine intake, leading to anecdotal improvements in sleep for some individuals. However, the speaker cautions against dogmatic adherence to this supplement, emphasizing that its impact is gene-dependent. The speaker prefers taking glycine and magnesium separately, citing the unpleasant taste of glycine powder and the convenience and tastelessness of magnesium citrate powder. The importance of sleep tracking to assess the effectiveness of any supplement is stressed. Finally, potassium supplements are suggested as another potential sleep aid, along with low-dose lithium (5mg/day).
Sleep Tracking and Improvement Strategies
01:23:20 - 01:24:34
This segment focuses on the importance of sleep tracking and the impact of various factors on sleep quality. One individual mentions using a sleep tracker and observing the effects of different interventions. They discuss the significance of REM sleep for emotional well-being and the less noticeable but crucial role of deep sleep in overall health. The individual highlights a 10% increase in deep sleep after darkening their room and a similar positive effect after starting Nicotinamide Riboside (NR) supplementation. Another individual expresses interest in trying NR and mentions having a large supply of supplements. The discussion concludes with a brief mention of ordering supplements through a clinic.
Post-Interview Reflections and Logistics
01:24:37 - 01:25:16
The speakers discuss the experimental nature of the interview's content, with one expressing surprise at the breadth of topics covered. One speaker mentions taking extensive notes, highlighting the interview's richness. The conversation then shifts to logistics, with a request to share the recorded file via Dropbox. A confirmation of this action is given.
Podcast Perks and International Shipping Challenges
01:25:16 - 01:26:15
One speaker explains their usual practice of sending T-shirts and roasted coffee to podcast guests, but notes that this won't be feasible for guests in Australia due to high shipping costs. An anecdote is shared about a famous Australian requesting several copies of the speaker's book, where the shipping cost significantly exceeded the book's value. The high cost of international shipping to Australia is reiterated, and a future visit to Australia is mentioned as a potential solution for delivering the gifts.
Hunting and Australian Wildlife
01:26:15 - 01:27:07
The conversation shifts to hunting, with one speaker mentioning deer hunting and the other sharing that kangaroo hunting is permitted in Australia, contrasting the perception of kangaroos in America versus Australia. The Australian speaker notes that kangaroo meat is readily available in supermarkets, and the other speaker expresses amusement and interest. Future plans to meet for coffee and engage in spearfishing and scuba diving in Australia are discussed.
Coffee Maker and AeroPress Discussion
01:27:07 - 01:27:34
One speaker mentions a copper AeroPress-style coffee maker they had custom-made, highlighting the difference between the plastic AeroPress and their copper version. The superior heat retention properties of the copper maker are discussed, emphasizing the importance of pouring hot water over coffee oils for optimal brewing.
Podcast Discussion and File Transfer
01:27:34 - 01:28:11
The conversation begins with a discussion about a copper mold, described as "amazing," contrasting it with a potentially problematic "soft plastic" alternative. One speaker mentions a recent message and tag in a post, expressing appreciation for the other's participation in a podcast. Gratitude is expressed for the podcast version and the enjoyable conversation. Finally, one speaker offers to send a file, suggesting they will either receive a message when it's ready or proactively check for it. The conversation concludes with pleasantries and farewells.
DNA with Dr. Jay, Episode 12.
CURED HIS ALLERGIES Firefighter Vincent (from Quebec)
CURED HIS ALLERGIES Firefighter Vincent (from Quebec)
Detailed A.I. Summary
**CLICK HERE TO READ
Podcast Introduction and Host Background
00:00:00 - 00:01:38
Anthony J. Cast introduces his podcast, highlighting its high audio quality and focus on DNA analysis. He mentions his affiliations with the Mayo Clinic, his consulting company (AJ Consulting Company), his authorship, and his two YouTube channels (Anthony J. Cast and Anthony J. Family Cast). He then previews his conversation with Vincent, a Canadian firefighter, noting the slightly lower audio quality due to Skype recording but emphasizing the fascinating discussion, particularly Vincent's experience with allergy elimination through improved breathing. Cast also shares his own similar experience with allergy relief.
Fishing and Firefighting in Montreal
00:01:38 - 00:03:33
The conversation begins with a discussion about Vincent's profile picture featuring a walleye, leading to a discussion of fishing in the Montreal area, specifically the St. Lawrence River and its muskie population. Vincent describes his work as a full-time firefighter in Montreal, clarifying that part-time positions are uncommon in larger cities. Cast mentions the high job satisfaction associated with firefighting, which Vincent confirms. The segment concludes with Vincent confirming receipt of a PDF sent by Cast.
Genetic Report Overview and Interpretation
00:03:33 - 00:06:29
Anthony J. Cast explains the report, highlighting that it analyzes genes from both parents. He focuses on identifying "bad genes" rather than good ones. He notes that a "plus plus" indicates a bad gene from both parents, while "plus minus" signifies a bad gene from one parent and a good one from the other. The discussion centers on the patient's relatively young age (37) and the preventative potential of addressing identified genetic risks. The first "plus plus" gene discussed is CETP (cholesterol ester transfer protein), a minor Alzheimer's risk factor, significantly mitigated by maintaining low triglycerides. The importance of optimizing triglyceride levels, considering the different units used in Canada, is emphasized. Vincent confirms having converted the units previously.
Blood Sugar Optimization and HbA1c Levels
00:06:36 - 00:09:06
This segment focuses on optimizing blood sugar levels. Anthony J. Cast emphasizes the difference between merely avoiding illness and actively optimizing health metrics, using blood sugar as an example. He aims for blood sugar levels below 90 (American units), contrasting this with doctors' acceptance of levels around 95. Vincent shares his recent non-fasting blood work results, mentioning a HbA1c level of around 5.2. Anthony notes this is slightly high, ideally aiming for below 5. Vincent explains his typically low-carb diet and mentions Rob Wolf's explanation for potentially higher HbA1c levels in low-carb individuals, attributing it to longer red blood cell lifespan. Anthony acknowledges this explanation but also points out that often, perceived "adaptive glucose sparing" actually masks higher blood sugar levels. He concludes by stating that Vincent's HbA1c is already near optimal.
Blood Test Results and Lifestyle Discussion
00:09:06 - 00:11:00
Anthony J. Cast discusses Vincent's blood test results, noting the variability in blood test values over time. He emphasizes the importance of monitoring triglycerides and suggests that Vincent's regular cardio training likely contributes to good triglyceride levels. The conversation then shifts to intermittent fasting. Anthony suggests intermittent fasting, particularly if Vincent stops training in the morning, noting Vincent's email mentioning breakfast. Vincent explains his past experience with intermittent fasting, including extended fasts of three days, and his current preference for a less consistent approach due to changes in routine and convenience. He describes his current diet, which includes a small breakfast of rice, beans, vegetables, and eggs, providing him with energy for daily training. Anthony acknowledges the consistency of Vincent's daily training.
Breakfast, Training, and Carb Metabolism
00:00:00 - 00:12:17
The conversation begins with a discussion about the speaker's usual breakfast and training schedule, with a two-hour gap between the two. Anthony J. Cast repeatedly affirms the speaker's routine. The discussion then shifts to the speaker's carb metabolism and how their body handles carbs, noting a lack of significant fatigue from carb intake. Anthony J. Cast attributes this to good genes, referencing a later discussion on diabetes risk genes. The speaker mentions noticing a difference in their energy levels when consuming a standard American diet at the firehouse versus their controlled diet at home. Anthony J. Cast agrees and mentions a future discussion about the risks of diabetes, reiterating that the speaker's body handles carbs well compared to most. The conversation concludes with Anthony J. Cast expressing preference for intermittent fasting when not training.
Anxiety Gene Discussion
00:12:18 - 00:13:01
Anthony J. Cast discusses Vincent's TPH2 gene, a serotonin transporter. He explains that since 90% of serotonin is produced in the gut, good gut health is key. He notes that the plus plus genotype is common in 60% of people and not necessarily a major concern unless anxiety is a significant issue. He also mentions Vincent's rapid caffeine metabolism.
Caffeine Metabolism and Pre-Workout Supplements
00:13:02 - 00:14:00
Vincent confirms his ability to tolerate caffeine late in the day. Anthony J. Cast explains that efficient caffeine metabolism can aid glucose uptake in muscle cells, making caffeine a good pre-workout option for Vincent. They discuss the difference in caffeine tolerance between coffee and pre-workout supplements, with Anthony J. Cast suggesting coffee as a preferable source due to the higher caffeine concentration in pre-workout supplements. He concludes by stating that a plus plus genotype in this gene isn't inherently negative.
Lifespan Genes: NYN and SIRT1
00:14:01 - 00:14:35
Anthony J. Cast moves on to lifespan genes, mentioning NYN and SIRT1. He expresses less concern about NYN, suggesting sufficient zinc intake likely mitigates any potential issues. He focuses on SIRT1 (Sirtun), explaining that higher levels are associated with longer lifespans, while lower levels are linked to shorter lifespans. He notes that Vincent's body produces less Sirtun.
Sirtuin-Boosting Supplements and Their Effects
00:14:35 - 00:16:33
Anthony J. Cast discusses supplements that increase Sirtuin levels, focusing on resveratrol and apigenin. He explains that resveratrol's effectiveness depends on an individual's genetic makeup, affecting about 50% of the population. He notes that high doses of resveratrol can act like estrogen, advising caution, especially for those with specific estrogen genes. As an alternative, he suggests proanthocyanidins. The conversation then shifts to apigenin, another Sirtuin booster included in Vincent's night cocktail alongside magnesium, L-theanine, and epigenin. Anthony J. Cast mentions that while noticeable effects might not be immediate, apigenin offers prostate cancer protection. However, he cautions that apigenin, like resveratrol, exhibits mild estrogenic effects, recommending discontinuation if estrogen-related symptoms appear and suggesting a switch to proanthocyanidins. The discussion concludes with an explanation of the difference in the way testosterone and estrogen bind to receptors in the body.
Apigenin and Receptor Activation
00:16:33 - 00:18:56
Anthony J. Cast explains that apigenin activates the beta receptor, which is protective against prostate and breast cancer, unlike the alpha receptor, which increases the risk of these cancers. While apigenin's beta receptor activation is beneficial, it also acts like estrogen, potentially causing issues for some individuals. Vincent mentions switching supplements to keep receptors active and avoid desensitization. Anthony J. Cast agrees, suggesting rotating supplements and researching those that increase sirtuin, a gene linked to lifespan extension, but cautions about verifying the research behind such supplements due to misinformation online. He notes that significant amounts of certain supplements are needed to increase sirtuin, and these amounts might also act like estrogen.
Genetic Predisposition Discussion
00:18:58 - 00:21:21
Anthony J. Cast reassures Vincent about potential estrogen gene concerns, stating that unless Vincent has terrible estrogen genes, he shouldn't worry. The conversation then shifts to Vincent's past gut issues, acne, and treatment with antibiotics and Accutane. Vincent mentions significant dietary changes that resolved many of these problems. Dr. Cast notes Vincent's gut and sleep genes as potentially weak areas, although Vincent reports managing stress and sleep through breathwork. Dr. Cast emphasizes the importance of stress management and sleep, suggesting that genetic predispositions may become more apparent with age. The discussion then turns to Vincent's diet, noting a couple of diabetes risk genes but emphasizing that humans aren't built for high-carb diets. Dr. Cast contrasts Vincent's relatively few genetic concerns with cases where patients have numerous gene issues leading to prevalent family history of diabetes.
Genetic Predisposition and Lifestyle Recommendations
00:21:22 - 00:23:35
Anthony J. Cast discusses the patient's genetic predispositions, specifically mentioning the HEX gene, which increases the risk of type 2 diabetes threefold, especially with a standard American diet. He explains that this gene is related to nitric oxide production in the pancreas. He recommends exercise as the best way to increase nitric oxide, and suggests citrulline supplements as an alternative if exercise isn't feasible. Zinc intake is also emphasized, either through diet or supplementation. Regarding intermittent fasting, Anthony mentions the MC4R and AdiPoQ genes, suggesting that intermittent fasting is beneficial, especially considering the prevalence of the MC4R gene. However, he notes that regular exercise can modify the impact of these genes. Vincent shares his current eating habits, which naturally incorporate a form of intermittent fasting due to his family dinner schedule. Anthony affirms the benefits of this pattern and highlights that late-evening snacks negatively affect sleep quality.
Dietary Strategies and Genetic Predisposition
00:23:40 - 00:25:09
Anthony J. Cast discusses dietary strategies for weight management, suggesting more aggressive intermittent fasting if training decreases. He notes the individual's genetic profile, mentioning common genes (adipoq, mcm4r) and their implications for dietary frequency. He highlights that the individual's genetic makeup allows for more frequent eating than most. The conversation then shifts to metformin, its use for lifespan extension, and the individual's higher responsiveness due to their genetic profile. Metformin is recommended if blood sugar levels (above 90 in American units or 5 in millimoles) or hemoglobin A1c remain elevated.
Challenges in Accessing Metformin
00:25:09 - 00:25:38
Vincent points out the challenges of obtaining metformin in Canada, requiring a prescription and blood work, which adds to the cost and difficulty of accessing it. Anthony J. Cast agrees, noting the difficulty in convincing doctors to prescribe metformin if blood sugar levels appear normal.
Metformin and Lifespan Extension
00:25:41 - 00:27:53
Anthony J. Cast discusses the use of metformin for lifespan extension, noting that while doctors may be hesitant to prescribe it if the patient mentions research on its effects, it's more readily available in Canada. He contrasts the American healthcare system's focus on managing risk versus optimization. Anthony explains that biostatisticians employed by healthcare systems use statistical analysis to determine the acceptability of certain risks for the general population, similar to insurance companies but with less flexibility. He recommends a 500mg dose of metformin before bed to help manage blood sugar and mentions potential mild nausea as a side effect. The conversation then shifts to Vincent's family history, revealing some instances of diabetes and heart disease, but also a 90-year-old grandfather who survived COVID-19. Anthony comments positively on Vincent's seemingly good genes related to aging, particularly concerning heart disease and cholesterol.
Triglyceride and Cholesterol Levels Discussion
00:27:54 - 00:30:13
Anthony J. Cast advises Vincent to monitor his cholesterol and, more importantly, his triglycerides. Vincent reveals his previous triglyceride level was 0.43 millimolar. After a brief conversion calculation, Anthony J. Cast clarifies that this equates to approximately 38 milligrams per deciliter, which is exceptionally low and considered excellent. He notes this is lower than most individuals he's consulted, regardless of age. The conversation then shifts to Vincent's diet, with Anthony J. Cast inquiring about his fat intake. Vincent describes his diet as normal, not high in fat, mentioning his consumption of eggs, butter, and specific oils like olive, avocado, and coconut. Anthony J. Cast approves of these choices, emphasizing the positive impact of animal fats. He concludes that Vincent possesses excellent genes regarding heart disease, particularly concerning the LPL gene, and expresses less concern about the LPA gene. Vincent agrees that maintaining low triglycerides is key, and Anthony J. Cast suggests checking the LPA level, specifically mentioning the "LPLittle A" test.
Lipid Panel and Genetic Predisposition to Gluten Sensitivity
00:30:13 - 00:32:12
Anthony J. Cast discusses the patient's lipid panel, suggesting an optimal level below 30 milligrams per deciliter. While acknowledging the presence of the LPA gene, he notes the low triglycerides make high LPA unlikely, but recommends checking it. He expresses less concern about CRP. The discussion then shifts to the "leaky gut" section of the genetic report, highlighting multiple "plus plus" markers, including CDKAL1, ATG16L1, and another ATG gene. Based on these findings, Dr. Cast hypothesizes a significant gluten sensitivity, emphasizing the strong correlation between the ATG gene markers and gluten-related inflammation. He explains that having two "plus plus" markers on the same gene significantly increases the risk of gut issues, potentially fivefold, and strongly suggests avoiding gluten, despite acknowledging that the gene isn't entirely predictive. The conversation concludes with a reference to the patient's previous dietary inquiries, noting the omission of grains in the discussion.
Grain Consumption and its Effects
00:32:12 - 00:34:14
Anthony J. Cast inquires about Vincent's grain consumption, noting that Vincent doesn't regularly eat a lot of grains and doesn't experience significant discomfort when he does. Vincent mentions possible childhood acne as a potential link to grain consumption, though he wasn't aware of it at the time. Anthony J. Cast points out the common correlation between removing gluten or grains and improved acne. Vincent explains that he tries to cook or ferment grains well to minimize negative effects. Anthony J. Cast shares his own gluten sensitivity, describing experiencing fatigue but not gut pain from gluten, unless he foam rolls his abs afterward, which then causes significant pain. He uses this foam rolling technique to assess potential underlying issues in his patients, emphasizing the importance of establishing a baseline foam rolling experience to differentiate between normal discomfort and pain indicating a problem. He concludes that this method is crucial for identifying sensitivities, given the numerous potential factors influencing gut health.
Gut Health and Gene Interactions
00:34:20 - 00:35:06
Anthony J. Cast discusses various genes related to gut health. He mentions that several genes contribute to potential gut issues, but the presence of "good versions" of these genes mitigates the risk. Specifically, he highlights the CDK AL1 gene, which is sensitive to flavanoids found in plant supplements like grape seed proanthocyanidins, apigenin, and resveratrol. He emphasizes that consuming colorful plants regularly benefits this gene and overall gut health. Other genes are deemed less concerning unless active gut issues are present. Finally, he points out CNR1, the cannabinoid receptor gene, as another beneficial gene, suggesting that CBD may help with inflammation in those with gut problems, but not necessarily for chronic use.
Dietary Considerations and Proanthocyanidins
00:35:06 - 00:35:58
Vincent inquires about proanthocyanidins. Anthony J. Cast clarifies that proanthocyanidin is a specific compound found in grape seed extract, highlighting its significant health benefits. He notes that despite these benefits, proanthocyanidins are not widely discussed.
Grape Seed Extract and Resveratrol Discussion
00:35:59 - 00:36:37
Anthony J. Cast explains that grape seed extract is a phenomenal supplement that increases lifespan in animals tested. He notes that it typically contains around 50% proanthocyanidins and 50% resveratrol, clarifying that it's different from resveratrol itself. Vincent confirms understanding the distinction between the two. The discussion concludes with Anthony J. Cast asking if there are any further questions, to which Vincent replies negatively.
Acne, Genes, and Seramides
00:36:37 - 00:37:23
Anthony J. Cast shifts the conversation to acne and genes, mentioning the ARSAARL sulfatease gene, which is less common and affects ceramide production. He explains that ceramides are crucial for skin hydration, and supplementing with serums to increase ceramide levels can improve skin conditions. He notes that while Vincent doesn't currently have significant skin issues, increasing ceramides could be beneficial if problems arise. Vincent confirms experiencing occasional acne.
Supplement Recommendations and Vitamin D Tracking
00:37:24 - 00:38:30
Anthony J. Cast suggests exploring phyto-ceramides as a supplement option, noting that regular ceramides aren't readily available as supplements. He also proposes acetyl cysteine (referred to as "knack") due to its sulfur content, relevant to aryl sulfatease. While acknowledging sulfur's potential benefits, he prioritizes phyto-ceramides. Vitamin D supplementation is strongly recommended, with Anthony J. Cast emphasizing its importance. Vincent mentions increased vitamin D intake during winter and uses the "D-minder" app for tracking vitamin D levels, a tool unfamiliar to Anthony J. Cast. The discussion concludes with Vincent explaining the D-minder app's functionality in tracking vitamin D needs.
Vitamin D Deficiency and Seasonal Depression
00:38:31 - 00:39:38
Vincent discusses the impact of latitude on vitamin D production, noting that sufficient vitamin D synthesis from sunlight is limited to early November to early March. Anthony confirms this, adding that even with sun exposure during winter months, sufficient vitamin D production is unlikely. Vincent considers using a vitamin D lamp as a solution. Anthony suggests checking the last gene in a report, possibly overlooked, which is identified as D-E-R-T, a gene often linked to winter depression. The vitamin D lamp is presented as a potential solution to address this gene's influence.
Addressing Vitamin D Deficiency and Seasonal Depression
00:39:38 - 00:40:46
Anthony J. Cast discusses the importance of vitamin D, especially as one ages, noting that while vitamin D supplements might help, they aren't a complete solution. Vincent mentions experiencing more depressive thoughts after working 24-hour shifts with limited sleep. He describes his post-shift routine of a light breakfast, shower, and returning to sleep. Anthony J. Cast affirms this routine is beneficial and emphasizes the importance of sufficient vitamin D, particularly during winter months in Canada's southern regions where sunlight is limited. He suggests continuing current practices, including vitamin D supplementation and maximizing sun exposure in summer. He also mentions SAD lamps as an option for seasonal affective disorder but expresses reservations due to their lack of vitamin D increase.
Vitamin D Lamps and Supplements
00:40:47 - 00:41:56
Anthony J. Cast discusses the use of vitamin D lamps, noting their effectiveness but also their danger to the eyes and high cost (around $500). He mentions owning one and testing it. The conversation shifts to the cost of travel to sunnier locations as an alternative to the lamp. Vincent inquires about the difference between vitamin D supplements and sunshine-derived vitamin D. Anthony J. Cast states there isn't a huge difference, but highlights the many unknowns in the science surrounding vitamin D, with most research focusing on diseases rather than benefits. He mentions that scientists don't have a complete understanding of vitamin D's effects.
The Benefits and Risks of Sunshine
00:41:57 - 00:43:16
Anthony J. Cast asserts that while sunshine is beneficial, there is limited research on its effects compared to the extensive research on topics like coronavirus. He uses this to illustrate the lack of comprehensive understanding of sunshine's impact. Vincent brings up the risk versus benefit aspect of sunshine, particularly concerning vitamin intake. Anthony J. Cast argues that sunburn is the primary risk, and without it, the risk is minimal, although he acknowledges dermatologists might disagree. He challenges the validity of research based on extreme cases, such as individuals who frequently get severe sunburns. He suggests that even moderate tanning bed use could be an effective alternative to natural sunlight exposure.
Estrogen Receptor Alpha Discussion
00:43:16 - 00:44:22
Anthony J. Cast discusses Vincent's genetic predisposition to higher estrogen levels due to a "plus plus" rating on the ESR1 gene (estrogen receptor alpha). He explains that this means Vincent's alpha receptor is more active than average, similar to a dimmer switch set higher than normal. This increased activity doesn't necessarily mean higher estrogen production, but rather that when estrogen is present, its effects are amplified. He notes that Vincent is already avoiding flax and seed oils, which is positive, and that the overall genetic picture isn't overly concerning due to the absence of other genes contributing to higher estrogen levels. The advice given is to simply be mindful of estrogen exposure, as its effects will be more pronounced.
Supplement and Hormone Considerations
00:44:22 - 00:45:19
Anthony J. Cast discusses the impact of supplements and certain foods on hormone levels. He mentions that sonus can help lower estrogen, and that members of the Brasica family (like broccoli) are also beneficial. However, he cautions against supplements that activate the alpha receptor, citing examples such as soy products and certain essential oils like rose and lavender. He emphasizes the importance of being careful with supplements and avoiding those with unknown estrogenic effects. The conversation concludes with Anthony J. Cast noting that consistently using unusual substances might be a concern, but the current situation doesn't seem to indicate such a pattern.
Genetic Predisposition to Vitamin A Conversion
00:45:19 - 00:46:28
Anthony J. Cast discusses the patient's genetic predisposition affecting vitamin A conversion. He notes the patient has good thyroid genes but a 50% reduction in the conversion of beta-carotene (plant-based vitamin A) to retinol (animal-based vitamin A) due to additive gene variations. This means the patient's body doesn't efficiently utilize carotene from plants. The good news is that the patient takes cod liver oil, which contains retinol, compensating for the inefficient conversion. Vincent clarifies this genetic limitation affects the conversion of vitamin A from plant sources versus animal sources. Anthony J. Cast confirms this, explaining that plants contain a different form of vitamin A that the body doesn't directly use, hence the need for conversion. He debunks the common belief that carrots are directly beneficial for eyesight due to this conversion limitation.
Dietary Habits and Cannabis Use
00:46:29 - 00:47:25
This segment focuses on Vincent's diet and past cannabis use. Anthony inquires about Vincent's diet, noting the importance of proper nutrient conversion for eye health. Vincent mentions consuming four to eight ounces of beef liver weekly and using supplements with calibere oil. Anthony praises his diet. The conversation then shifts to cannabis use. Anthony asks if Vincent uses cannabis, and Vincent replies negatively, stating that while he's not tested for it as a firefighter, he used it sparingly in his teenage years. Anthony explains that cannabis can be demotivating due to its effect on dopamine levels, but since Vincent doesn't currently use it, he shouldn't worry. The discussion concludes with Anthony mentioning the B9 section and some pluses and minuses.
Vitamin E and Dietary Considerations
00:47:27 - 00:48:26
Anthony J. Cast discusses vitamin E supplementation, stating that it's likely unnecessary if one consumes sufficient leafy greens. He highlights the importance of distinguishing between different forms of vitamin E, specifically mentioning tocotrienols and tocopherols. He emphasizes the need to avoid tocopherols, as they can trigger inflammation by activating the GSTP1 gene and increasing interleukin levels in the body. This inflammation is deemed unnecessary, and he advises against consuming tocopherols found in multivitamins and similar products. The focus shifts from what to consume to what to avoid regarding vitamin E intake.
Supplement List and Detox Section Discussion
00:48:26 - 00:49:33
Anthony J. Cast reviews a supplement list, noting the limited number of supplements and the absence of vitamin E, explaining that plant-based vitamin E alternatives are derived from petroleum and thus unlikely to be included in plant-based supplements. He then asks about questions regarding the detox section, mentioning additional genes but focusing on the discussion of nightshades. Vincent raises concerns about nightshades and other items like caffeine, GenCo, pepper, and GMG, noting that these are broken down more slowly. Anthony J. Cast clarifies that these restrictions only apply if individuals experience food sensitivities.
Food Sensitivities and Genetic Predisposition
00:49:33 - 00:50:25
Anthony J. Cast discusses the impact of a plus-minus gene on food sensitivities. He explains that while the presence of this gene might not significantly affect someone without existing issues, it's worth paying attention to if food sensitivities are present. He suggests that eliminating foods like tomatoes and peppers temporarily and then reintroducing them can help determine if there's a noticeable difference. However, given the absence of current problems, he doubts the plus-minus gene will have a significant impact. The conversation concludes with Vincent expressing satisfaction and agreement.
Gym Section and Muscle Fiber Type
00:50:25 - 00:50:36
Anthony J. Cast transitions to discussing the gym section and muscle fiber type. He notes that Vincent has a mix of fast and slow-twitch muscle fibers, making him versatile in his workout approach.
Genetic Predisposition to Arthritis and Training Considerations
00:50:37 - 00:51:55
Anthony J. Cast discusses the AC-VR-1B gene, which enhances muscle strength but presents potential drawbacks. He explains that while this gene is beneficial for power, it's crucial to consider its interaction with blood sugar levels. High blood sugar significantly increases the risk of rheumatoid arthritis due to inflammation and insulin triggering. Vincent agrees, emphasizing the importance of blood sugar control. The conversation then shifts to the DiO2 gene, another risk factor for arthritis, specifically osteoarthritis, as opposed to the rheumatoid arthritis linked to the AC-VR-1B gene and high blood sugar. Anthony J. Cast briefly explains the difference between rheumatoid arthritis (immune system attacking joints) and osteoarthritis.
Understanding Osteoarthritis and its Genetic Link
00:51:55 - 00:53:03
This segment focuses on osteoarthritis, differentiating it from other joint tissue degradation. Dr. Cast explains that osteoarthritis involves the slow degradation of soft tissue in joints, leading to bone-on-bone friction and pain. He highlights a gene's influence on osteoarthritis risk, linking it to thyroid function. He explains that imbalances in thyroid hormones, potentially due to iodine deficiency, increase osteoarthritis risk. He recommends iodine supplementation, achievable through iodine-rich foods like seafood or sea vegetables, to support thyroid health. He also emphasizes the importance of maintaining good blood flow through joint movement. Finally, he addresses a gene related to fructose transport, suggesting that high blood sugar levels might exacerbate the condition.
Low Back Issues and the IL-1 Gene
00:53:05 - 00:54:03
Anthony J. Cast discusses the increased risk of low back problems associated with the IL-1 gene, noting a two-fold higher risk. He and Vincent both share experiences of low back issues, with Vincent managing his through training and mobility exercises. Anthony J. Cast reveals he also carries the IL-1 gene, explaining that even minor movements can trigger significant back pain after seemingly innocuous activities. Both individuals describe the sudden onset of debilitating pain from seemingly minor actions, highlighting the unpredictable and crippling nature of the condition.
Treatment Options for Interleukin Gene
00:54:03 - 00:54:59
Anthony J. Cast discusses treatment options for an interleukin gene. He suggests testosterone as a highly effective treatment, explaining that it inhibits interleukin. He notes that while natural supplements exist, they are less effective than testosterone. He recommends exploring a website link for more information on these supplements, mentioning curcumin as an example. He also emphasizes lifestyle factors like stress, sleep, and sunshine as contributors to increased interleukin levels. He further mentions that fake vitamin E can also increase interleukin. Finally, he expresses no concern about blood pressure due to the individual's good body weight and training regimen.
Blood Pressure and Bone Density Analysis
00:54:59 - 00:56:02
Anthony J. Cast inquires about Vincent's blood pressure, expressing surprise if it's high. Vincent initially hesitates, noting he was writing down information. After confirming Vincent's blood pressure is good, Cast emphasizes the importance of continued exercise, especially given Vincent's genetic profile. Cast highlights Vincent's possession of four "plus plus" genes related to bone strength, a significant number compared to the average of zero. He points out the fascinating presence of offsetting genes in Vincent's profile: genes for both low and high bone density appear in alternating fashion. Cast hypothesizes that this genetic balance likely results in normal bone density overall.
Genetic Predisposition Analysis
00:56:04 - 00:57:07
Anthony J. Cast analyzes the patient's genetic profile, focusing on the presence of "plus plus" genes across various categories. He explains that the combination of these genes in the patient's children will depend on the wife's genetic makeup. He speculates that the patient's good genes likely offset any potential negative effects, citing the patient's lack of bone fractures as evidence of strong bone density. The discussion then shifts to the sleep section of the genetic report, noting that it's typically shorter and less concerning. While mentioning seasonal affective disorder as a potential risk, particularly with age, he emphasizes that the patient's "ABCC-9 one plus plus" gene could trigger sleep issues, especially if combined with high blood pressure.
Potassium Channels and Sleep Improvement
00:57:07 - 00:58:18
This segment focuses on improving sleep quality through understanding potassium channels and other factors. Anthony J. Cast explains that ABCC9 is a potassium channel and an oxygen sensor, suggesting that ensuring sufficient potassium intake, potentially supplementing in the evening, is crucial. He mentions the use of magnesium in the evening as well. While the effects might not be immediately noticeable, it could lead to improved deep sleep. Vincent shares his experience with blue light blockers, noting that while they didn't directly induce sleep, they reduced nighttime awakenings. Anthony J. Cast notes Vincent's blue light sensitivity gene, making the effect plausible. The conversation then shifts to the role of ABCC9 and potassium, and the benefits of Noah's breathing techniques for sleep. Anthony J. Cast even mentions mouth taping as a method used by some to improve breathing and sleep. Vincent confirms having tried mouth taping at night.
Overcoming Seasonal Allergies Through Breathwork
00:58:18 - 00:59:20
Vincent discusses how he uses breathwork, specifically following Brian McKenzie from par speed endurance, to manage his seasonal allergies. He explains that he initially started using breathwork for allergies and it significantly reduced his symptoms. He used to experience severe allergy symptoms, including puffy eyes, but now his symptoms are minor, even with a cat at home, to which he is allergic. Anthony J. Cast shares a similar experience, stating he also eliminated his previously severe allergies. Vincent confirms that his allergies are now minimal, even with a cat in the house.
Vincent's Allergy and Asthma Symptoms
00:59:20 - 01:00:17
Vincent describes experiencing skin rashes as an allergy symptom, but not breathing difficulties. He notes that this is unusual, as most allergies are lifelong. He also mentions experiencing asthma-like symptoms, particularly wheezing, at night if he consumes alcohol after 8 PM. He attributes this to the alcohol consumption and notes that this occurs even with the bedroom door closed to keep the cat out.
Alcohol Consumption and Asma Symptoms
01:00:19 - 01:01:22
Vincent describes experiencing Asma symptoms after consuming alcohol, particularly if he drinks past a certain time (before 8 pm). He notes that limiting his alcohol consumption to before 8 pm alleviates these symptoms. Anthony finds this interesting and connects it to the APC-C9 gene, an oxygen sensor. He explains that mouth breathing leads to faster CO2 expulsion, while nasal breathing helps regulate CO2 levels, improving the body's ability to handle stress and exertion. Vincent agrees, noting a significant improvement in his stress tolerance since adopting nasal breathing. Anthony mentions his own experience with a three-day fast and its impact, although the connection to the previous discussion is unclear due to the transcript's truncation.
Personal Health and Wellness Practices
01:01:22 - 01:02:24
Anthony discusses his personal experience with ketogenic diet and its impact on his allergies, noting his high responsiveness to it. He also shares his experience with mouth taping as a sleep aid, highlighting its effectiveness despite its unconventional nature. Vincent adds his perspective on mouth taping, mentioning the challenge of habit formation and its impact on sleep. Anthony emphasizes the importance of the WWC1 gene in relation to these practices and their overall success.
Genetic Predisposition and Cognitive Performance
01:02:26 - 01:03:28
Anthony J. Cast discusses the prevalence of a particular gene, noting variations across nationalities, with some populations exhibiting rates as low as 1%. He explains that poor sleep reduces memory recall by approximately 25% in individuals with this gene. However, the gene itself doesn't cause poor sleep; it merely impacts cognitive performance under conditions of sleep deprivation. He mentions that nicotine can potentially boost the gene's expression, suggesting nicotine gum or similar products as a possible (though not necessarily recommended) solution. Vincent corroborates this, sharing his experience of using nicotine to improve information retention during intense training sessions. Anthony J. Cast cautions against excessive nicotine use.
Discussion on Sleep Patterns and Genetics
01:03:28 - 01:04:28
Anthony J. Cast discusses the complexities of sleep patterns, noting that while Vincent may be genetically predisposed to being a night owl, his early-rising habits are likely influenced by cultural norms and his job. He explains that training the body to wake up early is difficult. Vincent confirms he's usually an early riser, a habit enforced by his need to wake up early regardless of bedtime. Anthony J. Cast agrees, stating that most jobs don't allow for late nights. He suggests that if Vincent's genetic predisposition were strongly in favor of late nights, he would encourage strategies to help him adjust, such as blue light blockers, given Vincent's blue light sensitivity gene and the gene indicating a preference for either early rising or late nights.
Sleep and Lifestyle Strategies
01:04:28 - 01:05:04
Anthony J. Cast explains that while our bodies naturally want to stay up later, blue blockers can trick the brain into thinking it's late, aiding sleep. Vincent agrees, adding that getting sunlight early in the day also helps his evening sleep. Anthony confirms these are good strategies, acknowledging that they have both pros and cons, but aren't overwhelmingly impactful. He then asks if Vincent has any questions about the sleep section or any other part of the discussion. Vincent replies that he doesn't, finding the information interesting and helpful in identifying areas for improvement.
Gut Health and Future Considerations
01:05:05 - 01:05:40
Vincent expresses appreciation for learning about his weaker areas. Anthony points out that Vincent has good genes overall, but his gut health is likely his weakest area. He advises Vincent to be mindful of this in the future, as sensitivity to such issues increases with age. Anthony uses examples of conversations with older individuals (50-60 years old and older) who report experiencing these issues, contrasting this with the responses of younger individuals (30 years old) who may not yet notice such problems.
Early DNA Testing and Preventative Health
01:05:40 - 01:06:08
Anthony J. Cast explains the benefits of early DNA testing, suggesting it can often prevent health issues from arising by allowing for proactive measures. He contrasts this with waiting for problems to develop and then attempting to fix them. Vincent agrees, noting that early awareness of potential risks is advantageous.
Addressing Skin Issues and Genetic Predisposition
01:06:08 - 01:06:51
The conversation shifts to Vincent's recent experience with increased skin issues, specifically mentioning "cherry and Jomas" (likely referring to cherry angiomas). Vincent inquires about potential genetic links to the development of these skin issues over time, questioning whether it's solely attributed to aging or if specific genes play a role. Anthony J. Cast acknowledges the question.
Skin Issues and Detoxification
01:06:52 - 01:07:48
Anthony and Vincent discuss Vincent's skin issues, characterized by bumps on his thighs, face, and other areas. Anthony suggests that this might be a detox mechanism, possibly linked to diet and iodine levels, given the thyroid's role in metabolism. Anthony recommends using a sauna three times a week for detoxification. He also mentions skin patch testing studies comparing sauna users to a control group, suggesting further research into the topic.
Sauna Detoxification and Chemical Sensitivity
01:07:48 - 01:08:54
Anthony J. Cast discusses a study showing that sauna users excrete significantly more chemicals through sweat compared to a control group. He highlights that while neither group eliminated chemicals through urine, sauna users demonstrated a substantial increase in chemical expulsion via sweat. This leads to a discussion on the correlation between consuming processed foods, like Doritos, and subsequent skin reactions. Anthony J. Cast uses himself as an example, explaining that consuming processed foods results in specific skin breakouts on the inside of his thighs, serving as a personal indicator to avoid such foods. Vincent expresses a similar concern about maintaining a healthy diet, even with workplace precautions in place, suggesting a shared awareness of the impact of diet on overall health and well-being.
Sauna's Health Benefits and Podcast Discussion
01:08:56 - 01:09:44
Anthony J. Cast discusses the numerous health benefits of saunas, citing decreases in cancer, Alzheimer's, and heart disease. He emphasizes that even without specific health issues, using a sauna is beneficial and poses no harm. He highlights the sauna as a first choice treatment option for those with conditions where it could offer direct help. The conversation concludes with pleasantries and gratitude from both Anthony J. Cast and Vincent for the podcast interview, noting the early start time due to Anthony J. Cast's prior male clinic meeting and expressing appreciation for the flexibility shown.
00:00:00 - 00:01:38
Anthony J. Cast introduces his podcast, highlighting its high audio quality and focus on DNA analysis. He mentions his affiliations with the Mayo Clinic, his consulting company (AJ Consulting Company), his authorship, and his two YouTube channels (Anthony J. Cast and Anthony J. Family Cast). He then previews his conversation with Vincent, a Canadian firefighter, noting the slightly lower audio quality due to Skype recording but emphasizing the fascinating discussion, particularly Vincent's experience with allergy elimination through improved breathing. Cast also shares his own similar experience with allergy relief.
Fishing and Firefighting in Montreal
00:01:38 - 00:03:33
The conversation begins with a discussion about Vincent's profile picture featuring a walleye, leading to a discussion of fishing in the Montreal area, specifically the St. Lawrence River and its muskie population. Vincent describes his work as a full-time firefighter in Montreal, clarifying that part-time positions are uncommon in larger cities. Cast mentions the high job satisfaction associated with firefighting, which Vincent confirms. The segment concludes with Vincent confirming receipt of a PDF sent by Cast.
Genetic Report Overview and Interpretation
00:03:33 - 00:06:29
Anthony J. Cast explains the report, highlighting that it analyzes genes from both parents. He focuses on identifying "bad genes" rather than good ones. He notes that a "plus plus" indicates a bad gene from both parents, while "plus minus" signifies a bad gene from one parent and a good one from the other. The discussion centers on the patient's relatively young age (37) and the preventative potential of addressing identified genetic risks. The first "plus plus" gene discussed is CETP (cholesterol ester transfer protein), a minor Alzheimer's risk factor, significantly mitigated by maintaining low triglycerides. The importance of optimizing triglyceride levels, considering the different units used in Canada, is emphasized. Vincent confirms having converted the units previously.
Blood Sugar Optimization and HbA1c Levels
00:06:36 - 00:09:06
This segment focuses on optimizing blood sugar levels. Anthony J. Cast emphasizes the difference between merely avoiding illness and actively optimizing health metrics, using blood sugar as an example. He aims for blood sugar levels below 90 (American units), contrasting this with doctors' acceptance of levels around 95. Vincent shares his recent non-fasting blood work results, mentioning a HbA1c level of around 5.2. Anthony notes this is slightly high, ideally aiming for below 5. Vincent explains his typically low-carb diet and mentions Rob Wolf's explanation for potentially higher HbA1c levels in low-carb individuals, attributing it to longer red blood cell lifespan. Anthony acknowledges this explanation but also points out that often, perceived "adaptive glucose sparing" actually masks higher blood sugar levels. He concludes by stating that Vincent's HbA1c is already near optimal.
Blood Test Results and Lifestyle Discussion
00:09:06 - 00:11:00
Anthony J. Cast discusses Vincent's blood test results, noting the variability in blood test values over time. He emphasizes the importance of monitoring triglycerides and suggests that Vincent's regular cardio training likely contributes to good triglyceride levels. The conversation then shifts to intermittent fasting. Anthony suggests intermittent fasting, particularly if Vincent stops training in the morning, noting Vincent's email mentioning breakfast. Vincent explains his past experience with intermittent fasting, including extended fasts of three days, and his current preference for a less consistent approach due to changes in routine and convenience. He describes his current diet, which includes a small breakfast of rice, beans, vegetables, and eggs, providing him with energy for daily training. Anthony acknowledges the consistency of Vincent's daily training.
Breakfast, Training, and Carb Metabolism
00:00:00 - 00:12:17
The conversation begins with a discussion about the speaker's usual breakfast and training schedule, with a two-hour gap between the two. Anthony J. Cast repeatedly affirms the speaker's routine. The discussion then shifts to the speaker's carb metabolism and how their body handles carbs, noting a lack of significant fatigue from carb intake. Anthony J. Cast attributes this to good genes, referencing a later discussion on diabetes risk genes. The speaker mentions noticing a difference in their energy levels when consuming a standard American diet at the firehouse versus their controlled diet at home. Anthony J. Cast agrees and mentions a future discussion about the risks of diabetes, reiterating that the speaker's body handles carbs well compared to most. The conversation concludes with Anthony J. Cast expressing preference for intermittent fasting when not training.
Anxiety Gene Discussion
00:12:18 - 00:13:01
Anthony J. Cast discusses Vincent's TPH2 gene, a serotonin transporter. He explains that since 90% of serotonin is produced in the gut, good gut health is key. He notes that the plus plus genotype is common in 60% of people and not necessarily a major concern unless anxiety is a significant issue. He also mentions Vincent's rapid caffeine metabolism.
Caffeine Metabolism and Pre-Workout Supplements
00:13:02 - 00:14:00
Vincent confirms his ability to tolerate caffeine late in the day. Anthony J. Cast explains that efficient caffeine metabolism can aid glucose uptake in muscle cells, making caffeine a good pre-workout option for Vincent. They discuss the difference in caffeine tolerance between coffee and pre-workout supplements, with Anthony J. Cast suggesting coffee as a preferable source due to the higher caffeine concentration in pre-workout supplements. He concludes by stating that a plus plus genotype in this gene isn't inherently negative.
Lifespan Genes: NYN and SIRT1
00:14:01 - 00:14:35
Anthony J. Cast moves on to lifespan genes, mentioning NYN and SIRT1. He expresses less concern about NYN, suggesting sufficient zinc intake likely mitigates any potential issues. He focuses on SIRT1 (Sirtun), explaining that higher levels are associated with longer lifespans, while lower levels are linked to shorter lifespans. He notes that Vincent's body produces less Sirtun.
Sirtuin-Boosting Supplements and Their Effects
00:14:35 - 00:16:33
Anthony J. Cast discusses supplements that increase Sirtuin levels, focusing on resveratrol and apigenin. He explains that resveratrol's effectiveness depends on an individual's genetic makeup, affecting about 50% of the population. He notes that high doses of resveratrol can act like estrogen, advising caution, especially for those with specific estrogen genes. As an alternative, he suggests proanthocyanidins. The conversation then shifts to apigenin, another Sirtuin booster included in Vincent's night cocktail alongside magnesium, L-theanine, and epigenin. Anthony J. Cast mentions that while noticeable effects might not be immediate, apigenin offers prostate cancer protection. However, he cautions that apigenin, like resveratrol, exhibits mild estrogenic effects, recommending discontinuation if estrogen-related symptoms appear and suggesting a switch to proanthocyanidins. The discussion concludes with an explanation of the difference in the way testosterone and estrogen bind to receptors in the body.
Apigenin and Receptor Activation
00:16:33 - 00:18:56
Anthony J. Cast explains that apigenin activates the beta receptor, which is protective against prostate and breast cancer, unlike the alpha receptor, which increases the risk of these cancers. While apigenin's beta receptor activation is beneficial, it also acts like estrogen, potentially causing issues for some individuals. Vincent mentions switching supplements to keep receptors active and avoid desensitization. Anthony J. Cast agrees, suggesting rotating supplements and researching those that increase sirtuin, a gene linked to lifespan extension, but cautions about verifying the research behind such supplements due to misinformation online. He notes that significant amounts of certain supplements are needed to increase sirtuin, and these amounts might also act like estrogen.
Genetic Predisposition Discussion
00:18:58 - 00:21:21
Anthony J. Cast reassures Vincent about potential estrogen gene concerns, stating that unless Vincent has terrible estrogen genes, he shouldn't worry. The conversation then shifts to Vincent's past gut issues, acne, and treatment with antibiotics and Accutane. Vincent mentions significant dietary changes that resolved many of these problems. Dr. Cast notes Vincent's gut and sleep genes as potentially weak areas, although Vincent reports managing stress and sleep through breathwork. Dr. Cast emphasizes the importance of stress management and sleep, suggesting that genetic predispositions may become more apparent with age. The discussion then turns to Vincent's diet, noting a couple of diabetes risk genes but emphasizing that humans aren't built for high-carb diets. Dr. Cast contrasts Vincent's relatively few genetic concerns with cases where patients have numerous gene issues leading to prevalent family history of diabetes.
Genetic Predisposition and Lifestyle Recommendations
00:21:22 - 00:23:35
Anthony J. Cast discusses the patient's genetic predispositions, specifically mentioning the HEX gene, which increases the risk of type 2 diabetes threefold, especially with a standard American diet. He explains that this gene is related to nitric oxide production in the pancreas. He recommends exercise as the best way to increase nitric oxide, and suggests citrulline supplements as an alternative if exercise isn't feasible. Zinc intake is also emphasized, either through diet or supplementation. Regarding intermittent fasting, Anthony mentions the MC4R and AdiPoQ genes, suggesting that intermittent fasting is beneficial, especially considering the prevalence of the MC4R gene. However, he notes that regular exercise can modify the impact of these genes. Vincent shares his current eating habits, which naturally incorporate a form of intermittent fasting due to his family dinner schedule. Anthony affirms the benefits of this pattern and highlights that late-evening snacks negatively affect sleep quality.
Dietary Strategies and Genetic Predisposition
00:23:40 - 00:25:09
Anthony J. Cast discusses dietary strategies for weight management, suggesting more aggressive intermittent fasting if training decreases. He notes the individual's genetic profile, mentioning common genes (adipoq, mcm4r) and their implications for dietary frequency. He highlights that the individual's genetic makeup allows for more frequent eating than most. The conversation then shifts to metformin, its use for lifespan extension, and the individual's higher responsiveness due to their genetic profile. Metformin is recommended if blood sugar levels (above 90 in American units or 5 in millimoles) or hemoglobin A1c remain elevated.
Challenges in Accessing Metformin
00:25:09 - 00:25:38
Vincent points out the challenges of obtaining metformin in Canada, requiring a prescription and blood work, which adds to the cost and difficulty of accessing it. Anthony J. Cast agrees, noting the difficulty in convincing doctors to prescribe metformin if blood sugar levels appear normal.
Metformin and Lifespan Extension
00:25:41 - 00:27:53
Anthony J. Cast discusses the use of metformin for lifespan extension, noting that while doctors may be hesitant to prescribe it if the patient mentions research on its effects, it's more readily available in Canada. He contrasts the American healthcare system's focus on managing risk versus optimization. Anthony explains that biostatisticians employed by healthcare systems use statistical analysis to determine the acceptability of certain risks for the general population, similar to insurance companies but with less flexibility. He recommends a 500mg dose of metformin before bed to help manage blood sugar and mentions potential mild nausea as a side effect. The conversation then shifts to Vincent's family history, revealing some instances of diabetes and heart disease, but also a 90-year-old grandfather who survived COVID-19. Anthony comments positively on Vincent's seemingly good genes related to aging, particularly concerning heart disease and cholesterol.
Triglyceride and Cholesterol Levels Discussion
00:27:54 - 00:30:13
Anthony J. Cast advises Vincent to monitor his cholesterol and, more importantly, his triglycerides. Vincent reveals his previous triglyceride level was 0.43 millimolar. After a brief conversion calculation, Anthony J. Cast clarifies that this equates to approximately 38 milligrams per deciliter, which is exceptionally low and considered excellent. He notes this is lower than most individuals he's consulted, regardless of age. The conversation then shifts to Vincent's diet, with Anthony J. Cast inquiring about his fat intake. Vincent describes his diet as normal, not high in fat, mentioning his consumption of eggs, butter, and specific oils like olive, avocado, and coconut. Anthony J. Cast approves of these choices, emphasizing the positive impact of animal fats. He concludes that Vincent possesses excellent genes regarding heart disease, particularly concerning the LPL gene, and expresses less concern about the LPA gene. Vincent agrees that maintaining low triglycerides is key, and Anthony J. Cast suggests checking the LPA level, specifically mentioning the "LPLittle A" test.
Lipid Panel and Genetic Predisposition to Gluten Sensitivity
00:30:13 - 00:32:12
Anthony J. Cast discusses the patient's lipid panel, suggesting an optimal level below 30 milligrams per deciliter. While acknowledging the presence of the LPA gene, he notes the low triglycerides make high LPA unlikely, but recommends checking it. He expresses less concern about CRP. The discussion then shifts to the "leaky gut" section of the genetic report, highlighting multiple "plus plus" markers, including CDKAL1, ATG16L1, and another ATG gene. Based on these findings, Dr. Cast hypothesizes a significant gluten sensitivity, emphasizing the strong correlation between the ATG gene markers and gluten-related inflammation. He explains that having two "plus plus" markers on the same gene significantly increases the risk of gut issues, potentially fivefold, and strongly suggests avoiding gluten, despite acknowledging that the gene isn't entirely predictive. The conversation concludes with a reference to the patient's previous dietary inquiries, noting the omission of grains in the discussion.
Grain Consumption and its Effects
00:32:12 - 00:34:14
Anthony J. Cast inquires about Vincent's grain consumption, noting that Vincent doesn't regularly eat a lot of grains and doesn't experience significant discomfort when he does. Vincent mentions possible childhood acne as a potential link to grain consumption, though he wasn't aware of it at the time. Anthony J. Cast points out the common correlation between removing gluten or grains and improved acne. Vincent explains that he tries to cook or ferment grains well to minimize negative effects. Anthony J. Cast shares his own gluten sensitivity, describing experiencing fatigue but not gut pain from gluten, unless he foam rolls his abs afterward, which then causes significant pain. He uses this foam rolling technique to assess potential underlying issues in his patients, emphasizing the importance of establishing a baseline foam rolling experience to differentiate between normal discomfort and pain indicating a problem. He concludes that this method is crucial for identifying sensitivities, given the numerous potential factors influencing gut health.
Gut Health and Gene Interactions
00:34:20 - 00:35:06
Anthony J. Cast discusses various genes related to gut health. He mentions that several genes contribute to potential gut issues, but the presence of "good versions" of these genes mitigates the risk. Specifically, he highlights the CDK AL1 gene, which is sensitive to flavanoids found in plant supplements like grape seed proanthocyanidins, apigenin, and resveratrol. He emphasizes that consuming colorful plants regularly benefits this gene and overall gut health. Other genes are deemed less concerning unless active gut issues are present. Finally, he points out CNR1, the cannabinoid receptor gene, as another beneficial gene, suggesting that CBD may help with inflammation in those with gut problems, but not necessarily for chronic use.
Dietary Considerations and Proanthocyanidins
00:35:06 - 00:35:58
Vincent inquires about proanthocyanidins. Anthony J. Cast clarifies that proanthocyanidin is a specific compound found in grape seed extract, highlighting its significant health benefits. He notes that despite these benefits, proanthocyanidins are not widely discussed.
Grape Seed Extract and Resveratrol Discussion
00:35:59 - 00:36:37
Anthony J. Cast explains that grape seed extract is a phenomenal supplement that increases lifespan in animals tested. He notes that it typically contains around 50% proanthocyanidins and 50% resveratrol, clarifying that it's different from resveratrol itself. Vincent confirms understanding the distinction between the two. The discussion concludes with Anthony J. Cast asking if there are any further questions, to which Vincent replies negatively.
Acne, Genes, and Seramides
00:36:37 - 00:37:23
Anthony J. Cast shifts the conversation to acne and genes, mentioning the ARSAARL sulfatease gene, which is less common and affects ceramide production. He explains that ceramides are crucial for skin hydration, and supplementing with serums to increase ceramide levels can improve skin conditions. He notes that while Vincent doesn't currently have significant skin issues, increasing ceramides could be beneficial if problems arise. Vincent confirms experiencing occasional acne.
Supplement Recommendations and Vitamin D Tracking
00:37:24 - 00:38:30
Anthony J. Cast suggests exploring phyto-ceramides as a supplement option, noting that regular ceramides aren't readily available as supplements. He also proposes acetyl cysteine (referred to as "knack") due to its sulfur content, relevant to aryl sulfatease. While acknowledging sulfur's potential benefits, he prioritizes phyto-ceramides. Vitamin D supplementation is strongly recommended, with Anthony J. Cast emphasizing its importance. Vincent mentions increased vitamin D intake during winter and uses the "D-minder" app for tracking vitamin D levels, a tool unfamiliar to Anthony J. Cast. The discussion concludes with Vincent explaining the D-minder app's functionality in tracking vitamin D needs.
Vitamin D Deficiency and Seasonal Depression
00:38:31 - 00:39:38
Vincent discusses the impact of latitude on vitamin D production, noting that sufficient vitamin D synthesis from sunlight is limited to early November to early March. Anthony confirms this, adding that even with sun exposure during winter months, sufficient vitamin D production is unlikely. Vincent considers using a vitamin D lamp as a solution. Anthony suggests checking the last gene in a report, possibly overlooked, which is identified as D-E-R-T, a gene often linked to winter depression. The vitamin D lamp is presented as a potential solution to address this gene's influence.
Addressing Vitamin D Deficiency and Seasonal Depression
00:39:38 - 00:40:46
Anthony J. Cast discusses the importance of vitamin D, especially as one ages, noting that while vitamin D supplements might help, they aren't a complete solution. Vincent mentions experiencing more depressive thoughts after working 24-hour shifts with limited sleep. He describes his post-shift routine of a light breakfast, shower, and returning to sleep. Anthony J. Cast affirms this routine is beneficial and emphasizes the importance of sufficient vitamin D, particularly during winter months in Canada's southern regions where sunlight is limited. He suggests continuing current practices, including vitamin D supplementation and maximizing sun exposure in summer. He also mentions SAD lamps as an option for seasonal affective disorder but expresses reservations due to their lack of vitamin D increase.
Vitamin D Lamps and Supplements
00:40:47 - 00:41:56
Anthony J. Cast discusses the use of vitamin D lamps, noting their effectiveness but also their danger to the eyes and high cost (around $500). He mentions owning one and testing it. The conversation shifts to the cost of travel to sunnier locations as an alternative to the lamp. Vincent inquires about the difference between vitamin D supplements and sunshine-derived vitamin D. Anthony J. Cast states there isn't a huge difference, but highlights the many unknowns in the science surrounding vitamin D, with most research focusing on diseases rather than benefits. He mentions that scientists don't have a complete understanding of vitamin D's effects.
The Benefits and Risks of Sunshine
00:41:57 - 00:43:16
Anthony J. Cast asserts that while sunshine is beneficial, there is limited research on its effects compared to the extensive research on topics like coronavirus. He uses this to illustrate the lack of comprehensive understanding of sunshine's impact. Vincent brings up the risk versus benefit aspect of sunshine, particularly concerning vitamin intake. Anthony J. Cast argues that sunburn is the primary risk, and without it, the risk is minimal, although he acknowledges dermatologists might disagree. He challenges the validity of research based on extreme cases, such as individuals who frequently get severe sunburns. He suggests that even moderate tanning bed use could be an effective alternative to natural sunlight exposure.
Estrogen Receptor Alpha Discussion
00:43:16 - 00:44:22
Anthony J. Cast discusses Vincent's genetic predisposition to higher estrogen levels due to a "plus plus" rating on the ESR1 gene (estrogen receptor alpha). He explains that this means Vincent's alpha receptor is more active than average, similar to a dimmer switch set higher than normal. This increased activity doesn't necessarily mean higher estrogen production, but rather that when estrogen is present, its effects are amplified. He notes that Vincent is already avoiding flax and seed oils, which is positive, and that the overall genetic picture isn't overly concerning due to the absence of other genes contributing to higher estrogen levels. The advice given is to simply be mindful of estrogen exposure, as its effects will be more pronounced.
Supplement and Hormone Considerations
00:44:22 - 00:45:19
Anthony J. Cast discusses the impact of supplements and certain foods on hormone levels. He mentions that sonus can help lower estrogen, and that members of the Brasica family (like broccoli) are also beneficial. However, he cautions against supplements that activate the alpha receptor, citing examples such as soy products and certain essential oils like rose and lavender. He emphasizes the importance of being careful with supplements and avoiding those with unknown estrogenic effects. The conversation concludes with Anthony J. Cast noting that consistently using unusual substances might be a concern, but the current situation doesn't seem to indicate such a pattern.
Genetic Predisposition to Vitamin A Conversion
00:45:19 - 00:46:28
Anthony J. Cast discusses the patient's genetic predisposition affecting vitamin A conversion. He notes the patient has good thyroid genes but a 50% reduction in the conversion of beta-carotene (plant-based vitamin A) to retinol (animal-based vitamin A) due to additive gene variations. This means the patient's body doesn't efficiently utilize carotene from plants. The good news is that the patient takes cod liver oil, which contains retinol, compensating for the inefficient conversion. Vincent clarifies this genetic limitation affects the conversion of vitamin A from plant sources versus animal sources. Anthony J. Cast confirms this, explaining that plants contain a different form of vitamin A that the body doesn't directly use, hence the need for conversion. He debunks the common belief that carrots are directly beneficial for eyesight due to this conversion limitation.
Dietary Habits and Cannabis Use
00:46:29 - 00:47:25
This segment focuses on Vincent's diet and past cannabis use. Anthony inquires about Vincent's diet, noting the importance of proper nutrient conversion for eye health. Vincent mentions consuming four to eight ounces of beef liver weekly and using supplements with calibere oil. Anthony praises his diet. The conversation then shifts to cannabis use. Anthony asks if Vincent uses cannabis, and Vincent replies negatively, stating that while he's not tested for it as a firefighter, he used it sparingly in his teenage years. Anthony explains that cannabis can be demotivating due to its effect on dopamine levels, but since Vincent doesn't currently use it, he shouldn't worry. The discussion concludes with Anthony mentioning the B9 section and some pluses and minuses.
Vitamin E and Dietary Considerations
00:47:27 - 00:48:26
Anthony J. Cast discusses vitamin E supplementation, stating that it's likely unnecessary if one consumes sufficient leafy greens. He highlights the importance of distinguishing between different forms of vitamin E, specifically mentioning tocotrienols and tocopherols. He emphasizes the need to avoid tocopherols, as they can trigger inflammation by activating the GSTP1 gene and increasing interleukin levels in the body. This inflammation is deemed unnecessary, and he advises against consuming tocopherols found in multivitamins and similar products. The focus shifts from what to consume to what to avoid regarding vitamin E intake.
Supplement List and Detox Section Discussion
00:48:26 - 00:49:33
Anthony J. Cast reviews a supplement list, noting the limited number of supplements and the absence of vitamin E, explaining that plant-based vitamin E alternatives are derived from petroleum and thus unlikely to be included in plant-based supplements. He then asks about questions regarding the detox section, mentioning additional genes but focusing on the discussion of nightshades. Vincent raises concerns about nightshades and other items like caffeine, GenCo, pepper, and GMG, noting that these are broken down more slowly. Anthony J. Cast clarifies that these restrictions only apply if individuals experience food sensitivities.
Food Sensitivities and Genetic Predisposition
00:49:33 - 00:50:25
Anthony J. Cast discusses the impact of a plus-minus gene on food sensitivities. He explains that while the presence of this gene might not significantly affect someone without existing issues, it's worth paying attention to if food sensitivities are present. He suggests that eliminating foods like tomatoes and peppers temporarily and then reintroducing them can help determine if there's a noticeable difference. However, given the absence of current problems, he doubts the plus-minus gene will have a significant impact. The conversation concludes with Vincent expressing satisfaction and agreement.
Gym Section and Muscle Fiber Type
00:50:25 - 00:50:36
Anthony J. Cast transitions to discussing the gym section and muscle fiber type. He notes that Vincent has a mix of fast and slow-twitch muscle fibers, making him versatile in his workout approach.
Genetic Predisposition to Arthritis and Training Considerations
00:50:37 - 00:51:55
Anthony J. Cast discusses the AC-VR-1B gene, which enhances muscle strength but presents potential drawbacks. He explains that while this gene is beneficial for power, it's crucial to consider its interaction with blood sugar levels. High blood sugar significantly increases the risk of rheumatoid arthritis due to inflammation and insulin triggering. Vincent agrees, emphasizing the importance of blood sugar control. The conversation then shifts to the DiO2 gene, another risk factor for arthritis, specifically osteoarthritis, as opposed to the rheumatoid arthritis linked to the AC-VR-1B gene and high blood sugar. Anthony J. Cast briefly explains the difference between rheumatoid arthritis (immune system attacking joints) and osteoarthritis.
Understanding Osteoarthritis and its Genetic Link
00:51:55 - 00:53:03
This segment focuses on osteoarthritis, differentiating it from other joint tissue degradation. Dr. Cast explains that osteoarthritis involves the slow degradation of soft tissue in joints, leading to bone-on-bone friction and pain. He highlights a gene's influence on osteoarthritis risk, linking it to thyroid function. He explains that imbalances in thyroid hormones, potentially due to iodine deficiency, increase osteoarthritis risk. He recommends iodine supplementation, achievable through iodine-rich foods like seafood or sea vegetables, to support thyroid health. He also emphasizes the importance of maintaining good blood flow through joint movement. Finally, he addresses a gene related to fructose transport, suggesting that high blood sugar levels might exacerbate the condition.
Low Back Issues and the IL-1 Gene
00:53:05 - 00:54:03
Anthony J. Cast discusses the increased risk of low back problems associated with the IL-1 gene, noting a two-fold higher risk. He and Vincent both share experiences of low back issues, with Vincent managing his through training and mobility exercises. Anthony J. Cast reveals he also carries the IL-1 gene, explaining that even minor movements can trigger significant back pain after seemingly innocuous activities. Both individuals describe the sudden onset of debilitating pain from seemingly minor actions, highlighting the unpredictable and crippling nature of the condition.
Treatment Options for Interleukin Gene
00:54:03 - 00:54:59
Anthony J. Cast discusses treatment options for an interleukin gene. He suggests testosterone as a highly effective treatment, explaining that it inhibits interleukin. He notes that while natural supplements exist, they are less effective than testosterone. He recommends exploring a website link for more information on these supplements, mentioning curcumin as an example. He also emphasizes lifestyle factors like stress, sleep, and sunshine as contributors to increased interleukin levels. He further mentions that fake vitamin E can also increase interleukin. Finally, he expresses no concern about blood pressure due to the individual's good body weight and training regimen.
Blood Pressure and Bone Density Analysis
00:54:59 - 00:56:02
Anthony J. Cast inquires about Vincent's blood pressure, expressing surprise if it's high. Vincent initially hesitates, noting he was writing down information. After confirming Vincent's blood pressure is good, Cast emphasizes the importance of continued exercise, especially given Vincent's genetic profile. Cast highlights Vincent's possession of four "plus plus" genes related to bone strength, a significant number compared to the average of zero. He points out the fascinating presence of offsetting genes in Vincent's profile: genes for both low and high bone density appear in alternating fashion. Cast hypothesizes that this genetic balance likely results in normal bone density overall.
Genetic Predisposition Analysis
00:56:04 - 00:57:07
Anthony J. Cast analyzes the patient's genetic profile, focusing on the presence of "plus plus" genes across various categories. He explains that the combination of these genes in the patient's children will depend on the wife's genetic makeup. He speculates that the patient's good genes likely offset any potential negative effects, citing the patient's lack of bone fractures as evidence of strong bone density. The discussion then shifts to the sleep section of the genetic report, noting that it's typically shorter and less concerning. While mentioning seasonal affective disorder as a potential risk, particularly with age, he emphasizes that the patient's "ABCC-9 one plus plus" gene could trigger sleep issues, especially if combined with high blood pressure.
Potassium Channels and Sleep Improvement
00:57:07 - 00:58:18
This segment focuses on improving sleep quality through understanding potassium channels and other factors. Anthony J. Cast explains that ABCC9 is a potassium channel and an oxygen sensor, suggesting that ensuring sufficient potassium intake, potentially supplementing in the evening, is crucial. He mentions the use of magnesium in the evening as well. While the effects might not be immediately noticeable, it could lead to improved deep sleep. Vincent shares his experience with blue light blockers, noting that while they didn't directly induce sleep, they reduced nighttime awakenings. Anthony J. Cast notes Vincent's blue light sensitivity gene, making the effect plausible. The conversation then shifts to the role of ABCC9 and potassium, and the benefits of Noah's breathing techniques for sleep. Anthony J. Cast even mentions mouth taping as a method used by some to improve breathing and sleep. Vincent confirms having tried mouth taping at night.
Overcoming Seasonal Allergies Through Breathwork
00:58:18 - 00:59:20
Vincent discusses how he uses breathwork, specifically following Brian McKenzie from par speed endurance, to manage his seasonal allergies. He explains that he initially started using breathwork for allergies and it significantly reduced his symptoms. He used to experience severe allergy symptoms, including puffy eyes, but now his symptoms are minor, even with a cat at home, to which he is allergic. Anthony J. Cast shares a similar experience, stating he also eliminated his previously severe allergies. Vincent confirms that his allergies are now minimal, even with a cat in the house.
Vincent's Allergy and Asthma Symptoms
00:59:20 - 01:00:17
Vincent describes experiencing skin rashes as an allergy symptom, but not breathing difficulties. He notes that this is unusual, as most allergies are lifelong. He also mentions experiencing asthma-like symptoms, particularly wheezing, at night if he consumes alcohol after 8 PM. He attributes this to the alcohol consumption and notes that this occurs even with the bedroom door closed to keep the cat out.
Alcohol Consumption and Asma Symptoms
01:00:19 - 01:01:22
Vincent describes experiencing Asma symptoms after consuming alcohol, particularly if he drinks past a certain time (before 8 pm). He notes that limiting his alcohol consumption to before 8 pm alleviates these symptoms. Anthony finds this interesting and connects it to the APC-C9 gene, an oxygen sensor. He explains that mouth breathing leads to faster CO2 expulsion, while nasal breathing helps regulate CO2 levels, improving the body's ability to handle stress and exertion. Vincent agrees, noting a significant improvement in his stress tolerance since adopting nasal breathing. Anthony mentions his own experience with a three-day fast and its impact, although the connection to the previous discussion is unclear due to the transcript's truncation.
Personal Health and Wellness Practices
01:01:22 - 01:02:24
Anthony discusses his personal experience with ketogenic diet and its impact on his allergies, noting his high responsiveness to it. He also shares his experience with mouth taping as a sleep aid, highlighting its effectiveness despite its unconventional nature. Vincent adds his perspective on mouth taping, mentioning the challenge of habit formation and its impact on sleep. Anthony emphasizes the importance of the WWC1 gene in relation to these practices and their overall success.
Genetic Predisposition and Cognitive Performance
01:02:26 - 01:03:28
Anthony J. Cast discusses the prevalence of a particular gene, noting variations across nationalities, with some populations exhibiting rates as low as 1%. He explains that poor sleep reduces memory recall by approximately 25% in individuals with this gene. However, the gene itself doesn't cause poor sleep; it merely impacts cognitive performance under conditions of sleep deprivation. He mentions that nicotine can potentially boost the gene's expression, suggesting nicotine gum or similar products as a possible (though not necessarily recommended) solution. Vincent corroborates this, sharing his experience of using nicotine to improve information retention during intense training sessions. Anthony J. Cast cautions against excessive nicotine use.
Discussion on Sleep Patterns and Genetics
01:03:28 - 01:04:28
Anthony J. Cast discusses the complexities of sleep patterns, noting that while Vincent may be genetically predisposed to being a night owl, his early-rising habits are likely influenced by cultural norms and his job. He explains that training the body to wake up early is difficult. Vincent confirms he's usually an early riser, a habit enforced by his need to wake up early regardless of bedtime. Anthony J. Cast agrees, stating that most jobs don't allow for late nights. He suggests that if Vincent's genetic predisposition were strongly in favor of late nights, he would encourage strategies to help him adjust, such as blue light blockers, given Vincent's blue light sensitivity gene and the gene indicating a preference for either early rising or late nights.
Sleep and Lifestyle Strategies
01:04:28 - 01:05:04
Anthony J. Cast explains that while our bodies naturally want to stay up later, blue blockers can trick the brain into thinking it's late, aiding sleep. Vincent agrees, adding that getting sunlight early in the day also helps his evening sleep. Anthony confirms these are good strategies, acknowledging that they have both pros and cons, but aren't overwhelmingly impactful. He then asks if Vincent has any questions about the sleep section or any other part of the discussion. Vincent replies that he doesn't, finding the information interesting and helpful in identifying areas for improvement.
Gut Health and Future Considerations
01:05:05 - 01:05:40
Vincent expresses appreciation for learning about his weaker areas. Anthony points out that Vincent has good genes overall, but his gut health is likely his weakest area. He advises Vincent to be mindful of this in the future, as sensitivity to such issues increases with age. Anthony uses examples of conversations with older individuals (50-60 years old and older) who report experiencing these issues, contrasting this with the responses of younger individuals (30 years old) who may not yet notice such problems.
Early DNA Testing and Preventative Health
01:05:40 - 01:06:08
Anthony J. Cast explains the benefits of early DNA testing, suggesting it can often prevent health issues from arising by allowing for proactive measures. He contrasts this with waiting for problems to develop and then attempting to fix them. Vincent agrees, noting that early awareness of potential risks is advantageous.
Addressing Skin Issues and Genetic Predisposition
01:06:08 - 01:06:51
The conversation shifts to Vincent's recent experience with increased skin issues, specifically mentioning "cherry and Jomas" (likely referring to cherry angiomas). Vincent inquires about potential genetic links to the development of these skin issues over time, questioning whether it's solely attributed to aging or if specific genes play a role. Anthony J. Cast acknowledges the question.
Skin Issues and Detoxification
01:06:52 - 01:07:48
Anthony and Vincent discuss Vincent's skin issues, characterized by bumps on his thighs, face, and other areas. Anthony suggests that this might be a detox mechanism, possibly linked to diet and iodine levels, given the thyroid's role in metabolism. Anthony recommends using a sauna three times a week for detoxification. He also mentions skin patch testing studies comparing sauna users to a control group, suggesting further research into the topic.
Sauna Detoxification and Chemical Sensitivity
01:07:48 - 01:08:54
Anthony J. Cast discusses a study showing that sauna users excrete significantly more chemicals through sweat compared to a control group. He highlights that while neither group eliminated chemicals through urine, sauna users demonstrated a substantial increase in chemical expulsion via sweat. This leads to a discussion on the correlation between consuming processed foods, like Doritos, and subsequent skin reactions. Anthony J. Cast uses himself as an example, explaining that consuming processed foods results in specific skin breakouts on the inside of his thighs, serving as a personal indicator to avoid such foods. Vincent expresses a similar concern about maintaining a healthy diet, even with workplace precautions in place, suggesting a shared awareness of the impact of diet on overall health and well-being.
Sauna's Health Benefits and Podcast Discussion
01:08:56 - 01:09:44
Anthony J. Cast discusses the numerous health benefits of saunas, citing decreases in cancer, Alzheimer's, and heart disease. He emphasizes that even without specific health issues, using a sauna is beneficial and poses no harm. He highlights the sauna as a first choice treatment option for those with conditions where it could offer direct help. The conversation concludes with pleasantries and gratitude from both Anthony J. Cast and Vincent for the podcast interview, noting the early start time due to Anthony J. Cast's prior male clinic meeting and expressing appreciation for the flexibility shown.
DNA with Dr. Jay, Episode 13.
BLUE LIGHT SENSITIVE Cat Lover Megan (from Louisiana)
BLUE LIGHT SENSITIVE Cat Lover Megan (from Louisiana)
Detailed A.I. Summary
**CLICK HERE TO READ
Podcast Introduction and Overview
00:00:00 - 00:01:35
Anthony J introduces his podcast, AJConsultingCompany.com, which offers pristine audio quality and DNA analysis using 23andMe data. He describes himself as a Mayo Clinic scientist, author, and YouTuber with two channels: Anthony J Cast (scientific content) and Anthony J Family Cast (outdoor adventures). He previews the episode, featuring Megan from Louisiana, a 28-year-old with complex genetic issues related to inflammation, highlighting the sometimes complicated nature of genetic analysis.
Initial Client Contact and Scheduling
00:01:36 - 00:02:04
The episode begins with Anthony J greeting Megan. A brief discussion ensues regarding a minor scheduling delay caused by Megan misplacing her headphones. Anthony J assures Megan that the delay is insignificant. Megan confirms the delay was on her end due to the misplaced headphones. Anthony J confirms Megan's location as Louisiana.
Initial Consultation and Patient History
00:02:05 - 00:03:30
Anthony J begins the consultation by acknowledging Megan's presence. Megan reports various health issues including IBS, rheumatoid conditions, brittle hair and nails, and significant sleep disturbances. She describes her sleep as restless, with difficulty falling asleep (1-2 hours), frequent waking, and sensitivity to movement. She uses a smartwatch to track sleep, revealing that despite spending eight hours in bed, she only gets 5 hours (or less) of actual sleep. Megan confirms she only takes Vitamin C and Biotin supplements.
Review of Alzheimer's Risk Factors and PDF Discussion
00:03:31 - 00:04:00
Anthony J states they will review a PDF sent to Megan. He points out five Alzheimer's categories within the PDF, noting that Megan has none of the associated risk genes or brain performance optimization issue genes, which is considered positive.
Understanding Genetic Report Results
00:04:00 - 00:05:28
Anthony J explains the meaning of "plus-plus" and "plus-minus" notations in a genetic report. He clarifies that these notations reflect the two copies of DNA in each cell, one from each parent. A "plus-plus" result indicates inheriting a bad gene copy from both parents, representing a more significant issue. A "plus-minus" result signifies inheriting one bad and one good gene copy, generally less problematic than "plus-plus". The discussion focuses on identifying problematic genes to understand the root cause of health issues. Anthony J emphasizes that the report focuses on identifying problem genes, not the thousands of good genes present. He aims to pinpoint the root cause of the problem to find a solution.
Sleep and Anxiety Gene Discussion
00:05:28 - 00:07:18
Anthony J discusses a client's anxiety gene, tph2, which impacts sleep. He explains that this gene affects serotonin transport to the brain, and increased serotonin can cause tiredness. He suggests trying the supplement 5-HTP, which increases serotonin, along with tryptophan (a serotonin building block), as a potential solution for sleep issues. The conversation then shifts to the client's diet, initially described as salads for lunch and grains for dinner, with occasional pizza or pasta. This is clarified by Megan, who specifies that their dinners usually include fish, chicken, ground beef, or ground turkey, with occasional Mexican food or pizza. Anthony J acknowledges the clarification and notes the corrected dietary information.
Dairy Sensitivity Discussion
00:07:25 - 00:09:01
Anthony J discusses Megan's known dairy sensitivity. They explore the varying effects of different dairy products, with Megan noting that cheese consumption causes issues only when consumed in large quantities, while yogurt is completely off-limits. Anthony J suggests substituting goat products for cow's milk products, particularly goat cheese as a replacement for regular cheese. He also inquires about butter and whipping cream, with Megan stating that while they don't usually cause significant problems, she limits her butter intake and prefers using avocado or coconut oil for cooking. The conversation concludes with Megan confirming that even small amounts of dairy products can sometimes cause issues.
Dairy Sensitivity and Sleep Issues
00:09:01 - 00:09:42
Anthony J discusses the client's dairy sensitivity, advising caution and suggesting goat products as an alternative. He connects the sensitivity to sleep issues, explaining that a specific gene impacts serotonin production in the gut, affecting brain serotonin levels and sleep. He mentions supplements as a potential aid, but emphasizes dietary changes as the primary solution.
Caffeine Metabolism and Lifespan Genes
00:09:43 - 00:10:43
Anthony J reviews two additional genes: the caffeine metabolism gene, which the client processes rapidly, and a sirtuin gene linked to lifespan. The client possesses a variant associated with shorter lifespan, but Anthony J explains this can be mitigated with grapeseed extract supplements containing proanthocyanidins or resveratrol. He cautions that high doses of resveratrol mimic estrogen.
Hormone Imbalance and Sleep Issues
00:10:43 - 00:11:43
Anthony J suggests that the client's hormonal imbalances, particularly sex hormones and estrogen genes, might be the root cause of many of her issues. He specifically mentions progesterone as a potential solution for improving sleep, highlighting its impact on metabolic issues. He notes that while hormonal imbalances can manifest early, stress levels play a significant role. He emphasizes the importance of addressing sleep issues first, as improved sleep can positively impact various health problems. He recommends a grape seed supplement to address a specific gene and then transitions to discussing diet.
Diet and Diabetes Risk
00:11:45 - 00:12:09
Anthony J shifts the conversation to diet, focusing on vitamin and hormone detoxification. He notes the presence of several type 2 diabetes genes in the client's genetic profile, which aligns with the family history of diabetes mentioned by the client (Megan). The presence of these genes in both her maternal and paternal family lines is noted by both Anthony J and Megan.
Assessing Client's Health Risks and Lifestyle
00:12:11 - 00:13:44
Anthony J discusses three genetic markers (HEX and two others) indicating increased risk for type 2 diabetes in Megan. He inquires about her blood sugar levels, learning that she hasn't had them checked in a year, and notes that the normal range for blood sugar has broadened due to high levels in many Americans. The conversation shifts to the importance of exercise for Megan, who explains that her 70-hour work week and resulting lack of time and motivation have hindered her fitness routine. She also mentions experiencing stress from juggling multiple work projects.
Stress and Weight Gain
00:13:46 - 00:15:17
Megan describes experiencing significant stress around Christmas due to multiple projects, family visiting, and recently buying a house. This stress led to severe insomnia and, subsequently, a weight gain of approximately 20 pounds since then. Anthony J relates this weight gain to potential hormone-related genetic factors and the impact of elevated blood sugar levels. He explains that high blood sugar triggers increased insulin production, which, being a fat storage hormone, promotes fat storage and weight gain. He uses the example of bodybuilders using insulin for muscle growth to illustrate this point, emphasizing that while insulin promotes growth, it's undesirable for weight loss.
Dietary and Lifestyle Advice
00:15:18 - 00:17:00
Anthony J suggests Megan check her blood sugar levels and prioritize exercise, emphasizing the importance of scheduling it. He mentions zinc as an important nutrient, suggesting supplementation if she doesn't get enough from her diet (meat). He notes that Megan's intermittent fasting habits (eating around noon or 2 pm) are beneficial due to her "intermittent fasting gene." He recommends adding more protein to her lunch salads (currently containing ground turkey or chicken). Anthony J contrasts Megan's healthy eating habits with those of other clients who consume fast food, highlighting Megan's awareness of how food affects her well-being. He concludes by recommending two tools for health monitoring: a $20 finger-pricking blood sugar monitor and a more advanced continuous glucose monitor as an option.
Favorite Health Tracking Tools and Metformin Discussion
00:17:01 - 00:18:29
Anthony J shares his preferred health tracking tools: a continuous glucose monitor checked before eating and an Oura Ring for sleep tracking. He emphasizes the importance of sleep and blood sugar monitoring. The discussion then turns to metformin, noting the client's high response to it. Anthony J explains that metformin is commonly prescribed for diabetes to lower blood sugar, and studies show it extends lifespan in various animals. He mentions that while some experience side effects like diarrhea, others benefit from improved blood sugar and metabolism. The client's "plus-plus" genetic marker indicates a high likelihood of benefiting from metformin, although obtaining a prescription may require convincing a doctor.
Metformin Discussion and IBS Treatment Options
00:18:29 - 00:20:07
Anthony J discusses the possibility of obtaining a metformin prescription, mentioning its derivation from a natural plant and suggesting it's easier to obtain than other medications. He shares his personal experience with metformin, noting its effectiveness and mentioning potential side effects like constipation. The conversation then shifts to Megan's IBS and constipation, and her current use of Trulance. Anthony J suggests magnesium as a natural alternative to Trulance, recommending Natural Calm magnesium powder as a convenient option for improving bowel movements.
Magnesium Supplementation and Heart Palpitations
00:20:08 - 00:21:34
Anthony J recommends Megan try Natural Calm, a magnesium supplement, to address her heart palpitations. He suggests starting with a small dose and gradually increasing it until she experiences loose stools, then decreasing the dose. He explains that this is particularly relevant due to Megan's genetic predisposition to heart palpitations, which is linked to magnesium levels. Megan confirms experiencing irregular heartbeats, often detected by her heart rate tracking watch. Anthony J explains that many Americans are magnesium deficient due to depleted soil nutrients in modern agriculture, suggesting that Megan's deficiency might be significant. He notes that while leafy greens are a good source, modern farming practices often lack sufficient magnesium.
Supplement Recommendations and Heart Disease Risk Factors
00:21:34 - 00:23:00
Anthony J discusses the client's need for micronutrients, recommending magnesium and grapeseed extract as priorities. Magnesium is highlighted for its sleep-promoting and calming effects, suggesting taking it before bed. The conversation then shifts to heart disease risk, specifically mentioning the lipoprotein lipase (LPL) gene and the importance of keeping triglycerides below 125. A rarer gene, MTHFD1L, is also discussed, explaining its link to increased homocysteine levels, a heart disease risk factor sometimes checked in blood tests. The conversation includes confirmation that the client is recording the session.
Homocysteine Levels and Genetic Predisposition
00:23:01 - 00:24:38
Anthony J emphasizes the importance of checking homocysteine levels, particularly for the client due to a genetic predisposition. High homocysteine indicates inflammation and artery damage. He explains that while it's usually normal for most people, the client's genetic profile increases their risk. He suggests that if homocysteine levels are high, lifestyle factors like vitamin B deficiency, smoking, alcohol consumption, and stress should be addressed. Even with B complex supplementation, persistently high levels might indicate a thyroid issue. The client mentions past thyroid medication use, which Anthony J finds unsurprising given her genetic risk and past medical history.
Genetic Health Assessment and Recommendations
00:24:38 - 00:26:21
Megan and Anthony J discuss Megan's genetic test results. Megan reveals a family history of thyroid and hormone issues, attributing her own genetic predispositions to this. Anthony J reassures her that most of her genetic markers are positive, with one easily manageable risk factor (potentially thyroid-related, easily checked via vitamin B complex supplementation and retesting). He notes some gut issues indicated by the test, but emphasizes that the number of problematic gene markers is relatively low compared to most patients. The conversation then focuses on the gut section of the report, highlighting several positive markers indicating gut inflammation. Anthony J specifically recommends grapeseed extract as a supplement to address this inflammation, citing its potential benefits for both gut health and lifespan.
NOD2 Gene and Ketogenic Diet Discussion
00:26:21 - 00:27:57
Anthony J discusses the NOD2 gene, its response to ketogenic diets and ketones, and suggests the client try a keto diet. He explains that the NOD2 gene triggers inflammasomes, which are sources of inflammation, and that ketones inhibit these inflammasomes. He recommends a ketogenic approach, focusing on fats and minimizing carbs and protein for at least a couple of weeks to induce ketosis, acknowledging the difficulty, especially given the client's dairy restrictions. Anthony J mentions his own current state of ketosis and offers this dietary approach as a next step to improve metabolism and hormone regulation beyond the previously discussed magnesium and grape seed supplements.
Keto Diet Discussion
00:27:58 - 00:29:45
Anthony J describes his experience with the keto diet, noting that after two weeks he achieves a six-pack, something he doesn't usually have despite not being overweight. He emphasizes the difficulty of maintaining the diet due to carb cravings. Megan shares that carbs, particularly savory options like pasta, bread, pizza, and garlic bread, are her weakness. Anthony J suggests a two-week trial of the keto diet, followed by a reassessment, ideally extending to six weeks. He recommends the "keto brick," a high-fat, moderate-protein, low-carb protein bar, explaining that excess protein can be converted to carbs, hindering the diet's effectiveness. He highlights the importance of consuming sufficient fat and mentions that leafy greens have minimal calories, allowing for generous consumption.
Gut Health and Dietary Recommendations
00:29:45 - 00:31:20
Anthony J discusses the client's gut issues, relating them to genetic predispositions. He suggests a ketogenic diet as a priority, noting that it's a difficult diet but beneficial for gut health. He also mentions the ATG16L1 gene, associated with grain sensitivity and inflammation from gluten. While the client is often gluten-free, Anthony J recommends a month-long trial of complete gluten elimination followed by reintroduction to assess its impact. He highlights the importance of the SLC22A4 gene, which affects ergothionine transport, a vitamin beneficial for gut lining health. Mushrooms are suggested as a good source of ergothionine, given the client's apparent deficiency in its absorption. The conversation concludes with the client expressing understanding of the genetic and dietary connections explained.
Mushroom Supplements for Gut Health and Cognitive Enhancement
00:31:20 - 00:32:33
Anthony J discusses the benefits of mushrooms, particularly Lion's Mane, for gut health and cognitive function. He highlights that mushrooms contain a high concentration of a specific vitamin crucial for gut lining improvement. He recommends consuming mushrooms or a mushroom extract, referencing a product from his website, ajconsultingcompany.com/whatIuse. He personally uses Lion's Mane, noting its energizing effect, making it unsuitable for consumption in the afternoon or evening due to its stimulating properties. He contrasts Lion's Mane with other mushroom types like Reishi, Turkey Tail, and Cordyceps, which offer different benefits, including calming effects and improvements to hair and nails, but all contribute to gut health. He reiterates his preference for Lion's Mane due to its combined gut and cognitive benefits, suggesting it's particularly helpful for individuals engaged in demanding mental tasks.
CNR1 Gene and Cannabinoid Receptors
00:32:35 - 00:32:40
Anthony J introduces the CNR1 gene, identifying it as the cannabinoid receptor (CBD receptor).
Supplementing CBD for Gut and Joint Issues
00:32:40 - 00:33:04
Anthony J suggests supplementing CBD for gut issues, recommending 20 milligrams or more as needed, noting its anti-inflammatory properties beneficial for gut and joint problems. He clarifies that while not for continuous use, it's helpful for these specific issues.
Ketogenic Diet and Magnesium Recommendations
00:33:06 - 00:33:37
Anthony J summarizes the client's numerous gene issues and recommends a ketogenic diet and magnesium supplementation. He highlights keto's potential to resolve many of the client's problems by resetting hormones and addressing underlying issues. He encourages the client to try keto, emphasizing its potential benefits and describing it as an interesting and productive experience.
Ketogenic Diet and Personal Productivity
00:33:38 - 00:34:05
Megan acknowledges the ketogenic diet suggestion. Anthony J shares his personal experience with keto, stating he uses it to boost productivity, contrasting his preference for keto with his dislike of writing, despite having written a book. The conversation briefly touches on Megan's enjoyment of writing and her accounting profession, which requires mathematical skills.
Overcoming Challenges and the Role of Genetics
00:34:05 - 00:35:46
Anthony J discusses personal challenges related to tasks he dislikes, explaining that his motivation increases significantly when following a ketogenic diet. He then shifts to discussing the HCP5 gene, an ancient virus gene present in all humans, and its connection to skin issues. He explains that this gene can be activated by inflammation, particularly through the immune system genes HLA and ERAP1, often triggered by gut bacteria. The overall implication is that skin problems are linked to inflammation, potentially stemming from gut health.
Gut Health and Skin Issues
00:35:46 - 00:38:00
Anthony J explains the connection between gut inflammation and skin issues, suggesting that improving gut health is key to resolving skin problems. He mentions the potential benefits of mushroom supplements like turkey tail in improving gut health. Megan then describes her experience with severe heat rashes and hives triggered by anxiety and nervousness. Anthony J shares a similar experience with his daughter, suspecting a fungus or mold issue possibly linked to a kitten. He describes treating his daughter's hives with a one-day keto diet, eliminating carbs. He suggests Megan's issue might be related to a gut problem, possibly candida overgrowth, a yeast infection that can cause significant problems if it overgrows.
Gut Health and Skin Condition Discussion
00:38:00 - 00:39:41
Anthony J suggests that the client's skin condition might be related to gut health, proposing that an overgrowth of fungus, thriving on carbohydrates, could be a factor. He recommends a diet high in fat and low in carbohydrates to combat this, citing studies on coconut oil's effectiveness against candida. He mentions that butter and other fats are beneficial for gut health and help control yeast, molds, and fungus. Anthony J acknowledges that doctors often label such conditions as "idiopathic," offering immunosuppressants without addressing the root cause. Megan shares her experience with a recurring skin rash since fifth grade, describing an incident where she experienced hives during a class presentation. Anthony J finds this information interesting and suggests a possible connection to the gut health theory.
Histamine Intolerance and Gut Issues
00:39:41 - 00:41:17
Megan describes experiencing stress-induced flare-ups, even from seemingly minor interactions like being stared at. Anthony J then shifts the discussion to a related gut issue: histamine intolerance. He points to a specific section ("vitamin hormone detox genes," page 10 online) in the client's report detailing histamine intolerance, noting the client has three gene issues related to this, which is significantly higher than the average of zero. He explains that this indicates a high sensitivity to histamines, similar to allergies, where immune cells release histamines, particularly when gut issues are present. This excessive histamine secretion can unpredictably trigger the immune system, leading to various symptoms.
Histamine Intolerance and Genetic Factors
00:41:17 - 00:42:57
Anthony J discusses the client's symptoms, linking them to histamine intolerance. He explains that high histamine levels manifest in various ways, including disrupted sleep, stomach acid release, and hives. He notes the difficulty of a histamine-free diet due to the widespread presence of histamines in food. The conversation then shifts to the AOC1 gene, a copper-dependent gene involved in histamine metabolism. Anthony J emphasizes the importance of copper supplementation, suggesting a copper and zinc supplement as a convenient way to address both potential deficiencies. He also mentions that gut issues and yeast could be contributing factors, making the situation complex. He suggests a ketogenic diet as another approach to lower histamine levels, before proposing to revisit the vitamin section of the discussion.
Vitamin D Supplementation Recommendation
00:43:04 - 00:44:43
Anthony J discusses the importance of vitamin D supplementation, particularly in relation to COVID-19 mortality rates. He notes a strong correlation between low vitamin D levels and COVID-19 deaths, suggesting that almost all deaths occur in individuals with abysmal vitamin D levels. While acknowledging potential confounding factors, he emphasizes the compelling evidence linking low vitamin D to increased COVID-19 risk. He recommends the client, Megan, supplement with 5,000 IUs of vitamin D daily, a dosage higher than government recommendations, to achieve optimal blood levels. He suggests blood testing to verify the effectiveness of the supplementation and emphasizes the importance of vitamin D, especially given Megan's genetics and limited sun exposure due to her office-based work.
The Negative Effects of Low Vitamin D and Seed Oils
00:44:44 - 00:45:40
Anthony J discusses studies showing a correlation between low vitamin D levels and worsened gut lining, leading to various gut issues. He emphasizes the extensive list of problems associated with vitamin D deficiency, comparing it to the lengthy side effect lists of prescription drugs. He highlights muscle weakness, low energy, brain fog, and other symptoms as potential consequences of low vitamin D. He concludes that maintaining sufficient vitamin D levels is crucial and that it's a relatively inexpensive supplement.
Avoiding Seed Oils and the Importance of Healthy Fats
00:45:40 - 00:46:05
Anthony J advises avoiding seed oils like soybean oil, suggesting a preference for fruit oils such as coconut, olive, and avocado oils. The conversation briefly touches upon the client's existing avoidance of seed oils and then transitions to a discussion about hormones, specifically mentioning testosterone and a "plus-plus gene" related to it.
Addressing Low Testosterone Levels
00:46:05 - 00:47:40
Anthony J discusses the importance of addressing low testosterone levels in women. He explains that low testosterone can lead to various issues, including low sex drive, metabolic problems, and decreased motivation to exercise. He criticizes the "normal range" for testosterone provided by some lab testing companies, pointing out that a zero level is unacceptable and often misrepresented by doctors. He emphasizes the need to find a doctor willing to optimize testosterone levels, recommending Dr. Keith Nichols as an example of a doctor who takes a proactive approach to optimizing hormone levels rather than simply accepting a "normal" but potentially suboptimal reading. Anthony J highlights the significant positive impact that balanced testosterone levels can have on various aspects of health and well-being, including sleep quality.
Hormone Imbalance and Holistic Treatment
00:47:40 - 00:49:36
Anthony J discusses the patient's symptoms, highlighting significant estrogen and progesterone gene issues, potentially impacting thyroid levels. He emphasizes the need for blood tests and collaboration with a doctor to fine-tune hormone levels, optimize metabolism, and improve gut health and sleep. Anthony J explains the interconnectedness of gut health, sleep, and hormones, stating that imbalances in one area can negatively affect the others. He notes the patient's existing thyroid issues, which are not uncommon in older clients but are notable at the patient's age. Megan confirms past thyroid medication use but states she is no longer on any replacement therapy.
Negative Experience with Armor Thyroid and Subsequent Discussion on Thyroid Health
00:49:36 - 00:50:15
Megan describes a negative experience with Armor Thyroid, citing difficulties with dosing, sleep disruption, and feeling unwell. The medication was also expensive because it wasn't covered by insurance. She ultimately stopped taking it. Anthony J expresses understanding and empathy.
Importance of Iodine and Addressing Underlying Inflammation
00:50:16 - 00:51:12
Anthony J emphasizes the importance of iodine intake, especially given Megan's genetic predispositions. He explains that iodine is a crucial building block for thyroid hormones. The conversation then shifts to inflammation, specifically mentioning the TG gene (thyroglobulin), which indicates a significantly increased risk of autoimmune thyroid issues. Anthony J explains that autoimmune responses, triggered by histamines and gut problems in Megan's case, are attacking her thyroid. He suggests that addressing these underlying histamine and gut issues should, in the long term, resolve the thyroid problems.
Addressing Client's Hormonal and Thyroid Issues
00:51:12 - 00:53:24
Anthony J explains that the cheapest way to address the client's hormone issues is a six-week keto diet to reset sex hormones. Exercise also helps, but keto allows for some flexibility if motivation or stress levels are high. He emphasizes that inflammation is a key issue impacting thyroid function, stating that thyroid supplements won't be effective without addressing gut inflammation, homocysteine levels, and iodine intake. The client agrees, likening the process to a stepping stool where one issue must be addressed before moving to the next. Anthony J explains the interconnectedness of various factors, suggesting that multiple facets could be contributing to the client's problems. He recommends a comprehensive approach: iodine, magnesium, 5-HTP before bed, a keto diet, vitamin D, and grapeseed extract. The client expresses concern about the impact of such a drastic change, but Anthony J reassures her that it's unlikely to be a shock given probable deficiencies in magnesium and iodine.
Magnesium Deficiency and Ketogenic Diet
00:53:24 - 00:55:50
Anthony J explains that the gold standard magnesium test involves supplementing with magnesium and observing urinary excretion. Low excretion indicates deficiency, while high excretion suggests sufficient levels. He hypothesizes that the patient's cells are magnesium-deficient, hence the low excretion. He suggests that instead of a "shock" approach, gradually providing magnesium will better meet cellular needs. The ketogenic diet, while beneficial, might initially cause low energy or flu-like symptoms due to the body's adaptation to burning fat instead of sugar. He recommends starting the keto diet on a Thursday or Friday to allow for weekend rest. He emphasizes the importance of electrolytes, particularly salt, to mitigate these symptoms. The keto diet will also help reset sex hormones. He briefly mentions estrogen dominance and the patient's lack of access to saunas, suggesting alternatives like portable saunas or sauna blankets, or even sweating in a hot car.
Sauna Use and its Benefits
00:55:50 - 00:56:45
Anthony J discusses the benefits of sweating, noting that even 10 minutes of intense exercise can provide similar advantages to sauna use, although achieving this level of sweat is difficult for many. He emphasizes that saunas are particularly effective at reducing inflammation, which he considers a root cause of various health issues. He cites a 20-year Scandinavian study showing significant decreases in cancer, heart disease, and Alzheimer's with regular sauna use, attributing this to hormonal balance and other benefits. He reiterates that sweating, whether through exercise or saunas, offers similar advantages.
Review of Client's Lifestyle and Potential Issues
00:56:46 - 00:57:55
Anthony J asks the client if they have any further questions or comments. He reviews previously discussed topics, stating that he's not concerned about the carotene gene and histamines. He inquires about cannabis use, which the client (Megan) denies. Megan also mentions limited alcohol consumption and family history of substance use. Anthony J notes that this eliminates a potential issue, and prepares to move to the next section of the discussion, acknowledging the complexity and interconnectedness of the information covered so far, highlighting inflammation as a key factor.
MTHFR Gene and Pregnancy
00:57:55 - 00:59:34
Megan indicates she will likely have more questions when discussing supplements later. Anthony J then focuses on the client's MTHFR C677T gene, noting a "plus plus" result, which is strongly associated with miscarriages. He emphasizes the importance of avoiding folic acid and instead using methylfolate, especially during pregnancy. He explains that folic acid is synthetic, requiring conversion to methylfolate for use in the body, a process crucial for DNA creation, particularly vital for fetal development due to rapid cell growth. He highlights the frequent misdiagnosis and incorrect advice from doctors regarding folic acid versus methylfolate in relation to pregnancy and miscarriage. The client acknowledges understanding.
Methylfolate and B Vitamin Deficiency
00:59:35 - 01:01:15
Anthony J explains the importance of methylfolate, especially during pregnancy, highlighting its superior absorption compared to folic acid (90% less efficient conversion). He recommends consuming leafy greens, particularly spinach, as a rich source of methylfolate. Supplements are suggested as an alternative if dietary intake is insufficient, citing improved sleep as a reported benefit based on Amazon reviews. The discussion then shifts to related genes influencing methylfolate processing and the potential need for B12 supplementation, particularly since the client is a vegetarian. Anthony J advises increasing meat consumption or taking B12 supplements due to the client's genetic predisposition to B vitamin deficiencies. Finally, he recommends limiting fructose intake (high fructose corn syrup, soda) to avoid fat storage and suggests exploring low-fructose berries as alternatives, providing a web link for further information.
Genetic Predisposition and Health Recommendations
01:01:16 - 01:02:47
Anthony J reviews Megan's genetic report, noting her surprisingly good genes for a 28-year-old, particularly concerning joints, despite having arthritis. He attributes this to likely gut health rather than genetics. While she has a 1++ risk for gout due to a fructose gene, he emphasizes that this is manageable with diet. Her rheumatoid arthritis stems from an overactive immune system and inflammation. He expresses less concern about her collagen gene and blood pressure gene, given her low blood pressure. However, he highlights a couple of genes indicating weaker bones, recommending increased vitamin D, magnesium, and potentially calcium intake, suggesting a slight increase in meat consumption as a source of calcium. The overall tone is positive, focusing on manageable risk factors and dietary adjustments.
Sleep Optimization Strategies
01:02:50 - 01:04:24
Anthony J reviews Megan's genetic predisposition to sleep, noting a strong genetic basis for good sleep but highlighting a blue light sensitivity gene. He inquires about the darkness of her sleeping environment. Megan explains that an air purifier with a blue ring light illuminates part of her room due to her boyfriend's cat allergies. Anthony J suggests covering the air purifier's light with electrical tape to minimize blue light exposure, emphasizing the importance of minimizing all light sources, even small ones from power strips, for optimal sleep.
Strategies for Improving Sleep Quality
01:04:24 - 01:06:17
Anthony J suggests using electric tape or dark curtains to block out light, as light sensitivity can significantly disrupt sleep. Megan mentions using a Bluetooth-enabled sleep mask with calming audio, but finds it uncomfortable due to its design and her side-sleeping habit. Anthony J reiterates the importance of a completely dark room and explains that blue light interferes with melatonin production, impacting sleep quality. He notes that while this is a common issue, it's particularly impactful for Megan due to her rare "plus-plus gene." Megan confirms she already uses blue blocker glasses and a blue light filter on her phone, but still experiences severe headaches if these measures aren't in place. Anthony J shares that he uses a blue light blocking app called Flux on his computer to mitigate blue light exposure.
Blue Light Exposure and Sleep Issues
01:06:17 - 01:08:07
Anthony J discusses his use of blue light filtering apps on his work computers due to photosensitivity and corneal erosion. He recommends these apps to Megan, emphasizing the importance of reducing blue light exposure, especially in the evenings. He notes that blue light from computer screens is generally detrimental to eye health. The conversation then shifts to Megan's sleep issues, with Anthony J suggesting that her sleep genes appear good, but underlying issues like serotonin levels and inflammation could be contributing factors. He highlights the importance of a dark sleep environment and addressing gut health to improve sleep quality.
Seasonal Depression and Potential Underlying Causes
01:08:07 - 01:08:23
Anthony J summarizes the discussion, acknowledging the numerous factors discussed. He reiterates the potential impact of serotonin and inflammation on sleep. He suggests that addressing gut health is key to improving sleep. Megan indicates she has a question.
Megan's Retina Detachment and Further Questions
01:08:23 - 01:08:46
Megan shares that she experienced a retinal detachment three years prior. The conversation ends abruptly at this point.
Megan's Unexpected Eye Condition and Potential Stickler Syndrome
01:08:46 - 01:11:23
Megan describes a spontaneous retinal detachment requiring scleral buckle surgery and laser treatment for lattice degeneration in both eyes. The surgeon noted her increased risk for recurrence due to severe myopia and suggested the possibility of Stickler syndrome after learning about her history of braces for a small jaw, slight scoliosis, and poor eyesight. Megan had never heard of Stickler syndrome, and her previous doctors hadn't mentioned it. The surgeon recommended genetic testing at the Mayo Clinic to confirm or rule out the syndrome, suggesting that early diagnosis could have prevented some issues. Anthony J comments on the rarity of Stickler syndrome, noting that it's unlikely to be detected by common genetic testing services like 23andMe and suggesting that more specific gene testing would be necessary for confirmation. He expresses doubt about Megan actually having the syndrome.
Family Medical History and Genetic Predisposition
01:11:28 - 01:13:01
Anthony J and Megan discuss Megan's family history of eye problems, specifically glaucoma and retinal detachments. Anthony J suggests that her mother's potential undiagnosed diabetes or high blood sugar during pregnancy could be a contributing factor. Megan mentions a family history of retinal detachments and glaucoma on her mother's side. Anthony J then notes Megan's collagen gene (collagen 11A1), which is usually associated with joint issues but could potentially impact her eyes. He suggests she check her 23andMe or Self-Decode results for this gene and email him the information so he can investigate further. He offers to look for the gene information for free if it's included in her results, but notes that it might require some research or contacting the genetic testing company.
Supplement Recommendations and Code Review
01:13:01 - 01:15:04
Anthony J explains that checking for specific code requires some digging, which he doesn't have time for, but the client can do it. He mentions that if the code is found, he can easily review it. Megan then requests a review of the recommended supplements. Anthony J states he doesn't have a formal list but details several supplements: 5-HTP and tryptophan are considered optional, for later use if other supplements don't improve sleep. He recommends daily intake of grape seed pro-amphacianidins, a B-complex with methylfolate (or methylfolate and B12 separately as a cheaper alternative), zinc and copper together, and magnesium nightly (increasing dosage until loose stools occur). He also suggests daily mushroom consumption (mentioning a preferred brand, Life Cycle) and notes that some supplements may require further discussion.
Ketogenic Diet and Hormone Reset
01:15:09 - 01:16:34
Anthony J recommends a six-week ketogenic diet to reset sex and thyroid hormones, alongside Vitamin D and iodine supplementation. He explains that switching the body's metabolic processes from carb-burning to fat-burning is a significant undertaking, like changing a factory's production from semi-trucks to airplanes. He acknowledges the initial difficulties, including carb cravings, low energy, and flu-like symptoms, suggesting electrolyte pills to mitigate these side effects. The initial discomfort is expected to last about a week, after which the benefits of the hormonal reset should become apparent. The keto diet is not intended to be permanent, but rather a six-week reset period.
Keto Diet and Electrolytes
01:16:34 - 01:17:25
Anthony J summarizes the importance of electrolytes when following a keto diet, emphasizing that insufficient electrolytes can lead to flu-like symptoms. He notes that even with sufficient electrolytes, some discomfort might persist, but it will be less severe. He also recommends collagen protein powder as an anti-inflammatory supplement that may help with Megan's eye condition. Finally, he stresses the importance of maintaining a completely dark room for optimal sleep and eye health.
Mailing Delays and Closing Remarks
01:17:26 - 01:17:57
Anthony J apologizes for the delay in mailing, attributing it to both general mail slowdowns due to protests and his own slower-than-usual processing. He expresses appreciation for Megan's patience. Megan thanks Anthony J for his time and assistance. The conversation concludes with pleasantries.
Meeting Adjournment
01:17:57 - 01:17:59
The meeting concluded with brief farewells exchanged between Megan, Anthony J, and the Client.
00:00:00 - 00:01:35
Anthony J introduces his podcast, AJConsultingCompany.com, which offers pristine audio quality and DNA analysis using 23andMe data. He describes himself as a Mayo Clinic scientist, author, and YouTuber with two channels: Anthony J Cast (scientific content) and Anthony J Family Cast (outdoor adventures). He previews the episode, featuring Megan from Louisiana, a 28-year-old with complex genetic issues related to inflammation, highlighting the sometimes complicated nature of genetic analysis.
Initial Client Contact and Scheduling
00:01:36 - 00:02:04
The episode begins with Anthony J greeting Megan. A brief discussion ensues regarding a minor scheduling delay caused by Megan misplacing her headphones. Anthony J assures Megan that the delay is insignificant. Megan confirms the delay was on her end due to the misplaced headphones. Anthony J confirms Megan's location as Louisiana.
Initial Consultation and Patient History
00:02:05 - 00:03:30
Anthony J begins the consultation by acknowledging Megan's presence. Megan reports various health issues including IBS, rheumatoid conditions, brittle hair and nails, and significant sleep disturbances. She describes her sleep as restless, with difficulty falling asleep (1-2 hours), frequent waking, and sensitivity to movement. She uses a smartwatch to track sleep, revealing that despite spending eight hours in bed, she only gets 5 hours (or less) of actual sleep. Megan confirms she only takes Vitamin C and Biotin supplements.
Review of Alzheimer's Risk Factors and PDF Discussion
00:03:31 - 00:04:00
Anthony J states they will review a PDF sent to Megan. He points out five Alzheimer's categories within the PDF, noting that Megan has none of the associated risk genes or brain performance optimization issue genes, which is considered positive.
Understanding Genetic Report Results
00:04:00 - 00:05:28
Anthony J explains the meaning of "plus-plus" and "plus-minus" notations in a genetic report. He clarifies that these notations reflect the two copies of DNA in each cell, one from each parent. A "plus-plus" result indicates inheriting a bad gene copy from both parents, representing a more significant issue. A "plus-minus" result signifies inheriting one bad and one good gene copy, generally less problematic than "plus-plus". The discussion focuses on identifying problematic genes to understand the root cause of health issues. Anthony J emphasizes that the report focuses on identifying problem genes, not the thousands of good genes present. He aims to pinpoint the root cause of the problem to find a solution.
Sleep and Anxiety Gene Discussion
00:05:28 - 00:07:18
Anthony J discusses a client's anxiety gene, tph2, which impacts sleep. He explains that this gene affects serotonin transport to the brain, and increased serotonin can cause tiredness. He suggests trying the supplement 5-HTP, which increases serotonin, along with tryptophan (a serotonin building block), as a potential solution for sleep issues. The conversation then shifts to the client's diet, initially described as salads for lunch and grains for dinner, with occasional pizza or pasta. This is clarified by Megan, who specifies that their dinners usually include fish, chicken, ground beef, or ground turkey, with occasional Mexican food or pizza. Anthony J acknowledges the clarification and notes the corrected dietary information.
Dairy Sensitivity Discussion
00:07:25 - 00:09:01
Anthony J discusses Megan's known dairy sensitivity. They explore the varying effects of different dairy products, with Megan noting that cheese consumption causes issues only when consumed in large quantities, while yogurt is completely off-limits. Anthony J suggests substituting goat products for cow's milk products, particularly goat cheese as a replacement for regular cheese. He also inquires about butter and whipping cream, with Megan stating that while they don't usually cause significant problems, she limits her butter intake and prefers using avocado or coconut oil for cooking. The conversation concludes with Megan confirming that even small amounts of dairy products can sometimes cause issues.
Dairy Sensitivity and Sleep Issues
00:09:01 - 00:09:42
Anthony J discusses the client's dairy sensitivity, advising caution and suggesting goat products as an alternative. He connects the sensitivity to sleep issues, explaining that a specific gene impacts serotonin production in the gut, affecting brain serotonin levels and sleep. He mentions supplements as a potential aid, but emphasizes dietary changes as the primary solution.
Caffeine Metabolism and Lifespan Genes
00:09:43 - 00:10:43
Anthony J reviews two additional genes: the caffeine metabolism gene, which the client processes rapidly, and a sirtuin gene linked to lifespan. The client possesses a variant associated with shorter lifespan, but Anthony J explains this can be mitigated with grapeseed extract supplements containing proanthocyanidins or resveratrol. He cautions that high doses of resveratrol mimic estrogen.
Hormone Imbalance and Sleep Issues
00:10:43 - 00:11:43
Anthony J suggests that the client's hormonal imbalances, particularly sex hormones and estrogen genes, might be the root cause of many of her issues. He specifically mentions progesterone as a potential solution for improving sleep, highlighting its impact on metabolic issues. He notes that while hormonal imbalances can manifest early, stress levels play a significant role. He emphasizes the importance of addressing sleep issues first, as improved sleep can positively impact various health problems. He recommends a grape seed supplement to address a specific gene and then transitions to discussing diet.
Diet and Diabetes Risk
00:11:45 - 00:12:09
Anthony J shifts the conversation to diet, focusing on vitamin and hormone detoxification. He notes the presence of several type 2 diabetes genes in the client's genetic profile, which aligns with the family history of diabetes mentioned by the client (Megan). The presence of these genes in both her maternal and paternal family lines is noted by both Anthony J and Megan.
Assessing Client's Health Risks and Lifestyle
00:12:11 - 00:13:44
Anthony J discusses three genetic markers (HEX and two others) indicating increased risk for type 2 diabetes in Megan. He inquires about her blood sugar levels, learning that she hasn't had them checked in a year, and notes that the normal range for blood sugar has broadened due to high levels in many Americans. The conversation shifts to the importance of exercise for Megan, who explains that her 70-hour work week and resulting lack of time and motivation have hindered her fitness routine. She also mentions experiencing stress from juggling multiple work projects.
Stress and Weight Gain
00:13:46 - 00:15:17
Megan describes experiencing significant stress around Christmas due to multiple projects, family visiting, and recently buying a house. This stress led to severe insomnia and, subsequently, a weight gain of approximately 20 pounds since then. Anthony J relates this weight gain to potential hormone-related genetic factors and the impact of elevated blood sugar levels. He explains that high blood sugar triggers increased insulin production, which, being a fat storage hormone, promotes fat storage and weight gain. He uses the example of bodybuilders using insulin for muscle growth to illustrate this point, emphasizing that while insulin promotes growth, it's undesirable for weight loss.
Dietary and Lifestyle Advice
00:15:18 - 00:17:00
Anthony J suggests Megan check her blood sugar levels and prioritize exercise, emphasizing the importance of scheduling it. He mentions zinc as an important nutrient, suggesting supplementation if she doesn't get enough from her diet (meat). He notes that Megan's intermittent fasting habits (eating around noon or 2 pm) are beneficial due to her "intermittent fasting gene." He recommends adding more protein to her lunch salads (currently containing ground turkey or chicken). Anthony J contrasts Megan's healthy eating habits with those of other clients who consume fast food, highlighting Megan's awareness of how food affects her well-being. He concludes by recommending two tools for health monitoring: a $20 finger-pricking blood sugar monitor and a more advanced continuous glucose monitor as an option.
Favorite Health Tracking Tools and Metformin Discussion
00:17:01 - 00:18:29
Anthony J shares his preferred health tracking tools: a continuous glucose monitor checked before eating and an Oura Ring for sleep tracking. He emphasizes the importance of sleep and blood sugar monitoring. The discussion then turns to metformin, noting the client's high response to it. Anthony J explains that metformin is commonly prescribed for diabetes to lower blood sugar, and studies show it extends lifespan in various animals. He mentions that while some experience side effects like diarrhea, others benefit from improved blood sugar and metabolism. The client's "plus-plus" genetic marker indicates a high likelihood of benefiting from metformin, although obtaining a prescription may require convincing a doctor.
Metformin Discussion and IBS Treatment Options
00:18:29 - 00:20:07
Anthony J discusses the possibility of obtaining a metformin prescription, mentioning its derivation from a natural plant and suggesting it's easier to obtain than other medications. He shares his personal experience with metformin, noting its effectiveness and mentioning potential side effects like constipation. The conversation then shifts to Megan's IBS and constipation, and her current use of Trulance. Anthony J suggests magnesium as a natural alternative to Trulance, recommending Natural Calm magnesium powder as a convenient option for improving bowel movements.
Magnesium Supplementation and Heart Palpitations
00:20:08 - 00:21:34
Anthony J recommends Megan try Natural Calm, a magnesium supplement, to address her heart palpitations. He suggests starting with a small dose and gradually increasing it until she experiences loose stools, then decreasing the dose. He explains that this is particularly relevant due to Megan's genetic predisposition to heart palpitations, which is linked to magnesium levels. Megan confirms experiencing irregular heartbeats, often detected by her heart rate tracking watch. Anthony J explains that many Americans are magnesium deficient due to depleted soil nutrients in modern agriculture, suggesting that Megan's deficiency might be significant. He notes that while leafy greens are a good source, modern farming practices often lack sufficient magnesium.
Supplement Recommendations and Heart Disease Risk Factors
00:21:34 - 00:23:00
Anthony J discusses the client's need for micronutrients, recommending magnesium and grapeseed extract as priorities. Magnesium is highlighted for its sleep-promoting and calming effects, suggesting taking it before bed. The conversation then shifts to heart disease risk, specifically mentioning the lipoprotein lipase (LPL) gene and the importance of keeping triglycerides below 125. A rarer gene, MTHFD1L, is also discussed, explaining its link to increased homocysteine levels, a heart disease risk factor sometimes checked in blood tests. The conversation includes confirmation that the client is recording the session.
Homocysteine Levels and Genetic Predisposition
00:23:01 - 00:24:38
Anthony J emphasizes the importance of checking homocysteine levels, particularly for the client due to a genetic predisposition. High homocysteine indicates inflammation and artery damage. He explains that while it's usually normal for most people, the client's genetic profile increases their risk. He suggests that if homocysteine levels are high, lifestyle factors like vitamin B deficiency, smoking, alcohol consumption, and stress should be addressed. Even with B complex supplementation, persistently high levels might indicate a thyroid issue. The client mentions past thyroid medication use, which Anthony J finds unsurprising given her genetic risk and past medical history.
Genetic Health Assessment and Recommendations
00:24:38 - 00:26:21
Megan and Anthony J discuss Megan's genetic test results. Megan reveals a family history of thyroid and hormone issues, attributing her own genetic predispositions to this. Anthony J reassures her that most of her genetic markers are positive, with one easily manageable risk factor (potentially thyroid-related, easily checked via vitamin B complex supplementation and retesting). He notes some gut issues indicated by the test, but emphasizes that the number of problematic gene markers is relatively low compared to most patients. The conversation then focuses on the gut section of the report, highlighting several positive markers indicating gut inflammation. Anthony J specifically recommends grapeseed extract as a supplement to address this inflammation, citing its potential benefits for both gut health and lifespan.
NOD2 Gene and Ketogenic Diet Discussion
00:26:21 - 00:27:57
Anthony J discusses the NOD2 gene, its response to ketogenic diets and ketones, and suggests the client try a keto diet. He explains that the NOD2 gene triggers inflammasomes, which are sources of inflammation, and that ketones inhibit these inflammasomes. He recommends a ketogenic approach, focusing on fats and minimizing carbs and protein for at least a couple of weeks to induce ketosis, acknowledging the difficulty, especially given the client's dairy restrictions. Anthony J mentions his own current state of ketosis and offers this dietary approach as a next step to improve metabolism and hormone regulation beyond the previously discussed magnesium and grape seed supplements.
Keto Diet Discussion
00:27:58 - 00:29:45
Anthony J describes his experience with the keto diet, noting that after two weeks he achieves a six-pack, something he doesn't usually have despite not being overweight. He emphasizes the difficulty of maintaining the diet due to carb cravings. Megan shares that carbs, particularly savory options like pasta, bread, pizza, and garlic bread, are her weakness. Anthony J suggests a two-week trial of the keto diet, followed by a reassessment, ideally extending to six weeks. He recommends the "keto brick," a high-fat, moderate-protein, low-carb protein bar, explaining that excess protein can be converted to carbs, hindering the diet's effectiveness. He highlights the importance of consuming sufficient fat and mentions that leafy greens have minimal calories, allowing for generous consumption.
Gut Health and Dietary Recommendations
00:29:45 - 00:31:20
Anthony J discusses the client's gut issues, relating them to genetic predispositions. He suggests a ketogenic diet as a priority, noting that it's a difficult diet but beneficial for gut health. He also mentions the ATG16L1 gene, associated with grain sensitivity and inflammation from gluten. While the client is often gluten-free, Anthony J recommends a month-long trial of complete gluten elimination followed by reintroduction to assess its impact. He highlights the importance of the SLC22A4 gene, which affects ergothionine transport, a vitamin beneficial for gut lining health. Mushrooms are suggested as a good source of ergothionine, given the client's apparent deficiency in its absorption. The conversation concludes with the client expressing understanding of the genetic and dietary connections explained.
Mushroom Supplements for Gut Health and Cognitive Enhancement
00:31:20 - 00:32:33
Anthony J discusses the benefits of mushrooms, particularly Lion's Mane, for gut health and cognitive function. He highlights that mushrooms contain a high concentration of a specific vitamin crucial for gut lining improvement. He recommends consuming mushrooms or a mushroom extract, referencing a product from his website, ajconsultingcompany.com/whatIuse. He personally uses Lion's Mane, noting its energizing effect, making it unsuitable for consumption in the afternoon or evening due to its stimulating properties. He contrasts Lion's Mane with other mushroom types like Reishi, Turkey Tail, and Cordyceps, which offer different benefits, including calming effects and improvements to hair and nails, but all contribute to gut health. He reiterates his preference for Lion's Mane due to its combined gut and cognitive benefits, suggesting it's particularly helpful for individuals engaged in demanding mental tasks.
CNR1 Gene and Cannabinoid Receptors
00:32:35 - 00:32:40
Anthony J introduces the CNR1 gene, identifying it as the cannabinoid receptor (CBD receptor).
Supplementing CBD for Gut and Joint Issues
00:32:40 - 00:33:04
Anthony J suggests supplementing CBD for gut issues, recommending 20 milligrams or more as needed, noting its anti-inflammatory properties beneficial for gut and joint problems. He clarifies that while not for continuous use, it's helpful for these specific issues.
Ketogenic Diet and Magnesium Recommendations
00:33:06 - 00:33:37
Anthony J summarizes the client's numerous gene issues and recommends a ketogenic diet and magnesium supplementation. He highlights keto's potential to resolve many of the client's problems by resetting hormones and addressing underlying issues. He encourages the client to try keto, emphasizing its potential benefits and describing it as an interesting and productive experience.
Ketogenic Diet and Personal Productivity
00:33:38 - 00:34:05
Megan acknowledges the ketogenic diet suggestion. Anthony J shares his personal experience with keto, stating he uses it to boost productivity, contrasting his preference for keto with his dislike of writing, despite having written a book. The conversation briefly touches on Megan's enjoyment of writing and her accounting profession, which requires mathematical skills.
Overcoming Challenges and the Role of Genetics
00:34:05 - 00:35:46
Anthony J discusses personal challenges related to tasks he dislikes, explaining that his motivation increases significantly when following a ketogenic diet. He then shifts to discussing the HCP5 gene, an ancient virus gene present in all humans, and its connection to skin issues. He explains that this gene can be activated by inflammation, particularly through the immune system genes HLA and ERAP1, often triggered by gut bacteria. The overall implication is that skin problems are linked to inflammation, potentially stemming from gut health.
Gut Health and Skin Issues
00:35:46 - 00:38:00
Anthony J explains the connection between gut inflammation and skin issues, suggesting that improving gut health is key to resolving skin problems. He mentions the potential benefits of mushroom supplements like turkey tail in improving gut health. Megan then describes her experience with severe heat rashes and hives triggered by anxiety and nervousness. Anthony J shares a similar experience with his daughter, suspecting a fungus or mold issue possibly linked to a kitten. He describes treating his daughter's hives with a one-day keto diet, eliminating carbs. He suggests Megan's issue might be related to a gut problem, possibly candida overgrowth, a yeast infection that can cause significant problems if it overgrows.
Gut Health and Skin Condition Discussion
00:38:00 - 00:39:41
Anthony J suggests that the client's skin condition might be related to gut health, proposing that an overgrowth of fungus, thriving on carbohydrates, could be a factor. He recommends a diet high in fat and low in carbohydrates to combat this, citing studies on coconut oil's effectiveness against candida. He mentions that butter and other fats are beneficial for gut health and help control yeast, molds, and fungus. Anthony J acknowledges that doctors often label such conditions as "idiopathic," offering immunosuppressants without addressing the root cause. Megan shares her experience with a recurring skin rash since fifth grade, describing an incident where she experienced hives during a class presentation. Anthony J finds this information interesting and suggests a possible connection to the gut health theory.
Histamine Intolerance and Gut Issues
00:39:41 - 00:41:17
Megan describes experiencing stress-induced flare-ups, even from seemingly minor interactions like being stared at. Anthony J then shifts the discussion to a related gut issue: histamine intolerance. He points to a specific section ("vitamin hormone detox genes," page 10 online) in the client's report detailing histamine intolerance, noting the client has three gene issues related to this, which is significantly higher than the average of zero. He explains that this indicates a high sensitivity to histamines, similar to allergies, where immune cells release histamines, particularly when gut issues are present. This excessive histamine secretion can unpredictably trigger the immune system, leading to various symptoms.
Histamine Intolerance and Genetic Factors
00:41:17 - 00:42:57
Anthony J discusses the client's symptoms, linking them to histamine intolerance. He explains that high histamine levels manifest in various ways, including disrupted sleep, stomach acid release, and hives. He notes the difficulty of a histamine-free diet due to the widespread presence of histamines in food. The conversation then shifts to the AOC1 gene, a copper-dependent gene involved in histamine metabolism. Anthony J emphasizes the importance of copper supplementation, suggesting a copper and zinc supplement as a convenient way to address both potential deficiencies. He also mentions that gut issues and yeast could be contributing factors, making the situation complex. He suggests a ketogenic diet as another approach to lower histamine levels, before proposing to revisit the vitamin section of the discussion.
Vitamin D Supplementation Recommendation
00:43:04 - 00:44:43
Anthony J discusses the importance of vitamin D supplementation, particularly in relation to COVID-19 mortality rates. He notes a strong correlation between low vitamin D levels and COVID-19 deaths, suggesting that almost all deaths occur in individuals with abysmal vitamin D levels. While acknowledging potential confounding factors, he emphasizes the compelling evidence linking low vitamin D to increased COVID-19 risk. He recommends the client, Megan, supplement with 5,000 IUs of vitamin D daily, a dosage higher than government recommendations, to achieve optimal blood levels. He suggests blood testing to verify the effectiveness of the supplementation and emphasizes the importance of vitamin D, especially given Megan's genetics and limited sun exposure due to her office-based work.
The Negative Effects of Low Vitamin D and Seed Oils
00:44:44 - 00:45:40
Anthony J discusses studies showing a correlation between low vitamin D levels and worsened gut lining, leading to various gut issues. He emphasizes the extensive list of problems associated with vitamin D deficiency, comparing it to the lengthy side effect lists of prescription drugs. He highlights muscle weakness, low energy, brain fog, and other symptoms as potential consequences of low vitamin D. He concludes that maintaining sufficient vitamin D levels is crucial and that it's a relatively inexpensive supplement.
Avoiding Seed Oils and the Importance of Healthy Fats
00:45:40 - 00:46:05
Anthony J advises avoiding seed oils like soybean oil, suggesting a preference for fruit oils such as coconut, olive, and avocado oils. The conversation briefly touches upon the client's existing avoidance of seed oils and then transitions to a discussion about hormones, specifically mentioning testosterone and a "plus-plus gene" related to it.
Addressing Low Testosterone Levels
00:46:05 - 00:47:40
Anthony J discusses the importance of addressing low testosterone levels in women. He explains that low testosterone can lead to various issues, including low sex drive, metabolic problems, and decreased motivation to exercise. He criticizes the "normal range" for testosterone provided by some lab testing companies, pointing out that a zero level is unacceptable and often misrepresented by doctors. He emphasizes the need to find a doctor willing to optimize testosterone levels, recommending Dr. Keith Nichols as an example of a doctor who takes a proactive approach to optimizing hormone levels rather than simply accepting a "normal" but potentially suboptimal reading. Anthony J highlights the significant positive impact that balanced testosterone levels can have on various aspects of health and well-being, including sleep quality.
Hormone Imbalance and Holistic Treatment
00:47:40 - 00:49:36
Anthony J discusses the patient's symptoms, highlighting significant estrogen and progesterone gene issues, potentially impacting thyroid levels. He emphasizes the need for blood tests and collaboration with a doctor to fine-tune hormone levels, optimize metabolism, and improve gut health and sleep. Anthony J explains the interconnectedness of gut health, sleep, and hormones, stating that imbalances in one area can negatively affect the others. He notes the patient's existing thyroid issues, which are not uncommon in older clients but are notable at the patient's age. Megan confirms past thyroid medication use but states she is no longer on any replacement therapy.
Negative Experience with Armor Thyroid and Subsequent Discussion on Thyroid Health
00:49:36 - 00:50:15
Megan describes a negative experience with Armor Thyroid, citing difficulties with dosing, sleep disruption, and feeling unwell. The medication was also expensive because it wasn't covered by insurance. She ultimately stopped taking it. Anthony J expresses understanding and empathy.
Importance of Iodine and Addressing Underlying Inflammation
00:50:16 - 00:51:12
Anthony J emphasizes the importance of iodine intake, especially given Megan's genetic predispositions. He explains that iodine is a crucial building block for thyroid hormones. The conversation then shifts to inflammation, specifically mentioning the TG gene (thyroglobulin), which indicates a significantly increased risk of autoimmune thyroid issues. Anthony J explains that autoimmune responses, triggered by histamines and gut problems in Megan's case, are attacking her thyroid. He suggests that addressing these underlying histamine and gut issues should, in the long term, resolve the thyroid problems.
Addressing Client's Hormonal and Thyroid Issues
00:51:12 - 00:53:24
Anthony J explains that the cheapest way to address the client's hormone issues is a six-week keto diet to reset sex hormones. Exercise also helps, but keto allows for some flexibility if motivation or stress levels are high. He emphasizes that inflammation is a key issue impacting thyroid function, stating that thyroid supplements won't be effective without addressing gut inflammation, homocysteine levels, and iodine intake. The client agrees, likening the process to a stepping stool where one issue must be addressed before moving to the next. Anthony J explains the interconnectedness of various factors, suggesting that multiple facets could be contributing to the client's problems. He recommends a comprehensive approach: iodine, magnesium, 5-HTP before bed, a keto diet, vitamin D, and grapeseed extract. The client expresses concern about the impact of such a drastic change, but Anthony J reassures her that it's unlikely to be a shock given probable deficiencies in magnesium and iodine.
Magnesium Deficiency and Ketogenic Diet
00:53:24 - 00:55:50
Anthony J explains that the gold standard magnesium test involves supplementing with magnesium and observing urinary excretion. Low excretion indicates deficiency, while high excretion suggests sufficient levels. He hypothesizes that the patient's cells are magnesium-deficient, hence the low excretion. He suggests that instead of a "shock" approach, gradually providing magnesium will better meet cellular needs. The ketogenic diet, while beneficial, might initially cause low energy or flu-like symptoms due to the body's adaptation to burning fat instead of sugar. He recommends starting the keto diet on a Thursday or Friday to allow for weekend rest. He emphasizes the importance of electrolytes, particularly salt, to mitigate these symptoms. The keto diet will also help reset sex hormones. He briefly mentions estrogen dominance and the patient's lack of access to saunas, suggesting alternatives like portable saunas or sauna blankets, or even sweating in a hot car.
Sauna Use and its Benefits
00:55:50 - 00:56:45
Anthony J discusses the benefits of sweating, noting that even 10 minutes of intense exercise can provide similar advantages to sauna use, although achieving this level of sweat is difficult for many. He emphasizes that saunas are particularly effective at reducing inflammation, which he considers a root cause of various health issues. He cites a 20-year Scandinavian study showing significant decreases in cancer, heart disease, and Alzheimer's with regular sauna use, attributing this to hormonal balance and other benefits. He reiterates that sweating, whether through exercise or saunas, offers similar advantages.
Review of Client's Lifestyle and Potential Issues
00:56:46 - 00:57:55
Anthony J asks the client if they have any further questions or comments. He reviews previously discussed topics, stating that he's not concerned about the carotene gene and histamines. He inquires about cannabis use, which the client (Megan) denies. Megan also mentions limited alcohol consumption and family history of substance use. Anthony J notes that this eliminates a potential issue, and prepares to move to the next section of the discussion, acknowledging the complexity and interconnectedness of the information covered so far, highlighting inflammation as a key factor.
MTHFR Gene and Pregnancy
00:57:55 - 00:59:34
Megan indicates she will likely have more questions when discussing supplements later. Anthony J then focuses on the client's MTHFR C677T gene, noting a "plus plus" result, which is strongly associated with miscarriages. He emphasizes the importance of avoiding folic acid and instead using methylfolate, especially during pregnancy. He explains that folic acid is synthetic, requiring conversion to methylfolate for use in the body, a process crucial for DNA creation, particularly vital for fetal development due to rapid cell growth. He highlights the frequent misdiagnosis and incorrect advice from doctors regarding folic acid versus methylfolate in relation to pregnancy and miscarriage. The client acknowledges understanding.
Methylfolate and B Vitamin Deficiency
00:59:35 - 01:01:15
Anthony J explains the importance of methylfolate, especially during pregnancy, highlighting its superior absorption compared to folic acid (90% less efficient conversion). He recommends consuming leafy greens, particularly spinach, as a rich source of methylfolate. Supplements are suggested as an alternative if dietary intake is insufficient, citing improved sleep as a reported benefit based on Amazon reviews. The discussion then shifts to related genes influencing methylfolate processing and the potential need for B12 supplementation, particularly since the client is a vegetarian. Anthony J advises increasing meat consumption or taking B12 supplements due to the client's genetic predisposition to B vitamin deficiencies. Finally, he recommends limiting fructose intake (high fructose corn syrup, soda) to avoid fat storage and suggests exploring low-fructose berries as alternatives, providing a web link for further information.
Genetic Predisposition and Health Recommendations
01:01:16 - 01:02:47
Anthony J reviews Megan's genetic report, noting her surprisingly good genes for a 28-year-old, particularly concerning joints, despite having arthritis. He attributes this to likely gut health rather than genetics. While she has a 1++ risk for gout due to a fructose gene, he emphasizes that this is manageable with diet. Her rheumatoid arthritis stems from an overactive immune system and inflammation. He expresses less concern about her collagen gene and blood pressure gene, given her low blood pressure. However, he highlights a couple of genes indicating weaker bones, recommending increased vitamin D, magnesium, and potentially calcium intake, suggesting a slight increase in meat consumption as a source of calcium. The overall tone is positive, focusing on manageable risk factors and dietary adjustments.
Sleep Optimization Strategies
01:02:50 - 01:04:24
Anthony J reviews Megan's genetic predisposition to sleep, noting a strong genetic basis for good sleep but highlighting a blue light sensitivity gene. He inquires about the darkness of her sleeping environment. Megan explains that an air purifier with a blue ring light illuminates part of her room due to her boyfriend's cat allergies. Anthony J suggests covering the air purifier's light with electrical tape to minimize blue light exposure, emphasizing the importance of minimizing all light sources, even small ones from power strips, for optimal sleep.
Strategies for Improving Sleep Quality
01:04:24 - 01:06:17
Anthony J suggests using electric tape or dark curtains to block out light, as light sensitivity can significantly disrupt sleep. Megan mentions using a Bluetooth-enabled sleep mask with calming audio, but finds it uncomfortable due to its design and her side-sleeping habit. Anthony J reiterates the importance of a completely dark room and explains that blue light interferes with melatonin production, impacting sleep quality. He notes that while this is a common issue, it's particularly impactful for Megan due to her rare "plus-plus gene." Megan confirms she already uses blue blocker glasses and a blue light filter on her phone, but still experiences severe headaches if these measures aren't in place. Anthony J shares that he uses a blue light blocking app called Flux on his computer to mitigate blue light exposure.
Blue Light Exposure and Sleep Issues
01:06:17 - 01:08:07
Anthony J discusses his use of blue light filtering apps on his work computers due to photosensitivity and corneal erosion. He recommends these apps to Megan, emphasizing the importance of reducing blue light exposure, especially in the evenings. He notes that blue light from computer screens is generally detrimental to eye health. The conversation then shifts to Megan's sleep issues, with Anthony J suggesting that her sleep genes appear good, but underlying issues like serotonin levels and inflammation could be contributing factors. He highlights the importance of a dark sleep environment and addressing gut health to improve sleep quality.
Seasonal Depression and Potential Underlying Causes
01:08:07 - 01:08:23
Anthony J summarizes the discussion, acknowledging the numerous factors discussed. He reiterates the potential impact of serotonin and inflammation on sleep. He suggests that addressing gut health is key to improving sleep. Megan indicates she has a question.
Megan's Retina Detachment and Further Questions
01:08:23 - 01:08:46
Megan shares that she experienced a retinal detachment three years prior. The conversation ends abruptly at this point.
Megan's Unexpected Eye Condition and Potential Stickler Syndrome
01:08:46 - 01:11:23
Megan describes a spontaneous retinal detachment requiring scleral buckle surgery and laser treatment for lattice degeneration in both eyes. The surgeon noted her increased risk for recurrence due to severe myopia and suggested the possibility of Stickler syndrome after learning about her history of braces for a small jaw, slight scoliosis, and poor eyesight. Megan had never heard of Stickler syndrome, and her previous doctors hadn't mentioned it. The surgeon recommended genetic testing at the Mayo Clinic to confirm or rule out the syndrome, suggesting that early diagnosis could have prevented some issues. Anthony J comments on the rarity of Stickler syndrome, noting that it's unlikely to be detected by common genetic testing services like 23andMe and suggesting that more specific gene testing would be necessary for confirmation. He expresses doubt about Megan actually having the syndrome.
Family Medical History and Genetic Predisposition
01:11:28 - 01:13:01
Anthony J and Megan discuss Megan's family history of eye problems, specifically glaucoma and retinal detachments. Anthony J suggests that her mother's potential undiagnosed diabetes or high blood sugar during pregnancy could be a contributing factor. Megan mentions a family history of retinal detachments and glaucoma on her mother's side. Anthony J then notes Megan's collagen gene (collagen 11A1), which is usually associated with joint issues but could potentially impact her eyes. He suggests she check her 23andMe or Self-Decode results for this gene and email him the information so he can investigate further. He offers to look for the gene information for free if it's included in her results, but notes that it might require some research or contacting the genetic testing company.
Supplement Recommendations and Code Review
01:13:01 - 01:15:04
Anthony J explains that checking for specific code requires some digging, which he doesn't have time for, but the client can do it. He mentions that if the code is found, he can easily review it. Megan then requests a review of the recommended supplements. Anthony J states he doesn't have a formal list but details several supplements: 5-HTP and tryptophan are considered optional, for later use if other supplements don't improve sleep. He recommends daily intake of grape seed pro-amphacianidins, a B-complex with methylfolate (or methylfolate and B12 separately as a cheaper alternative), zinc and copper together, and magnesium nightly (increasing dosage until loose stools occur). He also suggests daily mushroom consumption (mentioning a preferred brand, Life Cycle) and notes that some supplements may require further discussion.
Ketogenic Diet and Hormone Reset
01:15:09 - 01:16:34
Anthony J recommends a six-week ketogenic diet to reset sex and thyroid hormones, alongside Vitamin D and iodine supplementation. He explains that switching the body's metabolic processes from carb-burning to fat-burning is a significant undertaking, like changing a factory's production from semi-trucks to airplanes. He acknowledges the initial difficulties, including carb cravings, low energy, and flu-like symptoms, suggesting electrolyte pills to mitigate these side effects. The initial discomfort is expected to last about a week, after which the benefits of the hormonal reset should become apparent. The keto diet is not intended to be permanent, but rather a six-week reset period.
Keto Diet and Electrolytes
01:16:34 - 01:17:25
Anthony J summarizes the importance of electrolytes when following a keto diet, emphasizing that insufficient electrolytes can lead to flu-like symptoms. He notes that even with sufficient electrolytes, some discomfort might persist, but it will be less severe. He also recommends collagen protein powder as an anti-inflammatory supplement that may help with Megan's eye condition. Finally, he stresses the importance of maintaining a completely dark room for optimal sleep and eye health.
Mailing Delays and Closing Remarks
01:17:26 - 01:17:57
Anthony J apologizes for the delay in mailing, attributing it to both general mail slowdowns due to protests and his own slower-than-usual processing. He expresses appreciation for Megan's patience. Megan thanks Anthony J for his time and assistance. The conversation concludes with pleasantries.
Meeting Adjournment
01:17:57 - 01:17:59
The meeting concluded with brief farewells exchanged between Megan, Anthony J, and the Client.
DNA with Dr. Jay, Episode 14.
AUTOIMMUNE ISSUES with Atheatos (from Greece)
AUTOIMMUNE ISSUES with Atheatos (from Greece)
Detailed A.I. Summary
**CLICK HERE TO READ
Patient Case Study: Schnitzler Syndrome and Keto Carnivore Diet
00:00:00 - 00:00:35
A discussion begins with a case study of a patient, Afietas, from Greece (currently residing in Austria), who suffers from Schnitzler syndrome, a rare autoimmune condition. He's been successfully managing his condition for the past two years with anakinra, an interleukin-1 blocker, and a strict keto carnivore diet including organ meats and some dairy. His primary goal is to heal himself from his autoimmune condition. He doesn't engage in much exercise.
Podcast Introduction and Host Background
00:00:36 - 00:01:16
The speaker introduces their podcast, highlighting it as the number one DNA podcast globally, focused on intelligent health investments and translating knowledge into action. They invite listeners to visit ajconsultingcompany.com for confidential DNA consultations. The host identifies themselves as a Mayo Clinic scientist, author, and YouTube personality (Anthony J. Cast channel) with content covering science and nature.
Discussion on Greek Language and Ancestry
00:01:20 - 00:02:04
A brief conversation ensues regarding the host's familiarity with Greek language and culture. The patient clarifies his current residence in Austria, while acknowledging his Greek origins. The host mentions their experience with ancient Greek, noting differences in pronunciation compared to modern Greek.
Patient's Genetic Testing History
00:02:05 - 00:02:32
The conversation shifts to the patient's genetic testing history. The patient has utilized Ancestry, 23andMe, Dante Labs, and BGI Genomics for DNA testing, including full genome sequencing from the latter two companies. The discussion then transitions to a new topic.
DNA File Comparison and Gene Analysis
00:02:32 - 00:04:51
The discussion begins with a comparison of Ancestry and 23andMe DNA files. The speaker notes that while both files generally agree, some genes appear in one but not the other. For example, the ApoE gene, related to Alzheimer's risk, is present in the 23andMe file but absent from the Ancestry file. The client's family history lacks Alzheimer's, although some age-related degeneration was observed. Conversely, the Sirtuin gene, related to lifespan, is present in the Ancestry file but missing from the 23andMe file. The speaker highlights that the presence or absence of these genes in different reports doesn't indicate conflicting information but rather reflects the different gene panels included in each service. The speaker emphasizes the importance of both services for a comprehensive genetic profile, with 23andMe providing ApoE data and Ancestry providing Sirtuin data. The speaker also mentions that the accuracy of the DNA sequencing is validated by the consistency of non-conflicting information between the two services.
Genetic Predisposition and Dietary Strategies
00:04:58 - 00:06:57
This segment focuses on discussing genetic predispositions, specifically concerning the ApoE gene and its relation to Alzheimer's disease. The conversation begins with a mention of supplements like grape seed extract or resveratrol, used by some to address this gene. The speakers then clarify that while some genetic differences exist between platforms like 23andMe and Ancestry, the core information regarding the sirtuin gene (relevant to brain health) remains consistent. The discussion centers on the ApoE gene, with a strong recommendation to consume high-quality fish oil (DHA) or eat seafood daily to mitigate potential risks. One speaker shares their experience of maintaining low triglycerides despite dietary changes, attributing it to a carnivore diet rich in omega-3s from cod liver oil and high-quality animal products sourced in Austria. The conversation touches upon other Alzheimer's-related genes linked to inflammation and carbohydrate intake, transitioning into a discussion about dietary strategies to manage inflammation, which will be covered later. Intermittent fasting (two meals a day, an 8/16 hour eating window) is mentioned as a key component, aligning with the speaker's recommendation.
Ketone Levels and Health Status
00:06:57 - 00:08:07
The conversation begins with a discussion of high ketone levels in blood and urine. The speaker mentions infrequent ketone monitoring due to a consistent diet. Three-monthly check-ups provide blood and urine measurements. The speaker reports feeling well, attributing it to increased sun exposure and exercise. This is followed by a description of a DNA consultation with a 16-year-old girl suffering from depression, ovarian cysts, and taking multiple prescription drugs (SSRIs like Zoloft). The girl has a sedentary lifestyle, consumes a standard American diet, avoids sun exposure, and sleeps 16 hours daily.
Lifestyle Factors and Health Conditions
00:08:08 - 00:08:43
The importance of sleep quality over quantity is emphasized, suggesting exercise, sun exposure, and dietary changes to improve it. The conversation shifts to another individual with PCOS and IBS, highlighting the challenges faced by those with such conditions and the common practice of doctors prescribing medication for PCOS and diabetes.
IBS Treatment and Dietary Approaches
00:08:44 - 00:09:50
The discussion begins with a critique of the current IBS treatment approach, which involves eliminating individual food items rather than a systematic approach. The speaker advocates for a more comprehensive method of eliminating all foods initially and then gradually reintroducing them. The benefits of removing certain foods from the diet are highlighted, with intermittent fasting mentioned as a positive aspect. The speaker's genetic predisposition to process carbohydrates well is discussed, contrasting with the usual association of "plus-plus" genes with problematic health aspects. The impact of a keto carnivore diet on mental clarity is assessed, with the speaker noting improvement but not a dramatic change.
Keto Carnivore Diet and Inflammation
00:09:50 - 00:10:25
The conversation shifts to the effects of the keto carnivore diet on inflammation. The speaker expresses a somewhat underwhelming reduction in inflammation despite the dietary change, still requiring medication. The speaker mentions having a rare autoimmune disorder, identified as Schnitzler syndrome, which is noted as extremely rare.
Patient's Treatment and Condition
00:10:29 - 00:12:34
The patient discusses their immune suppression medication, noting a reduction in dosage from daily to every other day while maintaining effectiveness. They mention the absence of joint pain, a positive outcome after two years of treatment. The conversation then shifts to the specific medication, an interleukin-1 blocker, which targets cytokines involved in inflammatory responses, similar to those seen in conditions like COVID-19. The patient highlights the drug's rapid symptom relief. The possibility of low testosterone is raised, prompting the patient to consider testing, especially given their weight training. The unusual early onset of the condition at age 25, progressing over six years from minor dermatological issues to more severe symptoms, is discussed, contrasting with the typical onset in people aged 60 and older.
Patient Health Update and Discussion of Treatment
00:12:41 - 00:14:22
The conversation begins with an update on a patient's health. The patient describes experiencing joint pain, fever, and inflammation, symptoms that took several years to diagnose. Their C-reactive protein (CRP) level was initially very high (up to 5) but is now significantly reduced (0.1) after treatment. The discussion then shifts to the patient's daughter, who experienced hives possibly due to a mold infection, and whose CRP level was also elevated (8). The patient's proactive approach to understanding their condition, including researching nutrition and genetics, is highlighted. The patient mentions having anxiety and stress genes, specifically an oxytocin receptor gene. The conversation touches upon the use of oxytocin injections by some individuals for various health benefits, including anti-inflammation and stress reduction, although the practicality and accessibility of this method are acknowledged as challenges. The discussion concludes with a mention of natural ways to increase oxytocin levels, such as consuming dark chocolate.
Natural Ways to Increase Serotonin and Optimize Brain Health
00:14:22 - 00:16:46
This segment focuses on natural methods to boost serotonin levels and overall brain health. The discussion includes the importance of gut health in serotonin production (90% is produced in the gut), highlighting the impact of gut issues on serotonin levels and consequently on learning, motivation, and sleep. The speaker mentions the roles of genes SLC6A4 and TPH2 in serotonin transport and suggests warm showers and saunas as natural ways to improve mood. The conversation then shifts to the impact of sleep on learning and memory, acknowledging the complex relationship between serotonin, sleep, and cognitive function. Anxiety and depression are briefly discussed in relation to serotonin, with the speaker emphasizing the importance of maintaining gut health. Caffeine's potential negative impact on anxiety is noted. Finally, the discussion touches upon lifespan genes (sirtuins), suggesting resveratrol, grape seed supplements, and cyanidins as potential options, along with the importance of zinc for the telomere gene (MNN). The speaker concludes by asking if there are any questions before moving on to the diet section.
Dairy Consumption and its Impact
00:16:52 - 00:18:22
The discussion centers on the impact of dairy consumption, particularly in light of 2++ genes indicating dairy avoidance. One participant mentions periods of dairy-free diets, noting that while butter and cream were generally well-tolerated, cheeses presented more variability. The suggestion is made to experiment with goat cheese. Casein, a dairy protein, is identified as potentially addictive and inflammatory due to its interaction with morphine receptors. However, the quality of dairy is also considered, with a participant highlighting the difference between raw, local dairy products and those from other sources, referencing positive experiences with Austrian dairy.
Location and Language Barriers
00:18:22 - 00:18:54
Speakers discuss the location of a place called "Gaming," noting its remote location west of Vienna in the mountains. The remoteness is highlighted as problematic due to the lack of English speakers. Despite this, the speaker expresses their love for the country and mentions the presence of cows, specifically brown cows, in the area.
Food and Product Differences
00:18:54 - 00:19:19
The conversation shifts to the local dairy products, comparing Gouda cheese from a supermarket to Gouda cheese from a local farm, emphasizing the significant difference in taste. The presence of goats in the area is also mentioned.
Type 2 Diabetes Risk and Lifestyle Factors
00:19:24 - 00:19:47
The discussion turns to type 2 diabetes risk genes, acknowledging that everyone possesses some of these genes. The conversation touches upon low-carb diets, exercise, and intermittent fasting as important factors in mitigating risk. A mention is made of Ancestry's identification of an additional gene related to this risk.
Insulin Resistance and Carb Consumption
00:19:47 - 00:21:28
This segment discusses the impact of PPP1R3A on insulin resistance, particularly within muscles. The speakers note that consuming carbohydrates around workouts, ideally right before, allows muscles to efficiently clear the sugar. Even on a carnivore diet, blood sugar can sometimes rise, suggesting that working out after eating might be beneficial in such cases. One speaker mentions their blood sugar levels typically range from 80 to 90 on a full keto carnivore diet, while others have reported lower levels (50-70). Maintaining blood sugar below 90 is considered ideal. The discussion concludes by highlighting that while the brain functions well with carbs, the body struggles to clear sugar efficiently, potentially impacting muscle performance if insulin resistance is present. The speakers agree that training muscles to burn ketones is a key strategy to mitigate this.
Exercise and Autoimmune Condition
00:21:30 - 00:22:04
The conversation begins with a discussion about the speaker's limited exercise due to an autoimmune condition. The speaker mentions recently feeling better and the other person suggests incorporating exercise to further improve their condition. High ketone levels in the urine are also mentioned, indicating the body isn't burning them efficiently. The suggestion is made to start exercising to address this.
Exercise Recommendations and Genetics
00:22:05 - 00:23:15
The discussion shifts to specific exercise recommendations. Given the speaker's endurance-focused genetic profile, low-impact endurance training like rowing or jogging is suggested as a starting point. The conversation then touches upon the FTO gene, which plays a role in converting white fat to brown fat, and its potential relevance to the speaker's situation. The speaker acknowledges familiarity with the gene but hasn't checked their own status. The importance of brown fat's high mitochondria content is also highlighted.
Metabolism and Cold Showers
00:23:15 - 00:24:18
The discussion centers on the speaker's metabolism and potential reasons for higher ketone levels in their urine. It's suggested that their genes may not efficiently convert white fat to brown fat, leading to fat storage instead of burning. Cold showers or a sauna followed by a cold shower are proposed as a potential remedy to improve metabolism. The speaker mentions the initial discomfort of cold showers but notes adaptation occurs within three days.
Low Metabolism and Heart Disease Risk
00:24:18 - 00:25:04
The speaker expresses concern about a potentially low metabolism, noting stable weight despite a considerable calorie intake. Exercise is suggested as a solution. The conversation then shifts to heart disease risk, specifically mentioning a gene (SOD2) that poses a significantly increased risk only when iron levels are high.
Hemochromatosis and Anemia Discussion
00:25:04 - 00:26:47
The conversation begins with a discussion of hemochromatosis, a genetic condition affecting iron storage. The speaker mentions having genes that predispose to higher iron levels and an autoimmune condition causing chronic anemia. The mild anemia is described as being caused by a different mechanism than the hemochromatosis. The doctor suggests checking iron levels and possibly donating blood periodically. Exercise and testosterone are mentioned as potential ways to improve blood cell count, although high blood cell counts from testosterone can be a concern. The speaker's CRP levels are noted as slightly elevated, likely due to the autoimmune condition, which is considered under control. Finally, the speaker's gut gene profile is reviewed, noting the presence of the CNR1 gene, which doesn't typically cause gut issues but might respond to CBD. However, caution is advised regarding CBD use due to the autoimmune condition.
Discussion on CBD and Gut Health
00:26:56 - 00:28:30
The conversation begins with a discussion about CBD legality in Austria and the speaker's general aversion to substances. The benefits of CBD as an anti-inflammatory are acknowledged, but concerns about introducing unusual compounds, especially with autoimmune conditions, are raised. The discussion shifts to the speaker's gut health, noting a generally healthy gut with some minor genetic predispositions indicated by "plus minuses" in gut gene analysis. The NOD2 gene, responsive to ketones, is highlighted as important, and the speaker's current ketogenic diet is deemed sufficient. The speaker mentions a lack of personal gut issues but notes their mother possibly had IBS. The conversation concludes with a discussion of genes related to white fat and obesity, with the speaker acknowledging a family history of obesity and a similar body type.
Cryotherapy and Cold Exposure for FTO Gene
00:28:30 - 00:29:14
Discussion on managing the FTO gene, focusing on cryotherapy as an effective method but acknowledging the difficulty in accessing affordable cryotherapy centers. Cold showers are suggested as a readily available alternative. The conversation then shifts to a participant's upcoming vacation plans, mentioning potential cold water exposure through swimming in cold lakes or the open sea in Greece.
Vitamin and Hormone Detox Discussion: Iron and Vitamin D Levels
00:29:14 - 00:29:54
The discussion moves to a review of vitamin and hormone levels, specifically focusing on iron and vitamin D. The participant's genetic predisposition for higher iron levels (plus minus) and lower vitamin D levels (multiple positive indicators from 23andMe and Ancestry tests) are noted. The participant confirms prior vitamin D supplementation. Past mild anemia and low ferritin levels (before adopting a carnivore diet) are also discussed.
Addressing Anemia and Ferritin Levels
00:30:08 - 00:31:09
The discussion begins with a patient reporting improvements in anemia after adopting a carnivore diet, particularly after incorporating organ meats like liver. While their iron levels are now good, ferritin levels are rising, causing concern due to the risk of hemochromatosis. The patient notes that liver consumption is a likely contributor to the elevated ferritin. Strategies to lower ferritin, such as reducing liver intake frequency, are discussed. The conversation clarifies that ferritin is an iron transporter, and its fluctuations are normal, but the patient's elevated levels remain a concern given their hemochromatosis.
Vitamin D Supplementation and Results
00:31:09 - 00:31:35
The conversation shifts to vitamin D levels. The patient reveals a previously low vitamin D level (25) which significantly increased to 70 within two months of supplementation with 5000 IU of vitamin D daily. The rapid increase is noted and deemed positive.
Personal Experience with Vitamin D and Genes
00:31:38 - 00:32:22
The speaker discusses their experience with Vitamin D levels, noting a significant drop after stopping supplementation, followed by a return to higher levels with resumed supplementation (2000-3000 IU daily at 60-70% of the recommended dose). They plan to increase sun exposure in the summer, citing the strong sun in Greece as a contributing factor to their genetic predisposition. The conversation then shifts to the importance of continued supplementation, especially during winter. A mention is made of a potential ancestral link to flaxseed avoidance.
Flaxseed Consumption and Phytoestrogens
00:32:22 - 00:33:27
The speaker recounts their past consumption of flax seeds as part of a healthy diet, correlating it with a period of illness. This leads to a discussion about phytoestrogens, with one speaker expressing their belief that they negatively impact the immune system. The other speaker questions this, citing scientific literature that describes estrogen's dual role as both immunostimulative and immunosuppressive, highlighting the apparent contradiction in its effects on the immune system and its behavior during pregnancy.
Hormonal Imbalance and Genetic Predisposition
00:33:27 - 00:35:25
This segment discusses the speaker's hormonal imbalances, specifically focusing on estrogen and testosterone levels. The speaker mentions experiencing various health issues potentially linked to fluctuating estrogen levels, including immune system overreactions. Prior supplement use and diet are also considered as contributing factors. Genetic testing results from both Ancestry and 23andMe are reviewed, revealing a gene for low testosterone and a plus-plus SHBG gene, leading to higher SHBG levels that bind testosterone, rendering it less effective. The speaker's genetic profile shows conflicting genes related to estrogen, with some indicating higher levels and others lower, suggesting a potential balance. The discussion concludes by emphasizing the need to address low testosterone levels as a primary concern, while acknowledging the influence of dietary factors like flax and plant estrogens on estrogen levels.
Concerns about Low Testosterone and Vitamin D Levels
00:35:25 - 00:37:03
The conversation shifts to concerns about low testosterone and vitamin D levels. Participants discuss the dangers of environmental estrogens from sources like plastic bottles. One participant expresses worry about low testosterone levels, suggesting that optimal levels should be above 500, contrasting this with doctors' acceptance of levels as low as 250. The inadequacy of current medical standards is highlighted by comparing current testosterone levels to those in the 1980s, where levels around 500 were common. The discussion then turns to the complexities of testosterone testing and the different forms of testosterone available, including creams and injections. The advantages of bioavailable testosterone cream are emphasized due to its daily application, maintaining consistent levels unlike the fluctuating levels caused by weekly injections. The speakers discuss the preference for cream application to avoid the undesirable effects of fluctuating testosterone levels from injections.
Glutathione Treatment Options and Efficacy
00:37:04 - 00:38:09
Discussion centers on the efficacy of glutathione for Schnitzler syndrome. The speaker considers both cream and injection options, noting a preference for injections despite comfort with injections. Past experiences with various glutathione supplements are shared, including unsuccessful attempts to obtain glutathione injections from doctors. The speaker mentions low glutathione levels indicated by blood tests, possibly related to oxidase deficiency. The other speaker emphasizes the superiority of injections over supplements, acknowledging the slow healing process.
Thyroid Hormone Levels and Dietary Considerations
00:38:09 - 00:39:13
The conversation shifts to thyroid hormone levels and their relation to diet. The speaker reports that thyroid hormone levels are currently within the normal range, both before and after adopting a carnivore diet. The impact of the diet on PSA levels is also mentioned. The discussion includes the speaker's seafood and cod liver oil consumption, highlighting the importance of iodine intake for thyroid health. The other speaker suggests that thyroid optimization might be necessary in the future due to age-related decline.
Bilirubin Levels and Health Concerns
00:39:13 - 00:40:45
This segment focuses on a patient's slightly elevated bilirubin levels. The doctor discusses the patient's genetic predisposition to higher bilirubin, mentioning the presence of two "plus plus" genes that increase bilirubin. While slightly elevated bilirubin isn't necessarily problematic, the doctor expresses concern about excessively high levels, which can lead to gallstones and other health issues, especially when following a ketogenic diet. The doctor recommends increasing sun exposure and potentially taking a daily baby aspirin to manage bilirubin levels. The discussion also touches upon the patient's thyroid problems, retinol levels, and the lack of cannabis use. The exact mechanism by which the patient's genes affect bilirubin production or breakdown is unclear, but the doctor notes that it's an antioxidant and therefore potentially beneficial. The doctor emphasizes the importance of monitoring bilirubin levels to prevent future complications.
Bilirubin Levels and Sun Exposure
00:40:45 - 00:41:25
The conversation begins with a discussion about high bilirubin levels. One participant notes that high bilirubin can be problematic, but they are unsure of the mechanism related to a specific gene. They mention strategies to lower bilirubin. Another participant reveals their high bilirubin level, lacking previous measurements for comparison. The suggestion is made to re-measure bilirubin after spending an hour a day in the sun with their shirt off. If the levels remain high after sun exposure, more active intervention might be necessary, but it's anticipated that sun exposure will resolve the issue.
MTHFR Gene and Methylfolate Supplementation
00:41:26 - 00:42:33
The discussion shifts to the MTHFR gene and its implications. One participant mentions having several "bad genes," including MTHFR. The importance of methylfolate supplementation, particularly for sleep and mood, is highlighted. While some on the carnivore diet may not supplement, it's suggested that methylfolate supplementation is beneficial. A participant shares their experience with methylfolate supplementation on a carnivore diet, noting initial low levels that improved to mid-to-high levels with supplementation, after which supplementation was stopped. The benefits of methylfolate as a DNA precursor, crucial for immune cell function and turnover, are emphasized.
Dietary Considerations and Supplement Use
00:42:33 - 00:44:19
The discussion centers on the importance of sufficient methylfolate, especially when the immune system is suppressed, due to the high DNA demand of regenerating cells. One participant mentions their diet includes eggs and liver, providing some methylfolate, but acknowledges a lack of leafy greens, the richest source. They also mention supplementing to maintain high levels. Vitamin E is deemed not a concern as supplements aren't used. Fructose consumption is also discussed; both participants report low intake, contrasting it with the high fructose corn syrup prevalent in processed US foods. The conversation concludes by identifying fructose and omega-6 fatty acids as major dietary culprits contributing to health issues like obesity, regardless of specific diet plans. Genetic variations in sugar metabolism are acknowledged, and the discussion transitions to the next topic.
Gene Variations and Endurance
00:44:33 - 00:45:12
The speakers discuss slight variations in genetic information provided by 23andMe and Ancestry, noting that both platforms indicate a rare endurance gene, BDKRB2 (bradykinin), which is prevalent in Olympic endurance athletes. One speaker expresses skepticism about the health benefits of marathons.
Marathon Running and Heart Health
00:45:12 - 00:46:02
A discussion ensues regarding the potential heart damage associated with marathon running. The speakers acknowledge that intense, prolonged exertion during marathons can lead to increased troponin I levels and potential heart damage. However, they also suggest that gradually increasing training intensity over time can mitigate these risks. One speaker expresses concern that marathon running is not an ancestral activity.
Hunting vs. Marathon Running: A Comparison
00:46:03 - 00:46:58
The conversation shifts to a comparison between hunting and marathon running. One speaker argues that hunting, particularly bow hunting, requires significantly more exertion and physical demands than marathon running. An anecdote is shared about a marathon-running doctor who found a single day of bow hunting far more strenuous than a marathon.
Hunting and Exercise Regimen
00:46:58 - 00:48:44
The conversation begins with a discussion of the speaker's hunting experiences in western Minnesota, characterized by intense walking and occasional running through snowy grasslands. The speaker mentions the legal requirements for hunting and contrasts modern hunting methods with those of Paleolithic humans, who relied on intimidation, traps, and stone-throwing rather than pursuit. The discussion then shifts to the speaker's personal exercise regimen and the influence of genetics. It's noted that while the speaker possesses endurance genes suggesting a predisposition for endurance training, their autoimmune condition necessitates a cautious approach to exercise. The speaker's advice generally favors heavy lifting for most individuals, but recommends endurance training for a significant minority (20%), particularly those with genetic predispositions like the speaker. The benefits of endurance training, such as improved metabolism, blood flow, and inflammation reduction, are highlighted, but the speaker emphasizes that this is a suggestion, not a requirement.
Joint Health and Risk Factors
00:48:44 - 00:50:36
The discussion centers on joint health risks, specifically concerning interleukin and the DIO2 gene. The speaker notes that interleukin inhibitors and a healthy diet mitigate interleukin-related risks. The DIO2 gene is highlighted as a concern, as its impact increases with age, potentially leading to osteoarthritis due to declining thyroid hormones. The cost-effectiveness of thyroid hormone supplementation ($30/month) compared to knee replacement surgery ($20,000) is emphasized as a preventative measure for joint health. The conversation then shifts to the patient's grandfather, who had past health issues, and the importance of blood flow and movement for overall health. Gout is briefly discussed, deemed less of a concern due to the patient's diet, although high uric acid levels are noted, potentially linked to a period of inactivity.
High Uric Acid and Ketone Levels
00:50:36 - 00:51:31
The conversation begins with a discussion about high uric acid levels (12, exceeding the limit of 7) despite a lack of symptoms. The speaker suggests that the high ketone levels, possibly due to poor carb metabolism, might be contributing to the elevated uric acid. Exercise is proposed as a solution. The speaker also mentions other potential factors, including organ function (particularly the liver) and high ketone production without sufficient burning. The speaker's good spinal health is noted, contrasting with a brother's experience of a split disc after gym workouts.
Pain Sensitivity and Genetic Testing
00:51:32 - 00:52:33
The discussion shifts to pain sensitivity. The speaker mentions the complexities of pain perception, highlighting the yin-yang aspect of high and low pain sensitivity. The speaker points out an interesting discrepancy between genetic testing results (23andMe showing only the high pain sensitivity gene) and the individual's actual experience. The speaker concludes that the individual likely has lower pain sensitivity than initially suggested by the genetic test alone, emphasizing the difficulty in accurately assessing pain sensitivity.
Sleep Patterns and Quality
00:52:33 - 00:54:32
The conversation shifts to the topic of sleep patterns and quality. One participant mentions that their sleep section data isn't too bad, and they are generally a morning person, although they haven't consistently tried waking up early. Another participant discusses their sleep habits, noting consistency but also a history of sleeping from 2 AM to 10 AM. They now wake up earlier and feel better, considering maintaining a 5:30 AM or 6 AM wake-up time. The discussion touches upon genetics and sleep, mentioning a specific gene (WWC1 1++) that affects memory recall based on sleep quality. One participant emphasizes the importance of at least 8 hours of sleep for overall well-being and managing autoimmune issues, noting that sleep was crucial in reducing symptoms before medication. They currently fall asleep quickly and sleep well. The use of a sleep tracker, such as the Aura ring, is suggested to further improve sleep quality and identify patterns. Finally, one participant mentions working better at night.
Addressing Sleep Issues and Lifestyle Factors
00:54:32 - 00:56:22
The conversation shifts to the individual's sleep problems, particularly the difficulty of working in the afternoon and evening due to high concentration levels leading to late nights. The impact of blue light and overthinking are mentioned as contributing factors. However, the speaker is reassured that their sleep genes are good, and the focus should be on other lifestyle aspects. Scheduling more time for relaxation during vacation is suggested, along with cold showers in the morning. A question arises about the "worst" gene impacting sleep, with the response being that it's the one causing the most significant problems, possibly vitamin D or testosterone, given the individual's past avoidance of sunlight and late sleep schedule (between 2 and 4 AM). The overall progress made is highlighted, emphasizing the positive changes from previously avoiding sunlight and consistently sleeping very late.
Lifestyle Changes and Health Challenges
00:56:22 - 00:57:15
The conversation centers on the speaker's health journey, focusing on diet (seeds), sun exposure, sleep, and exercise. The speaker mentions making small changes and conducting further tests related to testosterone. The difficulty of maintaining a healthy lifestyle is highlighted, with the speaker noting the challenges of encouraging friends to prioritize their health, emphasizing that people often only take action when facing serious health issues.
Challenges in Health Communication and Prevention
00:57:16 - 00:58:03
The discussion shifts to the difficulties of communicating health advice to others. The speaker shares an anecdote about a friend with IBS and PCOS who ignored their advice, leading to the conclusion that individual conversations are often ineffective. As a result, the speaker is using YouTube to reach a wider audience. The conversation concludes with a reflection on the preventative nature of healthy habits and the regret of not prioritizing health earlier.
Closing Remarks and Appreciation
00:58:04 - 00:59:34
The conversation concludes with mutual appreciation and well wishes. One participant expresses gratitude for the other's work and mentions the value of their information for people with autoimmune issues and those interested in comparing 23andMe and Ancestry DNA results. The speakers acknowledge the helpfulness of the interview and its potential reach. The conversation ends with pleasantries and goodbyes, noting the time difference and wishing each other a good evening.
00:00:00 - 00:00:35
A discussion begins with a case study of a patient, Afietas, from Greece (currently residing in Austria), who suffers from Schnitzler syndrome, a rare autoimmune condition. He's been successfully managing his condition for the past two years with anakinra, an interleukin-1 blocker, and a strict keto carnivore diet including organ meats and some dairy. His primary goal is to heal himself from his autoimmune condition. He doesn't engage in much exercise.
Podcast Introduction and Host Background
00:00:36 - 00:01:16
The speaker introduces their podcast, highlighting it as the number one DNA podcast globally, focused on intelligent health investments and translating knowledge into action. They invite listeners to visit ajconsultingcompany.com for confidential DNA consultations. The host identifies themselves as a Mayo Clinic scientist, author, and YouTube personality (Anthony J. Cast channel) with content covering science and nature.
Discussion on Greek Language and Ancestry
00:01:20 - 00:02:04
A brief conversation ensues regarding the host's familiarity with Greek language and culture. The patient clarifies his current residence in Austria, while acknowledging his Greek origins. The host mentions their experience with ancient Greek, noting differences in pronunciation compared to modern Greek.
Patient's Genetic Testing History
00:02:05 - 00:02:32
The conversation shifts to the patient's genetic testing history. The patient has utilized Ancestry, 23andMe, Dante Labs, and BGI Genomics for DNA testing, including full genome sequencing from the latter two companies. The discussion then transitions to a new topic.
DNA File Comparison and Gene Analysis
00:02:32 - 00:04:51
The discussion begins with a comparison of Ancestry and 23andMe DNA files. The speaker notes that while both files generally agree, some genes appear in one but not the other. For example, the ApoE gene, related to Alzheimer's risk, is present in the 23andMe file but absent from the Ancestry file. The client's family history lacks Alzheimer's, although some age-related degeneration was observed. Conversely, the Sirtuin gene, related to lifespan, is present in the Ancestry file but missing from the 23andMe file. The speaker highlights that the presence or absence of these genes in different reports doesn't indicate conflicting information but rather reflects the different gene panels included in each service. The speaker emphasizes the importance of both services for a comprehensive genetic profile, with 23andMe providing ApoE data and Ancestry providing Sirtuin data. The speaker also mentions that the accuracy of the DNA sequencing is validated by the consistency of non-conflicting information between the two services.
Genetic Predisposition and Dietary Strategies
00:04:58 - 00:06:57
This segment focuses on discussing genetic predispositions, specifically concerning the ApoE gene and its relation to Alzheimer's disease. The conversation begins with a mention of supplements like grape seed extract or resveratrol, used by some to address this gene. The speakers then clarify that while some genetic differences exist between platforms like 23andMe and Ancestry, the core information regarding the sirtuin gene (relevant to brain health) remains consistent. The discussion centers on the ApoE gene, with a strong recommendation to consume high-quality fish oil (DHA) or eat seafood daily to mitigate potential risks. One speaker shares their experience of maintaining low triglycerides despite dietary changes, attributing it to a carnivore diet rich in omega-3s from cod liver oil and high-quality animal products sourced in Austria. The conversation touches upon other Alzheimer's-related genes linked to inflammation and carbohydrate intake, transitioning into a discussion about dietary strategies to manage inflammation, which will be covered later. Intermittent fasting (two meals a day, an 8/16 hour eating window) is mentioned as a key component, aligning with the speaker's recommendation.
Ketone Levels and Health Status
00:06:57 - 00:08:07
The conversation begins with a discussion of high ketone levels in blood and urine. The speaker mentions infrequent ketone monitoring due to a consistent diet. Three-monthly check-ups provide blood and urine measurements. The speaker reports feeling well, attributing it to increased sun exposure and exercise. This is followed by a description of a DNA consultation with a 16-year-old girl suffering from depression, ovarian cysts, and taking multiple prescription drugs (SSRIs like Zoloft). The girl has a sedentary lifestyle, consumes a standard American diet, avoids sun exposure, and sleeps 16 hours daily.
Lifestyle Factors and Health Conditions
00:08:08 - 00:08:43
The importance of sleep quality over quantity is emphasized, suggesting exercise, sun exposure, and dietary changes to improve it. The conversation shifts to another individual with PCOS and IBS, highlighting the challenges faced by those with such conditions and the common practice of doctors prescribing medication for PCOS and diabetes.
IBS Treatment and Dietary Approaches
00:08:44 - 00:09:50
The discussion begins with a critique of the current IBS treatment approach, which involves eliminating individual food items rather than a systematic approach. The speaker advocates for a more comprehensive method of eliminating all foods initially and then gradually reintroducing them. The benefits of removing certain foods from the diet are highlighted, with intermittent fasting mentioned as a positive aspect. The speaker's genetic predisposition to process carbohydrates well is discussed, contrasting with the usual association of "plus-plus" genes with problematic health aspects. The impact of a keto carnivore diet on mental clarity is assessed, with the speaker noting improvement but not a dramatic change.
Keto Carnivore Diet and Inflammation
00:09:50 - 00:10:25
The conversation shifts to the effects of the keto carnivore diet on inflammation. The speaker expresses a somewhat underwhelming reduction in inflammation despite the dietary change, still requiring medication. The speaker mentions having a rare autoimmune disorder, identified as Schnitzler syndrome, which is noted as extremely rare.
Patient's Treatment and Condition
00:10:29 - 00:12:34
The patient discusses their immune suppression medication, noting a reduction in dosage from daily to every other day while maintaining effectiveness. They mention the absence of joint pain, a positive outcome after two years of treatment. The conversation then shifts to the specific medication, an interleukin-1 blocker, which targets cytokines involved in inflammatory responses, similar to those seen in conditions like COVID-19. The patient highlights the drug's rapid symptom relief. The possibility of low testosterone is raised, prompting the patient to consider testing, especially given their weight training. The unusual early onset of the condition at age 25, progressing over six years from minor dermatological issues to more severe symptoms, is discussed, contrasting with the typical onset in people aged 60 and older.
Patient Health Update and Discussion of Treatment
00:12:41 - 00:14:22
The conversation begins with an update on a patient's health. The patient describes experiencing joint pain, fever, and inflammation, symptoms that took several years to diagnose. Their C-reactive protein (CRP) level was initially very high (up to 5) but is now significantly reduced (0.1) after treatment. The discussion then shifts to the patient's daughter, who experienced hives possibly due to a mold infection, and whose CRP level was also elevated (8). The patient's proactive approach to understanding their condition, including researching nutrition and genetics, is highlighted. The patient mentions having anxiety and stress genes, specifically an oxytocin receptor gene. The conversation touches upon the use of oxytocin injections by some individuals for various health benefits, including anti-inflammation and stress reduction, although the practicality and accessibility of this method are acknowledged as challenges. The discussion concludes with a mention of natural ways to increase oxytocin levels, such as consuming dark chocolate.
Natural Ways to Increase Serotonin and Optimize Brain Health
00:14:22 - 00:16:46
This segment focuses on natural methods to boost serotonin levels and overall brain health. The discussion includes the importance of gut health in serotonin production (90% is produced in the gut), highlighting the impact of gut issues on serotonin levels and consequently on learning, motivation, and sleep. The speaker mentions the roles of genes SLC6A4 and TPH2 in serotonin transport and suggests warm showers and saunas as natural ways to improve mood. The conversation then shifts to the impact of sleep on learning and memory, acknowledging the complex relationship between serotonin, sleep, and cognitive function. Anxiety and depression are briefly discussed in relation to serotonin, with the speaker emphasizing the importance of maintaining gut health. Caffeine's potential negative impact on anxiety is noted. Finally, the discussion touches upon lifespan genes (sirtuins), suggesting resveratrol, grape seed supplements, and cyanidins as potential options, along with the importance of zinc for the telomere gene (MNN). The speaker concludes by asking if there are any questions before moving on to the diet section.
Dairy Consumption and its Impact
00:16:52 - 00:18:22
The discussion centers on the impact of dairy consumption, particularly in light of 2++ genes indicating dairy avoidance. One participant mentions periods of dairy-free diets, noting that while butter and cream were generally well-tolerated, cheeses presented more variability. The suggestion is made to experiment with goat cheese. Casein, a dairy protein, is identified as potentially addictive and inflammatory due to its interaction with morphine receptors. However, the quality of dairy is also considered, with a participant highlighting the difference between raw, local dairy products and those from other sources, referencing positive experiences with Austrian dairy.
Location and Language Barriers
00:18:22 - 00:18:54
Speakers discuss the location of a place called "Gaming," noting its remote location west of Vienna in the mountains. The remoteness is highlighted as problematic due to the lack of English speakers. Despite this, the speaker expresses their love for the country and mentions the presence of cows, specifically brown cows, in the area.
Food and Product Differences
00:18:54 - 00:19:19
The conversation shifts to the local dairy products, comparing Gouda cheese from a supermarket to Gouda cheese from a local farm, emphasizing the significant difference in taste. The presence of goats in the area is also mentioned.
Type 2 Diabetes Risk and Lifestyle Factors
00:19:24 - 00:19:47
The discussion turns to type 2 diabetes risk genes, acknowledging that everyone possesses some of these genes. The conversation touches upon low-carb diets, exercise, and intermittent fasting as important factors in mitigating risk. A mention is made of Ancestry's identification of an additional gene related to this risk.
Insulin Resistance and Carb Consumption
00:19:47 - 00:21:28
This segment discusses the impact of PPP1R3A on insulin resistance, particularly within muscles. The speakers note that consuming carbohydrates around workouts, ideally right before, allows muscles to efficiently clear the sugar. Even on a carnivore diet, blood sugar can sometimes rise, suggesting that working out after eating might be beneficial in such cases. One speaker mentions their blood sugar levels typically range from 80 to 90 on a full keto carnivore diet, while others have reported lower levels (50-70). Maintaining blood sugar below 90 is considered ideal. The discussion concludes by highlighting that while the brain functions well with carbs, the body struggles to clear sugar efficiently, potentially impacting muscle performance if insulin resistance is present. The speakers agree that training muscles to burn ketones is a key strategy to mitigate this.
Exercise and Autoimmune Condition
00:21:30 - 00:22:04
The conversation begins with a discussion about the speaker's limited exercise due to an autoimmune condition. The speaker mentions recently feeling better and the other person suggests incorporating exercise to further improve their condition. High ketone levels in the urine are also mentioned, indicating the body isn't burning them efficiently. The suggestion is made to start exercising to address this.
Exercise Recommendations and Genetics
00:22:05 - 00:23:15
The discussion shifts to specific exercise recommendations. Given the speaker's endurance-focused genetic profile, low-impact endurance training like rowing or jogging is suggested as a starting point. The conversation then touches upon the FTO gene, which plays a role in converting white fat to brown fat, and its potential relevance to the speaker's situation. The speaker acknowledges familiarity with the gene but hasn't checked their own status. The importance of brown fat's high mitochondria content is also highlighted.
Metabolism and Cold Showers
00:23:15 - 00:24:18
The discussion centers on the speaker's metabolism and potential reasons for higher ketone levels in their urine. It's suggested that their genes may not efficiently convert white fat to brown fat, leading to fat storage instead of burning. Cold showers or a sauna followed by a cold shower are proposed as a potential remedy to improve metabolism. The speaker mentions the initial discomfort of cold showers but notes adaptation occurs within three days.
Low Metabolism and Heart Disease Risk
00:24:18 - 00:25:04
The speaker expresses concern about a potentially low metabolism, noting stable weight despite a considerable calorie intake. Exercise is suggested as a solution. The conversation then shifts to heart disease risk, specifically mentioning a gene (SOD2) that poses a significantly increased risk only when iron levels are high.
Hemochromatosis and Anemia Discussion
00:25:04 - 00:26:47
The conversation begins with a discussion of hemochromatosis, a genetic condition affecting iron storage. The speaker mentions having genes that predispose to higher iron levels and an autoimmune condition causing chronic anemia. The mild anemia is described as being caused by a different mechanism than the hemochromatosis. The doctor suggests checking iron levels and possibly donating blood periodically. Exercise and testosterone are mentioned as potential ways to improve blood cell count, although high blood cell counts from testosterone can be a concern. The speaker's CRP levels are noted as slightly elevated, likely due to the autoimmune condition, which is considered under control. Finally, the speaker's gut gene profile is reviewed, noting the presence of the CNR1 gene, which doesn't typically cause gut issues but might respond to CBD. However, caution is advised regarding CBD use due to the autoimmune condition.
Discussion on CBD and Gut Health
00:26:56 - 00:28:30
The conversation begins with a discussion about CBD legality in Austria and the speaker's general aversion to substances. The benefits of CBD as an anti-inflammatory are acknowledged, but concerns about introducing unusual compounds, especially with autoimmune conditions, are raised. The discussion shifts to the speaker's gut health, noting a generally healthy gut with some minor genetic predispositions indicated by "plus minuses" in gut gene analysis. The NOD2 gene, responsive to ketones, is highlighted as important, and the speaker's current ketogenic diet is deemed sufficient. The speaker mentions a lack of personal gut issues but notes their mother possibly had IBS. The conversation concludes with a discussion of genes related to white fat and obesity, with the speaker acknowledging a family history of obesity and a similar body type.
Cryotherapy and Cold Exposure for FTO Gene
00:28:30 - 00:29:14
Discussion on managing the FTO gene, focusing on cryotherapy as an effective method but acknowledging the difficulty in accessing affordable cryotherapy centers. Cold showers are suggested as a readily available alternative. The conversation then shifts to a participant's upcoming vacation plans, mentioning potential cold water exposure through swimming in cold lakes or the open sea in Greece.
Vitamin and Hormone Detox Discussion: Iron and Vitamin D Levels
00:29:14 - 00:29:54
The discussion moves to a review of vitamin and hormone levels, specifically focusing on iron and vitamin D. The participant's genetic predisposition for higher iron levels (plus minus) and lower vitamin D levels (multiple positive indicators from 23andMe and Ancestry tests) are noted. The participant confirms prior vitamin D supplementation. Past mild anemia and low ferritin levels (before adopting a carnivore diet) are also discussed.
Addressing Anemia and Ferritin Levels
00:30:08 - 00:31:09
The discussion begins with a patient reporting improvements in anemia after adopting a carnivore diet, particularly after incorporating organ meats like liver. While their iron levels are now good, ferritin levels are rising, causing concern due to the risk of hemochromatosis. The patient notes that liver consumption is a likely contributor to the elevated ferritin. Strategies to lower ferritin, such as reducing liver intake frequency, are discussed. The conversation clarifies that ferritin is an iron transporter, and its fluctuations are normal, but the patient's elevated levels remain a concern given their hemochromatosis.
Vitamin D Supplementation and Results
00:31:09 - 00:31:35
The conversation shifts to vitamin D levels. The patient reveals a previously low vitamin D level (25) which significantly increased to 70 within two months of supplementation with 5000 IU of vitamin D daily. The rapid increase is noted and deemed positive.
Personal Experience with Vitamin D and Genes
00:31:38 - 00:32:22
The speaker discusses their experience with Vitamin D levels, noting a significant drop after stopping supplementation, followed by a return to higher levels with resumed supplementation (2000-3000 IU daily at 60-70% of the recommended dose). They plan to increase sun exposure in the summer, citing the strong sun in Greece as a contributing factor to their genetic predisposition. The conversation then shifts to the importance of continued supplementation, especially during winter. A mention is made of a potential ancestral link to flaxseed avoidance.
Flaxseed Consumption and Phytoestrogens
00:32:22 - 00:33:27
The speaker recounts their past consumption of flax seeds as part of a healthy diet, correlating it with a period of illness. This leads to a discussion about phytoestrogens, with one speaker expressing their belief that they negatively impact the immune system. The other speaker questions this, citing scientific literature that describes estrogen's dual role as both immunostimulative and immunosuppressive, highlighting the apparent contradiction in its effects on the immune system and its behavior during pregnancy.
Hormonal Imbalance and Genetic Predisposition
00:33:27 - 00:35:25
This segment discusses the speaker's hormonal imbalances, specifically focusing on estrogen and testosterone levels. The speaker mentions experiencing various health issues potentially linked to fluctuating estrogen levels, including immune system overreactions. Prior supplement use and diet are also considered as contributing factors. Genetic testing results from both Ancestry and 23andMe are reviewed, revealing a gene for low testosterone and a plus-plus SHBG gene, leading to higher SHBG levels that bind testosterone, rendering it less effective. The speaker's genetic profile shows conflicting genes related to estrogen, with some indicating higher levels and others lower, suggesting a potential balance. The discussion concludes by emphasizing the need to address low testosterone levels as a primary concern, while acknowledging the influence of dietary factors like flax and plant estrogens on estrogen levels.
Concerns about Low Testosterone and Vitamin D Levels
00:35:25 - 00:37:03
The conversation shifts to concerns about low testosterone and vitamin D levels. Participants discuss the dangers of environmental estrogens from sources like plastic bottles. One participant expresses worry about low testosterone levels, suggesting that optimal levels should be above 500, contrasting this with doctors' acceptance of levels as low as 250. The inadequacy of current medical standards is highlighted by comparing current testosterone levels to those in the 1980s, where levels around 500 were common. The discussion then turns to the complexities of testosterone testing and the different forms of testosterone available, including creams and injections. The advantages of bioavailable testosterone cream are emphasized due to its daily application, maintaining consistent levels unlike the fluctuating levels caused by weekly injections. The speakers discuss the preference for cream application to avoid the undesirable effects of fluctuating testosterone levels from injections.
Glutathione Treatment Options and Efficacy
00:37:04 - 00:38:09
Discussion centers on the efficacy of glutathione for Schnitzler syndrome. The speaker considers both cream and injection options, noting a preference for injections despite comfort with injections. Past experiences with various glutathione supplements are shared, including unsuccessful attempts to obtain glutathione injections from doctors. The speaker mentions low glutathione levels indicated by blood tests, possibly related to oxidase deficiency. The other speaker emphasizes the superiority of injections over supplements, acknowledging the slow healing process.
Thyroid Hormone Levels and Dietary Considerations
00:38:09 - 00:39:13
The conversation shifts to thyroid hormone levels and their relation to diet. The speaker reports that thyroid hormone levels are currently within the normal range, both before and after adopting a carnivore diet. The impact of the diet on PSA levels is also mentioned. The discussion includes the speaker's seafood and cod liver oil consumption, highlighting the importance of iodine intake for thyroid health. The other speaker suggests that thyroid optimization might be necessary in the future due to age-related decline.
Bilirubin Levels and Health Concerns
00:39:13 - 00:40:45
This segment focuses on a patient's slightly elevated bilirubin levels. The doctor discusses the patient's genetic predisposition to higher bilirubin, mentioning the presence of two "plus plus" genes that increase bilirubin. While slightly elevated bilirubin isn't necessarily problematic, the doctor expresses concern about excessively high levels, which can lead to gallstones and other health issues, especially when following a ketogenic diet. The doctor recommends increasing sun exposure and potentially taking a daily baby aspirin to manage bilirubin levels. The discussion also touches upon the patient's thyroid problems, retinol levels, and the lack of cannabis use. The exact mechanism by which the patient's genes affect bilirubin production or breakdown is unclear, but the doctor notes that it's an antioxidant and therefore potentially beneficial. The doctor emphasizes the importance of monitoring bilirubin levels to prevent future complications.
Bilirubin Levels and Sun Exposure
00:40:45 - 00:41:25
The conversation begins with a discussion about high bilirubin levels. One participant notes that high bilirubin can be problematic, but they are unsure of the mechanism related to a specific gene. They mention strategies to lower bilirubin. Another participant reveals their high bilirubin level, lacking previous measurements for comparison. The suggestion is made to re-measure bilirubin after spending an hour a day in the sun with their shirt off. If the levels remain high after sun exposure, more active intervention might be necessary, but it's anticipated that sun exposure will resolve the issue.
MTHFR Gene and Methylfolate Supplementation
00:41:26 - 00:42:33
The discussion shifts to the MTHFR gene and its implications. One participant mentions having several "bad genes," including MTHFR. The importance of methylfolate supplementation, particularly for sleep and mood, is highlighted. While some on the carnivore diet may not supplement, it's suggested that methylfolate supplementation is beneficial. A participant shares their experience with methylfolate supplementation on a carnivore diet, noting initial low levels that improved to mid-to-high levels with supplementation, after which supplementation was stopped. The benefits of methylfolate as a DNA precursor, crucial for immune cell function and turnover, are emphasized.
Dietary Considerations and Supplement Use
00:42:33 - 00:44:19
The discussion centers on the importance of sufficient methylfolate, especially when the immune system is suppressed, due to the high DNA demand of regenerating cells. One participant mentions their diet includes eggs and liver, providing some methylfolate, but acknowledges a lack of leafy greens, the richest source. They also mention supplementing to maintain high levels. Vitamin E is deemed not a concern as supplements aren't used. Fructose consumption is also discussed; both participants report low intake, contrasting it with the high fructose corn syrup prevalent in processed US foods. The conversation concludes by identifying fructose and omega-6 fatty acids as major dietary culprits contributing to health issues like obesity, regardless of specific diet plans. Genetic variations in sugar metabolism are acknowledged, and the discussion transitions to the next topic.
Gene Variations and Endurance
00:44:33 - 00:45:12
The speakers discuss slight variations in genetic information provided by 23andMe and Ancestry, noting that both platforms indicate a rare endurance gene, BDKRB2 (bradykinin), which is prevalent in Olympic endurance athletes. One speaker expresses skepticism about the health benefits of marathons.
Marathon Running and Heart Health
00:45:12 - 00:46:02
A discussion ensues regarding the potential heart damage associated with marathon running. The speakers acknowledge that intense, prolonged exertion during marathons can lead to increased troponin I levels and potential heart damage. However, they also suggest that gradually increasing training intensity over time can mitigate these risks. One speaker expresses concern that marathon running is not an ancestral activity.
Hunting vs. Marathon Running: A Comparison
00:46:03 - 00:46:58
The conversation shifts to a comparison between hunting and marathon running. One speaker argues that hunting, particularly bow hunting, requires significantly more exertion and physical demands than marathon running. An anecdote is shared about a marathon-running doctor who found a single day of bow hunting far more strenuous than a marathon.
Hunting and Exercise Regimen
00:46:58 - 00:48:44
The conversation begins with a discussion of the speaker's hunting experiences in western Minnesota, characterized by intense walking and occasional running through snowy grasslands. The speaker mentions the legal requirements for hunting and contrasts modern hunting methods with those of Paleolithic humans, who relied on intimidation, traps, and stone-throwing rather than pursuit. The discussion then shifts to the speaker's personal exercise regimen and the influence of genetics. It's noted that while the speaker possesses endurance genes suggesting a predisposition for endurance training, their autoimmune condition necessitates a cautious approach to exercise. The speaker's advice generally favors heavy lifting for most individuals, but recommends endurance training for a significant minority (20%), particularly those with genetic predispositions like the speaker. The benefits of endurance training, such as improved metabolism, blood flow, and inflammation reduction, are highlighted, but the speaker emphasizes that this is a suggestion, not a requirement.
Joint Health and Risk Factors
00:48:44 - 00:50:36
The discussion centers on joint health risks, specifically concerning interleukin and the DIO2 gene. The speaker notes that interleukin inhibitors and a healthy diet mitigate interleukin-related risks. The DIO2 gene is highlighted as a concern, as its impact increases with age, potentially leading to osteoarthritis due to declining thyroid hormones. The cost-effectiveness of thyroid hormone supplementation ($30/month) compared to knee replacement surgery ($20,000) is emphasized as a preventative measure for joint health. The conversation then shifts to the patient's grandfather, who had past health issues, and the importance of blood flow and movement for overall health. Gout is briefly discussed, deemed less of a concern due to the patient's diet, although high uric acid levels are noted, potentially linked to a period of inactivity.
High Uric Acid and Ketone Levels
00:50:36 - 00:51:31
The conversation begins with a discussion about high uric acid levels (12, exceeding the limit of 7) despite a lack of symptoms. The speaker suggests that the high ketone levels, possibly due to poor carb metabolism, might be contributing to the elevated uric acid. Exercise is proposed as a solution. The speaker also mentions other potential factors, including organ function (particularly the liver) and high ketone production without sufficient burning. The speaker's good spinal health is noted, contrasting with a brother's experience of a split disc after gym workouts.
Pain Sensitivity and Genetic Testing
00:51:32 - 00:52:33
The discussion shifts to pain sensitivity. The speaker mentions the complexities of pain perception, highlighting the yin-yang aspect of high and low pain sensitivity. The speaker points out an interesting discrepancy between genetic testing results (23andMe showing only the high pain sensitivity gene) and the individual's actual experience. The speaker concludes that the individual likely has lower pain sensitivity than initially suggested by the genetic test alone, emphasizing the difficulty in accurately assessing pain sensitivity.
Sleep Patterns and Quality
00:52:33 - 00:54:32
The conversation shifts to the topic of sleep patterns and quality. One participant mentions that their sleep section data isn't too bad, and they are generally a morning person, although they haven't consistently tried waking up early. Another participant discusses their sleep habits, noting consistency but also a history of sleeping from 2 AM to 10 AM. They now wake up earlier and feel better, considering maintaining a 5:30 AM or 6 AM wake-up time. The discussion touches upon genetics and sleep, mentioning a specific gene (WWC1 1++) that affects memory recall based on sleep quality. One participant emphasizes the importance of at least 8 hours of sleep for overall well-being and managing autoimmune issues, noting that sleep was crucial in reducing symptoms before medication. They currently fall asleep quickly and sleep well. The use of a sleep tracker, such as the Aura ring, is suggested to further improve sleep quality and identify patterns. Finally, one participant mentions working better at night.
Addressing Sleep Issues and Lifestyle Factors
00:54:32 - 00:56:22
The conversation shifts to the individual's sleep problems, particularly the difficulty of working in the afternoon and evening due to high concentration levels leading to late nights. The impact of blue light and overthinking are mentioned as contributing factors. However, the speaker is reassured that their sleep genes are good, and the focus should be on other lifestyle aspects. Scheduling more time for relaxation during vacation is suggested, along with cold showers in the morning. A question arises about the "worst" gene impacting sleep, with the response being that it's the one causing the most significant problems, possibly vitamin D or testosterone, given the individual's past avoidance of sunlight and late sleep schedule (between 2 and 4 AM). The overall progress made is highlighted, emphasizing the positive changes from previously avoiding sunlight and consistently sleeping very late.
Lifestyle Changes and Health Challenges
00:56:22 - 00:57:15
The conversation centers on the speaker's health journey, focusing on diet (seeds), sun exposure, sleep, and exercise. The speaker mentions making small changes and conducting further tests related to testosterone. The difficulty of maintaining a healthy lifestyle is highlighted, with the speaker noting the challenges of encouraging friends to prioritize their health, emphasizing that people often only take action when facing serious health issues.
Challenges in Health Communication and Prevention
00:57:16 - 00:58:03
The discussion shifts to the difficulties of communicating health advice to others. The speaker shares an anecdote about a friend with IBS and PCOS who ignored their advice, leading to the conclusion that individual conversations are often ineffective. As a result, the speaker is using YouTube to reach a wider audience. The conversation concludes with a reflection on the preventative nature of healthy habits and the regret of not prioritizing health earlier.
Closing Remarks and Appreciation
00:58:04 - 00:59:34
The conversation concludes with mutual appreciation and well wishes. One participant expresses gratitude for the other's work and mentions the value of their information for people with autoimmune issues and those interested in comparing 23andMe and Ancestry DNA results. The speakers acknowledge the helpfulness of the interview and its potential reach. The conversation ends with pleasantries and goodbyes, noting the time difference and wishing each other a good evening.